Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hexokinase | 0.2687 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.2687 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1833 | 0.5396 | 0.5396 |
Onchocerca volvulus | 0.2687 | 1 | 1 | |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.2122 | 0.6954 | 0.4355 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.2071 | 0.668 | 0.668 |
Plasmodium falciparum | hexokinase | 0.2687 | 1 | 0.5 |
Onchocerca volvulus | 0.2687 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.1686 | 0.4604 | 0.4604 |
Schistosoma mansoni | hexokinase | 0.2687 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.2687 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0854 | 0.0123 | 0.0123 |
Trypanosoma cruzi | hexokinase, putative | 0.2687 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.2687 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.2687 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.1686 | 0.4604 | 0.4604 |
Brugia malayi | Hexokinase family protein | 0.2687 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.2687 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.2687 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.2687 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.2687 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.2687 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2026 | 0.6435 | 0.6435 |
Echinococcus multilocularis | hexokinase | 0.2687 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.2687 | 1 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.2071 | 0.668 | 0.668 |
Onchocerca volvulus | 0.2687 | 1 | 1 | |
Plasmodium vivax | hexokinase, putative | 0.2687 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.2687 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.2687 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.2687 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0854 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hexokinase | 0.2687 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.2687 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.2687 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.2687 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.2687 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0854 | 0.0123 | 0.0123 |
Trypanosoma cruzi | hexokinase, putative | 0.2687 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DHP-I susceptibility (functional) | = 2.12 | Relative rate of hydrolysis of porcine renal dehydropeptidase-I (DHP-I) to imipenem | ChEMBL. | No reference |
DHP-I susceptibility (functional) | = 2.12 | Compound was measured for DHP-I susceptibility | ChEMBL. | No reference |
DHP-I susceptibility (functional) | = 2.12 | Relative rate of hydrolysis of porcine renal dehydropeptidase-I (DHP-I) to imipenem | ChEMBL. | No reference |
DHP-I susceptibility (functional) | = 2.12 | Compound was measured for DHP-I susceptibility | ChEMBL. | No reference |
ED50 (functional) | = 5.91 ug ml-1 | Compound was tested in vivo for its anti-methicillin-resistant staphylococcus aureus(MRSA) | ChEMBL. | No reference |
Epileptogenicity (functional) | = 0 | Epileptogenicity of compound was measured at 100 microg/rat head by the rat intraventricular assay; 0/5 | ChEMBL. | No reference |
IC50 (functional) | = 9.6 ug ml-1 | PBP-2'' affinity was determined by the competition assay with [14C]-benzylpenicillin using membrane isolated from MRSA BB6294 strain | ChEMBL. | No reference |
MIC (functional) | = 0.012 ug ml-1 | In vitro antibacterial activity against staphylococcus aureus 209P NIHJ JC1 organism | ChEMBL. | No reference |
MIC (functional) | = 3.13 ug ml-1 | In vitro antibacterial activity against staphylococcus aureus BB6294 organism(Methicillin-resistant strain) | ChEMBL. | No reference |
MIC (functional) | = 4.59 ug ml-1 | Compound was tested in vitro for its anti-methicillin-resistant staphylococcus aureus(MRSA); 3.13-6.25 | ChEMBL. | No reference |
MIC (functional) | = 6.25 ug ml-1 | In vitro antibacterial activity against staphylococcus aureus CSa1009 (Methicillin-resistant strain and b beta-Lactamase producing strain) | ChEMBL. | No reference |
MIC (functional) | = 6.25 ug ml-1 | In vitro antibacterial activity against S. epidermidis MB5181a organism | ChEMBL. | No reference |
MIC (functional) | = 6.25 ug ml-1 | In vitro antibacterial activity against E. coli NIHJ JC2 organism | ChEMBL. | No reference |
MIC (functional) | = 6.25 ug ml-1 | In vitro antibacterial activity against E. coli NIHJ JC2 organism | ChEMBL. | No reference |
MIC (functional) | = 12.5 ug ml-1 | In vitro antibacterial activity against E. faecalis MB4996 organism | ChEMBL. | No reference |
MIC (functional) | = 25 ug ml-1 | In vitro antibacterial activity against P. aeruginosa MB5002 organism | ChEMBL. | No reference |
PPB (functional) | = 69 % | Compound was measured for binding rate for mouse serum at a carbapenem concentration of 10 ug/mL | ChEMBL. | No reference |
Protein binding (functional) | = 69 % | Compound was measured for binding rate for mouse serum at a carbapenem concentration of 10 ug/mL | ChEMBL. | No reference |
Protein binding (functional) | = 69 % | Compound was measured for binding rate for mouse serum at a carbapenem concentration of 10 ug/mL | ChEMBL. | No reference |
Protein binding (ADMET) | = 88 % | Compound was measured for binding rate for human serum at a carbapenem concentration of 10 ug/mL | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.