Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0113 | 0.0113 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0892 | 0.2352 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0333 | 0.0333 |
Echinococcus granulosus | Endonuclease G | 0.002 | 0.0363 | 0.0363 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0113 | 0.0113 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0892 | 0.0892 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0333 | 0.0333 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.6861 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.6861 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3744 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0042 | 0.0892 | 0.0578 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.019 | 0.0506 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0333 | 0.0889 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3744 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0113 | 0.0113 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0113 | 0.0113 |
Trypanosoma brucei | endonuclease G, putative | 0.002 | 0.0363 | 0.0969 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0333 | 0.0333 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0006 | 0.0015 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0892 | 0.0892 |
Onchocerca volvulus | 0.0034 | 0.0689 | 0.4211 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0892 | 0.0892 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Echinococcus multilocularis | ectonucleotide | 0.0028 | 0.0561 | 0.0561 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.014 | 0.3286 | 0.3055 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0892 | 0.0578 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.0892 | 0.2352 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.0892 | 0.2381 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0113 | 0.0113 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0042 | 0.0042 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0597 | 0.0597 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0042 | 0.0042 |
Onchocerca volvulus | 0.0042 | 0.0892 | 0.5446 | |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0113 | 0.0113 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0689 | 0.0689 |
Onchocerca volvulus | 0.0072 | 0.1637 | 1 | |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0597 | 0.0597 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.1328 | 0.1328 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0558 | 0.0558 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0333 | 0.0889 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0333 | 0.0333 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0889 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0891 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0892 | 0.0892 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0015 | 0.0015 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0333 | 0.0889 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0333 | 0.0333 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0333 | 0.0333 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0072 | 0.1637 | 0.1637 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0113 | 0.0113 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.3744 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0889 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0113 | 0.0113 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0113 | 0.0113 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0892 | 0.0578 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0891 | 0.1298 |
Giardia lamblia | DNA damage repair protein | 0.0006 | 0.0015 | 0.0021 |
Echinococcus granulosus | ectonucleotide | 0.0028 | 0.0561 | 0.0561 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0889 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0113 | 0.0113 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0006 | 0.0015 | 0.0015 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0113 | 0.0113 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.6861 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0333 | 0.0333 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0006 | 0.0015 | 0.0039 |
Onchocerca volvulus | 0.0028 | 0.0558 | 0.3409 | |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.014 | 0.3286 | 0.3286 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0689 | 0.0689 |
Onchocerca volvulus | 0.0034 | 0.0689 | 0.4211 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0113 | 0.0113 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.6861 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0113 | 0.0113 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0113 | 0.0691 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0113 | 0.0113 |
Brugia malayi | polk-prov protein | 0.0006 | 0.0015 | 0.0015 |
Leishmania major | endonuclease G, putative | 0.002 | 0.0363 | 0.0969 |
Leishmania major | DNA polymerase eta, putative | 0.0006 | 0.0015 | 0.0039 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0558 | 0.0558 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0333 | 0.0485 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0006 | 0.0015 | 0.0039 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0333 | 0.0889 |
Echinococcus multilocularis | Endonuclease G | 0.002 | 0.0363 | 0.0363 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0892 | 0.1265 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.6861 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0.0892 | 0.2381 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0892 | 0.0892 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0113 | 0.0113 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0853 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0028 | 0.0561 | 0.0561 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0333 | 0.0333 |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.0892 | 0.1265 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.6861 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0113 | 0.0113 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.002 | 0.0363 | 0.0363 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0113 | 0.0113 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0965 | 0.0965 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0113 | 0.0113 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0891 | 0.0891 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0113 | 0.0113 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0084 | 0.0084 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3744 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0853 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0891 | 0.0891 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0333 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0113 | 0.0113 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0892 | 0.0892 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0889 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0113 | 0.0113 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0042 | 0.0892 | 0.0578 |
Mycobacterium ulcerans | lipase LipD | 0.0042 | 0.0892 | 0.0892 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0113 | 0.0113 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0113 | 0.0113 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0891 | 0.1298 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0965 | 0.0965 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0892 | 0.0892 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0042 | 0.0892 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0113 | 0.0113 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0113 | 0.0113 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0891 | 0.0891 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0006 | 0.0015 | 0.0039 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.014 | 0.3286 | 0.3286 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0034 | 0.0689 | 0.0689 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0889 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0892 | 0.0892 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0113 | 0.0113 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0333 | 0.0448 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0006 | 0.0015 | 0.0039 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0892 | 0.0578 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.002 | 0.0363 | 0.0934 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0333 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0113 | 0.0113 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.019 | 0.0506 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0891 | 0.0891 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0042 | 0.0892 | 0.0578 |
Schistosoma mansoni | endonuclease related | 0.002 | 0.0363 | 0.0363 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0113 | 0.0113 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0072 | 0.1637 | 0.1637 |
Leishmania major | DNA damage repair protein, putative | 0.0006 | 0.0015 | 0.0039 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0892 | 0.0892 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.002 | 0.0363 | 0.0934 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0113 | 0.0113 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0965 | 0.0965 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0891 | 0.0891 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0113 | 0.0691 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0113 | 0.0113 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0042 | 0.0892 | 0.0578 |
Trypanosoma brucei | endonuclease G, putative | 0.002 | 0.0363 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0113 | 0.0113 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.019 | 0.0506 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3744 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.1637 | 0.1637 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0333 | 0.0333 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0333 | 0.0485 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0113 | 0.0113 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0113 | 0.0113 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0889 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0113 | 0.0113 |
Trypanosoma brucei | endonuclease G, putative | 0.002 | 0.0363 | 0.0969 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0597 | 0.0597 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0891 | 0.1298 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0113 | 0.0113 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0113 | 0.0113 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0113 | 0.0113 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.019 | 0.0506 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0286 | 0.6861 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0853 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0965 | 0.0965 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0286 | 0.6861 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0892 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0113 | 0.0113 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0889 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0892 | 0.1265 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0333 | 0.0333 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0042 | 0.0042 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.6861 | 1 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0042 | 0.0042 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0965 | 0.0965 |
Mycobacterium ulcerans | hypothetical protein | 0.0006 | 0.0015 | 0.0015 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0113 | 0.0113 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0892 | 0.0892 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0042 | 0.0892 | 0.0892 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.0892 | 0.0892 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0892 | 0.0892 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0561 | 0.0561 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0113 | 0.0113 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0028 | 0.0561 | 0.0561 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.002 | 0.0363 | 0.0969 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.019 | 0.0506 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0113 | 0.0113 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0965 | 0.0965 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0333 | 0.0853 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0853 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0113 | 0.0113 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.1173 | 0.3105 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0113 | 0.0113 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0113 | 0.0113 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0892 | 0.1265 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0113 | 0.0113 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0892 | 0.2352 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0113 | 0.0113 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0892 | 0.0892 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 1 | 1 |
Onchocerca volvulus | 0.0042 | 0.0892 | 0.5446 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0286 | 0.6861 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0113 | 0.0113 |
Trypanosoma cruzi | endonuclease G, putative | 0.002 | 0.0363 | 0.0934 |
Onchocerca volvulus | 0.001 | 0.0113 | 0.0691 | |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0333 | 0.0333 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0892 | 0.0892 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0892 | 0.1265 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0113 | 0.0113 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0113 | 0.0113 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0113 | 0.0113 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0333 | 0.0889 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3744 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0113 | 0.0113 |
Onchocerca volvulus | 0.0042 | 0.0892 | 0.5446 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0965 | 0.0965 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0558 | 0.0558 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0113 | 0.0113 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0286 | 0.6861 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0006 | 0.0015 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0689 | 0.0689 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0267 | 0.639 | 0.6266 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0965 | 0.0965 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0286 | 0.6861 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0084 | 0.0084 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0113 | 0.0113 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0113 | 0.0113 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0113 | 0.0113 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0892 | 0.0892 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0113 | 0.0113 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0965 | 0.0965 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0042 | 0.0892 | 0.0578 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0042 | 0.0892 | 0.0892 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0333 | 0.0333 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0006 | 0.0015 | 0.0039 |
Trypanosoma cruzi | endonuclease G, putative | 0.002 | 0.0363 | 0.0934 |
Leishmania major | DNA polymerase kappa, putative | 0.0006 | 0.0015 | 0.0039 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0889 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0113 | 0.0113 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0333 | 0.0889 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0333 | 0.0889 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0892 | 0.0892 |
Mycobacterium ulcerans | beta-lactamase | 0.0042 | 0.0892 | 0.0892 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0113 | 0.0113 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0892 | 0.0892 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0113 | 0.0113 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.002 | 0.0363 | 0.0934 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0892 | 0.0892 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0113 | 0.0691 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0034 | 0.0689 | 0.0689 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0333 | 0.0333 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0892 | 0.2352 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0892 | 0.0892 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0042 | 0.0892 | 0.0578 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0006 | 0.0015 | 0.0039 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0597 | 0.0597 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0.66 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.73 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.48 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 5 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 14 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 97 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 0.75 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 5 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 14 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 97 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.88 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.13076 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.