Detailed information for compound 59484

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.438 | Formula: C24H23N2NaO7
  • H donors: 0 H acceptors: 5 LogP: 3.01 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OCCN([C@@H]1CCC(=O)N1[C@@H](Cc2c1cccc2)C(=O)[O-])C(=O)OCc1ccccc1.[Na+]
  • InChi: 1S/C24H24N2O7.Na/c27-21(26-18-9-5-4-8-17(18)14-20(26)22(28)29)11-10-19-23(30)32-13-12-25(19)24(31)33-15-16-6-2-1-3-7-16;/h1-9,19-20H,10-15H2,(H,28,29);/q;+1/p-1/t19-,20+;/m1./s1
  • InChiKey: WKMRDOSVSJSXMC-FDOHDBATSA-M  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Angiotensin-converting enzyme Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Angiotensin-converting enzyme family protein Get druggable targets OG5_131988 All targets in OG5_131988
Loa Loa (eye worm) angiotensin-converting enzyme family protein Get druggable targets OG5_131988 All targets in OG5_131988

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0952 0.7152 1
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0662 0.1258
Onchocerca volvulus 0.0057 0.0332 0.1462
Onchocerca volvulus 0.0018 0.0037 0.0163
Echinococcus multilocularis dna polymerase kappa 0.002 0.0047 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0064 0.0115
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0149 0.0648
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0214 0.0383
Loa Loa (eye worm) hypothetical protein 0.0125 0.0849 0.1516
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0037 0.006
Loa Loa (eye worm) fatty acid synthase 0.0028 0.0112 0.0199
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0094 0.0074
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0149 0.0648
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0019 0.0038 0.0138
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0147 0.0236
Loa Loa (eye worm) hypothetical protein 0.0312 0.227 0.4054
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0662 0.1067
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0037 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0214 0.0383
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0149 0.0648
Trypanosoma brucei heat shock protein, putative 0.0033 0.0149 0.0648
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0214 0.0383
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0214 0.0383
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Toxoplasma gondii hypothetical protein 0.0051 0.0284 0.1036
Loa Loa (eye worm) notch protein 0.0018 0.0037 0.0066
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0047 0.0083
Giardia lamblia DINP protein human, muc B family 0.002 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0052 0.0031
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0046 0.0083
Schistosoma mansoni hypothetical protein 0.0018 0.0037 0.0071
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0046 0.0088
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0098 0.0186
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1326 1 1
Trichomonas vaginalis heat shock protein, putative 0.002 0.0052 0.0231
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0046 0.0075
Echinococcus granulosus geminin 0.0506 0.3753 0.7132
Loa Loa (eye worm) endoplasmin 0.0033 0.0149 0.0266
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Echinococcus granulosus protein jagged 1 0.0018 0.0037 0.0071
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0235 0.102
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0202
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0149 0.0648
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0202
Schistosoma mansoni hypothetical protein 0.0042 0.0213 0.0405
Brugia malayi MH2 domain containing protein 0.0122 0.0825 0.1473
Brugia malayi hypothetical protein 0.0125 0.0849 0.1516
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0214 0.0346
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0028 0.0108 0.0123
Plasmodium falciparum endoplasmin, putative 0.002 0.0052 0.345
Onchocerca volvulus 0.0027 0.01 0.0441
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0047 0.0209
Treponema pallidum fructose-bisphosphate aldolase 0.0306 0.2224 0.2147
Trichomonas vaginalis endoplasmin, putative 0.002 0.0052 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0214 0.0383
Leishmania major hypothetical protein, conserved 0.0026 0.0092 0.0402
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0214 0.0383
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0047 0.0088
Echinococcus multilocularis peroxidasin 0.0057 0.0332 0.0535
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0147 0.0237
Brugia malayi EGF-like domain containing protein 0.0018 0.0037 0.0066
Giardia lamblia Fructose-bisphosphate aldolase 0.0306 0.2224 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0214 0.0383
Schistosoma mansoni hypothetical protein 0.0018 0.0037 0.0071
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0147 0.0263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0214 0.0383
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Brugia malayi ecdysteroid receptor 0.0042 0.0214 0.0383
Loa Loa (eye worm) hypothetical protein 0.0042 0.0214 0.0383
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0098 0.0439
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0225 0.0428
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0046 0.0088
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0064 0.0115
Echinococcus multilocularis neural cadherin 0.0018 0.0037 0.006
Echinococcus multilocularis fibropellin Ia 0.0018 0.0037 0.006
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Echinococcus granulosus neurogenic locus notch protein 4 0.0018 0.0037 0.0071
Leishmania major mitochondrial DNA polymerase beta 0.0316 0.2302 1
Onchocerca volvulus Dual oxidase homolog 0.0057 0.0332 0.1462
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0332 0.0592
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0147 0.0639
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0214 0.0383
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1035 0.4496
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0149 0.0671
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0094 0.0074
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0662 0.1182
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0149 0.0671
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.0279
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0225 0.0402
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Echinococcus granulosus delta-like protein 1 0.0018 0.0037 0.0071
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0674 0.128
Echinococcus multilocularis heat shock protein 90 0.0026 0.0098 0.0158
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Loa Loa (eye worm) hypothetical protein 0.0026 0.0092 0.0165
Schistosoma mansoni hypothetical protein 0.0294 0.2136 0.406
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.0279
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0149 0.0648
Echinococcus granulosus fibropellin Ia 0.0018 0.0037 0.0071
Loa Loa (eye worm) blistered cuticle protein 3 0.0057 0.0332 0.0592
Mycobacterium ulcerans polyketide synthase 0.0028 0.0108 0.0088
Onchocerca volvulus Peroxidase homolog 0.0057 0.0332 0.1462
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0374 0.2745 0.382
Echinococcus multilocularis microtubule associated protein 2 0.0704 0.5261 0.8485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0214 0.0383
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0028 0.0108 0.0123
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0214 0.0407
Echinococcus granulosus neural cadherin 0.0018 0.0037 0.0071
Schistosoma mansoni nuclear hormone receptor 0.002 0.0046 0.0088
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.0108 0.0088
Trypanosoma brucei heat shock protein, putative 0.0033 0.0149 0.0648
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0214 0.0407
Brugia malayi notch-like transmembrane receptor 0.0018 0.0037 0.0066
Brugia malayi nuclear receptor NHR-88 0.002 0.0046 0.0083
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Brugia malayi heat shock protein 90 0.0033 0.0149 0.0266
Trypanosoma brucei heat shock protein, putative 0.0033 0.0149 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0214 0.0383
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0147 0.0639
Schistosoma mansoni septate junction protein 0.0018 0.0037 0.0071
Brugia malayi EGF-like domain containing protein 0.0018 0.0037 0.0066
Echinococcus multilocularis protein jagged 2 0.0018 0.0037 0.006
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Brugia malayi Angiotensin-converting enzyme family protein 0.0749 0.56 1
Brugia malayi Endoplasmin precursor 0.0033 0.0149 0.0266
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0047 0.0202
Plasmodium vivax endoplasmin, putative 0.0033 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0147 0.0262
Trypanosoma brucei unspecified product 0.002 0.0047 0.0202
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.0332 0.0592
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0064 0.0115
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0047 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2224 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0214 0.0383
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0046 0.0075
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0094 0.0104
Echinococcus multilocularis X box binding protein 1 0.0294 0.2136 0.3445
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0214 0.0944
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0047 0.0202
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0147 0.0639
Loa Loa (eye worm) hypothetical protein 0.01 0.0662 0.1182
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0332 0.0592
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2224 1
Echinococcus granulosus neurogenic locus protein delta 0.0018 0.0037 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Echinococcus granulosus heat shock protein 0.0033 0.0149 0.0283
Loa Loa (eye worm) hypothetical protein 0.0022 0.0064 0.0115
Loa Loa (eye worm) hypothetical protein 0.0125 0.0849 0.1516
Loa Loa (eye worm) hypothetical protein 0.0042 0.0214 0.0383
Onchocerca volvulus Peroxidase homolog 0.0057 0.0332 0.1462
Onchocerca volvulus 0.002 0.0046 0.0204
Schistosoma mansoni microtubule-associated protein tau 0.0704 0.5261 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0092 0.0402
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2224 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0064 0.0115
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0214 0.0383
Brugia malayi nuclear hormone receptor 0.002 0.0046 0.0083
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0047 0.0088
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.1034 0.1421
Brugia malayi Delta serrate ligand family protein 0.0018 0.0037 0.0066
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.004 0.0202 0.0255
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0202
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Echinococcus multilocularis fat cadherin tumor suppressor 0.0018 0.0037 0.006
Schistosoma mansoni patched 1 0.0043 0.0225 0.0428
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0046 0.0088
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0037 0.0066
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0047 0.0026
Schistosoma mansoni hypothetical protein 0.0018 0.0037 0.0071
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0149 0.0648
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0214 0.0407
Loa Loa (eye worm) hypothetical protein 0.0043 0.0225 0.0402
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0225 0.0428
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0149 0.0648
Echinococcus granulosus X box binding protein 1 0.0294 0.2136 0.406
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0024 0.0078 0.0081
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Onchocerca volvulus Neurogenic locus notch homolog 0.0018 0.0037 0.0163
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0147 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Schistosoma mansoni coup transcription factor 0.0042 0.0214 0.0407
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0214 0.0407
Brugia malayi hypothetical protein 0.0312 0.227 0.4054
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0094 0.0168
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0332 0.0592
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0214 0.0383
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0149 0.0266
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.1035 0.4496
Echinococcus multilocularis slit 2 protein 0.0018 0.0037 0.006
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0047 0.0075
Brugia malayi CHE-14 protein 0.0043 0.0225 0.0402
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0149 0.0648
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0108 0.0123
Brugia malayi Peroxidasin 0.0057 0.0332 0.0592
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0046 0.0075
Loa Loa (eye worm) hypothetical protein 0.0052 0.0296 0.0529
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0214 0.0944
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0147 0.0279
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0108 0.0088
Brugia malayi steroid hormone receptor 0.0042 0.0214 0.0383
Onchocerca volvulus Huntingtin homolog 0.0125 0.0849 0.374
Onchocerca volvulus 0.0018 0.0037 0.0163
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0225 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0202
Onchocerca volvulus Slit protein homolog 0.0018 0.0037 0.0163
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0094 0.0104
Onchocerca volvulus 0.0057 0.0332 0.1462
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0098 0.0108
Echinococcus multilocularis expressed conserved protein 0.0094 0.0616 0.0993
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0149 0.0543
Echinococcus granulosus protein jagged 1 0.0018 0.0037 0.0071
Brugia malayi ecdysone receptor 0.002 0.0046 0.0083
Onchocerca volvulus Peroxidasin homolog 0.0057 0.0332 0.1462
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0021 0.0055 0.0048
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.0037 0.006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0828 0.6201 1
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0046 0.0083
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0052 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0214 0.0407
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Loa Loa (eye worm) hypothetical protein 0.0042 0.0214 0.0383
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0092 0.0337
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0214 0.0407
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0046 0.0083
Mycobacterium ulcerans polyketide synthase 0.0026 0.0094 0.0074
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1326 1 1
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0149 0.0671
Brugia malayi hypothetical protein 0.0022 0.0064 0.0115
Echinococcus multilocularis protein dispatched 1 0.0049 0.0271 0.0438
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0214 0.0346
Plasmodium falciparum heat shock protein 90 0.0033 0.0149 1
Loa Loa (eye worm) Notch2 0.0018 0.0037 0.0066
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0214 0.0407
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0046 0.0083
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0214 0.0407
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0046 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0214 0.0383
Echinococcus granulosus protein jagged 2 0.0018 0.0037 0.0071
Brugia malayi Pax transcription factor protein 2 0.0255 0.1842 0.329
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Loa Loa (eye worm) hypothetical protein 0.0071 0.0437 0.078
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0214 0.0383
Leishmania major DNA polymerase kappa, putative 0.002 0.0047 0.0202
Echinococcus granulosus slit 2 protein 0.0018 0.0037 0.0071
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0374 0.2745 0.273
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0332 0.0592
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0825 0.1473
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.2302 1
Brugia malayi Cadherin domain containing protein 0.0018 0.0037 0.0066
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0028 0.0108 0.0123
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0046 0.0088
Brugia malayi hypothetical protein 0.0017 0.0023 0.0041
Echinococcus multilocularis protein jagged 1 0.0018 0.0037 0.006
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0214 0.0944
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0094 0.0074
Schistosoma mansoni hypothetical protein 0.0018 0.0037 0.0071
Trypanosoma brucei heat shock protein, putative 0.0033 0.0149 0.0648
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0749 0.56 1
Schistosoma mansoni peroxidasin 0.0057 0.0332 0.0631
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0147 0.0279
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0094 0.0104
Onchocerca volvulus 0.0052 0.0296 0.1305
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0214 0.0407
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0047 0.0202
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0037 0.0071
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0047 0.0202
Schistosoma mansoni nuclear receptor 0.002 0.0046 0.0088
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0027 0.01 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0202
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0214 0.0407
Brugia malayi hypothetical protein 0.002 0.0046 0.0083
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0047 0.0088
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0214 0.0346
Schistosoma mansoni hypothetical protein 0.0042 0.0213 0.0405
Brugia malayi Cadherin domain containing protein 0.0018 0.0037 0.0066
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0147 0.0262
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.0279
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0147 0.0262
Echinococcus multilocularis endoplasmin 0.0026 0.0098 0.0158
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Brugia malayi Nuclear hormone receptor E75 0.002 0.0046 0.0083
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.1163 0.1603
Mycobacterium leprae Polyketide synthase Pks13 0.004 0.0202 0.0255
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.099 0.1597
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0235 0.102
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0202
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0028 0.0108 0.0123
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0047 0.0209
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0147 0.0279
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1326 1 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0052 0.0031
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0046 0.0204
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2224 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0149 0.0648
Schistosoma mansoni heat shock protein 0.0033 0.0149 0.0283
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0149 1
Brugia malayi Nuclear hormone receptor E75 0.002 0.0046 0.0083
Onchocerca volvulus 0.0018 0.0037 0.0163
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Onchocerca volvulus 0.0018 0.0037 0.0163
Schistosoma mansoni notch 0.0018 0.0037 0.0071
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0046 0.0088
Brugia malayi hypothetical protein 0.002 0.0046 0.0083
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0147 0.0639
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0092 0.6197
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0064 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0214 0.0383
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.0332 0.0592
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2224 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0214 0.0383
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0047 0.0202
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0147 0.0279
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0296 0.0563
Echinococcus multilocularis protein jagged 1 0.0018 0.0037 0.006
Onchocerca volvulus 0.002 0.0046 0.0204
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0037 0.0066
Echinococcus granulosus heat shock protein 90 0.0026 0.0098 0.0186
Mycobacterium ulcerans hypothetical protein 0.0166 0.1163 0.1145
Onchocerca volvulus Chorion peroxidase homolog 0.0057 0.0332 0.1462
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.099 0.1882
Brugia malayi EGF-like domain containing protein 0.0018 0.0037 0.0066
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.0332 0.0592
Brugia malayi Blistered cuticle protein 3 0.0057 0.0332 0.0592
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Loa Loa (eye worm) hypothetical protein 0.0042 0.0214 0.0383
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0018 0.0037 0.0163
Schistosoma mansoni notch 0.0018 0.0037 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0214 0.0383
Onchocerca volvulus 0.0255 0.1842 0.8116
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Trypanosoma brucei heat shock protein, putative 0.0033 0.0149 0.0648
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0214 0.0346
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0098 0.0108
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0046 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0202
Loa Loa (eye worm) hypothetical protein 0.0053 0.0299 0.0534
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0052 0.0188
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0047 0.0202
Echinococcus multilocularis notch 0.0018 0.0037 0.006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0214 0.0346
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0046 0.0088
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0046 0.0083
Echinococcus multilocularis dna polymerase eta 0.002 0.0047 0.0075
Loa Loa (eye worm) hypothetical protein 0.0022 0.0064 0.0115
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0094 0.0104
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Mycobacterium tuberculosis Polyketide synthase Pks13 0.004 0.0202 0.0255
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0147 0.0237
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0214 0.0407
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0108 0.0393
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.2224 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0092 0.0402
Schistosoma mansoni hypothetical protein 0.0018 0.0037 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0202
Schistosoma mansoni nuclear receptor 0.002 0.0046 0.0088
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0149 0.0543
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0018 0.0037 0.0066
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0064 0.0122
Echinococcus multilocularis heat shock protein 0.0033 0.0149 0.0241
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0687 0.1227
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0098 0.0439
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0046 0.0088
Echinococcus multilocularis neurogenic locus notch protein 4 0.0018 0.0037 0.006
Schistosoma mansoni slit 0.0018 0.0037 0.0071
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0028 0.0108 0.0123
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0147 0.0237
Schistosoma mansoni notch 0.0018 0.0037 0.0071
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.1034 0.1015
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0214 0.0383
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0018 0.0037 0.0071
Mycobacterium leprae Probable polyketide synthase Pks1 0.0028 0.0108 0.0123
Echinococcus granulosus dna polymerase kappa 0.002 0.0047 0.0088
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0021 0.0053 0.0046
Echinococcus multilocularis protein patched 0.0043 0.0225 0.0363
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0098 0.0424
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0046 0.0083
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0098 0.0439
Schistosoma mansoni cell polarity protein 0.0018 0.0037 0.0071
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0214 0.0346
Echinococcus granulosus dna polymerase eta 0.002 0.0047 0.0088
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0332 0.0592
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0214 0.0346
Echinococcus multilocularis GPCR, family 2 0.0033 0.0147 0.0236
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0309 0.1341
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0046 0.0204
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Onchocerca volvulus 0.0312 0.227 1
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0098 0.0424
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.2302 1
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0098 0.0077
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.0279
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0047 0.0026
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0052 0.029 0.0517
Schistosoma mansoni zinc finger protein 0.002 0.0046 0.0088
Mycobacterium ulcerans thioesterase 0.0024 0.0078 0.0058
Leishmania major DNA polymerase eta, putative 0.002 0.0047 0.0202
Trypanosoma brucei heat shock protein, putative 0.0033 0.0149 0.0648
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0825 0.1473
Brugia malayi nuclear receptor RXR 0.002 0.0046 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2224 1
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0046 0.0198
Giardia lamblia Grp94/Hsp90 0.0026 0.0098 0.0277
Schistosoma mansoni notch 0.0018 0.0037 0.0071
Schistosoma mansoni hypothetical protein 0.0042 0.0213 0.0405
Loa Loa (eye worm) hypothetical protein 0.0104 0.0687 0.1227
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0083
Schistosoma mansoni hypothetical protein 0.0506 0.3753 0.7132
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0047 0.0037
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0092 0.0402
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0214 0.0407
Mycobacterium ulcerans thioesterase TesA 0.0024 0.0078 0.0058
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.1034 0.1421
Brugia malayi nuclear receptor NHR-67 0.002 0.0046 0.0083
Loa Loa (eye worm) hypothetical protein 0.0042 0.0214 0.0383
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0952 0.7152 1
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0094 0.0104
Brugia malayi nuclear hormone receptor 0.0042 0.0214 0.0383
Brugia malayi hypothetical protein 0.0026 0.0092 0.0165
Brugia malayi isocitrate dehydrogenase 0.0033 0.0147 0.0263
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Brugia malayi Muscle positioning protein 4 0.0018 0.0037 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0202
Schistosoma mansoni hypothetical protein 0.0042 0.0213 0.0405
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0687 0.1227
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0092 0.6197
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0047 0.0202
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0147 0.0639
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0214 0.0407
Echinococcus granulosus peroxidasin 0.0057 0.0332 0.0631
Brugia malayi EGF-like domain containing protein 0.0018 0.0037 0.0066
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0147 0.0536
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0225 0.1011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Schistosoma mansoni heat shock protein 0.0033 0.0149 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0214 0.0383
Schistosoma mansoni notch 0.0018 0.0037 0.0071
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0046 0.0075
Brugia malayi tailless protein 0.002 0.0046 0.0083
Brugia malayi GCC2 and GCC3 family protein 0.0018 0.0037 0.0066
Brugia malayi nuclear receptor RXR 0.0022 0.0064 0.0115
Echinococcus granulosus notch 0.0018 0.0037 0.0071
Mycobacterium ulcerans polyketide synthase Pks13 0.004 0.0202 0.0182
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0214 0.0407
Schistosoma mansoni laminin gamma-3 chain 0.0018 0.0037 0.0071
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0092 0.6197
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0147 0.0237
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0147 0.9857
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0214 0.0407
Loa Loa (eye worm) hypothetical protein 0.0022 0.0064 0.0115
Echinococcus granulosus microtubule associated protein 2 0.0704 0.5261 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0047 0.0202
Onchocerca volvulus 0.0057 0.0332 0.1462
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0214 0.0407
Toxoplasma gondii EGF family domain-containing protein 0.0018 0.0037 0.0135
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0007 0.0024
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0037 0.0066
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648
Loa Loa (eye worm) hypothetical protein 0.0042 0.0214 0.0383
Loa Loa (eye worm) hypothetical protein 0.0042 0.0214 0.0383
Schistosoma mansoni hypothetical protein 0.0018 0.0037 0.0071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0214 0.0407
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0662 0.2976
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.0332 0.0592
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0147 0.9857
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0028 0.0108 0.0123
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.2224 1
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0214 0.0383
Trypanosoma brucei heat shock protein, putative 0.0033 0.0149 0.0648
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0214 0.0346
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0046 0.0075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0064 0.0122
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0235 0.102
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0147 0.0263
Onchocerca volvulus 0.0042 0.0214 0.0944
Brugia malayi AMP-binding enzyme family protein 0.0027 0.01 0.0179
Echinococcus granulosus expressed conserved protein 0.0094 0.0616 0.117
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0235 0.102
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0098 0.0424
Onchocerca volvulus Putative cubilin 0.0018 0.0037 0.0163
Brugia malayi hypothetical protein 0.0057 0.0332 0.0592
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0098 0.0277
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0147 0.0177
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0094 0.0074
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0149 0.0512
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0214 0.0407
Echinococcus granulosus endoplasmin 0.0026 0.0098 0.0186
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0046 0.0088
Loa Loa (eye worm) DR-78 0.002 0.0046 0.0083
Echinococcus granulosus protein jagged 2 0.0018 0.0037 0.0071
Schistosoma mansoni hypothetical protein 0.0071 0.0437 0.083
Echinococcus multilocularis geminin 0.0506 0.3753 0.6052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0214 0.0346
Echinococcus granulosus tumor protein p63 0.0359 0.2628 0.4995
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0047 0.0083
Schistosoma mansoni DNA polymerase eta 0.002 0.0047 0.0088
Loa Loa (eye worm) hypothetical protein 0.0057 0.0332 0.0592
Brugia malayi EGF-like domain containing protein 0.0018 0.0037 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Schistosoma mansoni peroxidasin 0.0057 0.0332 0.0631
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0374 0.2745 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0147 0.0236
Onchocerca volvulus Huntingtin homolog 0.0125 0.0849 0.374
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0214 0.0407
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0147 0.0536
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0147 0.0262
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0046 0.0075
Echinococcus granulosus GPCR family 2 0.0033 0.0147 0.0279
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.0037 0.006
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0047 0.0037
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0214 0.0407
Echinococcus multilocularis heat shock protein 90 0.0033 0.0149 0.0241
Schistosoma mansoni hypothetical protein 0.0018 0.0037 0.0071
Onchocerca volvulus 0.0018 0.0037 0.0163
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0037 0.0071
Echinococcus granulosus heat shock protein 90 0.0033 0.0149 0.0283
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Loa Loa (eye worm) hypothetical protein 0.0042 0.0214 0.0383
Schistosoma mansoni nuclear hormone receptor 0.002 0.0046 0.0088
Echinococcus multilocularis tumor protein p63 0.0359 0.2628 0.4239
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0214 0.0383
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0687 0.1227
Brugia malayi EGF-like domain containing protein 0.0018 0.0037 0.0066
Schistosoma mansoni notch 0.0018 0.0037 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0083
Loa Loa (eye worm) pax transcription factor protein 2 0.0255 0.1842 0.329
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0316 0.2302 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0024 0.0078 0.0081
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0064 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0202
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0047 0.0202
Brugia malayi EGF-like domain containing protein 0.0018 0.0037 0.0066
Schistosoma mansoni hypothetical protein 0.0506 0.3753 0.7132
Schistosoma mansoni endoplasmin 0.0033 0.0149 0.0283
Onchocerca volvulus 0.005 0.0276 0.1216
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0214 0.0383
Onchocerca volvulus Peroxidasin homolog 0.0057 0.0332 0.1462
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2224 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0066
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0437 0.078
Brugia malayi hypothetical protein 0.0022 0.0064 0.0115
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1035 0.4496
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0027 0.01 0.0112
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0214 0.0407
Onchocerca volvulus Fatty acid synthase homolog 0.0052 0.029 0.1276
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0064 0.0115
Brugia malayi conserved hypotetical protein 0.002 0.0046 0.0083
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0047 0.0209
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0433
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.2224 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0047 0.0083
Schistosoma mansoni endoplasmin 0.0033 0.0149 0.0283
Brugia malayi nuclear receptor NHR-88 0.0042 0.0214 0.0383
Leishmania major heat shock protein 83-1 0.0033 0.0149 0.0648

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 52 nM In vitro inhibition of angiotensin I converting enzyme from rabbit lung ChEMBL. 2999395
IC50 (binding) = 52 nM In vitro inhibition of angiotensin I converting enzyme from rabbit lung ChEMBL. 2999395

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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