TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 391.466 | Formula: C22H25N5O2
H donors: 3 H acceptors: 3 LogP: 3.91 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCNc1nc(Nc2ccc(cc2)NC(=O)Cc2ccc(cc2)OC)nc(c1)C
InChi: 1S/C22H25N5O2/c1-4-23-20-13-15(2)24-22(27-20)26-18-9-7-17(8-10-18)25-21(28)14-16-5-11-19(29-3)12-6-16/h5-13H,4,14H2,1-3H3,(H,25,28)(H2,23,24,26,27)
InChiKey: GHFQNZZIIVLYMM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0037	0.0368	0.3653
Onchocerca volvulus		0.0093	0.1421	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0105	0.0388
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0037	0.0368	0.0243
Mycobacterium ulcerans	short chain dehydrogenase	0.0037	0.0368	0.0243
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0105	0.046
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0037	0.0368	0.0243
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0105	0.0388
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0105	0.046
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0784	0.3445
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0105	0.0388
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0105	0.0388
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0119	0.1917	0.7103
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0337	0.125
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0037	0.0368	0.0243
Schistosoma mansoni	coup transcription factor	0.0023	0.0105	0.046
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0302	0.1119
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1049	0.3887
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1049	0.3887
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0037	0.0368	0.1363
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0105	0.0388
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0548	1	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0037	0.0368	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0784	0.0459
Treponema pallidum	sodium- and chloride- dependent transporter	0.0073	0.1049	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0037	0.0368	0.0243
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0341	0.8867
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0548	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0105	0.0388
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0037	0.0368	0.1616
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0105	0.046
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0341	0.3239
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0596	0.2207
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0105	0.0388
Trypanosoma brucei	pteridine reductase 1	0.0037	0.0368	1
Schistosoma mansoni	alpha glucosidase	0.0036	0.0341	0.1496
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0105	0.0388
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0105	0.0388
Schistosoma mansoni	hypothetical protein	0.0034	0.0302	0.1327
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0784	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0596	0.2207
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0105	0.0388
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0037	0.0368	0.1363
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0105	0.0388
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0784	0.0432
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0037	0.0368	0.0243
Loa Loa (eye worm)	CYP4Cod1	0.0024	0.0128	0.0475
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0037	0.0368	0.0243
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.0128	0.0475
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0341	0.8867
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0073	0.1049	0.4607
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0037	0.0368	0.0243
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0105	0.046
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0037	0.0368	0.0243
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0037	0.0368	0.3653
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0105	0.0388
Schistosoma mansoni	sodium/chloride dependent transporter	0.0073	0.1049	0.4607
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0037	0.0368	0.1363
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0037	0.0368	0.0243
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0105	0.0388
Onchocerca volvulus		0.0037	0.0368	0.1999
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0037	0.0368	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0105	0.0388
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0341	0.1262
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0037	0.0368	0.1363
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0105	0.046
Schistosoma mansoni	alpha-glucosidase	0.0138	0.2277	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0037	0.0368	0.0243
Mycobacterium ulcerans	short chain dehydrogenase	0.0037	0.0368	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0105	0.0388
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0548	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0105	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0105	0.0388
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0105	0.046
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0105	0.0388
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0548	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0105	0.0388
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0037	0.0368	0.0243
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0105	0.046
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0784	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1049	0.3887
Brugia malayi	Cytochrome P450 family protein	0.0024	0.0128	0.0475
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0037	0.0368	0.0243
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0105	0.0388
Echinococcus multilocularis	serotonin transporter	0.0073	0.1049	0.3887
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0784	0.0665
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0161	0.2699	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0105	0.0388
Brugia malayi	nuclear hormone receptor	0.0023	0.0105	0.0388
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0037	0.0368	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0105	0.0388
Mycobacterium ulcerans	short chain dehydrogenase	0.0037	0.0368	0.0243
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0037	0.0368	0.0243
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0105	0.0388
Mycobacterium ulcerans	short chain dehydrogenase	0.0037	0.0368	0.0243
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0596	0.2207
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0105	0.0388
Mycobacterium ulcerans	short chain dehydrogenase	0.0037	0.0368	0.0243
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0105	0.0388
Mycobacterium ulcerans	short chain dehydrogenase	0.0037	0.0368	0.0243
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0105	0.046
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0105	0.0388
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0784	0.2906
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0105	0.0388
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0161	0.2699	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0341	0.1262
Loa Loa (eye worm)	norepinephrine transporter	0.0073	0.1049	0.3887
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0073	0.1049	0.3887
Mycobacterium ulcerans	oxidoreductase	0.0037	0.0368	0.0243
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0548	1	1
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0037	0.0368	0.3653
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0341	0.1262
Mycobacterium ulcerans	short chain dehydrogenase	0.0037	0.0368	0.0243
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0105	0.0388
Loa Loa (eye worm)	serotonin transporter b	0.0073	0.1049	0.3887
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0105	0.0388
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0105	0.0388
Echinococcus granulosus	serotonin transporter	0.0073	0.1049	0.3887
Brugia malayi	ecdysteroid receptor	0.0023	0.0105	0.0388
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0037	0.0368	0.0028
Leishmania major	pteridine reductase 1	0.0037	0.0368	0.3653
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0105	0.0388
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0105	0.0388
Trypanosoma brucei	oxidoreductase-like protein	0.0037	0.0368	1
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0337	0.1482
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0548	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0105	0.0388
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.0128	0.0475
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0105	0.0388
Trichomonas vaginalis	hypothetical protein	0.0548	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0337	0.125
Onchocerca volvulus		0.0037	0.0368	0.1999
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0037	0.0368	0.0028
Schistosoma mansoni	dihydropteridine reductase	0.0037	0.0368	0.1616
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0784	0.2906
Schistosoma mansoni	alpha-glucosidase	0.0138	0.2277	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0161	0.2699	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0105	0.0388
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0105	0.0388
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0105	0.046
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0037	0.0368	0.0243
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0037	0.0368	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0105	0.0388
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0037	0.0368	0.1363
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0105	0.0388
Trypanosoma brucei	glucosidase, putative	0.0036	0.0341	0.8867
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0073	0.1049	0.3887
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0548	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0105	0.0388
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0341	0.1072
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0105	0.0388
Echinococcus granulosus	lysosomal alpha glucosidase	0.0161	0.2699	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0037	0.0368	0.0243
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0037	0.0368	0.0243
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0596	0.2207
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0302	0.1119
Schistosoma mansoni	hypothetical protein	0.0035	0.0337	0.1482
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0105	0.0388
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0105	0.0388
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0105	0.0388
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0037	0.0368	0.0243
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0105	0.0388
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0784	0.0665
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0037	0.0368	0.1363
Brugia malayi	steroid hormone receptor	0.0023	0.0105	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0105	0.0388
Onchocerca volvulus		0.0073	0.1049	0.7173
Leishmania major	oxidoreductase-like protein	0.0037	0.0368	0.3653
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0105	0.0388
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0105	0.0388
Mycobacterium ulcerans	short chain dehydrogenase	0.0037	0.0368	0.0243
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0037	0.0368	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0107	0.1686	0.6248
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0105	0.0388
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0105	0.0388
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0341	0.1262
Loa Loa (eye worm)	oxidoreductase	0.0037	0.0368	0.1363
Mycobacterium ulcerans	short chain dehydrogenase	0.0037	0.0368	0.0243
Brugia malayi	hypothetical protein	0.0035	0.0337	0.125
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0037	0.0368	0.0028
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0341	0.1072
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0037	0.0368	0.0243
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0784	0.3445
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0105	0.046
Brugia malayi	Cytochrome P450 family protein	0.0024	0.0128	0.0475
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0105	0.046
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0037	0.0368	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0368	0.1363
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0161	0.2699	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0119	0.1917	0.8419
Mycobacterium ulcerans	short chain dehydrogenase	0.0037	0.0368	0.0243
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0105	0.0388

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 0 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 4.74 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 10.13 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 10.78 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 30 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 47 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 100 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 13.46	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= -1 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 30 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 47 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 101 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 5.86	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 1.3793 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL587383
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 595693