TDR Targets

Basic information

Technical information

TDR Targets ID: 59731
Name: 1-[2-[3-(benzimidazol-1-yl)propoxy]-6-(dimeth ylamino)phenyl]-3-pentylurea
MW: 423.551 | Formula: C24H33N5O2
H donors: 2 H acceptors: 2 LogP: 4.32 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCNC(=O)Nc1c(OCCCn2cnc3c2cccc3)cccc1N(C)C
InChi: 1S/C24H33N5O2/c1-4-5-8-15-25-24(30)27-23-21(28(2)3)13-9-14-22(23)31-17-10-16-29-18-26-19-11-6-7-12-20(19)29/h6-7,9,11-14,18H,4-5,8,10,15-17H2,1-3H3,(H2,25,27,30)
InChiKey: AFXKWXLBLYFGRF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[2-[3-(benzimidazol-1-yl)propoxy]-6-(dimethylamino)phenyl]-3-pentyl-urea
1-[2-[3-(1-benzimidazolyl)propoxy]-6-(dimethylamino)phenyl]-3-pentylurea
1-amyl-3-[2-[3-(benzimidazol-1-yl)propoxy]-6-(dimethylamino)phenyl]urea
3-[2-[3-(benzimidazol-1-yl)propoxy]-6-dimethylaminophenyl]-1-pentylurea
3-[2-[3-(benzimidazol-1-yl)propoxy]-6-dimethylamino-phenyl]-1-pentyl-urea
3-[2-[3-(1-benzimidazolyl)propoxy]-6-dimethylaminophenyl]-1-pentylurea
1-amyl-3-[2-[3-(benzimidazol-1-yl)propoxy]-6-dimethylamino-phenyl]urea

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Oryctolagus cuniculus	Acyl-CoA:cholesterol acyltransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative	Get druggable targets OG5_133487	All targets in OG5_133487
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133487	All targets in OG5_133487
Echinococcus multilocularis	sterol O acyltransferase 1	Get druggable targets OG5_133487	All targets in OG5_133487
Schistosoma mansoni	sterol O-acyltransferase 1	Get druggable targets OG5_133487	All targets in OG5_133487
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133487	All targets in OG5_133487
Echinococcus granulosus	sterol O acyltransferase 1	Get druggable targets OG5_133487	All targets in OG5_133487

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Dictyostelium discoideum	diacylglycerol O-acyltransferase 1	Acyl-CoA:cholesterol acyltransferase	305 aa	278 aa	21.9 %
Neospora caninum	sterol O-acyltransferase, putative	Acyl-CoA:cholesterol acyltransferase	305 aa	258 aa	20.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0056	0.1282	1
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.145	0.2476
Schistosoma mansoni	sterol O-acyltransferase 1	0.0264	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Echinococcus multilocularis	cathepsin L cysteine protease	0.0056	0.1282	0.1282
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0056	0.1282	0.2191
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0056	0.1282	0.2191
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0056	0.1282	0.2191
Leishmania major	cathepsin L-like protease	0.0056	0.1282	0.2191
Onchocerca volvulus		0.0039	0.0565	0.4403
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Echinococcus multilocularis	cathepsin L cysteine protease	0.0056	0.1282	0.1282
Toxoplasma gondii	proteasome subunit beta type, putative	0.0165	0.5853	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0056	0.1282	0.2191
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0056	0.1282	0.2191
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0056	0.1282	0.2191
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0163	0.5777	0.5777
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0056	0.1282	0.2191
Echinococcus multilocularis	cathepsin b	0.0163	0.5777	0.5777
Leishmania major	cathepsin L-like protease	0.0056	0.1282	0.2191
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0165	0.5853	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0056	0.1282	0.2191
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.023	0.0392
Onchocerca volvulus	Cathepsin L homolog	0.0056	0.1282	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0056	0.1282	0.2191
Entamoeba histolytica	cysteine proteinase 1, putative	0.0031	0.023	0.0392
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0056	0.1282	0.2191
Trypanosoma cruzi	cysteine peptidase, putative	0.0056	0.1282	0.2191
Echinococcus granulosus	cathepsin b	0.0163	0.5777	0.5777
Entamoeba histolytica	cysteine proteinase 2	0.0031	0.023	0.0392
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0056	0.1282	0.2191
Trypanosoma cruzi	cysteine proteinase, putative	0.0031	0.023	0.0392
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0056	0.1282	0.1282
Echinococcus granulosus	cathepsin L cysteine protease	0.0031	0.023	0.023
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0163	0.5777	0.5777
Plasmodium falciparum	proteasome subunit beta type-5	0.0165	0.5853	1
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.023	0.0392
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0031	0.023	0.023
Brugia malayi	Cathepsin L-like precursor	0.0056	0.1282	0.2191
Echinococcus granulosus	proteasome prosome macropain	0.0165	0.5853	0.5853
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.023	0.0392
Toxoplasma gondii	cathepsin B	0.006	0.145	0.2476
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.145	0.2476
Trypanosoma cruzi	cysteine peptidase, putative	0.0056	0.1282	0.2191
Onchocerca volvulus		0.0056	0.1282	1
Echinococcus multilocularis	cathepsin b	0.0163	0.5777	0.5777
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0565	0.0965
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0165	0.5853	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0031	0.023	0.023
Echinococcus multilocularis	cysteine protease	0.0056	0.1282	0.1282
Onchocerca volvulus		0.0056	0.1282	1
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0165	0.5853	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0163	0.5777	0.5777
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0165	0.5853	1
Brugia malayi	Papain family cysteine protease containing protein	0.0031	0.023	0.0392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Echinococcus granulosus	cathepsin L	0.0031	0.023	0.023
Brugia malayi	cathepsin L-like precursor	0.0039	0.0565	0.0965
Loa Loa (eye worm)	cysteine protease	0.0056	0.1282	0.1282
Onchocerca volvulus	Cathepsin L homolog	0.0056	0.1282	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.145	0.2476
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0056	0.1282	0.2191
Loa Loa (eye worm)	ctsf protein	0.0056	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Loa Loa (eye worm)	fibroinase	0.0056	0.1282	0.1282
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Echinococcus multilocularis	cathepsin L	0.0031	0.023	0.023
Plasmodium vivax	vivapain-2	0.0056	0.1282	0.2191
Toxoplasma gondii	cathepsin CPL	0.0056	0.1282	0.2191
Plasmodium vivax	unspecified product	0.0031	0.023	0.0392
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.023	0.0392
Brugia malayi	Cathepsin L-like precursor	0.0056	0.1282	0.2191
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.023	0.0392
Leishmania major	cathepsin L-like protease	0.0056	0.1282	0.2191
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0165	0.5853	1
Leishmania major	cathepsin L-like protease	0.0056	0.1282	0.2191
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0565	0.0965
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0056	0.1282	0.2191
Entamoeba histolytica	cysteine proteinase, putative	0.0056	0.1282	0.2191
Echinococcus granulosus	cathepsin l1	0.0039	0.0565	0.0565
Brugia malayi	Papain family cysteine protease containing protein	0.0056	0.1282	0.2191
Echinococcus multilocularis	sterol O acyltransferase 1	0.0264	1	1
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Loa Loa (eye worm)	hypothetical protein	0.0238	0.8918	0.8918
Leishmania major	proteasome beta 5 subunit, putative	0.0165	0.5853	1
Leishmania major	cathepsin L-like protease	0.0056	0.1282	0.2191
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0565	0.0965
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0165	0.5853	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0056	0.1282	0.2191
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0565	0.0565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0165	0.5853	0.5853
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.145	0.2476
Onchocerca volvulus		0.0056	0.1282	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1282	0.1282
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0165	0.5853	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.023	0.0392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Brugia malayi	Cathepsin L-like precursor	0.0056	0.1282	0.2191
Brugia malayi	Cathepsin L-like precursor	0.0056	0.1282	0.2191
Schistosoma mansoni	cathepsin F (C01 family)	0.0056	0.1282	0.1282
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0056	0.1282	0.1282
Echinococcus granulosus	cathepsin b	0.0163	0.5777	0.5777
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0056	0.1282	0.2191
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0056	0.1282	0.2191
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0565	0.0965
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0163	0.5777	0.5777
Echinococcus granulosus	cathepsin l1	0.0056	0.1282	0.1282
Plasmodium vivax	vivapain-3	0.0031	0.023	0.0392
Schistosoma mansoni	cathepsin F (C01 family)	0.0039	0.0565	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0565	0.0565
Trypanosoma cruzi	cysteine protease, putative	0.0031	0.023	0.0392
Schistosoma mansoni	cathepsin F (C01 family)	0.0056	0.1282	0.1282
Leishmania major	cysteine peptidase A (CPA)	0.0056	0.1282	0.2191
Mycobacterium ulcerans	proteasome PrcB	0.0165	0.5853	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0056	0.1282	0.2191
Trypanosoma cruzi	cruzipain precursor, putative	0.0056	0.1282	0.2191
Brugia malayi	Cathepsin L-like precursor	0.0056	0.1282	0.2191
Plasmodium vivax	vivapain-2	0.0056	0.1282	0.2191
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.0565	0.0965
Brugia malayi	Cathepsin L-like precursor	0.0056	0.1282	0.2191
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0056	0.1282	0.2191
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Treponema pallidum	alginate O-acetylation protein (algI)	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0565	0.0565
Leishmania major	cathepsin L-like protease	0.0056	0.1282	0.2191
Trypanosoma cruzi	cysteine peptidase, putative	0.0056	0.1282	0.2191
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0031	0.023	0.0392
Entamoeba histolytica	cysteine proteinase, putative	0.0056	0.1282	0.2191
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0163	0.5777	0.9869
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0056	0.1282	0.1282
Loa Loa (eye worm)	cathepsin B	0.006	0.145	0.145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0165	0.5853	0.5853
Brugia malayi	Papain family cysteine protease containing protein	0.0031	0.023	0.0392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.023	0.0392
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0056	0.1282	0.2191
Onchocerca volvulus		0.0056	0.1282	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.023	0.0392
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0056	0.1282	0.2191
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0056	0.1282	0.1282
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0039	0.0565	0.0965
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0165	0.5853	0.5853
Entamoeba histolytica	cysteine protease, putative	0.0056	0.1282	0.2191
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0056	0.1282	0.2191
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0165	0.5853	1
Echinococcus granulosus	cysteine protease	0.0031	0.023	0.023
Trypanosoma cruzi	cysteine peptidase, putative	0.0056	0.1282	0.2191
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0056	0.1282	0.1282
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0039	0.0565	0.0965
Trypanosoma cruzi	cysteine proteinase, putative	0.0031	0.023	0.0392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0056	0.1282	0.2191
Brugia malayi	Proteasome A-type and B-type family protein	0.0165	0.5853	1
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0056	0.1282	0.2191
Onchocerca volvulus	Cathepsin F homolog	0.0056	0.1282	1
Plasmodium vivax	vivapain-1	0.0031	0.023	0.0392
Echinococcus multilocularis	cysteine protease	0.0056	0.1282	0.1282
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0056	0.1282	0.2191
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0056	0.1282	0.2191
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0165	0.5853	0.5
Leishmania major	cathepsin L-like protease	0.0056	0.1282	0.2191
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.145	0.145
Onchocerca volvulus		0.0056	0.1282	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0031	0.023	0.023
Brugia malayi	cathepsin B-like cysteine proteinase	0.0163	0.5777	0.9869
Entamoeba histolytica	cysteine protease, putative	0.0031	0.023	0.0392
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0056	0.1282	0.2191
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.023	0.0392
Leishmania major	cathepsin L-like protease	0.0056	0.1282	0.2191
Onchocerca volvulus		0.0056	0.1282	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0031	0.023	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0163	0.5777	0.5777
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0056	0.1282	0.1282

Activities

Activity type	Activity value	Assay description	Source	Reference
Cholesterol reduction (functional)	= -12 %	Tested for cholesterol lowering activity in rats after a dose of 10 mg/kg once a day for 5 days	ChEMBL.	8496930
IC50 (binding)	= 0.18 uM	Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit intestine microsomes.	ChEMBL.	8496930
IC50 (binding)	= 0.18 uM	Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit intestine microsomes.	ChEMBL.	8496930
IC50 (binding)	= 0.62 uM	Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit aorta homogenate.	ChEMBL.	8496930
IC50 (binding)	= 0.62 uM	Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit aorta homogenate.	ChEMBL.	8496930

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL40516
PubChem: 10251723

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 59731