Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0256 | 0.3553 | 0.413 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0386 | 0.1087 |
Schistosoma mansoni | nuclear receptor | 0.0033 | 0.0328 | 0.0328 |
Onchocerca volvulus | 0.0035 | 0.0356 | 0.0969 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0359 | 0.6802 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0359 | 0.1074 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0071 | 0.087 | 0.087 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0071 | 0.087 | 0.087 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.087 | 0.1011 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0071 | 0.087 | 0.2448 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0998 | 0.116 |
Echinococcus granulosus | GPCR family 2 | 0.008 | 0.0998 | 0.0998 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0147 | 0.0147 |
Echinococcus multilocularis | GPCR, family 2 | 0.008 | 0.0998 | 0.0998 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0356 | 0.0414 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0071 | 0.087 | 0.1011 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0359 | 0.1074 |
Loa Loa (eye worm) | RNA binding protein | 0.0256 | 0.3553 | 0.413 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0356 | 0.0414 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0147 | 0.2341 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0696 | 0.0696 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.3553 | 0.3553 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0292 | 0.0292 |
Entamoeba histolytica | hypothetical protein | 0.0046 | 0.051 | 0.5753 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.008 | 0.0998 | 0.2808 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0356 | 0.0356 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0696 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0356 | 0.5121 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.2917 | 0.8209 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0356 | 0.5121 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0486 | 0.0486 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0071 | 0.087 | 0.087 |
Brugia malayi | nuclear hormone receptor | 0.0071 | 0.087 | 0.2448 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.008 | 0.0998 | 0.116 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0037 | 0.0386 | 0.0386 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0036 | 0.0108 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0147 | 0.1659 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0293 | 0.0341 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0359 | 0.6802 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0033 | 0.0328 | 0.0328 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0033 | 0.0328 | 0.0328 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.016 | 0.216 | 0.216 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.087 | 0.1011 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0356 | 0.0414 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0147 | 0.0171 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0033 | 0.0328 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.087 | 0.1011 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0293 | 0.0293 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.3553 | 0.3553 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0037 | 0.0386 | 0.0386 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0071 | 0.087 | 0.2448 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0071 | 0.087 | 0.087 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0702 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.1838 | 0.1838 |
Onchocerca volvulus | 0.0035 | 0.0356 | 0.0969 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0071 | 0.087 | 0.2448 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0696 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.2336 | 0.2715 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0887 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 0.0887 | 0.0887 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0486 | 0.0486 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0486 | 0.0486 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0071 | 0.087 | 0.087 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0356 | 0.0356 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0268 | 0.0268 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0356 | 0.1003 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0071 | 0.087 | 0.087 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0696 | 0.0696 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0356 | 0.1003 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0071 | 0.087 | 0.2523 |
Brugia malayi | steroid hormone receptor | 0.0071 | 0.087 | 0.2448 |
Trichomonas vaginalis | importin beta-1, putative | 0.0046 | 0.051 | 0.1527 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0356 | 0.5357 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0036 | 0.0108 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0033 | 0.0328 | 0.0328 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0037 | 0.0386 | 0.0449 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0359 | 0.0417 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0037 | 0.0386 | 0.1087 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0486 | 0.0486 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0359 | 0.1074 |
Brugia malayi | tailless protein | 0.0033 | 0.0328 | 0.0924 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0293 | 0.0293 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0071 | 0.087 | 0.087 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0033 | 0.0328 | 0.0382 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.008 | 0.0998 | 0.0998 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0071 | 0.087 | 0.1011 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0071 | 0.087 | 0.2448 |
Onchocerca volvulus | 0.0242 | 0.334 | 1 | |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0033 | 0.0328 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0292 | 0.0292 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0359 | 0.1009 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0057 | 0.0665 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0356 | 0.1067 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0036 | 0.0042 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0486 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.3489 | 0.4055 |
Brugia malayi | nuclear receptor RXR | 0.0037 | 0.0386 | 0.1087 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.3553 | 0.3553 |
Brugia malayi | Latrophilin receptor protein 2 | 0.008 | 0.0998 | 0.2808 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0071 | 0.087 | 0.1011 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.087 | 0.1011 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0386 | 0.0449 |
Brugia malayi | nuclear receptor NHR-88 | 0.0033 | 0.0328 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0356 | 0.0414 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0046 | 0.051 | 0.1527 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0386 | 0.0449 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.008 | 0.0998 | 0.0998 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0071 | 0.087 | 0.087 |
Echinococcus granulosus | FTZ F1 alpha | 0.0071 | 0.087 | 0.087 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0696 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0057 | 0.0665 | 0.0665 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0356 | 0.1003 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0033 | 0.0328 | 0.0328 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0172 | 0.2336 | 0.6574 |
Brugia malayi | nuclear receptor RXR | 0.0033 | 0.0328 | 0.0924 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0033 | 0.0328 | 0.0328 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0998 | 0.0998 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0293 | 0.0293 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.008 | 0.0998 | 0.0998 |
Plasmodium falciparum | importin beta, putative | 0.0057 | 0.0665 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0033 | 0.0328 | 0.0924 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0696 | 0.1232 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0998 | 0.0998 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0226 | 0.3114 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0356 | 0.0356 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0356 | 0.6757 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0696 | 0.0696 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0071 | 0.087 | 0.2448 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0071 | 0.087 | 0.087 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Onchocerca volvulus | 0.0071 | 0.087 | 0.2523 | |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0033 | 0.0328 | 0.0328 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0071 | 0.087 | 0.2523 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0359 | 0.1074 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0147 | 0.0414 |
Brugia malayi | nuclear receptor NHR-67 | 0.0033 | 0.0328 | 0.0924 |
Brugia malayi | TAR-binding protein | 0.0256 | 0.3553 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0696 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0033 | 0.0328 | 0.0328 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0071 | 0.087 | 0.1011 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0071 | 0.087 | 0.087 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 0.0887 | 0.0887 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0037 | 0.0386 | 0.0386 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0359 | 0.0359 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0046 | 0.051 | 1 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0147 | 0.2211 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0147 | 0.5 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0359 | 0.0359 |
Schistosoma mansoni | zinc finger protein | 0.0033 | 0.0328 | 0.0328 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0356 | 0.0356 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0359 | 0.5389 |
Echinococcus granulosus | snurportin 1 | 0.0605 | 0.8604 | 0.8604 |
Schistosoma mansoni | hypothetical protein | 0.0605 | 0.8604 | 0.8604 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0356 | 0.1003 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0013 | 0.0036 | 0.0108 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0033 | 0.0328 | 0.0328 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0071 | 0.087 | 0.087 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0033 | 0.0328 | 0.0924 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0013 | 0.0036 | 0.0108 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0071 | 0.087 | 0.2448 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0071 | 0.087 | 0.087 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0359 | 0.1074 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0071 | 0.087 | 0.1011 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0356 | 0.1067 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Onchocerca volvulus | 0.0033 | 0.0328 | 0.0884 | |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0359 | 0.4043 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0328 | 0.0924 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0293 | 0.4215 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0887 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0036 | 0.0108 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0013 | 0.0036 | 0.0102 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0486 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0665 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0057 | 0.0665 | 0.9559 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0071 | 0.087 | 0.2448 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0293 | 0.0293 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0013 | 0.0036 | 0.0543 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0147 | 0.2341 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.2917 | 0.339 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0071 | 0.087 | 0.2523 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0071 | 0.087 | 0.087 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0057 | 0.0665 | 0.0665 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0147 | 0.2211 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0293 | 0.4409 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0292 | 0.0292 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0071 | 0.087 | 0.2448 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.334 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0293 | 0.0293 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0386 | 0.0449 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0267 | 0.0311 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0486 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0386 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0386 | 0.0449 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0702 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0071 | 0.087 | 0.087 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0359 | 0.4043 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.1838 | 0.1838 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0071 | 0.087 | 0.087 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0887 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0033 | 0.0328 | 0.0328 |
Brugia malayi | nuclear receptor NHR-88 | 0.0071 | 0.087 | 0.2448 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.087 | 0.1011 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.216 | 0.216 |
Brugia malayi | ecdysone receptor | 0.0033 | 0.0328 | 0.0924 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0486 | 0.0565 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0071 | 0.087 | 0.087 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0293 | 0.0826 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0071 | 0.087 | 0.087 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Schistosoma mansoni | coup transcription factor | 0.0071 | 0.087 | 0.087 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0033 | 0.0328 | 0.0884 |
Loa Loa (eye worm) | DR-78 | 0.0033 | 0.0328 | 0.0382 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0033 | 0.0328 | 0.0924 |
Schistosoma mansoni | ran | 0.0021 | 0.0147 | 0.0147 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0256 | 0.3553 | 0.413 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0033 | 0.0328 | 0.0884 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.0662 | 0.9506 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.3553 | 0.3553 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Schistosoma mansoni | thyroid hormone receptor | 0.0071 | 0.087 | 0.087 |
Schistosoma mansoni | nuclear hormone receptor | 0.0071 | 0.087 | 0.087 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0071 | 0.087 | 0.1011 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0071 | 0.087 | 0.2448 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.087 | 0.1011 |
Brugia malayi | conserved hypotetical protein | 0.0033 | 0.0328 | 0.0924 |
Plasmodium vivax | importin-beta 2, putative | 0.0057 | 0.0665 | 1 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0416 | 0.5864 | 0.5864 |
Brugia malayi | ecdysteroid receptor | 0.0071 | 0.087 | 0.2448 |
Leishmania major | importin beta-1 subunit, putative | 0.0046 | 0.051 | 0.733 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0033 | 0.0328 | 0.0328 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0998 | 0.0998 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0033 | 0.0328 | 0.0328 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0359 | 0.0359 |
Onchocerca volvulus | 0.0033 | 0.0328 | 0.0884 | |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.2336 | 0.2336 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0696 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0359 | 0.1074 |
Onchocerca volvulus | 0.0031 | 0.0293 | 0.0778 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0071 | 0.087 | 0.087 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0356 | 0.0414 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0033 | 0.0328 | 0.0328 |
Onchocerca volvulus | 0.0093 | 0.1184 | 0.3474 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.0757 | 0.0757 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0356 | 0.1067 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0071 | 0.087 | 0.2448 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0486 | 0.0486 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0033 | 0.0328 | 0.0328 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0071 | 0.087 | 0.1011 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.087 | 0.1011 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0036 | 0.0108 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0356 | 0.5 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0147 | 0.0441 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0293 | 0.0293 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0359 | 0.1074 |
Schistosoma mansoni | nuclear receptor | 0.0033 | 0.0328 | 0.0328 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0887 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0033 | 0.0328 | 0.0328 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0356 | 0.1067 |
Onchocerca volvulus | 0.0029 | 0.0267 | 0.07 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.016 | 0.216 | 0.251 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0252 | 0.3489 | 0.9819 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0071 | 0.087 | 0.2448 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0998 | 0.0998 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0356 | 0.1067 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0887 | 0.0887 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0071 | 0.087 | 0.087 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0292 | 0.0292 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0013 | 0.0036 | 0.0408 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0293 | 0.0293 |
Schistosoma mansoni | nuclear hormone receptor | 0.0033 | 0.0328 | 0.0328 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0359 | 0.5152 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0071 | 0.087 | 0.087 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0046 | 0.051 | 0.1527 |
Schistosoma mansoni | importin beta-1 | 0.0057 | 0.0665 | 0.0665 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.216 | 0.216 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0359 | 0.5152 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0356 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0356 | 0.5357 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.4915 | 0.4915 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0147 | 0.2114 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0356 | 0.0414 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0013 | 0.0036 | 0.0108 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0605 | 0.8604 | 1 |
Schistosoma mansoni | ran | 0.0021 | 0.0147 | 0.0147 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.008 | 0.0998 | 0.0998 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0071 | 0.087 | 0.2448 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.016 | 0.216 | 0.6079 |
Echinococcus granulosus | geminin | 0.035 | 0.4915 | 0.4915 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0071 | 0.087 | 0.087 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0252 | 0.3489 | 0.4055 |
Echinococcus multilocularis | snurportin 1 | 0.0605 | 0.8604 | 0.8604 |
Schistosoma mansoni | thyroid hormone receptor | 0.0071 | 0.087 | 0.087 |
Onchocerca volvulus | 0.0035 | 0.0356 | 0.0969 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 0.0887 | 0.0887 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0071 | 0.087 | 0.087 |
Brugia malayi | RNA binding protein | 0.0256 | 0.3553 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0033 | 0.0328 | 0.0382 |
Echinococcus multilocularis | geminin | 0.035 | 0.4915 | 0.4915 |
Echinococcus granulosus | tar DNA binding protein | 0.0256 | 0.3553 | 0.3553 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0356 | 0.6757 |
Brugia malayi | RNA, U transporter 1 | 0.0161 | 0.2178 | 0.613 |
Echinococcus multilocularis | tar DNA binding protein | 0.0256 | 0.3553 | 0.3553 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0033 | 0.0328 | 0.0924 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0267 | 0.0753 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0147 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0356 | 0.0414 |
Leishmania major | glycosyl hydrolase-like protein | 0.0013 | 0.0036 | 0.052 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0359 | 0.1074 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0071 | 0.087 | 0.087 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0328 | 0.0924 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0071 | 0.087 | 0.2448 |
Brugia malayi | Importin beta-1 subunit | 0.0057 | 0.0665 | 0.1873 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0356 | 0.0414 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0887 | 0.2496 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0252 | 0.3489 | 0.9819 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.3553 | 0.3553 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0057 | 0.0665 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0071 | 0.087 | 0.2448 |
Echinococcus granulosus | dnaJ subfamily B | 0.0416 | 0.5864 | 0.5864 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0328 | 0.0382 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0147 | 0.2114 |
Schistosoma mansoni | hypothetical protein | 0.0416 | 0.5864 | 0.5864 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0037 | 0.0386 | 0.1087 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0359 | 0.1074 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0036 | 0.0108 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0356 | 0.1067 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0071 | 0.087 | 0.087 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0071 | 0.087 | 0.2448 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0256 | 0.3553 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0071 | 0.087 | 0.2448 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0037 | 0.0386 | 0.0386 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0147 | 0.2211 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0071 | 0.087 | 0.087 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.087 | 0.1011 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0033 | 0.0328 | 0.0382 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.4915 | 0.4915 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0033 | 0.0328 | 0.0924 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0696 | 0.0696 |
Schistosoma mansoni | nuclear hormone receptor | 0.0033 | 0.0328 | 0.0328 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0386 | 0.1087 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0033 | 0.0328 | 0.0924 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0071 | 0.087 | 0.1011 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0071 | 0.087 | 0.087 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -0.56 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1.28 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.37 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 85 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 5.71 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -1 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 85 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 101 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.84 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.43643 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.