Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 1 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 62 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 91 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 94 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 17.01 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 1 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 62 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 91 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 94 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 8.49 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.0032 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.