Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0041 | 0.0041 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0041 | 0.0041 |
Onchocerca volvulus | 0.007 | 0.1297 | 1 | |
Schistosoma mansoni | acetylcholinesterase | 0.007 | 0.1297 | 0.1297 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1297 | 0.1297 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0432 | 0.0432 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.007 | 0.1297 | 0.1297 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.007 | 0.1297 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.007 | 0.1297 | 0.1297 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0041 | 0.0041 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1297 | 0.1297 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0041 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.007 | 0.1297 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Carboxylesterase family protein | 0.0413 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1297 | 0.1297 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.007 | 0.1297 | 0.1297 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0041 | 0.0041 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.007 | 0.1297 | 0.1297 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.007 | 0.1297 | 0.1297 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.007 | 0.1297 | 0.1297 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0041 | 0.0041 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.2771 | 0.2771 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.007 | 0.1297 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0041 | 0.0041 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0432 | 0.0432 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.007 | 0.1297 | 0.1297 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.007 | 0.1297 | 1 |
Onchocerca volvulus | 0.007 | 0.1297 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1297 | 0.1297 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0041 | 0.0041 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.007 | 0.1297 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | acetylcholinesterase | 0.0413 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0432 | 1 |
Onchocerca volvulus | 0.007 | 0.1297 | 1 | |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.002 | 0.0041 | 0.0041 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0432 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0041 | 0.0041 |
Echinococcus granulosus | neuroligin | 0.007 | 0.1297 | 0.1297 |
Loa Loa (eye worm) | carboxylesterase | 0.007 | 0.1297 | 0.1297 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0041 | 0.0041 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.007 | 0.1297 | 0.1297 |
Brugia malayi | Carboxylesterase family protein | 0.007 | 0.1297 | 0.1297 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0041 | 0.0041 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0432 | 0.0432 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1297 | 0.1297 |
Echinococcus multilocularis | acetylcholinesterase | 0.0413 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0432 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0413 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0413 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | gliotactin | 0.007 | 0.1297 | 0.1297 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0041 | 0.0041 |
Onchocerca volvulus | 0.007 | 0.1297 | 1 | |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0302 | 0.719 | 0.719 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | neuroligin | 0.007 | 0.1297 | 0.1297 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0041 | 0.0041 |
Onchocerca volvulus | 0.007 | 0.1297 | 1 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.007 | 0.1297 | 0.1297 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.007 | 0.1297 | 0.1297 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0041 | 0.0041 |
Echinococcus granulosus | BC026374 protein S09 family | 0.007 | 0.1297 | 0.1297 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1297 | 0.1297 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1147 | 0.1147 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0041 | 0.0041 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | carboxylesterase | 0.007 | 0.1297 | 0.1297 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0432 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1297 | 0.1297 |
Echinococcus granulosus | acetylcholinesterase | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.5565 | 0.5565 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0041 | 0.0041 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0041 | 0.0041 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.011 | 0.2321 | 0.2321 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.007 | 0.1297 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.007 | 0.1297 | 0.1297 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.007 | 0.1297 | 0.1297 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0041 | 0.0041 |
Brugia malayi | hypothetical protein | 0.007 | 0.1297 | 0.1297 |
Brugia malayi | Carboxylesterase family protein | 0.007 | 0.1297 | 0.1297 |
Loa Loa (eye worm) | carboxylesterase | 0.0413 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 2 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 3.94 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.83 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 5.14 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 9 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 95 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 97 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 4.85 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 9 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 95 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 97 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.38 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.41892 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.