Detailed information for compound 596885

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 571.462 | Formula: C27H31Cl2F3N4O2
  • H donors: 3 H acceptors: 2 LogP: 6.13 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)NC(=O)Nc1ccc(cc1)C(F)(F)F
  • InChi: 1S/C27H31Cl2F3N4O2/c28-23-10-4-19(18-24(23)29)5-11-25(37)33-14-2-1-3-15-36-16-12-22(13-17-36)35-26(38)34-21-8-6-20(7-9-21)27(30,31)32/h4-11,18,22H,1-3,12-17H2,(H,33,37)(H2,34,35,38)/b11-5+
  • InChiKey: OFVABPOBOTZHPP-VZUCSPMQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0149 0.0536
Onchocerca volvulus 0.0101 0.0463 0.1287
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0163
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.014 0.0389
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.004 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0036 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0081 0.0224
Brugia malayi sulfakinin receptor protein 0.0013 0.0012 0.0036
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0012 0.0011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0254 0.0254
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0406 0.5329
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.004 0.004
Echinococcus granulosus geminin 0.0552 0.2775 0.2775
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0149 0.0472
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0191 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0138 0.0382
Echinococcus multilocularis mitogen activated protein kinase 0.016 0.0761 0.0761
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0229 0.2241
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0009 0.0008
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0012 0.0011
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.014 0.1372
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0627 0.316 0.316
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Loa Loa (eye worm) hypothetical protein 0.004 0.0149 0.0472
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0022 0.0055 0.0173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0012 0.0117
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.011 0.0507 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0177 0.0177
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0012 0.0117
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0109 0.0345
Echinococcus multilocularis leucine aminopeptidase protein 0.011 0.0507 0.0506
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0.0012 0.0011
Onchocerca volvulus 0.0013 0.0012 0.0032
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0229 0.0635
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0012 0.0036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0149 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0149 0.0472
Onchocerca volvulus 0.0019 0.004 0.011
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0149 0.0149
Echinococcus multilocularis mitogen activated protein kinase 3 0.016 0.0761 0.0761
Schistosoma mansoni myosin xvIII 0.0013 0.0012 0.0041
Schistosoma mansoni chromobox protein 0.0068 0.0291 0.1046
Schistosoma mansoni biogenic amine receptor 0.0013 0.0012 0.0041
Schistosoma mansoni pyruvate kinase 0.0032 0.0109 0.0392
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Schistosoma mansoni neuropeptide receptor 0.0013 0.0012 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0012 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.021 0.1019 1
Brugia malayi nuclear receptor NHR-67 0.0019 0.004 0.0126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0149 0.0149
Echinococcus multilocularis allatostatin A receptor 0.0013 0.0012 0.0011
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0014 0.0012 0.0043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0067 0.0288 0.5677
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0.0012 0.0011
Brugia malayi putative neuropeptide receptor 0.0013 0.0012 0.0036
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0109 0.2149
Brugia malayi PHD-finger family protein 0.0028 0.0088 0.0279
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0109 0.0303
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.0536
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0163
Brugia malayi hypothetical protein 0.0013 0.0012 0.0036
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0149 0.0149
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0129 0.1259
Loa Loa (eye worm) hypothetical protein 0.0105 0.048 0.1521
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0149 0.0149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0012 0.0041
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0013 0.0012 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0149 0.0472
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.011 0.0507 1
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0012 0.0036
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0025 0.0071 0.0224
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0169 0.0811 0.2574
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.0728 0.231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0406 0.1462
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0149 0.0149
Plasmodium falciparum M17 leucyl aminopeptidase 0.011 0.0507 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0229 0.2648
Onchocerca volvulus 0.004 0.0149 0.0414
Brugia malayi neuropeptide F receptor 0.0013 0.0012 0.0036
Brugia malayi SET domain containing protein 0.0015 0.002 0.0062
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0052 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0149 0.0472
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Giardia lamblia Pyruvate kinase 0.0017 0.0028 0.0365
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0419 0.0419
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0129 0.0357
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.014 0.014
Echinococcus multilocularis pyruvate kinase 0.0017 0.0028 0.0028
Brugia malayi CXXC zinc finger family protein 0.0032 0.0105 0.0333
Trypanosoma brucei protein kinase, putative 0.016 0.0761 0.7467
Mycobacterium ulcerans leucyl aminopeptidase 0.011 0.0507 1
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0012 0.0117
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0067 0.065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0012 0.0041
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0049 0.0192 0.0609
Schistosoma mansoni nuclear hormone receptor 0.0019 0.004 0.0143
Echinococcus granulosus neuropeptide receptor 0.0013 0.0012 0.0011
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0013 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Brugia malayi Serotonin receptor 0.0013 0.0012 0.0036
Brugia malayi Pre-SET motif family protein 0.009 0.0406 0.1287
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.0012 0.0011
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.004 0.0126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0177 0.0177
Echinococcus multilocularis geminin 0.0552 0.2775 0.2775
Echinococcus granulosus sex peptide receptor 0.0013 0.0012 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.016 0.0761 0.2117
Trichomonas vaginalis set domain proteins, putative 0.0712 0.3594 1
Onchocerca volvulus Huntingtin homolog 0.0144 0.068 0.189
Schistosoma mansoni amine GPCR 0.0013 0.0012 0.0041
Schistosoma mansoni alpha-1 adrenergic receptor 0.0013 0.0012 0.0041
Brugia malayi Serotonin receptor 0.0013 0.0012 0.0036
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0149 0.0149
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.004 0.011
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0028 0.0553
Brugia malayi hypothetical protein 0.023 0.1124 0.3565
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0229 1
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0011 0 0.0005
Brugia malayi ecdysone receptor 0.0019 0.004 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Brugia malayi photoreceptor-specific nuclear receptor 0.0578 0.2906 0.922
Loa Loa (eye worm) histone methyltransferase 0.0013 0.001 0.003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0012 0.0011
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0229 0.4511
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.011 0.0507 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0419 0.0419
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0012 0.0011
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.0536
Echinococcus granulosus pyruvate kinase 0.0032 0.0109 0.0109
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0036 0.01
Echinococcus multilocularis neuropeptide s receptor 0.1961 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0191 0.0606
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0036 0.01
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0036 0.01
Schistosoma mansoni hypothetical protein 0.0048 0.0191 0.0688
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0057 0.0179
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0138 0.0382
Onchocerca volvulus 0.0047 0.0183 0.051
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0012 0.0117
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.014 0.014
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.011 0.0507 0.4968
Trichomonas vaginalis CMGC family protein kinase 0.016 0.0761 0.2117
Chlamydia trachomatis cytosol aminopeptidase 0.011 0.0507 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0267 0.3511
Echinococcus granulosus g-protein coupled receptor 0.0013 0.0012 0.0011
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0011 0 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0149 0.0472
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0052 0.0185
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0014 0.0012 0.0117
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0013 0.0012 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0254 0.0915
Schistosoma mansoni amine GPCR 0.0013 0.0012 0.0041
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0144 0.068 0.2156
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0088 0.1154
Onchocerca volvulus 0.0013 0.0012 0.0032
Schistosoma mansoni chromobox protein 0.0068 0.0291 0.1046
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0012 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0012 0.0041
Echinococcus multilocularis chromobox protein 1 0.0068 0.0291 0.029
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0014 0.0012 0.0117
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0175 0.0841 0.2669
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0191 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0149 0.0472
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.014 0.014
Brugia malayi hypothetical protein 0.0019 0.004 0.0126
Loa Loa (eye worm) DR-78 0.0019 0.004 0.0126
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0149 0.0149
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0055 0.0055
Leishmania major hypothetical protein, conserved 0.021 0.1019 1
Schistosoma mansoni hypothetical protein 0.0047 0.0183 0.066
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.0536
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0109 0.0001
Onchocerca volvulus 0.0013 0.0012 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0149 0.0472
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0291 0.0921
Schistosoma mansoni thyroid hormone receptor 0.004 0.0149 0.0536
Echinococcus multilocularis neuropeptide receptor A26 0.1961 1 1
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0109 0.0968
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Brugia malayi Dopamine receptor protein 2 0.0013 0.0012 0.0036
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0012 0.0011
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0129 0.5617
Echinococcus multilocularis cpg binding protein 0.0034 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0177 0.0562
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0129 0.0357
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0012 0.0011
Brugia malayi steroid hormone receptor 0.004 0.0149 0.0472
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0243 0.0771
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Echinococcus multilocularis somatostatin receptor 0.0013 0.0012 0.0011
Schistosoma mansoni pyruvate kinase 0.0032 0.0109 0.0392
Loa Loa (eye worm) hypothetical protein 0.0175 0.0841 0.2669
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.004 0.004
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0012 0.0036
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0288 0.0287
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0304 0.1096
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0012 0.0011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0128 0.046
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0088 0.0088
Loa Loa (eye worm) follicle stimulating hormone receptor 0.051 0.256 0.8123
Giardia lamblia Pyruvate kinase 0.0032 0.0109 0.143
Brugia malayi hypothetical protein 0.0013 0.0012 0.0036
Toxoplasma gondii leucyl aminopeptidase LAP 0.011 0.0507 0.6653
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0 0.0005
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.016 0.0761 0.7467
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0067 0.065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.0728 0.231
Onchocerca volvulus Neuropeptide F receptor homolog 0.0013 0.0012 0.0032
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0013 0.0012 0.0036
Echinococcus granulosus neuropeptide receptor A26 0.1961 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0149 0.0536
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.048 0.1521
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.0536
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0014 0.0012 0.0241
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0.0012 0.0011
Giardia lamblia PHD finger protein 15 0.0028 0.0088 0.1154
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Giardia lamblia Hypothetical protein 0.0014 0.0012 0.0157
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0047 0.017
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.0012 0.0011
Brugia malayi conserved hypotetical protein 0.0019 0.004 0.0126
Onchocerca volvulus Huntingtin homolog 0.0144 0.068 0.189
Brugia malayi nuclear receptor RXR 0.0021 0.0052 0.0163
Loa Loa (eye worm) inositol-1 0.0036 0.0129 0.0407
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0014 0.0012 0.0033
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0012 0.0041
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1124 0.1123
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0067 0.0288 0.1036
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0009 0.0027
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0149 0.0414
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0013 0.0012 0.0036
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0012 0.0011
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0014 0.0012 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0012 0.0041
Brugia malayi cytosol aminopeptidase 0.0022 0.0055 0.0173
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.0536
Loa Loa (eye worm) melatonin receptor type 1A 0.0013 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0149 0.0472
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0129 0.1259
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0009 0.003
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0011 0 0.0005
Brugia malayi neuropeptide F receptor 0.0013 0.0012 0.0036
Onchocerca volvulus 0.0013 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Trypanosoma brucei aminopeptidase, putative 0.0022 0.0055 0.0536
Brugia malayi hypothetical protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0014 0.0012 0.0117
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.0012 0.0011
Brugia malayi Cytochrome P450 family protein 0.003 0.0098 0.0311
Schistosoma mansoni inositol monophosphatase 0.0036 0.0129 0.0462
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Schistosoma mansoni hypothetical protein 0.0013 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.0012 0.0011
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.014 0.1838
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0152 0.0423
Brugia malayi hypothetical protein 0.0013 0.0012 0.0036
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.004 0.004
Schistosoma mansoni nuclear hormone receptor 0.004 0.0149 0.0536
Brugia malayi hypothetical protein 0.0013 0.0012 0.0036
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0022 0.0055 0.0173
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0014 0.0012 0.0012
Brugia malayi Pre-SET motif family protein 0.0626 0.3152 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.0728 0.231
Echinococcus multilocularis peregrin 0.0028 0.0088 0.0088
Brugia malayi Tachykinin-like peptides receptor 99D 0.0013 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0059 0.2558
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0191 0.0191
Echinococcus multilocularis orexin receptor type 2 0.0013 0.0012 0.0011
Brugia malayi MAP kinase sur-1 0.016 0.0761 0.2415
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0138 0.0382
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0014 0.0012 0.0012
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.011 0.0507 0.4968
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.004 0.0126
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0014 0.0012 0.0012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.0288 0.5026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Echinococcus granulosus chromobox protein 1 0.0068 0.0291 0.029
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.011 0.0507 0.4968
Brugia malayi Melatonin receptor type 1A 0.0013 0.0012 0.0036
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.014 0.0504
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Schistosoma mansoni nuclear hormone receptor 0.0019 0.004 0.0143
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0149 0.0149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0406 0.1462
Brugia malayi Dopamine receptor 0.0013 0.0012 0.0036
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0288 0.0287
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.004 0.0149 0.0472
Brugia malayi larval opioid receptor 0.0013 0.0012 0.0036
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0014 0.0012 0.0117
Onchocerca volvulus 0.0013 0.0012 0.0032
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0088 0.0279
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.0012 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0149 0.0536
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0149 0.0149
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0012 0.0011
Brugia malayi jmjC domain containing protein 0.0036 0.0128 0.0405
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0109 0.2154
Echinococcus granulosus serotonin receptor 0.0013 0.0012 0.0011
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.011 0.0507 1
Schistosoma mansoni leucine aminopeptidase 0.0022 0.0055 0.0197
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0149 0.0536
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.001 0.0009
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0013 0.0012 0.0041
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0145 0.0145
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0109 0.0303
Loa Loa (eye worm) hypothetical protein 0.009 0.0406 0.1287
Brugia malayi G-protein coupled receptor 0.0013 0.0012 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0052 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0053
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0 0.0005
Schistosoma mansoni amine GPCR 0.0013 0.0012 0.0041
Brugia malayi hypothetical protein 0.0144 0.068 0.2156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0229 0.2241
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0149 0.0472
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0169 0.0811 0.2923
Brugia malayi Dopamine receptor protein 1 0.0013 0.0012 0.0036
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0022 0.0055 0.0173
Schistosoma mansoni hypothetical protein 0.0552 0.2775 1
Schistosoma mansoni hypothetical protein 0.0048 0.0191 0.0688
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.0012 0.0011
Brugia malayi G-protein coupled receptor 0.0013 0.0012 0.0036
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.0012 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0229 0.0228
Brugia malayi Nuclear hormone receptor E75 0.0019 0.004 0.0126
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0149 0.0414
Brugia malayi follicle stimulating hormone receptor 0.051 0.256 0.8123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0017 0.0045
Loa Loa (eye worm) hypothetical protein 0.0578 0.2906 0.922
Schistosoma mansoni nuclear receptor 0.0019 0.004 0.0143
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0109 0.0345
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.004 0.011
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0012 0.0036
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0067 0.065
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0149 0.0472
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.016 0.0761 0.7467
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0012 0.0117
Loa Loa (eye worm) hypothetical protein 0.004 0.0149 0.0472
Brugia malayi G protein-coupled receptor 0.0013 0.0012 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0012 0.0041
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0012 0.0241
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0291 0.0808
Schistosoma mansoni amine GPCR 0.0013 0.0012 0.0041
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0229 0.3002
Loa Loa (eye worm) hypothetical protein 0.004 0.0149 0.0472
Loa Loa (eye worm) hypothetical protein 0.003 0.0095 0.0302
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.004 0.0126
Echinococcus granulosus fmrfamide receptor 0.0013 0.0012 0.0011
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0129 0.1259
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0014 0.0012 0.0157
Loa Loa (eye worm) hypothetical protein 0.0144 0.068 0.2156
Schistosoma mansoni hypothetical protein 0.0105 0.048 0.1728
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0109 0.1068
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0014 0.0012 0.0038
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0129 0.1259
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0169 0.0811 0.0811
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0109 0.0303
Onchocerca volvulus Alhambra homolog 0.0028 0.0088 0.0244
Echinococcus multilocularis pyruvate kinase 0.0017 0.0028 0.0028
Echinococcus multilocularis chromobox protein 1 0.0068 0.0291 0.029
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0012 0.0011
Onchocerca volvulus 0.0013 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0059 0.0185
Echinococcus granulosus pyruvate kinase 0.0032 0.0109 0.0109
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0109 0.215
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Schistosoma mansoni pyruvate kinase 0.0017 0.0028 0.01
Schistosoma mansoni biogenic amine receptor 0.0013 0.0012 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0177 0.0177
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0169 0.0811 0.0811
Brugia malayi nuclear hormone receptor 0.004 0.0149 0.0472
Onchocerca volvulus 0.0013 0.0012 0.0032
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0022 0.0055 0.0173
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0191 0.0606
Onchocerca volvulus 0.0013 0.0012 0.0032
Entamoeba histolytica phosphoinositide kinase, putative 0.0014 0.0012 0.0523
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0014 0.0012 0.0157
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0149 0.0149
Plasmodium falciparum DNase I-like protein, putative 0.0011 0 0.0005
Echinococcus multilocularis pyruvate kinase 0.0026 0.0074 0.0074
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0229 0.0725
Schistosoma mansoni opsin-like receptor 0.0013 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Schistosoma mansoni hypothetical protein 0.0013 0.0012 0.0041
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0013 0.0012 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0177 0.0177
Schistosoma mansoni opsin-like receptor 0.0013 0.0012 0.0041
Brugia malayi ORL1-like opioid receptor 0.0013 0.0012 0.0036
Echinococcus multilocularis pyruvate kinase 0.0032 0.0109 0.0109
Onchocerca volvulus 0.0013 0.0012 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0036 0.01
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.016 0.0761 0.7467
Loa Loa (eye worm) pip kinase 1 0.0014 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0014 0.0012 0.0033
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0022 0.0055 0.0055
Echinococcus granulosus dnaJ subfamily B 0.0451 0.2258 0.2258
Onchocerca volvulus 0.0019 0.004 0.011
Brugia malayi hypothetical protein 0.0021 0.0052 0.0163
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.016 0.0761 0.2415
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0626 0.3152 1
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0149 0.0472
Echinococcus granulosus neuropeptide receptor 0.0013 0.0012 0.0011
Echinococcus granulosus pyruvate kinase 0.0017 0.0028 0.0028
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0022 0.0055 0.0197
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.001 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Brugia malayi Bromodomain containing protein 0.0028 0.0088 0.0279
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.016 0.0761 1
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0012 0.0011
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0109 0.1068
Echinococcus multilocularis serotonin receptor 0.0013 0.0012 0.0011
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0014 0.0012 0.0043
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0014 0.0012 0.0012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0191 0.0191
Schistosoma mansoni biogenic amine receptor 0.0013 0.0012 0.0041
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.014 0.0389
Onchocerca volvulus 0.003 0.0095 0.0265
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0.0012 0.0011
Schistosoma mansoni opsin-like receptor 0.0013 0.0012 0.0041
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0014 0.0012 0.0117
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0055 0.0055
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0013 0.0012 0.0041
Echinococcus multilocularis muscleblind protein 1 0.0175 0.0841 0.0841
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0013 0.0012 0.0041
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.016 0.0761 0.7467
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.0012 0.0011
Brugia malayi chromobox protein homolog 3 0.0038 0.0138 0.0436
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0.0012 0.0011
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0012 0.0011
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0012 0.0157
Mycobacterium tuberculosis Conserved protein 0.0024 0.0067 0.1308
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1617 0.8234 0.8234
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0014 0.0012 0.0117
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0109 0.1068
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0028 0.0365
Schistosoma mansoni amine GPCR 0.0013 0.0012 0.0041
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0163
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0036 0.01
Schistosoma mansoni zinc finger protein 0.0019 0.004 0.0143
Echinococcus granulosus FTZ F1 alpha 0.004 0.0149 0.0149
Brugia malayi hypothetical protein 0.0013 0.0012 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0088 0.174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0149 0.0472
Loa Loa (eye worm) pip kinase 2 0.0169 0.0811 0.2574
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0229 0.4514
Brugia malayi Muscleblind-like protein 0.0175 0.0841 0.2669
Brugia malayi ecdysteroid receptor 0.004 0.0149 0.0472
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0013 0.0012 0.0041
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0067 0.0184
Schistosoma mansoni hypothetical protein 0.0048 0.0191 0.0688
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.004 0.0126
Schistosoma mansoni histamine h1 receptor 0.0013 0.0012 0.0041
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.004 0.004
Echinococcus granulosus g protein coupled receptor 0.0013 0.0012 0.0011
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0048 0.0191 0.0688
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0191 0.0606
Echinococcus multilocularis pyruvate kinase 0.0017 0.0028 0.0028
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0012 0.0011
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0.0012 0.0011
Schistosoma mansoni ap endonuclease 0.0056 0.0229 0.0823
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0229 0.0635
Echinococcus granulosus jumonji domain containing protein 0.004 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Onchocerca volvulus 0.0032 0.0105 0.0292
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0291 0.0808
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0101 0.0463 0.1667
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0436
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.004 0.004
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0012 0.0011
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.004 0.0126
Schistosoma mansoni cpg binding protein 0.0034 0.0114 0.0411
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0055 0.0055
Brugia malayi CHD4 protein 0.0013 0.0009 0.0027
Echinococcus multilocularis pyruvate kinase 0.0032 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0149 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0149 0.0472
Plasmodium vivax hypothetical protein, conserved 0.0011 0 0.0005
Schistosoma mansoni ap endonuclease 0.0056 0.0229 0.0823
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.0012 0.0011
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.0536
Brugia malayi nuclear receptor NHR-88 0.004 0.0149 0.0472
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0163
Trypanosoma brucei hypothetical protein, conserved 0.021 0.1019 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0012 0.0011
Brugia malayi hypothetical protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0149 0.0472
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0012 0.0011
Brugia malayi hypothetical protein 0.0019 0.004 0.0126
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0254 0.3338
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0183 0.0581
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.0728 0.231
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0088 0.1154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0177 0.0638
Schistosoma mansoni survival motor neuron protein 0.0047 0.0183 0.066
Echinococcus multilocularis GPCR, family 2 0.0048 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0039 0.014 0.0444
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0254 0.0254
Schistosoma mansoni hypothetical protein 0.0013 0.0012 0.0041
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.0288 0.0912
Loa Loa (eye worm) TYRA-2 protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0109 0.0345
Trypanosoma cruzi hypothetical protein, conserved 0.021 0.1019 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0013 0.0012 0.0041
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0129 0.1686
Echinococcus granulosus chromobox protein 1 0.0068 0.0291 0.029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0149 0.0149
Brugia malayi Pip kinase protein 2 0.0169 0.0811 0.2574
Echinococcus granulosus muscleblind protein 0.0175 0.0841 0.0841
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.0288 0.5026
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.014 0.6124
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0109 0.143
Echinococcus granulosus leucine aminopeptidase protein 0.011 0.0507 0.0506
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0109 0.0345
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0014 0.0012 0.0157
Echinococcus granulosus allatostatin A receptor 0.0013 0.0012 0.0011
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0014 0.0012 0.0117
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0013 0.0012 0.0036
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0129 0.0128
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.016 0.0761 0.7467
Schistosoma mansoni nuclear receptor 0.0019 0.004 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0149 0.0472
Echinococcus granulosus hypothetical protein 0.0013 0.0012 0.0011
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0014 0.0012 0.0038
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0191 0.0191
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0128 0.0128
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.004 0.0143
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0012 0.0041
Brugia malayi putative neuropeptide receptor NPR1 0.0013 0.0012 0.0036
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0119 0.0118
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0019 0.0053
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0177 0.0562
Brugia malayi Nuclear hormone receptor E75 0.0019 0.004 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0081 0.0224
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0013 0.0012 0.0041
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0012 0.0011
Brugia malayi AKH receptor 0.0013 0.0012 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Echinococcus multilocularis dnaJ subfamily B 0.0451 0.2258 0.2258
Schistosoma mansoni neuropeptide receptor 0.0013 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0254 0.2492
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0321 0.1157
Brugia malayi nuclear receptor NHR-88 0.0019 0.004 0.0126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0036 0.01
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0149 0.0472
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.014 0.0444
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0254 0.0915
Onchocerca volvulus 0.0013 0.0012 0.0032
Echinococcus granulosus g protein coupled receptor 0.0013 0.0012 0.0011
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0014 0.0012 0.0117
Echinococcus granulosus pyruvate kinase 0.0017 0.0028 0.0028
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0012 0.0011
Schistosoma mansoni adenoreceptor 0.0013 0.0012 0.0041
Brugia malayi G protein-coupled receptor F59B2.13 0.0013 0.0012 0.0036
Schistosoma mansoni hypothetical protein 0.0451 0.2258 0.8137
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0149 0.0472
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.004 0.004
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0055 0.0055
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.004 0.004
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Schistosoma mansoni coup transcription factor 0.004 0.0149 0.0536
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0129 0.141
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0013 0.0012 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0177 0.0638
Onchocerca volvulus 0.0013 0.0012 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0149 0.0472
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0036 0.01
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0229 0.3685
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0055 0.0536
Echinococcus granulosus mitogen activated protein kinase 3 0.016 0.0761 0.0761
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0149 0.0472
Schistosoma mansoni neuropeptide receptor 0.0013 0.0012 0.0041
Onchocerca volvulus 0.0013 0.0012 0.0032
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0088 0.0088
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.004 0.0126
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0012 0.0041
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0109 0.0303
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0169 0.0811 0.2923
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.004 0.004
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0012 0.0041
Onchocerca volvulus 0.0013 0.0012 0.0032
Brugia malayi Inositol-1 0.0036 0.0129 0.0407
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0385 0.0385
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.004 0.004
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.004 0.0126
Brugia malayi GnHR receptor homolog 0.0013 0.0012 0.0036
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0.0012 0.0011
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0129 0.0357
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0012 0.0041
Schistosoma mansoni hypothetical protein 0.0552 0.2775 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0052 0.0163
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0254 0.4267
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0229 0.2241
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0149 0.0536
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.014 0.0504
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0109 0.1068
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0149 0.0536
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0345
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.023 0.1124 0.3565
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0028 0.0553
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0149 0.0472
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0013 0.0012 0.0036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0128 0.046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0177 0.0638
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0052 0.0185
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0229 0.0725
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Toxoplasma gondii exonuclease III APE 0.0056 0.0229 0.3002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0229 0.0228
Leishmania major pyruvate kinase 0.0032 0.0109 0.1068
Brugia malayi jmjC domain containing protein 0.0093 0.0419 0.133
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0012 0.0011
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0012 0.0523
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0627 0.316 0.316
Schistosoma mansoni cpg binding protein 0.0032 0.0105 0.0378
Schistosoma mansoni cpg binding protein 0.0034 0.0114 0.0411
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Brugia malayi tailless protein 0.0019 0.004 0.0126
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0014 0.0012 0.0043
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.014 0.1372
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.014 0.1372
Schistosoma mansoni neuropeptide receptor 0.0013 0.0012 0.0041
Echinococcus granulosus mitogen activated protein kinase 0.016 0.0761 0.0761
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0149 0.0472
Plasmodium vivax exodeoxyribonuclease III, putative 0.0011 0 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.016 0.0761 0.2117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0088 0.0279
Plasmodium vivax SET domain protein, putative 0.009 0.0406 0.8012
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.011 0.0507 0.4968
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0149 0.0536
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0149 0.0149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0012 0.0041
Loa Loa (eye worm) FYVE zinc finger family protein 0.0014 0.0012 0.0038
Brugia malayi nuclear hormone receptor 0.0019 0.004 0.0126
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0014 0.0012 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.016 0.0761 0.2742
Brugia malayi nuclear receptor RXR 0.0019 0.004 0.0126
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0052 0.0051
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.004 0.0149 0.0472
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Echinococcus granulosus peregrin 0.0028 0.0088 0.0088
Brugia malayi RE15519p 0.0013 0.0012 0.0036
Onchocerca volvulus 0.0013 0.0012 0.0032
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0067 0.1308
Schistosoma mansoni neuropeptide f receptor 76f 0.0013 0.0012 0.0041
Leishmania major pyruvate kinase 0.0032 0.0109 0.1068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0406 0.1462
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0012 0.0011
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0254 0.5017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0011 0 0.0005
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0152 0.0423
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0152 0.0423
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0013 0.0012 0.0036
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0013 0.0012 0.0041
Echinococcus multilocularis muscleblind protein 0.0175 0.0841 0.0841
Echinococcus multilocularis sex peptide receptor 0.0013 0.0012 0.0011
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0109 0.0303
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.014 0.014
Echinococcus granulosus GPCR family 2 0.0048 0.0191 0.0191
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.004 0.004
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0012 0.0011
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0229 1
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0014 0.0012 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0149 0.0472
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Giardia lamblia Kinase, CMGC MAPK 0.016 0.0761 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0088 0.0317
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0149 0.0536
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1124 0.1123
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.004 0.0143
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0098 0.0311
Onchocerca volvulus 0.0013 0.0012 0.0032
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0406 0.0406
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.016 0.0761 0.7467
Plasmodium falciparum phd finger protein, putative 0.0028 0.0088 0.174
Echinococcus granulosus somatostatin receptor 0.0013 0.0012 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0012 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0012 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0128 0.0405
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0012 0.0041
Onchocerca volvulus 0.0013 0.0012 0.0032
Brugia malayi hypothetical protein 0.0013 0.0012 0.0036
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.014 0.014
Echinococcus multilocularis g-protein coupled receptor 0.0013 0.0012 0.0011
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0013 0.0012 0.0032
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.014 0.1372
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0014 0.0012 0.0043
Echinococcus granulosus orexin receptor type 2 0.0013 0.0012 0.0011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.014 0.014
Trichomonas vaginalis CMGC family protein kinase 0.016 0.0761 0.2117
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0264 0.0838
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0012 0.0011
Echinococcus granulosus pyruvate kinase 0.0017 0.0028 0.0028
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0012 0.0241
Onchocerca volvulus 0.0712 0.3594 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0149 0.0536
Onchocerca volvulus 0.0169 0.0811 0.2256
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0013 0.0012 0.0036
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0229 0.4514
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0059 0.0185
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0149 0.0414
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0129 0.0128
Onchocerca volvulus 0.0013 0.0012 0.0032
Echinococcus multilocularis serotonin receptor 0.0013 0.0012 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0254 0.4267
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0126
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0254 0.4267
Schistosoma mansoni hypothetical protein 0.0028 0.0088 0.0317
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0149 0.0472
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0.0012 0.0011
Plasmodium falciparum pyruvate kinase 0.0032 0.0109 0.2154
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0012 0.0041
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0105 0.0333
Echinococcus granulosus cpg binding protein 0.0034 0.0114 0.0114
Schistosoma mansoni inositol monophosphatase 0.0036 0.0129 0.0462
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0012 0.0011
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0012 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0406 0.0406
Schistosoma mansoni thyroid hormone receptor 0.004 0.0149 0.0536
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0013 0.0012 0.0041
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0067 0.0288 0.282
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0149 0.0472
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.016 0.0761 0.7467
Loa Loa (eye worm) hypothetical protein 0.004 0.0149 0.0472
Brugia malayi Heterochromatin protein 1 0.0068 0.0291 0.0921
Brugia malayi hypothetical protein 0.0021 0.0052 0.0163
Brugia malayi Pip kinase protein 1 0.0014 0.0012 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.014 0.0389
Brugia malayi hypothetical protein 0.0013 0.0012 0.0036
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0229 0.2241
Echinococcus granulosus g protein coupled receptor 0.0013 0.0012 0.0011
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.0012 0.0011
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0109 0.0345
Brugia malayi hypothetical protein 0.0013 0.0012 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0012 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0012 0.0011

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 3 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 8.19 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 8.67 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 8.81 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 34 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 58 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 94 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 10.6 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 3 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 34 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 58 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 94 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.12 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.75 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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