Detailed information for compound 596578

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 450.557 | Formula: C23H26N6O2S
  • H donors: 0 H acceptors: 5 LogP: 5.43 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCn1c(nnc1c1ccc(cc1)N(C)C)Sc1ccc(c(c1)[N+](=O)[O-])C#N
  • InChi: 1S/C23H26N6O2S/c1-4-5-6-7-14-28-22(17-8-11-19(12-9-17)27(2)3)25-26-23(28)32-20-13-10-18(16-24)21(15-20)29(30)31/h8-13,15H,4-7,14H2,1-3H3
  • InChiKey: UCPQLKVUZWGDHO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.0632 0.063
Schistosoma mansoni histone deacetylase 4 5 0.0059 0.1202 0.118
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.1007 0.1005
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0122 0.0649
Entamoeba histolytica histone deacetylase, putative 0.0063 0.1278 1
Leishmania major histone deacetylase, putative 0.0063 0.1278 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0063 0.1278 0.8399
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.039 0.291
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0122 0.0097
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0122 0.0649
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0122 0.0773
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.054 0.0538
Echinococcus granulosus dnaJ subfamily B 0.0409 0.9493 0.9493
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.039 0.291
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0255 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.039 0.291
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.1007 0.1005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.1007 0.1007
Trypanosoma cruzi histone deacetylase, putative 0.0059 0.1202 0.9394
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0917 0.7115
Schistosoma mansoni acetylcholinesterase 0.0073 0.1517 0.1495
Brugia malayi Carboxylesterase family protein 0.043 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.1007 0.1007
Brugia malayi Carboxylesterase family protein 0.0073 0.1517 0.1517
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0122 0.0319
Brugia malayi RNA binding protein 0.0127 0.2796 0.2796
Brugia malayi DKFZp564C0469 protein 0.001 0.0025 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0917 0.6873
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.1007 0.1005
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0122 0.0649
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0255 0.1831
Loa Loa (eye worm) hypothetical protein 0.0051 0.1007 0.1005
Onchocerca volvulus 0.0073 0.1517 1
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.1007 0.1005
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0122 0.0773
Loa Loa (eye worm) carboxylesterase 0.043 1 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.2796 0.2778
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0255 0.1831
Loa Loa (eye worm) hypothetical protein 0.0014 0.0122 0.0119
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0122 0.0773
Plasmodium vivax histone deacetylase 1, putative 0.0063 0.1278 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.1007 0.1005
Brugia malayi hypothetical protein 0.001 0.0025 0.0025
Brugia malayi ecdysone receptor 0.0024 0.0365 0.0365
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0073 0.1517 0.1495
Schistosoma mansoni hypothetical protein 0.0011 0.006 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.1007 0.1005
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.043 1 1
Plasmodium vivax histone deacetylase, putative 0.0059 0.1202 0.9394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.1007 0.1005
Onchocerca volvulus 0.0024 0.0365 0.2279
Echinococcus granulosus replication factor c subunit 1 0.001 0.0025 0.0023
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.1007 0.1005
Schistosoma mansoni hypothetical protein 0.0032 0.054 0.0516
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.1007 0.0984
Loa Loa (eye worm) hypothetical protein 0.0051 0.1007 0.1005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0255 0.1831
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.1007 0.1005
Echinococcus granulosus histone deacetylase 6 0.0059 0.1202 0.12
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.054 0.0538
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0073 0.1517 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0632 0.386
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0073 0.1517 0.1514
Echinococcus granulosus BC026374 protein S09 family 0.0073 0.1517 0.1514
Loa Loa (eye worm) hypothetical protein 0.0027 0.0434 0.0431
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.2796 0.2796
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Toxoplasma gondii histone deacetylase HDAC1 0.0059 0.1202 0.9394
Echinococcus multilocularis histone deacetylase 6 0.0059 0.1202 0.12
Echinococcus multilocularis histone deacetylase 6 0.0059 0.1202 0.12
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2624 0.2622
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.2157 0.2155
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0917 0.5976
Plasmodium vivax histone deacetylase, putative 0.0018 0.0216 0.1521
Brugia malayi nuclear hormone receptor 0.0051 0.1007 0.1007
Trypanosoma brucei histone deacetylase 1 0.0063 0.1278 1
Echinococcus granulosus neuroligin 0.0073 0.1517 0.1514
Brugia malayi nuclear receptor NHR-88 0.0024 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Schistosoma mansoni hypothetical protein 0.0032 0.054 0.0516
Echinococcus granulosus histone deacetylase 6 0.0059 0.1202 0.12
Schistosoma mansoni gliotactin 0.0073 0.1517 0.1495
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Schistosoma mansoni cpg binding protein 0.0029 0.0473 0.0449
Onchocerca volvulus 0.0073 0.1517 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0255 0.1238
Brugia malayi histone deacetylase 3 (HD3) 0.0063 0.1278 0.1278
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0122 0.0119
Entamoeba histolytica hypothetical protein 0.0037 0.0677 0.5203
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0122 0.0319
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0122 0.0649
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0434 0.041
Loa Loa (eye worm) hypothetical protein 0.0051 0.1007 0.1005
Trypanosoma cruzi histone deacetylase 1, putative 0.0063 0.1278 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.1007 0.1005
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0122 0.0649
Brugia malayi MH2 domain containing protein 0.0119 0.2624 0.2624
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0434 0.041
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0632 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.1007 0.1007
Loa Loa (eye worm) hypothetical protein 0.0051 0.1007 0.1005
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0122 0.0122
Entamoeba histolytica hypothetical protein 0.0037 0.0677 0.5203
Schistosoma mansoni tar DNA-binding protein 0.0127 0.2796 0.2778
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0255 0.1538
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.1007 0.1005
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0122 0.0649
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.006 0.0057
Loa Loa (eye worm) hypothetical protein 0.0042 0.0778 0.0776
Loa Loa (eye worm) hypothetical protein 0.043 1 1
Plasmodium falciparum histone deacetylase 1 0.0063 0.1278 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.1007 0.0984
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0365 0.0363
Loa Loa (eye worm) hypothetical protein 0.0047 0.0917 0.0914
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.0216 0.1521
Brugia malayi conserved hypotetical protein 0.0024 0.0365 0.0365
Schistosoma mansoni tar DNA-binding protein 0.0127 0.2796 0.2778
Brugia malayi hypothetical protein 0.0025 0.039 0.039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0917 0.5834
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.1007 0.1005
Trypanosoma cruzi histone deacetylase 1, putative 0.0063 0.1278 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0434 0.0431
Plasmodium vivax histone deacetylase 2, putative 0.0059 0.1202 0.9394
Schistosoma mansoni hypothetical protein 0.0032 0.054 0.0516
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0122 0.0122
Plasmodium falciparum histone deacetylase 2 0.0059 0.1202 0.9394
Echinococcus granulosus nibrin 0.001 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0047 0.0917 0.0914
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0122 0.0649
Schistosoma mansoni cpg binding protein 0.003 0.0512 0.0488
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.1007 0.0984
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0917 0.5976
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0365 0.0363
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.054 0.0538
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0063 0.1278 0.1276
Toxoplasma gondii histone deacetylase HDAC2 0.0063 0.1278 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0122 0.0319
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0122 0.1087
Echinococcus multilocularis tar DNA binding protein 0.0127 0.2796 0.2794
Echinococcus granulosus histone deacetylase 0.0059 0.1202 0.12
Brugia malayi CXXC zinc finger family protein 0.0029 0.0473 0.0473
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0122 0.1087
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0122 0.0649
Schistosoma mansoni histone deacetylase hda2 0.0018 0.0216 0.0191
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0255 0.1538
Loa Loa (eye worm) RNA binding protein 0.0127 0.2796 0.2794
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.1007 0.1005
Brugia malayi ecdysteroid receptor 0.0051 0.1007 0.1007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.1007 0.0984
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0255 0.0255
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0586 0.3541
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0122 0.0319
Echinococcus multilocularis histone deacetylase 8 0.0018 0.0216 0.0213
Brugia malayi histone deacetylase 1 (HD1) 0.0063 0.1278 0.1278
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.006 0.0057
Schistosoma mansoni nuclear receptor 0.0024 0.0365 0.0341
Brugia malayi Histone deacetylase family protein 0.0059 0.1202 0.1202
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0917 0.0917
Brugia malayi nuclear receptor NHR-67 0.0024 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0014 0.0122 0.0119
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.9493 0.9493
Trichomonas vaginalis histone deacetylase, putative 0.0063 0.1278 0.8399
Loa Loa (eye worm) hypothetical protein 0.0051 0.1007 0.1005
Leishmania major histone deacetylase, putative 0.0059 0.1202 0.9344
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.1007 0.1007
Loa Loa (eye worm) histone deacetylase 7A 0.0059 0.1202 0.12
Loa Loa (eye worm) hypothetical protein 0.0073 0.1517 0.1514
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.054 0.0538
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.1007 0.1005
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0632 0.4845
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0122 0.0773
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0073 0.1517 0.1514
Echinococcus multilocularis acetylcholinesterase 0.043 1 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0122 0.0319
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0122 0.0649
Schistosoma mansoni tar DNA-binding protein 0.0127 0.2796 0.2778
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0255 0.1831
Echinococcus multilocularis BC026374 protein (S09 family) 0.0073 0.1517 0.1514
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0255 0.0252
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.1007 0.1007
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0122 0.0319
Loa Loa (eye worm) hypothetical protein 0.0051 0.1007 0.1005
Loa Loa (eye worm) hypothetical protein 0.043 1 1
Onchocerca volvulus 0.0073 0.1517 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0073 0.1517 0.1495
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0917 0.7115
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0365 0.0363
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0255 0.1538
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0025 0.0023
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.1007 0.6584
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.1007 0.0984
Trichomonas vaginalis spcc417.12 protein, putative 0.0073 0.1517 1
Brugia malayi hypothetical protein 0.0024 0.0365 0.0365
Leishmania major histone deacetylase, putative 0.0063 0.1278 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1517 0.1514
Brugia malayi hypothetical protein 0.0037 0.0677 0.0677
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0365 0.0365
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0122 0.0122
Brugia malayi steroid hormone receptor 0.0051 0.1007 0.1007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.1007 0.0984
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0365 0.0341
Loa Loa (eye worm) TAR-binding protein 0.0127 0.2796 0.2794
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0586 0.3541
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0677 0.0675
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0122 0.0773
Onchocerca volvulus 0.0024 0.0365 0.2279
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0365 0.0341
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.2796 0.2794
Echinococcus multilocularis histone deacetylase 7 0.0059 0.1202 0.12
Schistosoma mansoni ap endonuclease 0.0019 0.0255 0.023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.054 0.0538
Brugia malayi histone deacetylase 11 0.0018 0.0216 0.0216
Brugia malayi Carboxylesterase family protein 0.0073 0.1517 0.1517
Loa Loa (eye worm) hypothetical protein 0.0025 0.039 0.0387
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0122 0.0122
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0122 0.0119
Schistosoma mansoni histone deacetylase 1 2 3 0.0018 0.0216 0.0191
Echinococcus multilocularis carboxylesterase 5A 0.043 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.1007 0.0984
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0063 0.1278 0.8399
Loa Loa (eye worm) hypothetical protein 0.0027 0.0434 0.0431
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0917 0.5976
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1408 0.1408
Schistosoma mansoni hypothetical protein 0.0037 0.0677 0.0653
Loa Loa (eye worm) hypothetical protein 0.0035 0.0632 0.063
Trichomonas vaginalis histone deacetylase, putative 0.0063 0.1278 0.8399
Echinococcus multilocularis neuroligin 0.0073 0.1517 0.1514
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0365 0.0363
Echinococcus multilocularis amiloride sensitive amine oxidase 0.0085 0.1808 0.1805
Brugia malayi hypothetical protein 0.0016 0.0178 0.0178
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1082 0.8439
Echinococcus granulosus histone deacetylase 3 0.0063 0.1278 0.1276
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0023
Schistosoma mansoni hypothetical protein 0.0068 0.1408 0.1387
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0365 0.0363
Entamoeba histolytica hypothetical protein 0.0037 0.0677 0.5203
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.1007 0.1007
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0122 0.0119
Brugia malayi topoisomerase 0.001 0.0025 0.0025
Trypanosoma brucei histone deacetylase, putative 0.0059 0.1202 0.9394
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0917 0.5834
Echinococcus granulosus amiloride sensitive amine oxidase 0.0085 0.1808 0.1805
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Toxoplasma gondii histone deacetylase HDAC3 0.0063 0.1278 1
Onchocerca volvulus 0.0029 0.0473 0.3003
Echinococcus multilocularis nibrin 0.001 0.0025 0.0023
Onchocerca volvulus Histone deacetylase 10 homolog 0.0018 0.0216 0.1278
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.1007 0.1007
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0111 0.2438 0.2419
Schistosoma mansoni thyroid hormone receptor 0.0051 0.1007 0.0984
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0255 0.1831
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0122 0.0649
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.054 0.054
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0677 0.0653
Loa Loa (eye worm) hypothetical protein 0.0073 0.1517 0.1514
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Loa Loa (eye worm) hypothetical protein 0.0051 0.1007 0.1005
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0122 0.0773
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0122 0.0649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.1007 0.1005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0255 0.1831
Loa Loa (eye worm) histone deacetylase 0.0059 0.1202 0.12
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0023
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0073 0.1517 0.1514
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.1007 0.1005
Schistosoma mansoni nuclear receptor 0.0024 0.0365 0.0341
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.1007 0.1005
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2624 0.2622
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0677 0.0675
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.1007 0.1005
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0035 0.0632 0.063
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0632 0.407
Trypanosoma brucei histone deacetylase 3 0.0059 0.1202 0.9394
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0365 0.0363
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0434 0.0431
Loa Loa (eye worm) histone deacetylase 11 0.0018 0.0216 0.0213
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Toxoplasma gondii hypothetical protein 0.0043 0.081 0.6266
Loa Loa (eye worm) hypothetical protein 0.0068 0.1408 0.1406
Brugia malayi hypothetical protein 0.0073 0.1517 0.1517
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.1007 0.1007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0122 0.0319
Loa Loa (eye worm) hypothetical protein 0.0051 0.1007 0.1005
Brugia malayi TAR-binding protein 0.0127 0.2796 0.2796
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0365 0.0363
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0917 0.5976
Schistosoma mansoni histone deacetylase 0.0063 0.1278 0.1256
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0365 0.0341
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0122 0.0319
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0365 0.0363
Loa Loa (eye worm) hypothetical protein 0.0073 0.1517 0.1514
Trichomonas vaginalis histone deacetylase, putative 0.0063 0.1278 0.8399
Onchocerca volvulus 0.0047 0.0917 0.5976
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0473 0.0471
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.1007 0.6584
Onchocerca volvulus 0.0073 0.1517 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0255 0.1831
Schistosoma mansoni copper/topaquinone oxidase 0.0085 0.1808 0.1787
Echinococcus granulosus GPCR family 2 0.0032 0.054 0.0538
Echinococcus multilocularis GPCR, family 2 0.0032 0.054 0.0538
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.1007 0.1005
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0306 0.7048 0.7048
Schistosoma mansoni neuroligin 3 (S09 family) 0.0073 0.1517 0.1495
Loa Loa (eye worm) hypothetical protein 0.0035 0.0632 0.063
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0122 0.0649
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0025 0.0025
Echinococcus multilocularis histone deacetylase 0.0059 0.1202 0.12
Echinococcus multilocularis histone deacetylase 6 0.0059 0.1202 0.12
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.1007 0.1005
Schistosoma mansoni hypothetical protein 0.0085 0.1808 0.1787
Echinococcus granulosus acetylcholinesterase 0.043 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.1007 0.1007
Loa Loa (eye worm) hypothetical protein 0.0129 0.2864 0.2862
Echinococcus granulosus acetylcholinesterase 0.043 1 1
Schistosoma mansoni nuclear hormone receptor 0.0051 0.1007 0.0984
Brugia malayi tailless protein 0.0024 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0027 0.0434 0.0431
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0122 0.0773
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.1007 0.0984
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0255 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0917 0.0917
Leishmania major histone deacetylase, putative 0.0059 0.1202 0.9344
Brugia malayi nuclear receptor RXR 0.0024 0.0365 0.0365
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0122 0.0319
Trypanosoma cruzi histone deacetylase, putative 0.0059 0.1202 0.9394
Loa Loa (eye worm) oxidoreductase 0.0014 0.0122 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.1007 0.1007
Mycobacterium ulcerans carboxylesterase, LipT 0.0073 0.1517 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.039 0.291
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0917 0.5976
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0365 0.0363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0365 0.0363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.1007 0.1005
Plasmodium falciparum histone deacetylase, putative 0.0059 0.1202 0.9394
Echinococcus multilocularis histone deacetylase 3 0.0063 0.1278 0.1276
Brugia malayi hypothetical protein 0.0027 0.0434 0.0434
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0365 0.0365
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0122 0.0649
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0365 0.2279
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Giardia lamblia Histone deacetylase 0.0063 0.1278 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0073 0.1517 1
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0434 0.0434
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0917 0.5976
Trichomonas vaginalis histone deacetylase, putative 0.0063 0.1278 0.8399
Schistosoma mansoni cpg binding protein 0.003 0.0512 0.0488
Trypanosoma cruzi histone deacetylase, putative 0.0059 0.1202 0.9394
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0023
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0365 0.0363
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0917 0.0917
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.2157 0.2157
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0917 0.5976
Loa Loa (eye worm) hypothetical protein 0.0073 0.1517 0.1514
Brugia malayi Histone deacetylase 1 0.0063 0.1278 0.1278
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0365 0.0363
Toxoplasma gondii histone deacetylase HDAC5 0.0018 0.0216 0.1521
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0255 0.0252
Loa Loa (eye worm) histone deacetylase 1 0.0063 0.1278 0.1276
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.039 0.291
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0632 0.4845
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0023
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0122 0.0773
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.039 0.291
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0917 0.6873
Loa Loa (eye worm) hypothetical protein 0.01 0.2157 0.2155
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.1007 0.1005
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.1007 0.6584
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0917 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0365 0.0341
Loa Loa (eye worm) hypothetical protein 0.0241 0.551 0.5508
Brugia malayi hypothetical protein 0.0027 0.0434 0.0434
Echinococcus multilocularis para nitrobenzyl esterase 0.0073 0.1517 0.1514
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0365 0.0365
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0073 0.1517 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.0363
Loa Loa (eye worm) carboxylesterase 0.0073 0.1517 0.1514
Echinococcus granulosus histone deacetylase 8 0.0018 0.0216 0.0213
Schistosoma mansoni histone deacetylase hda2 0.0059 0.1202 0.118
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.1007 0.1007
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0025 0.0025
Echinococcus granulosus FTZ F1 alpha 0.0051 0.1007 0.1005
Onchocerca volvulus 0.0073 0.1517 1
Brugia malayi nuclear receptor NHR-88 0.0051 0.1007 0.1007
Echinococcus multilocularis acetylcholinesterase 0.043 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0122 0.0649
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.1007 0.1007
Schistosoma mansoni histone deacetylase 0.0063 0.1278 0.1256
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0122 0.0649
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0122 0.0119
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0365 0.0341
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0255 0.1146
Brugia malayi nuclear hormone receptor 0.0024 0.0365 0.0365
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0122 0.0773
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0122 0.0773
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0122 0.0649
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.2157 0.2157
Loa Loa (eye worm) DR-78 0.0024 0.0365 0.0363
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0073 0.1517 0.1495
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.0216 0.1521
Brugia malayi nuclear receptor RXR 0.0027 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0027 0.0434 0.0431
Echinococcus multilocularis cpg binding protein 0.003 0.0512 0.0509
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1237 0.1215
Echinococcus granulosus tar DNA binding protein 0.0127 0.2796 0.2794
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0122 0.0649
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0122 0.0649
Loa Loa (eye worm) histone deacetylase 3 0.0063 0.1278 0.1276
Onchocerca volvulus 0.0014 0.0122 0.0649
Trypanosoma brucei histone deacetylase 4 0.0059 0.1202 0.9394
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.1007 0.1007
Schistosoma mansoni hypothetical protein 0.0409 0.9493 0.9492
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0917 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0365 0.0363
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0586 0.3541
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.1007 0.0984
Entamoeba histolytica hypothetical protein 0.0037 0.0677 0.5203
Toxoplasma gondii histone deacetylase HDAC4 0.0018 0.0216 0.1521
Loa Loa (eye worm) hypothetical protein 0.0018 0.0216 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.1007 0.1007
Loa Loa (eye worm) hypothetical protein 0.0027 0.0434 0.0431
Schistosoma mansoni ap endonuclease 0.0019 0.0255 0.023
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0365 0.2279
Mycobacterium ulcerans hypothetical protein 0.0047 0.0917 0.5976
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0365 0.0365
Brugia malayi hypothetical protein 0.001 0.0025 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0127 0.2796 0.2778
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0255 0.0252
Onchocerca volvulus 0.0014 0.0122 0.0649
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0122 0.0319
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0434 0.0431
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.1007 0.1005
Echinococcus granulosus cpg binding protein 0.003 0.0512 0.0509
Loa Loa (eye worm) hypothetical protein 0.0032 0.054 0.0538
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.1007 0.1005
Brugia malayi Histone deacetylase family protein 0.0059 0.1202 0.1202
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0365 0.0363
Echinococcus granulosus carboxylesterase 5A 0.043 1 1
Echinococcus granulosus histone deacetylase 1 0.0063 0.1278 0.1276
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0365 0.0365
Schistosoma mansoni coup transcription factor 0.0051 0.1007 0.0984
Onchocerca volvulus 0.0051 0.1007 0.6584
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.1007 0.1007
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0122 0.1087
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0122 0.0649
Leishmania major hypothetical protein, conserved 0.0025 0.039 0.2315
Loa Loa (eye worm) hypothetical protein 0.0035 0.0632 0.063
Trypanosoma brucei histone deacetylase 2 0.0018 0.0216 0.1521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0586 0.3541
Loa Loa (eye worm) hypothetical protein 0.0073 0.1517 0.1514
Loa Loa (eye worm) acetylcholinesterase 1 0.043 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0073 0.1517 0.1495
Trichomonas vaginalis histone deacetylase, putative 0.0063 0.1278 0.8399
Schistosoma mansoni zinc finger protein 0.0024 0.0365 0.0341
Brugia malayi hypothetical protein 0.0024 0.0365 0.0365
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0073 0.1517 1
Brugia malayi Carboxylesterase family protein 0.0073 0.1517 0.1517
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0917 0.7115
Loa Loa (eye worm) hypothetical protein 0.0047 0.0917 0.0914
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0255 0.1831
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0917 0.6873
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0122 0.0122
Brugia malayi Carboxylesterase family protein 0.0073 0.1517 0.1517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.1007 0.1005
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0122 0.0773
Loa Loa (eye worm) carboxylesterase 0.0073 0.1517 0.1514
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0122 0.0319
Schistosoma mansoni histone deacetylase 4 5 0.0059 0.1202 0.118
Onchocerca volvulus 0.0014 0.0122 0.0649
Echinococcus granulosus para nitrobenzyl esterase 0.0073 0.1517 0.1514
Brugia malayi Latrophilin receptor protein 2 0.0032 0.054 0.054
Echinococcus multilocularis histone deacetylase 1 0.0063 0.1278 0.1276
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0122 0.0773
Loa Loa (eye worm) hypothetical protein 0.0042 0.0778 0.0776
Schistosoma mansoni hypothetical protein 0.0032 0.054 0.0516
Onchocerca volvulus 0.0014 0.0122 0.0649
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0365 0.0363
Loa Loa (eye worm) hypothetical protein 0.0065 0.1326 0.1323
Echinococcus granulosus histone deacetylase 7 0.0059 0.1202 0.12
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0063 0.1278 0.8399
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0365 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.1007 0.1007
Echinococcus granulosus histone deacetylase 6 0.0059 0.1202 0.12
Schistosoma mansoni thyroid hormone receptor 0.0051 0.1007 0.0984
Trichomonas vaginalis histone deacetylase, putative 0.0063 0.1278 0.8399
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.039 0.291

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 7 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 15.34 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 16.09 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 17.58 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 25 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 92 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 8.39 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -1 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 7 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 25 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 92 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 5.97 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 1.06618 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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