Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Aldose reductase | 0.019 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.019 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.019 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0135 | 0.6211 | 0.6211 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.019 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.019 | 1 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.698 | 0.698 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.019 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.019 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0055 | 0.0708 | 0.0708 |
Onchocerca volvulus | 0.019 | 1 | 1 | |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.698 | 0.698 |
Toxoplasma gondii | aldose reductase, putative | 0.019 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.019 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0055 | 0.0708 | 0.5 |
Giardia lamblia | Aldose reductase | 0.019 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.019 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.019 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Onchocerca volvulus | 0.019 | 1 | 1 | |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0055 | 0.0708 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.019 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.019 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.019 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.019 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.019 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.019 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.019 | 1 | 1 |
Onchocerca volvulus | 0.019 | 1 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.019 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.019 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.019 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.019 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.019 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.019 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.019 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.019 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.019 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.019 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0055 | 0.0708 | 0.0708 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0055 | 0.0708 | 0.0708 |
Onchocerca volvulus | 0.019 | 1 | 1 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.019 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.019 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.019 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.019 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.019 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.698 | 0.698 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.019 | 1 | 1 |
Onchocerca volvulus | 0.019 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.019 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.019 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.019 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.698 | 0.698 |
Loa Loa (eye worm) | oxidoreductase | 0.019 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0135 | 0.6211 | 0.5922 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.019 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.019 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.019 | 1 | 1 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0055 | 0.0708 | 0.0708 |
Trypanosoma cruzi | aldo-keto reductase | 0.019 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.019 | 1 | 1 |
Onchocerca volvulus | 0.019 | 1 | 1 | |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.019 | 1 | 1 |
Schistosoma mansoni | potassium channel beta | 0.0055 | 0.0708 | 0.0708 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.019 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0055 | 0.0708 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.019 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.698 | 0.698 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0055 | 0.0708 | 0.0708 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.698 | 0.698 |
Leishmania major | prostaglandin f synthase, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.019 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.019 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0135 | 0.6211 | 0.6211 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0055 | 0.0708 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.019 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.019 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.019 | 1 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.0055 | 0.0708 | 0.0708 |
Echinococcus multilocularis | aldo keto reductase | 0.019 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.019 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.019 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0.85 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.51 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.96 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 5 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 9 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 33 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 83 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 1.49 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 5 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 9 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 33 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 83 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.03 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.93284 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.