TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 335.617 | Formula: C12H13Cl3N4O
H donors: 2 H acceptors: 2 LogP: 3.43 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Nc1nc(C)c(c(n1)N)OCc1ccc(c(c1)Cl)Cl.Cl
InChi: 1S/C12H12Cl2N4O.ClH/c1-6-10(11(15)18-12(16)17-6)19-5-7-2-3-8(13)9(14)4-7;/h2-4H,5H2,1H3,(H4,15,16,17,18);1H
InChiKey: XFLIZZDTOZIYNC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0113	0.0113
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0892	0.2352
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0333	0.0333
Echinococcus granulosus	Endonuclease G	0.002	0.0363	0.0363
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0415	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0113	0.0113
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0892	0.0892
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0333	0.0333
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.6861	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.6861	1
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0159	0.3744	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0892	0.0578
Trypanosoma brucei	unspecified product	0.0013	0.019	0.0506
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0333	0.0889
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0159	0.3744	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0113	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0333	0.0889
Loa Loa (eye worm)	hypothetical protein	0.001	0.0113	0.0113
Trypanosoma brucei	endonuclease G, putative	0.002	0.0363	0.0969
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0333	0.0333
Trypanosoma brucei	hypothetical protein, conserved	0.0006	0.0015	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0892	0.0892
Onchocerca volvulus		0.0034	0.0689	0.4211
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0892	0.0892
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0034	0.0689	0.0689
Echinococcus multilocularis	ectonucleotide	0.0028	0.0561	0.0561
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.014	0.3286	0.3055
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0892	0.0578
Toxoplasma gondii	ABC1 family protein	0.0042	0.0892	0.2352
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0892	0.2381
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0113	0.0113
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0042	0.0042
Schistosoma mansoni	cpg binding protein	0.003	0.0597	0.0597
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0042	0.0042
Onchocerca volvulus		0.0042	0.0892	0.5446
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0113	0.0113
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0689	0.0689
Onchocerca volvulus		0.0072	0.1637	1
Echinococcus multilocularis	cpg binding protein	0.003	0.0597	0.0597
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.1328	0.1328
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0415	1	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0558	0.0558
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0333	0.0889
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0333	0.0333
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0333	0.0889
Entamoeba histolytica	hypothetical protein	0.0042	0.0891	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0892	0.0892
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0333	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0015	0.0015
Trypanosoma brucei	unspecified product	0.0019	0.0333	0.0889
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0333	0.0333
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0333	0.0333
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0333	0.0333
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.0072	0.1637	0.1637
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0689	0.0689
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0333	0.0333
Loa Loa (eye worm)	hypothetical protein	0.001	0.0113	0.0113
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0159	0.3744	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0333	0.0889
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0113	0.0113
Schistosoma mansoni	coup transcription factor	0.001	0.0113	0.0113
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0892	0.0578
Entamoeba histolytica	hypothetical protein	0.0042	0.0891	0.1298
Giardia lamblia	DNA damage repair protein	0.0006	0.0015	0.0021
Echinococcus granulosus	ectonucleotide	0.0028	0.0561	0.0561
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0333	0.0889
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0113	0.0113
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0689	0.0689
Schistosoma mansoni	DNA polymerase IV / kappa	0.0006	0.0015	0.0015
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0113	0.0113
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0113	0.0113
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.6861	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0333	0.0333
Trypanosoma brucei	chrX additional, unordered contigs	0.0006	0.0015	0.0039
Onchocerca volvulus		0.0028	0.0558	0.3409
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.014	0.3286	0.3286
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0689	0.0689
Onchocerca volvulus		0.0034	0.0689	0.4211
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0113	0.0113
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.6861	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0113	0.0113
Schistosoma mansoni	dihydrofolate reductase	0.0415	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0113	0.0691
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0689	0.0689
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0113	0.0113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0113	0.0113
Brugia malayi	polk-prov protein	0.0006	0.0015	0.0015
Leishmania major	endonuclease G, putative	0.002	0.0363	0.0969
Leishmania major	DNA polymerase eta, putative	0.0006	0.0015	0.0039
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0558	0.0558
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0333	0.0485
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0689	0.0689
Trypanosoma brucei	DNA polymerase kappa, putative	0.0006	0.0015	0.0039
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0333	0.0889
Echinococcus multilocularis	Endonuclease G	0.002	0.0363	0.0363
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0892	0.1265
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0113	0.0113
Loa Loa (eye worm)	dihydrofolate reductase	0.0415	1	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.6861	1
Leishmania major	hypothetical protein, conserved	0.0042	0.0892	0.2381
Brugia malayi	steroid hormone receptor	0.001	0.0113	0.0113
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0892	0.0892
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0113	0.0113
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0333	0.0853
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0028	0.0561	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0333	0.0333
Trichomonas vaginalis	esterase, putative	0.0042	0.0892	0.1265
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.6861	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0113	0.0113
Brugia malayi	endonuclease G, mitochondrial precursor	0.002	0.0363	0.0363
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0113	0.0113
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0689	0.0689
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0965	0.0965
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0113	0.0113
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0891	0.0891
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0113	0.0113
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0084	0.0084
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0159	0.3744	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0333	0.0853
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0415	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0891	0.0891
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0333	0.0448
Loa Loa (eye worm)	hypothetical protein	0.001	0.0113	0.0113
Brugia malayi	beta-lactamase family protein	0.0042	0.0892	0.0892
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0333	0.0889
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0113	0.0113
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0892	0.0578
Mycobacterium ulcerans	lipase LipD	0.0042	0.0892	0.0892
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0113	0.0113
Brugia malayi	Dihydrofolate reductase	0.0415	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0113	0.0113
Entamoeba histolytica	hypothetical protein	0.0042	0.0891	0.1298
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0965	0.0965
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0892	0.0892
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0892	0.0578
Loa Loa (eye worm)	hypothetical protein	0.001	0.0113	0.0113
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0113	0.0113
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0891	0.0891
Trypanosoma brucei	hypothetical protein, conserved	0.0006	0.0015	0.0039
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.014	0.3286	0.3286
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0034	0.0689	0.0689
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0333	0.0889
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0892	0.0892
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0113	0.0113
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0333	0.0448
Trypanosoma brucei	DNA damage repair protein, putative	0.0006	0.0015	0.0039
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0892	0.0578
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.002	0.0363	0.0934
Leishmania major	DNA polymerase eta, putative	0.0019	0.0333	0.0889
Loa Loa (eye worm)	hypothetical protein	0.001	0.0113	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.019	0.0506
Brugia malayi	hypothetical protein	0.0042	0.0891	0.0891
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0892	0.0578
Schistosoma mansoni	endonuclease related	0.002	0.0363	0.0363
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0113	0.0113
Brugia malayi	Thrombospondin type 1 domain containing protein	0.0072	0.1637	0.1637
Leishmania major	DNA damage repair protein, putative	0.0006	0.0015	0.0039
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0892	0.0892
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.002	0.0363	0.0934
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0113	0.0113
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0965	0.0965
Schistosoma mansoni	hypothetical protein	0.0042	0.0891	0.0891
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0113	0.0691
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0113	0.0113
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0892	0.0578
Trypanosoma brucei	endonuclease G, putative	0.002	0.0363	0.0969
Loa Loa (eye worm)	hypothetical protein	0.001	0.0113	0.0113
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0689	0.0689
Trypanosoma brucei	unspecified product	0.0013	0.019	0.0506
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0159	0.3744	1
Schistosoma mansoni	hypothetical protein	0.0072	0.1637	0.1637
Echinococcus granulosus	dna polymerase eta	0.0019	0.0333	0.0333
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0333	0.0485
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0113	0.0113
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0113	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0333	0.0889
Brugia malayi	nuclear receptor NHR-88	0.001	0.0113	0.0113
Trypanosoma brucei	endonuclease G, putative	0.002	0.0363	0.0969
Schistosoma mansoni	cpg binding protein	0.003	0.0597	0.0597
Entamoeba histolytica	hypothetical protein	0.0042	0.0891	0.1298
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0113	0.0113
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0113	0.0113
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0113	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.019	0.0506
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0286	0.6861	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0333	0.0853
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0965	0.0965
Giardia lamblia	Fructose-bisphosphate aldolase	0.0286	0.6861	1
Echinococcus multilocularis	dihydrofolate reductase	0.0415	1	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0892	0.1265
Loa Loa (eye worm)	hypothetical protein	0.001	0.0113	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0333	0.0889
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0892	0.1265
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0034	0.0689	0.0689
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0333	0.0333
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0042	0.0042
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.6861	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0042	0.0042
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0965	0.0965
Mycobacterium ulcerans	hypothetical protein	0.0006	0.0015	0.0015
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0113	0.0113
Brugia malayi	beta-lactamase family protein	0.0042	0.0892	0.0892
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0892	0.0892
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0892	0.0892
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0892	0.0892
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0561	0.0561
Brugia malayi	ecdysteroid receptor	0.001	0.0113	0.0113
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0028	0.0561	0.0561
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.002	0.0363	0.0969
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0689	0.0689
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.019	0.0506
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0113	0.0113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0113	0.0113
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0965	0.0965
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0333	0.0853
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0333	0.0853
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0113	0.0113
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.1173	0.3105
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0113	0.0113
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0034	0.0689	0.0689
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0689	0.0689
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0689	0.0689
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0113	0.0113
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0892	0.1265
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0113	0.0113
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0892	0.2352
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0113	0.0113
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0892	0.0892
Echinococcus granulosus	dihydrofolate reductase	0.0415	1	1
Onchocerca volvulus		0.0042	0.0892	0.5446
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.6861	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0113	0.0113
Trypanosoma cruzi	endonuclease G, putative	0.002	0.0363	0.0934
Onchocerca volvulus		0.001	0.0113	0.0691
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0333	0.0333
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0892	0.0892
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0892	0.1265
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0113	0.0113
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0113	0.0113
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0081	0.0081
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0113	0.0113
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0333	0.0889
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0159	0.3744	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0113	0.0113
Onchocerca volvulus		0.0042	0.0892	0.5446
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0965	0.0965
Schistosoma mansoni	cpg binding protein	0.0028	0.0558	0.0558
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0113	0.0113
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0286	0.6861	1
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0689	0.0689
Trypanosoma brucei	DNA damage repair protein, putative	0.0006	0.0015	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0689	0.0689
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0267	0.639	0.6266
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0965	0.0965
Treponema pallidum	fructose-bisphosphate aldolase	0.0286	0.6861	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0084	0.0084
Brugia malayi	nuclear hormone receptor	0.001	0.0113	0.0113
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0113	0.0113
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0113	0.0113
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0892	0.0892
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0113	0.0113
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0965	0.0965
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0892	0.0578
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0892	0.0892
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0333	0.0333
Plasmodium falciparum	DNA repair protein REV1, putative	0.0006	0.0015	0.0039
Trypanosoma cruzi	endonuclease G, putative	0.002	0.0363	0.0934
Leishmania major	DNA polymerase kappa, putative	0.0006	0.0015	0.0039
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0333	0.0889
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0113	0.0113
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0333	0.0889
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0333	0.0889
Chlamydia trachomatis	dihydrofolate reductase	0.0415	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0892	0.0892
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0892	0.0892
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.001	0.0113	0.0113
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0689	0.0689
Brugia malayi	beta-lactamase	0.0042	0.0892	0.0892
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0113	0.0113
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.002	0.0363	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0892	0.0892
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0113	0.0691
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0034	0.0689	0.0689
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0333	0.0333
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0892	0.2352
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0892	0.0892
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0892	0.0578
Trypanosoma brucei	DNA polymerase kappa, putative	0.0006	0.0015	0.0039
Echinococcus granulosus	cpg binding protein	0.003	0.0597	0.0597

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 0 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 0.66 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 1.73 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 2.48 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 5 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 14 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 97 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 0.75	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= -2 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 5 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 14 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 97 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.88	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.13076 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL535001
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 597543