Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0298 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3977 | 0.3859 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5135 | 0.504 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3977 | 0.3859 |
Echinococcus granulosus | geminin | 0.0164 | 0.5135 | 0.504 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1035 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1069 | 0.0894 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1069 | 0.2317 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5135 | 0.504 |
Brugia malayi | RNA, U transporter 1 | 0.0079 | 0.2061 | 0.4938 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3977 | 0.3859 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1035 | 0.086 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1035 | 0.086 |
Brugia malayi | RNA binding protein | 0.0132 | 0.3977 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1035 | 0.086 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3977 | 0.3859 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1035 | 0.2228 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.3977 | 0.3859 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1035 | 0.086 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.3977 | 0.3859 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0192 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1035 | 0.086 |
Echinococcus multilocularis | geminin | 0.0164 | 0.5135 | 0.504 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.3977 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.047 | 0.0736 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0192 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1035 | 0.086 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1035 | 0.086 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.3977 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1069 | 0.2317 |
Echinococcus multilocularis | snurportin 1 | 0.0298 | 1 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0192 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.3977 | 0.3859 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.3977 | 0.3859 |
Schistosoma mansoni | hypothetical protein | 0.0298 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.047 | 0.0284 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0192 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1069 | 0.0894 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0 | 0.5 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0192 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.3977 | 0.3859 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.047 | 0.0284 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3977 | 0.3859 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 3.37 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.54 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.54 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 11 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 98 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 98 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 7.04 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -8 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 11 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 98 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 98 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.22 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.60321 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.