Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0957 | 0.0957 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0538 | 0.085 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0027 | 0.1777 | 0.2805 |
Echinococcus multilocularis | musashi | 0.0027 | 0.178 | 0.2808 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.028 | 0.028 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.028 | 0.0442 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.028 | 0.0442 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.028 | 0.0442 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0051 | 0.394 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0957 | 0.151 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.028 | 0.028 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.028 | 0.028 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.028 | 0.0442 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.6337 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.028 | 0.0442 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.028 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1736 | 0.1736 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0104 | 0.0104 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.178 | 0.2808 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.028 | 0.028 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.028 | 0.0442 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0104 | 0.0165 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0104 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0495 | 0.0495 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.028 | 0.028 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.028 | 0.028 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.087 | 0.2209 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0957 | 0.0957 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.087 | 0.2209 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.028 | 0.028 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.028 | 0.0442 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.028 | 0.028 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.149 | 0.2351 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.149 | 0.149 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.028 | 0.028 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0104 | 0.0165 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.028 | 0.0442 |
Onchocerca volvulus | 0.0027 | 0.178 | 1 | |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.394 | 0.6218 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.149 | 0.149 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.6337 | 1 |
Onchocerca volvulus | 0.0024 | 0.149 | 0.8371 | |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.028 | 0.028 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0104 | 0.0165 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.6337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0538 | 0.0538 |
Toxoplasma gondii | hypothetical protein | 0.0027 | 0.1777 | 0.2805 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0538 | 0.085 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.178 | 0.178 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.149 | 0.2351 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0104 | 0.0165 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5015 | 0.7915 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.028 | 0.0442 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.149 | 0.2351 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.028 | 0.0442 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0104 | 0.0165 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0666 | 0.0666 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0104 | 0.0165 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.178 | 1 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.149 | 0.2351 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.028 | 0.028 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.028 | 0.028 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0018 | 0.0957 | 0.151 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.149 | 0.149 |
Schistosoma mansoni | smad | 0.0008 | 0.0104 | 0.0165 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.028 | 0.1572 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.028 | 0.0442 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.028 | 0.028 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.028 | 0.028 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.5015 | 0.5015 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.028 | 0.0442 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0027 | 0.1777 | 0.2805 |
Brugia malayi | RNA binding protein | 0.0064 | 0.5015 | 0.5015 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.028 | 0.028 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0051 | 0.394 | 1 |
Echinococcus multilocularis | smad | 0.0008 | 0.0104 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.028 | 0.028 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0104 | 0.0104 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.6337 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.028 | 0.028 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.028 | 0.0442 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.028 | 0.0442 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0104 | 0.0104 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.028 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0957 | 0.0957 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.149 | 0.2351 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.028 | 0.0442 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.149 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0027 | 0.1777 | 0.2805 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.394 | 0.6218 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.5015 | 0.5015 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0666 | 0.0666 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.028 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0495 | 0.0495 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.149 | 0.2351 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.149 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0078 | 0.6337 | 0.6337 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.149 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0104 | 0.0165 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0957 | 0.0957 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.028 | 0.028 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0104 | 0.0104 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.149 | 0.149 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.6337 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0078 | 0.6337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6337 | 0.6337 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.6337 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0104 | 0.0165 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.087 | 0.2209 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.028 | 0.0442 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.149 | 0.3781 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.028 | 0.028 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.028 | 0.0442 |
Echinococcus granulosus | smad | 0.0008 | 0.0104 | 0.0165 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.5015 | 0.7915 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.028 | 0.0442 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0104 | 0.0165 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.149 | 0.2351 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.028 | 0.1572 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.028 | 0.028 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.149 | 0.2351 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5015 | 0.7915 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.028 | 0.028 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5015 | 0.7915 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.028 | 0.0442 |
Onchocerca volvulus | 0.001 | 0.028 | 0.1572 | |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.5015 | 0.5015 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.028 | 0.1572 |
Schistosoma mansoni | lamin | 0.0027 | 0.178 | 0.2808 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.5015 | 0.5015 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.028 | 0.028 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.028 | 0.028 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.149 | 0.2351 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.028 | 0.0442 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.6337 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0078 | 0.6337 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.028 | 0.028 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.5015 | 0.5015 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0957 | 0.2428 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0957 | 0.151 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.394 | 0.6218 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.149 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.149 | 0.2351 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.028 | 0.028 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.028 | 0.028 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.6337 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0078 | 0.6337 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.6337 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.028 | 0.028 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.028 | 0.0442 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.178 | 0.2808 |
Echinococcus multilocularis | lamin | 0.0027 | 0.178 | 0.2808 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.028 | 0.0442 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.178 | 0.178 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.6337 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.028 | 0.0442 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.178 | 0.2808 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.178 | 0.178 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.028 | 0.0442 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0104 | 0.0165 |
Echinococcus granulosus | lamin | 0.0027 | 0.178 | 0.2808 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.149 | 0.149 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.028 | 0.0442 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.028 | 0.028 |
Schistosoma mansoni | lamin | 0.0027 | 0.178 | 0.2808 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.028 | 0.028 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.087 | 0.2209 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.028 | 0.028 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.6337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.149 | 0.149 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.028 | 0.0442 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.028 | 0.0442 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.178 | 0.178 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.5015 | 0.7915 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5015 | 0.7915 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.149 | 0.3781 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5015 | 0.7915 |
Brugia malayi | Smad1 | 0.0008 | 0.0104 | 0.0104 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.028 | 0.0442 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.178 | 0.2808 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.149 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.178 | 0.178 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0957 | 0.0957 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0104 | 0.0104 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.149 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 1.35 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.64 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.85 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 28 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 33 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 91 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 5.38 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 28 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 33 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 91 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.04 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.90334 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.