Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.082 | 0.1287 |
Brugia malayi | AMP-binding enzyme family protein | 0.0078 | 0.2612 | 0.4695 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.082 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1728 | 0.3015 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.2612 | 0.4695 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1728 | 0.3015 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.082 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0729 | 0.1114 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.0811 | 0.2706 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.082 | 0.082 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0143 | 0.0143 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0055 | 0.1586 | 0.1586 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.537 | 0.5428 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0023 | 0.0143 | 0.0143 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0078 | 0.2612 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0078 | 0.2612 | 1 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0023 | 0.0143 | 0.0143 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0058 | 0.1728 | 0.1728 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0023 | 0.0143 | 0.0143 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0136 | 0.5226 | 0.703 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.082 | 0.8235 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.082 | 0.1287 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1475 | 0.2533 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.082 | 0.2742 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.082 | 0.082 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.7374 | 0.751 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0078 | 0.2612 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0055 | 0.1586 | 0.1586 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.0811 | 0.4214 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.082 | 0.0703 |
Brugia malayi | AMP-binding enzyme family protein | 0.0078 | 0.2612 | 0.4695 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0729 | 0.1114 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.0965 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0041 | 0.0965 | 0.5185 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0078 | 0.2612 | 0.2612 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.082 | 0.2742 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0078 | 0.2612 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.082 | 0.082 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1345 | 0.1663 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.014 | 0.537 | 0.9937 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1475 | 0.2533 |
Loa Loa (eye worm) | TAR-binding protein | 0.014 | 0.537 | 0.9937 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.082 | 0.0936 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0078 | 0.2612 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0078 | 0.2612 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0143 | 0.0143 |
Onchocerca volvulus | 0.0038 | 0.082 | 0.2742 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1345 | 0.1663 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.082 | 0.8235 |
Schistosoma mansoni | amine GPCR | 0.0238 | 0.9772 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.082 | 0.1287 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.0143 | 0.0143 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.082 | 0.082 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.082 | 0.082 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.082 | 0.2742 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.082 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.082 | 0.082 |
Onchocerca volvulus | 0.0038 | 0.082 | 0.2742 | |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.082 | 0.1287 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0078 | 0.2612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1728 | 0.3015 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.082 | 0.8235 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.082 | 0.8235 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.014 | 0.5403 | 0.7274 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0143 | 0.0143 |
Brugia malayi | beta-lactamase | 0.0038 | 0.082 | 0.1287 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0078 | 0.2612 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.082 | 0.082 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.082 | 0.082 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0023 | 0.0143 | 0.0143 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0078 | 0.2612 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0058 | 0.1728 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0143 | 0.0143 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.082 | 0.0936 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.082 | 0.2742 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1345 | 0.1249 |
Brugia malayi | AMP-binding enzyme family protein | 0.0078 | 0.2612 | 0.4695 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.082 | 0.1287 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.1345 | 0.2287 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0078 | 0.2612 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.014 | 0.5403 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0041 | 0.0965 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.082 | 0.082 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0058 | 0.1728 | 1 |
Onchocerca volvulus | 0.0078 | 0.2612 | 1 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0078 | 0.2612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1475 | 0.2533 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.537 | 0.5428 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1345 | 0.1249 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0811 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0078 | 0.2612 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.082 | 0.2742 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1728 | 0.3015 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.082 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1728 | 0.3015 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0078 | 0.2612 | 0.2612 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.7374 | 0.751 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0058 | 0.1728 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.2612 | 0.4695 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0058 | 0.1728 | 0.6421 |
Brugia malayi | RNA binding protein | 0.014 | 0.537 | 0.9937 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.014 | 0.5403 | 0.5462 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.082 | 0.8235 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.082 | 0.427 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1345 | 0.1663 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.082 | 0.8235 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.537 | 0.5428 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.082 | 0.2742 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0078 | 0.2612 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0055 | 0.1586 | 0.1586 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.014 | 0.5403 | 1 |
Echinococcus granulosus | geminin | 0.0184 | 0.7374 | 1 |
Onchocerca volvulus | 0.0038 | 0.082 | 0.2742 | |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0078 | 0.2612 | 1 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0023 | 0.0143 | 0.0143 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1475 | 0.2533 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.082 | 0.082 |
Brugia malayi | TAR-binding protein | 0.014 | 0.537 | 0.9937 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.082 | 0.1287 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.082 | 0.1287 |
Mycobacterium ulcerans | hypothetical protein | 0.0078 | 0.2612 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.014 | 0.537 | 0.7228 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.2612 | 0.4695 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0023 | 0.0143 | 0.0143 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0078 | 0.2612 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1345 | 0.1249 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.082 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0041 | 0.0965 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0729 | 0.0609 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.082 | 0.8235 |
Loa Loa (eye worm) | RNA binding protein | 0.014 | 0.537 | 0.9937 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.082 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.082 | 0.1287 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.082 | 0.2742 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1345 | 0.1663 |
Echinococcus multilocularis | geminin | 0.0184 | 0.7374 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.537 | 0.5428 |
Brugia malayi | RNA recognition motif domain containing protein | 0.014 | 0.537 | 0.9937 |
Echinococcus multilocularis | tar DNA binding protein | 0.014 | 0.537 | 0.7228 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0041 | 0.0965 | 0.1137 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.082 | 0.1287 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.537 | 0.5428 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0055 | 0.1586 | 0.1586 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.082 | 0.2742 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.1345 | 0.2287 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.0965 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 1 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 6.2 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 6.42 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 6.93 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 70 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 9.91 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 1 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 70 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 100 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 101 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.63 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.23532 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.