Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0162 | 0.0248 |
Loa Loa (eye worm) | thymidylate synthase | 0.081 | 0.6541 | 1 |
Brugia malayi | thymidylate synthase | 0.081 | 0.6541 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0653 | 0.5204 | 0.6297 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0162 | 0.0248 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0386 | 0.2929 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0653 | 0.5204 | 0.7955 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.1184 | 0.181 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1184 | 0.181 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.081 | 0.6541 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0653 | 0.5204 | 0.7955 |
Echinococcus multilocularis | thymidylate synthase | 0.081 | 0.6541 | 0.7888 |
Onchocerca volvulus | 0.081 | 0.6541 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1217 | 1 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.7976 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.081 | 0.6541 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1217 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0653 | 0.5204 | 0.5918 |
Schistosoma mansoni | dihydrofolate reductase | 0.0653 | 0.5204 | 0.7955 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.081 | 0.6541 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1217 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.081 | 0.6541 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1217 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0653 | 0.5204 | 0.7955 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0162 | 0.0248 |
Echinococcus granulosus | dihydrofolate reductase | 0.0653 | 0.5204 | 0.7503 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1217 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.081 | 0.6541 | 1 |
Brugia malayi | hypothetical protein | 0.0386 | 0.2929 | 0.4477 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0653 | 0.5204 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1184 | 0.181 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0162 | 0.0248 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 3.41 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 4.27 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 11.98 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 21 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 80 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 97 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 5.56 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 21 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 80 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 97 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.98 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.03696 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.