Detailed information for compound 596204

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 485.978 | Formula: C26H29ClFN3O3
  • H donors: 1 H acceptors: 2 LogP: 5.15 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cc(F)cc2c1ccc(n2)C.Cl
  • InChi: 1S/C26H28FN3O3.ClH/c1-17-2-4-21-22(28-17)14-20(27)15-25(21)32-11-10-30-8-6-18(7-9-30)12-19-3-5-24-23(13-19)29-26(31)16-33-24;/h2-5,13-15,18H,6-12,16H2,1H3,(H,29,31);1H
  • InChiKey: AFXWIJRSNQVGTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0346 0.3432
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0977 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0118 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0118 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0118 0.0198
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0647 0.6568
Schistosoma mansoni hypothetical protein 0.0432 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0088 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1358 0.1358
Loa Loa (eye worm) hypothetical protein 0.025 0.5725 0.9597
Loa Loa (eye worm) hypothetical protein 0.0047 0.0977 0.1637
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0346 0.3432
Schistosoma mansoni cpg binding protein 0.003 0.0579 0.0579
Brugia malayi nuclear hormone receptor 0.0011 0.0118 0.0198
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0088 0.0147
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1514 0.2537
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.2275 0.3814
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0118 0.0118
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0346 1
Trypanosoma brucei unspecified product 0.0014 0.0197 0.1887
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1001 0.1678
Loa Loa (eye worm) hypothetical protein 0.0011 0.0118 0.0198
Schistosoma mansoni hypothetical protein 0.0032 0.0629 0.0629
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0118 0.0118
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0118 0.0118
Brugia malayi steroid hormone receptor 0.0011 0.0118 0.0198
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0044 0.0044
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0259 0.0259
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1001 0.1001
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0085 0.0143
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0027
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0977 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.1358 0.1358
Loa Loa (eye worm) RNA binding protein 0.0064 0.1358 0.2276
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0118 0.0118
Schistosoma mansoni coup transcription factor 0.0011 0.0118 0.0118
Echinococcus multilocularis cpg binding protein 0.0032 0.062 0.062
Echinococcus granulosus geminin 0.0179 0.4065 0.4065
Schistosoma mansoni survival motor neuron protein 0.0051 0.1063 0.1063
Schistosoma mansoni hypothetical protein 0.0032 0.0629 0.0629
Echinococcus multilocularis GPCR, family 2 0.0032 0.0629 0.0629
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0118 0.0198
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.2275 0.3814
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0259 0.0259
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0118 0.0118
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1358 0.1358
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0259 0.0259
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0346 0.5
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0346 0.0346
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0179 0.4065 0.4065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1001 0.1001
Loa Loa (eye worm) hypothetical protein 0.026 0.5966 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0346 0.0346
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0346 0.3432
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1001 0.1001
Schistosoma mansoni cpg binding protein 0.0032 0.062 0.062
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0346 0.3432
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0346 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0629 0.1055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1001 0.1001
Schistosoma mansoni cpg binding protein 0.0032 0.062 0.062
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0118 0.0198
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0118 0.0118
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0118 0.0198
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0977 0.1637
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0346 0.3432
Brugia malayi hypothetical protein 0.025 0.5725 0.9597
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0259 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0118 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0118 0.0198
Brugia malayi RNA binding protein 0.0064 0.1358 0.2276
Echinococcus granulosus GPCR family 2 0.0032 0.0629 0.0629
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0346 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0118 0.0198
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0346 0.3432
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0118 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0118 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0197 0.1887
Onchocerca volvulus 0.003 0.0579 0.4882
Leishmania major DNA polymerase kappa, putative 0.002 0.0346 0.3432
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0118 0.0118
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0259 0.0259
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0044 0.0044
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0011 0.0118 0.0198
Echinococcus granulosus dna polymerase eta 0.0047 0.0977 0.0977
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0647 0.5261
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0118 0.0198
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0346 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0346 0.3432
Echinococcus granulosus dna polymerase kappa 0.002 0.0346 0.0346
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.1063 0.1781
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0118 0.0198
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0259 0.0434
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1001 0.1678
Brugia malayi CXXC zinc finger family protein 0.003 0.0579 0.0971
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.5725 0.5725
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0629 0.1055
Giardia lamblia DINP protein human, muc B family 0.002 0.0346 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0197 0.1887
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0118 0.0198
Leishmania major DNA polymerase eta, putative 0.0047 0.0977 1
Brugia malayi polk-prov protein 0.0006 0.0016 0.0027
Echinococcus multilocularis dna polymerase eta 0.0047 0.0977 0.0977
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0118 0.0118
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.2275 0.3814
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0118 0.0198
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0118 0.0118
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0346 0.058
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0032 0.0629 0.0629
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0118 0.0118
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1358 0.1358
Echinococcus multilocularis geminin 0.0179 0.4065 0.4065
Brugia malayi TAR-binding protein 0.0064 0.1358 0.2276
Brugia malayi ecdysteroid receptor 0.0011 0.0118 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0118 0.0198
Echinococcus granulosus tar DNA binding protein 0.0064 0.1358 0.1358
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1358 0.2276
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0118 0.0198
Loa Loa (eye worm) hypothetical protein 0.0011 0.0118 0.0198
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0118 0.0198
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0346 0.3432
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0346 0.3432
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0346 0.3432
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1358 0.1358
Brugia malayi isocitrate dehydrogenase 0.0017 0.0259 0.0434
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0259 0.2529
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0118 0.0198
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0259 0.0259
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0259 0.2529
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0629 0.0629
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0629 0.0629
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0346 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0346 0.3432
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0579 0.0971
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0051 0.1063 0.1063
Echinococcus granulosus survival motor neuron protein 1 0.025 0.5725 0.5725
Schistosoma mansoni hypothetical protein 0.007 0.1514 0.1514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1001 0.1001
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1358 0.1358
Schistosoma mansoni hypothetical protein 0.0179 0.4065 0.4065
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0118 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0118 0.0198
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0259 0.2026
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0346 0.058
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0118 0.0198
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0118 0.0118
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0118 0.0118
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0629 0.1055
Brugia malayi nuclear receptor NHR-88 0.0011 0.0118 0.0198
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0629 0.1055
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0259 1
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0118 0.0118
Brugia malayi photoreceptor-specific nuclear receptor 0.026 0.5966 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0346 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0346 0.3432
Leishmania major DNA polymerase eta, putative 0.0033 0.0647 0.6568
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0118 0.0198
Loa Loa (eye worm) hypothetical protein 0.0103 0.2275 0.3814
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0118 0.0118
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0118 0.0118
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0118 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1001 0.1001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1216 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0118 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0346 0.3432
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0346 0.0346
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0118 0.0118
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.1377 0.1377
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0118 0.0118
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0629 0.0629
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0346 0.3432
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0032 0.0629 0.0629
Echinococcus granulosus cpg binding protein 0.0032 0.062 0.062
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0629 0.0629
Trypanosoma brucei unspecified product 0.0014 0.0197 0.1887
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0259 0.2529
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0259 0.2529
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0118 0.0198
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0346 0.3432
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0118 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0118 0.0198
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0346 0.3432
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0044 0.0044
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1358 0.2276
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0118 0.0118
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0259 0.0434
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0346 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0259 0.2529
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0118 0.0118
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1358 0.2276
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1001 0.1001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.007 0.1514 0.2537
Onchocerca volvulus 0.0051 0.1063 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0259 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0346 0.3432
Echinococcus multilocularis dnaJ subfamily B 0.0432 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0118 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0197 0.1887
Trypanosoma brucei unspecified product 0.002 0.0346 0.3432
Schistosoma mansoni DNA polymerase eta 0.0047 0.0977 0.0977
Echinococcus multilocularis dna polymerase kappa 0.002 0.0346 0.0346
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0118 0.0118
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0259 0.2026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0259 0.0259

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 0.63 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 2.13 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 3.49 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 21 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 24 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 89 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 2.86 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -2 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 21 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 24 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 89 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.12 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.75459 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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