Detailed information for compound 595227

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 233.692 | Formula: C10H16ClNO3
  • H donors: 1 H acceptors: 0 LogP: 2.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NOCCCOc1ccc(cc1)OC.Cl
  • InChi: 1S/C10H15NO3.ClH/c1-12-9-3-5-10(6-4-9)13-7-2-8-14-11;/h3-6H,2,7-8,11H2,1H3;1H
  • InChiKey: LPQGWMGPKQGFTP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0382 0.174
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0529 0.0529
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0144 0.0144
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0017 0.0017
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.029 0.2326
Schistosoma mansoni hypothetical protein 0.0046 0.0464 0.0464
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0382 0.1099
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.029 0.1321
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0344 0.0922
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.1675 0.4495
Loa Loa (eye worm) Smad1 0.0009 0.0015 0.0039
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0657 0.0657
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0144 0.0385
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0008 0.0039
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0017 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0382 0.1099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0064 0.0184
Schistosoma mansoni tar DNA-binding protein 0.0315 0.3727 0.3727
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0005 0.0005
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0697 0.0697
Leishmania major hypothetical protein, conserved 0.0017 0.0104 0.0475
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0062 0.0062
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0144 0.0707
Brugia malayi hypothetical protein 0.0009 0.0008 0.0021
Brugia malayi steroid hormone receptor 0.002 0.0144 0.0385
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.029 0.1321
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0017 0.0045
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.029 0.1321
Schistosoma mansoni dishevelled 0.0009 0.0008 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0064 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0064 0.0184
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.029 0.0834
Loa Loa (eye worm) hypothetical protein 0.002 0.0144 0.0385
Schistosoma mansoni apoferritin-2 0.0008 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0064 0.0184
Schistosoma mansoni Smad4 0.0009 0.0015 0.0015
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0104 0.0104
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0657 0.0657
Brugia malayi hypothetical protein 0.001 0.003 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0144 0.0385
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0008 0.0008
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.3478 1
Toxoplasma gondii exonuclease III APE 0.0039 0.0382 0.3065
Trypanosoma brucei heat shock protein, putative 0.0032 0.029 0.1321
Schistosoma mansoni hypothetical protein 0.0831 1 1
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0529 0.0529
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0015 0.0039
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0017 0.0017
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0062 0.1616
Brugia malayi MH1 domain containing protein 0.0009 0.0015 0.0039
Brugia malayi jmjC domain containing protein 0.0017 0.0104 0.028
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0017 0.0017
Brugia malayi hypothetical protein 0.001 0.003 0.0081
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0017 0.0017
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0104 0.0104
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3478 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0104 0.0836
Onchocerca volvulus 0.0058 0.0612 0.3018
Brugia malayi hypothetical protein 0.0149 0.1717 0.4606
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0079 0.0079
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0697 0.0697
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0144 0.0385
Echinococcus multilocularis smad 0.0009 0.0015 0.0015
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0017 0.0017
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0189 0.2195 0.589
Schistosoma mansoni hypothetical protein 0.0035 0.0331 0.0331
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0144 0.0144
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0189 0.2195 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0104 0.0104
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0104 0.0475
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0008 0.0008
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0382 0.2301
Leishmania major heat shock protein, putative 0.0013 0.0062 0.0281
Schistosoma mansoni nuclear hormone receptor 0.002 0.0144 0.0144
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0008 0.0008
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0104 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0144 0.0385
Schistosoma mansoni smad1 5 8 and 0.0009 0.0015 0.0015
Brugia malayi jmjC domain containing protein 0.0062 0.0657 0.1762
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0529 0.0529
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0123 0.0329
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0017 0.0017
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0008 0.0008
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0062 0.0166
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0211 0.0211
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0003 0.0012
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.1246 1
Brugia malayi heat shock protein 90 0.0032 0.029 0.0778
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0382 0.1406
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0344 0.1566
Trypanosoma brucei heat shock protein, putative 0.0032 0.029 0.1321
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0344 0.0344
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0017 0.0082
Echinococcus multilocularis heat shock protein 90 0.0032 0.029 0.029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3478 1
Schistosoma mansoni ferritin 0.0008 0.0003 0.0003
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0315 0.3727 1
Brugia malayi MH1 domain containing protein 0.0009 0.0015 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0104 0.028
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0464 0.1245
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0081
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0697 0.1871
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0344 0.1566
Echinococcus multilocularis endoplasmin 0.0025 0.0211 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.2195 0.2195
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0064 0.0184
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.3478 1
Onchocerca volvulus 0.0036 0.0344 0.1694
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0144 0.0385
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0104 0.0104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0064 0.0184
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0529 0.142
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0211 0.0962
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0104 0.0475
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0211 0.0777
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0145 0.0145
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0003 0.0009
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0144 0.0144
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0015 0.0015
Schistosoma mansoni thyroid hormone receptor 0.002 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.01 0.1115 0.1115
Schistosoma mansoni cpg binding protein 0.0062 0.0653 0.0653
Brugia malayi Hsp90 protein 0.0013 0.0062 0.0166
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0003 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0529 0.0529
Mycobacterium tuberculosis Conserved protein 0.0036 0.0344 0.1265
Trypanosoma brucei heat shock protein, putative 0.0032 0.029 0.1321
Echinococcus granulosus Smad4 0.0009 0.0015 0.0015
Trypanosoma brucei heat shock protein, putative 0.0032 0.029 0.1321
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0064 0.0184
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0144 0.0385
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0464 0.0464
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0081
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0144 0.0385
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0529 0.0529
Toxoplasma gondii heat shock protein HSP90 0.0032 0.029 0.2326
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0144 0.0144
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0529 0.142
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0188 0.2183 0.5858
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0697 0.0697
Echinococcus granulosus GPCR family 2 0.0046 0.0464 0.0464
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0144 0.0144
Brugia malayi MH2 domain containing protein 0.0009 0.0015 0.0039
Trichomonas vaginalis endoplasmin, putative 0.002 0.014 0.0404
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0382 0.0382
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0144 0.0144
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0104 0.0104
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0144 0.0144
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0062 0.0281
Echinococcus multilocularis heat shock protein 0.0032 0.029 0.029
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.029 0.1321
Brugia malayi DIX domain containing protein 0.0009 0.0008 0.0021
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0144 0.0385
Schistosoma mansoni ap endonuclease 0.0039 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0175 0.2029 0.5444
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0104 0.028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3478 1
Plasmodium vivax heat shock protein 86, putative 0.0032 0.029 0.7588
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0064 0.0184
Schistosoma mansoni cpg binding protein 0.0062 0.0653 0.0653
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Echinococcus multilocularis ferritin 0.0008 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0035 0.0331 0.0952
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0123 0.0123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0529 0.0529
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0344 0.2068
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Loa Loa (eye worm) hypothetical protein 0.0036 0.0344 0.0922
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0149 0.1717 0.4606
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0344 0.0988
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0144 0.0144
Brugia malayi TAR-binding protein 0.0315 0.3727 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0017 0.0045
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.029 0.1321
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0064 0.0184
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0529 0.0529
Onchocerca volvulus 0.0009 0.0017 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0144 0.0385
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0008 0.0008
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0079 0.0079
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0344 0.1265
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0464 0.0464
Brugia malayi nuclear receptor NHR-67 0.0009 0.0017 0.0045
Loa Loa (eye worm) TAR-binding protein 0.0315 0.3727 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0211 0.0607
Loa Loa (eye worm) hypothetical protein 0.0017 0.0104 0.028
Entamoeba histolytica protein kinase, putative 0.0189 0.2195 0.6312
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0017 0.0045
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0017 0.0045
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0382 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0382 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0144 0.0385
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0062 0.0304
Echinococcus multilocularis heat shock protein 90 0.0025 0.0211 0.0211
Schistosoma mansoni ferritin 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0144 0.0385
Loa Loa (eye worm) heat shock protein 90 0.0032 0.029 0.0778
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0382 0.1025
Echinococcus multilocularis dnaJ subfamily B 0.0831 1 1
Echinococcus granulosus heat shock protein 90 0.0025 0.0211 0.0211
Schistosoma mansoni coup transcription factor 0.002 0.0144 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0144 0.0385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0144 0.0385
Schistosoma mansoni endoplasmin 0.0032 0.029 0.029
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0144 0.0707
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0211 0.549
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0344 0.1265
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0382 0.1099
Schistosoma mansoni ferritin 0.0008 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0189 0.2195 0.6312
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0008 0.0008
Mycobacterium leprae Probable lipase LipE 0.0036 0.0344 0.2068
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.029 0.1321
Brugia malayi ecdysteroid receptor 0.002 0.0144 0.0385
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0017 0.0017
Schistosoma mansoni zinc finger protein 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0144 0.0385
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0064 0.0184
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3478 1
Entamoeba histolytica hypothetical protein 0.0035 0.0331 0.0952
Toxoplasma gondii ABC1 family protein 0.0036 0.0344 0.2757
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0064 0.0184
Echinococcus multilocularis cpg binding protein 0.0062 0.0653 0.0653
Brugia malayi jmjC domain containing protein 0.0017 0.0104 0.028
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0382 1
Onchocerca volvulus 0.0009 0.0008 0.0039
Loa Loa (eye worm) hypothetical protein 0.01 0.1115 0.2991
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0612 0.1643
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0144 0.0144
Schistosoma mansoni cpg binding protein 0.0058 0.0612 0.0612
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0344 0.1265
Echinococcus granulosus heat shock protein 0.0032 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0081
Schistosoma mansoni ferritin 0.0008 0.0003 0.0003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0464 0.1245
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0064 0.0184
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Echinococcus granulosus FTZ F1 alpha 0.002 0.0144 0.0144
Brugia malayi beta-lactamase family protein 0.0036 0.0344 0.0922
Echinococcus multilocularis tar DNA binding protein 0.0315 0.3727 0.3727
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0008 0.0008
Schistosoma mansoni smad1 5 8 and 0.0009 0.0015 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0344 0.0988
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0064 0.0184
Loa Loa (eye worm) hypothetical protein 0.002 0.0144 0.0385
Brugia malayi hypothetical protein 0.0035 0.0331 0.0888
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0017 0.0017
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Schistosoma mansoni tar DNA-binding protein 0.0315 0.3727 0.3727
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.1675 0.4495
Loa Loa (eye worm) RNA binding protein 0.0315 0.3727 1
Echinococcus granulosus cpg binding protein 0.0062 0.0653 0.0653
Trypanosoma brucei heat shock protein, putative 0.0032 0.029 0.1321
Schistosoma mansoni dep domain containing protein 0.0009 0.0008 0.0008
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.3478 1
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0008 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0344 0.1566
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0017 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0315 0.3727 0.3727
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0344 0.0988
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0657 0.0657
Brugia malayi Smad1 0.0009 0.0015 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0344 0.0988
Echinococcus multilocularis GPCR, family 2 0.0046 0.0464 0.0464
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0008 0.0008
Echinococcus granulosus endoplasmin 0.0025 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0081
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0104 0.0475
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0062 0.0178
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0144 0.0385
Schistosoma mansoni hypothetical protein 0.0046 0.0464 0.0464
Mycobacterium tuberculosis Conserved protein 0.0036 0.0344 0.1265
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0008 0.0008
Schistosoma mansoni smad1 5 8 and 0.0009 0.0015 0.0015
Schistosoma mansoni nuclear receptor 0.0009 0.0017 0.0017
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.1536 0.4123
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.003 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.002 0.0144 0.0385
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.2029 1
Brugia malayi N-terminal motif family protein 0.0175 0.2029 0.5444
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Echinococcus granulosus phd:f box containing protein 0.0017 0.0104 0.0104
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0464 0.0464
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0657 0.0657
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Giardia lamblia Grp94/Hsp90 0.0025 0.0211 0.0607
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0144 0.0385
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0331 0.0331
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.003 0.003
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0344 0.0344
Brugia malayi beta-lactamase family protein 0.0036 0.0344 0.0922
Loa Loa (eye worm) hypothetical protein 0.0036 0.0344 0.0922
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0046 0.0464 0.1245
Schistosoma mansoni tar DNA-binding protein 0.0315 0.3727 0.3727
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0008 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0104 0.028
Schistosoma mansoni thyroid hormone receptor 0.002 0.0144 0.0144
Brugia malayi nuclear receptor NHR-88 0.0009 0.0017 0.0045
Loa Loa (eye worm) DR-78 0.0009 0.0017 0.0045
Loa Loa (eye worm) hypothetical protein 0.002 0.0144 0.0385
Mycobacterium ulcerans beta-lactamase 0.0036 0.0344 0.2068
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0211 0.0962
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0144 0.0144
Plasmodium vivax endoplasmin, putative 0.0032 0.029 0.7588
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0123 0.0123
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0062 0.0281
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3478 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0017 0.0017
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0144 0.0144
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0017 0.0045
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0189 0.2195 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0144 0.0144
Schistosoma mansoni ap endonuclease 0.0039 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Brugia malayi tailless protein 0.0009 0.0017 0.0045
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0144 0.0707
Echinococcus granulosus tar DNA binding protein 0.0315 0.3727 0.3727
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0344 0.1265
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.003 0.0081
Brugia malayi MH2 domain containing protein 0.0134 0.1536 0.4123
Trichomonas vaginalis heat shock protein, putative 0.0032 0.029 0.0834
Plasmodium vivax JmjC domain containing protein 0.0017 0.0104 0.2729
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0017 0.0017
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Brugia malayi nuclear receptor NHR-88 0.002 0.0144 0.0385
Echinococcus multilocularis expressed protein 0.0008 0.0003 0.0003
Plasmodium falciparum heat shock protein 90 0.0032 0.029 0.7588
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Trichomonas vaginalis esterase, putative 0.0036 0.0344 0.0988
Brugia malayi Endoplasmin precursor 0.0032 0.029 0.0778
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0064 0.0184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0144 0.0144
Echinococcus granulosus ferritin 0.0008 0.0003 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0344 0.0988
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0144 0.0144
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0382 0.1099
Schistosoma mansoni heat shock protein 0.0032 0.029 0.029
Onchocerca volvulus 0.0149 0.1717 0.8461
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0382 0.0382
Brugia malayi nuclear receptor RXR 0.001 0.003 0.0081
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.012 0.0322
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0144 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0144 0.0385
Schistosoma mansoni hypothetical protein 0.0046 0.0464 0.0464
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0344 0.2068
Loa Loa (eye worm) hypothetical protein 0.0036 0.0344 0.0922
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0017 0.0017
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0104 0.0104
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Schistosoma mansoni heat shock protein 0.0013 0.0062 0.0062
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0144 0.0385
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.1536 0.4123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0144 0.0385
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Brugia malayi RNA binding protein 0.0315 0.3727 1
Loa Loa (eye worm) hypothetical protein 0.0188 0.2183 0.5858
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0344 0.1265
Loa Loa (eye worm) endoplasmin 0.0032 0.029 0.0778
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0064 0.0184
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.029 0.1321
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0144 0.0144
Schistosoma mansoni ferritin light chain 0.0008 0.0003 0.0003
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1649 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0104 0.0104
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0144 0.0144
Schistosoma mansoni ferritin light chain 0.0008 0.0003 0.0003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0144 0.0144
Schistosoma mansoni nuclear receptor 0.0009 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0144 0.0385
Loa Loa (eye worm) beta-lactamase 0.0036 0.0344 0.0922
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.029 0.0834
Trichomonas vaginalis ferritin, putative 0.0008 0.0003 0.0009
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1649 0.6072
Brugia malayi jmjC domain containing protein 0.0017 0.0104 0.028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3478 1
Schistosoma mansoni endoplasmin 0.0032 0.029 0.029
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0008 0.0021
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0104 0.2729
Echinococcus granulosus expressed protein 0.0008 0.0003 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0464 0.1245
Trypanosoma brucei heat shock protein, putative 0.0032 0.029 0.1321
Trypanosoma brucei heat shock protein, putative 0.0032 0.029 0.1321
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0189 0.2195 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0104 0.028
Trichomonas vaginalis heat shock protein, putative 0.002 0.014 0.0404
Onchocerca volvulus 0.0036 0.0344 0.1694
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0015 0.0015
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0211 0.0607
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0062 0.1616
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0344 0.1265
Brugia malayi nuclear hormone receptor 0.0009 0.0017 0.0045
Brugia malayi nuclear receptor RXR 0.0009 0.0017 0.0045
Brugia malayi MH2 domain containing protein 0.0009 0.0015 0.0039
Loa Loa (eye worm) hypothetical protein 0.0036 0.0344 0.0922
Entamoeba histolytica hypothetical protein 0.0035 0.0331 0.0952
Echinococcus granulosus smad 0.0009 0.0015 0.0015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0344 0.0922
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0144 0.0385
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0046 0.0464 0.0464
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.003 0.003
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0017 0.0017
Brugia malayi hypothetical protein 0.0009 0.0017 0.0045
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0211 0.1263
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0104 0.0104
Treponema pallidum heat shock protein 90 0.0025 0.0211 0.0607
Echinococcus granulosus dual specificity 0.0189 0.2195 0.2195
Leishmania major hypothetical protein, conserved 0.0036 0.0344 0.1566
Entamoeba histolytica protein kinase, putative 0.0189 0.2195 0.6312
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0008 0.0021
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0062 0.0062
Brugia malayi RNA recognition motif domain containing protein 0.0315 0.3727 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0017 0.0045
Schistosoma mansoni dishevelled 0.0009 0.0008 0.0008
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0062 0.0495
Brugia malayi Protein kinase domain containing protein 0.0189 0.2195 0.589
Brugia malayi ecdysone receptor 0.0009 0.0017 0.0045
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.1675 0.4495
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0144 0.0385
Brugia malayi jmjC domain containing protein 0.0017 0.0104 0.028
Loa Loa (eye worm) hypothetical protein 0.0146 0.1675 0.4495
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0104 0.028
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0017 0.0045
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Onchocerca volvulus 0.0036 0.0344 0.1694
Plasmodium falciparum endoplasmin, putative 0.002 0.014 0.3677
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0081
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.1407 0.1407
Schistosoma mansoni tar DNA-binding protein 0.0315 0.3727 0.3727
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0211 0.0962
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0017 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0064 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0144 0.0385
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1649 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0015 0.0015
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0017 0.0017
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0015 0.0039
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0062 0.1616
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3478 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0015 0.0015
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0062 0.0495
Loa Loa (eye worm) hypothetical protein 0.0036 0.0344 0.0922
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0017 0.0017
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0079 0.0079
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0211 0.0607
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0344 0.0344
Entamoeba histolytica hypothetical protein 0.0035 0.0331 0.0952
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.029 0.0834
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0144 0.0385
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0344 0.1265
Schistosoma mansoni apoferritin-2 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3478 1
Schistosoma mansoni heat shock protein 0.0032 0.029 0.029
Brugia malayi hypothetical protein 0.0009 0.0017 0.0045
Plasmodium vivax heat shock protein, putative 0.0013 0.0062 0.1616
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0015 0.0015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0064 0.0184
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0079 0.0079
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0211 0.0607
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.3478 1
Brugia malayi hypothetical protein 0.0009 0.0008 0.0021
Mycobacterium ulcerans lipase LipD 0.0036 0.0344 0.2068
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0382 0.174
Echinococcus multilocularis Smad4 0.0009 0.0015 0.0015
Schistosoma mansoni smad 0.0009 0.0015 0.0015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0144 0.0144
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0008 0.0008
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0017 0.0017
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Onchocerca volvulus 0.002 0.0144 0.0707
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.1115 0.2991
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0211 0.1263
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0017 0.0082
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0045
Mycobacterium ulcerans hypothetical protein 0.0036 0.0344 0.2068
Brugia malayi nuclear hormone receptor 0.002 0.0144 0.0385
Toxoplasma gondii hypothetical protein 0.0009 0.0008 0.0064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0144 0.0385
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0344 0.8996
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0382 0.174
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0104 0.0104
Echinococcus multilocularis dual specificity 0.0189 0.2195 0.2195
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0144 0.0385
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0382 0.174
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0189 0.2195 1
Entamoeba histolytica protein kinase domain containing protein 0.0189 0.2195 0.6312
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0382 0.1099
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0145 0.0145
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0104 0.0104
Brugia malayi CXXC zinc finger family protein 0.0058 0.0612 0.1643
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0132 0.0599
Onchocerca volvulus 0.0009 0.0017 0.0082
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0008 0.0021
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0344 0.2068
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0331 0.0331
Brugia malayi jmjC domain containing protein 0.0065 0.0697 0.1871
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0104 0.0836
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.029 0.1321
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0331 0.0331
Mycobacterium tuberculosis Conserved protein 0.0036 0.0344 0.1265
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0062 0.0178
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.002 0.0144 0.0385
Echinococcus granulosus heat shock protein 90 0.0032 0.029 0.029
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Brugia malayi beta-lactamase 0.0036 0.0344 0.0922
Trichomonas vaginalis helicase, putative 0.0013 0.0064 0.0184
Leishmania major heat shock protein 83-1 0.0032 0.029 0.1321
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.003 0.0081
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.2716 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.029 0.1321
Loa Loa (eye worm) hypothetical protein 0.0036 0.0344 0.0922
Loa Loa (eye worm) hypothetical protein 0.002 0.0144 0.0385
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0144 0.0144
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0382 0.1025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0464 0.0464
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0144 0.0144
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0008 0.0021
Brugia malayi conserved hypotetical protein 0.0009 0.0017 0.0045

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 3 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 98 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 0 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -3 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = -1 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 3 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 98 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.78 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.16709 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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