Detailed information for compound 598375

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 390.321 | Formula: C18H24BrN5
  • H donors: 1 H acceptors: 2 LogP: 4.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCC(CC1)N(c1cc(C)nc(n1)Nc1ccc(cc1)Br)C
  • InChi: 1S/C18H24BrN5/c1-13-12-17(24(3)16-8-10-23(2)11-9-16)22-18(20-13)21-15-6-4-14(19)5-7-15/h4-7,12,16H,8-11H2,1-3H3,(H,20,21,22)
  • InChiKey: KUEUFWBHZKPEGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0105 0.059 0.059
Loa Loa (eye worm) hypothetical protein 0.0072 0.0356 0.0646
Loa Loa (eye worm) glutaminase 2 0.0244 0.1593 0.2889
Onchocerca volvulus 0.0137 0.0821 0.2988
Schistosoma mansoni lipoxygenase 0.0094 0.0516 0.0516
Toxoplasma gondii transporter, major facilitator family protein 0.0044 0.0155 0.0881
Brugia malayi Nuclear hormone receptor-like 1 0.0788 0.5514 0.9223
Brugia malayi nuclear receptor RXR 0.0072 0.0356 0.0596
Schistosoma mansoni RAR-like nuclear receptor 0.0137 0.0821 0.0821
Loa Loa (eye worm) runx1 0.0044 0.0154 0.0279
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0038 0.0113 0.0204
Schistosoma mansoni lamin 0.0072 0.0352 0.0352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0515 0.0515
Onchocerca volvulus Protein ultraspiracle homolog 0.0137 0.0821 0.2988
Echinococcus granulosus microtubule associated protein 2 0.0697 0.4862 0.4862
Echinococcus multilocularis RUN 0.0034 0.0079 0.0079
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0137 0.0821 0.0821
Schistosoma mansoni rab6-interacting 0.0034 0.0079 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0257 0.1076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0515 0.0515
Schistosoma mansoni polycystin 1-related 0.0034 0.0079 0.0079
Echinococcus granulosus lamin 0.0072 0.0352 0.0352
Leishmania major mitochondrial DNA polymerase beta 0.0276 0.1829 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0821 0.1489
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0027 0.0027
Echinococcus granulosus nmda type glutamate receptor 0.0077 0.0392 0.0392
Echinococcus multilocularis neuropeptide receptor A26 0.0441 0.3017 0.3017
Brugia malayi nuclear hormone receptor family member odr-7 0.0064 0.0301 0.0503
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0068 0.0328
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0205 0.1314 1
Trichomonas vaginalis proliferating cell nuclear antigen, putative 0.0097 0.0535 0.1938
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0068 0.0219
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0515 0.0515
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0052 0.0214 0.0214
Onchocerca volvulus 0.003 0.0054 0.0169
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0131 0.0779 0.4236
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0064 0.0301 0.0545
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0143 0.087 0.4737
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0376 0.1354
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0137 0.0821 0.1373
Mycobacterium ulcerans hypothetical protein 0.0086 0.0457 0.2552
Loa Loa (eye worm) hypothetical protein 0.0044 0.0155 0.0281
Onchocerca volvulus Putative organic anion transporter 0.0044 0.0155 0.054
Brugia malayi hypoxia-induced factor 1 0.0284 0.1881 0.3146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0257 0.1076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0232 0.1507 0.551
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0137 0.0821 0.0821
Echinococcus granulosus lamin dm0 0.0072 0.0352 0.0352
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0072 0.0356 0.0356
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0143 0.087 0.1456
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0039 0.0116 0.0596
Entamoeba histolytica hypothetical protein 0.0074 0.0368 0.2017
Leishmania major protein kinase, putative 0.0024 0.001 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0069 0.0069
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.0301 0.1076
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0178 0.0932
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0137 0.0821 0.1489
Echinococcus granulosus nuclear receptor nhr 48 0.0064 0.0301 0.0301
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0064 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0033 0.0076 0.0137
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0232 0.1507 0.551
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.0356 0.0356
Mycobacterium ulcerans hypothetical protein 0.0146 0.0886 0.5365
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0032 0.0068 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0257 0.1076
Plasmodium vivax proliferating cell nuclear antigen, putative 0.0097 0.0535 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0143 0.087 0.087
Brugia malayi nuclear receptor NHR-88 0.0137 0.0821 0.1373
Onchocerca volvulus 0.0032 0.0068 0.0219
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0076 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0044 0.0155 0.0281
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0137 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.007 0.0343 0.0622
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0072 0.0072
Mycobacterium ulcerans glutaminase 0.0244 0.1593 1
Schistosoma mansoni thyroid hormone receptor 0.0833 0.5842 0.5842
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0212 0.1363 0.1363
Toxoplasma gondii proliferating cell nuclear antigen PCNA1 0.0097 0.0535 0.4193
Loa Loa (eye worm) proliferating cell nuclear antigen 0.0097 0.0535 0.097
Echinococcus multilocularis microtubule associated protein 2 0.0697 0.4862 0.4862
Schistosoma mansoni hypothetical protein 0.0697 0.4857 0.4857
Echinococcus multilocularis ubiquitin specific protease 41 0.0034 0.008 0.008
Echinococcus multilocularis cpg binding protein 0.0105 0.059 0.059
Toxoplasma gondii histone lysine methyltransferase SET1 0.0189 0.1202 1
Brugia malayi hypothetical protein 0.0034 0.0079 0.0132
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0113 0.0652 0.3833
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0033 0.0072 0.0072
Echinococcus granulosus neuropeptide s receptor 0.0441 0.3017 0.3017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0085 0.0154
Echinococcus granulosus cpg binding protein 0.0105 0.059 0.059
Echinococcus multilocularis Protein lozenge 0.0044 0.0154 0.0154
Brugia malayi Steroid receptor seven-up type 2 0.0137 0.0821 0.1373
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0143 0.087 0.644
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0232 0.1507 0.551
Brugia malayi hypothetical protein 0.0072 0.0356 0.0596
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0143 0.087 0.5264
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0137 0.0821 0.0821
Schistosoma mansoni hypothetical protein 0.0076 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0044 0.0155 0.0281
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0068 0.0219
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0072 0.0072
Onchocerca volvulus 0.0064 0.0301 0.1076
Toxoplasma gondii aldehyde dehydrogenase 0.0104 0.0584 0.4618
Brugia malayi Nuclear hormone receptor-like 1 0.0852 0.5978 1
Schistosoma mansoni loxhd1 0.0034 0.0079 0.0079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0104 0.0584 0.3385
Echinococcus granulosus lipoxygenase domain containing protein 0.0034 0.0079 0.0079
Schistosoma mansoni coup transcription factor 0.0137 0.0821 0.0821
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0214 0.0214
Plasmodium vivax proliferating cell nuclear antigen, putative 0.0052 0.021 0.3047
Brugia malayi sodium-independent organic anion transporter family protein 0.007 0.0339 0.0567
Brugia malayi CXXC zinc finger family protein 0.0099 0.055 0.092
Loa Loa (eye worm) hypothetical protein 0.0032 0.0068 0.0122
Onchocerca volvulus 0.0351 0.2368 0.8674
Echinococcus granulosus Polycystic kidney disease protein 0.0034 0.0079 0.0079
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0573 0.1039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0137 0.0821 0.1373
Loa Loa (eye worm) hypothetical protein 0.0032 0.0068 0.0122
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.008 0.0266
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0034 0.008 0.008
Echinococcus multilocularis expressed protein 0.0438 0.2992 0.2992
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0053 0.0221 0.1168
Entamoeba histolytica hypothetical protein 0.0074 0.0368 0.2017
Schistosoma mansoni cpg binding protein 0.0099 0.055 0.055
Schistosoma mansoni hypothetical protein 0.0076 0.0383 0.0383
Echinococcus multilocularis musashi 0.0072 0.0352 0.0352
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0052 0.0214 0.0214
Brugia malayi hypothetical protein 0.0216 0.1396 0.2336
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0257 0.1369
Loa Loa (eye worm) hypothetical protein 0.0137 0.0821 0.1489
Brugia malayi cytoplasmic intermediate filament protein 0.0038 0.0113 0.0188
Brugia malayi Cytochrome P450 family protein 0.0024 0.001 0.0016
Schistosoma mansoni retinoic acid receptor RXR 0.0137 0.0821 0.0821
Schistosoma mansoni nuclear hormone receptor 0.0064 0.0301 0.0301
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0075 0.0376 0.0682
Brugia malayi sodium-independent organic anion transporter family protein 0.007 0.0339 0.0567
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0353 0.2379 0.4314
Schistosoma mansoni hypothetical protein 0.0044 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0034 0.008 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0137 0.0821 0.1489
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0137 0.0821 0.0821
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0064 0.0301 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0376 0.1354
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0027 0.0027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0048 0.0185 0.0185
Trichomonas vaginalis esterase, putative 0.0032 0.0068 0.0219
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0376 0.1354
Schistosoma mansoni nuclear hormone receptor 0.0064 0.0301 0.0301
Echinococcus multilocularis dnaJ subfamily B 0.141 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0137 0.0821 0.1489
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0515 0.0515
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.034 0.0568
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0075 0.0376 0.0376
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0137 0.0821 0.2988
Loa Loa (eye worm) hypothetical protein 0.007 0.034 0.0616
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.0301 0.1076
Entamoeba histolytica proliferating cell nuclear antigen, putative 0.0097 0.0535 0.3189
Schistosoma mansoni steroid hormone receptor ad4bp 0.0137 0.0821 0.0821
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0515 0.0861
Brugia malayi Doublecortin family protein 0.0034 0.0079 0.0132
Schistosoma mansoni hypothetical protein 0.141 1 1
Schistosoma mansoni lozenge 0.0044 0.0154 0.0154
Brugia malayi prostaglandin transporter 0.0044 0.0155 0.0259
Loa Loa (eye worm) hypothetical protein 0.0032 0.0068 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0214 0.0214
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.008 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0257 0.1076
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0068 0.0219
Brugia malayi tailless protein 0.0064 0.0301 0.0503
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0143 0.087 0.087
Echinococcus multilocularis muscleblind protein 1 0.0462 0.317 0.317
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0257 0.1369
Echinococcus multilocularis agrin 0.003 0.0054 0.0054
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0276 0.1829 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0232 0.1507 1
Leishmania major cathepsin L-like protease 0.0058 0.0257 0.1369
Echinococcus granulosus single minded 2 0.0068 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0014
Echinococcus multilocularis beta LACTamase domain containing family member 0.0032 0.0068 0.0068
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0214 0.0214
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0167 0.0874
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0076 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.003 0.0054 0.0097
Brugia malayi Pre-SET motif family protein 0.0052 0.0214 0.0358
Toxoplasma gondii ABC1 family protein 0.0032 0.0068 0.012
Brugia malayi Nuclear hormone receptor E75 0.0064 0.0301 0.0503
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0069 0.0069
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0044 0.0154 0.0258
Onchocerca volvulus 0.007 0.0339 0.1216
Echinococcus multilocularis survival motor neuron protein 1 0.0216 0.1396 0.1396
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0094 0.0516 0.0516
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.007 0.007
Brugia malayi Muscleblind-like protein 0.0462 0.317 0.5302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0137 0.0821 0.1489
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0068 0.0219
Loa Loa (eye worm) hypothetical protein 0.078 0.5458 0.9899
Schistosoma mansoni organic anion transporter 0.0044 0.0155 0.0155
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0055 0.0236 0.1103
Brugia malayi follicle stimulating hormone receptor 0.0224 0.1448 0.2423
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0257 0.1076
Brugia malayi secreted modular calcium-binding protein 1 0.003 0.0054 0.009
Schistosoma mansoni proliferating cell nuclear antigen 0.0097 0.0535 0.0535
Brugia malayi hypothetical protein 0.0072 0.0356 0.0596
Echinococcus granulosus nuclear factor of activated T cells 5 0.007 0.0338 0.0338
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0039 0.0116 0.0596
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0034 0.008 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0515 0.0515
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0137 0.0821 0.1373
Brugia malayi sodium-independent organic anion transporter family protein 0.0044 0.0155 0.0259
Loa Loa (eye worm) hypothetical protein 0.0072 0.0356 0.0646
Echinococcus multilocularis ecdysone induced protein 78C 0.0137 0.0821 0.0821
Schistosoma mansoni apoptosis regulator bax 0.0076 0.0383 0.0383
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0024 0.001 0.001
Schistosoma mansoni aryl hydrocarbon receptor 0.0092 0.0497 0.0497
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0137 0.0821 0.0821
Echinococcus multilocularis expressed protein 0.003 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0137 0.0821 0.1489
Schistosoma mansoni aldehyde dehydrogenase 0.0104 0.0584 0.0584
Loa Loa (eye worm) glutaminase 0.0244 0.1593 0.2889
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0143 0.087 0.087
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0069 0.0116
Onchocerca volvulus 0.0072 0.0352 0.1266
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0039 0.0116 0.0277
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0137 0.0821 0.0821
Brugia malayi beta-lactamase family protein 0.0032 0.0068 0.0113
Schistosoma mansoni hypothetical protein 0.0049 0.0189 0.0189
Brugia malayi serine/threonine-protein kinase plk-2 0.0075 0.0376 0.0629
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0137 0.0821 0.0821
Brugia malayi bHLH-PAS transcription factor 0.0068 0.0325 0.0544
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.0301 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0376 0.1354
Echinococcus multilocularis nuclear receptor nhr 48 0.0064 0.0301 0.0301
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0068 0.0068
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.003 0.0054 0.009
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0064 0.0301 0.0301
Brugia malayi Intermediate filament tail domain containing protein 0.0072 0.0352 0.0589
Schistosoma mansoni follistatin 0.003 0.0054 0.0054
Entamoeba histolytica hypothetical protein 0.0074 0.0368 0.2017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0137 0.0821 0.1373
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0103 0.0351
Echinococcus granulosus Solute carrier organic anion transporter family 0.0044 0.0155 0.0155
Onchocerca volvulus 0.0064 0.0301 0.1076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0032 0.0068 0.0122
Loa Loa (eye worm) hypothetical protein 0.0462 0.317 0.5749
Schistosoma mansoni microtubule-associated protein tau 0.0697 0.4862 0.4862
Echinococcus granulosus survival motor neuron protein 1 0.0216 0.1396 0.1396
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0131 0.0779 0.4041
Onchocerca volvulus Serine\/threonine kinase homolog 0.0075 0.0376 0.1353
Schistosoma mansoni nuclear hormone receptor 0.0137 0.0821 0.0821
Schistosoma mansoni survival motor neuron protein 0.0044 0.0154 0.0154
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0069 0.0069
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0697 0.4857 0.4857
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0104 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0307 0.2052 0.3722
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.003 0.0054 0.009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0214 0.0214
Brugia malayi hypothetical protein 0.0064 0.0301 0.0503
Schistosoma mansoni hypothetical protein 0.0034 0.0079 0.0079
Echinococcus granulosus organic anion transporting polypeptide 30B 0.007 0.0339 0.0339
Schistosoma mansoni hypothetical protein 0.0032 0.0069 0.0069
Onchocerca volvulus 0.0032 0.0068 0.0219
Loa Loa (eye worm) hypothetical protein 0.0216 0.1396 0.2532
Brugia malayi steroid hormone receptor 0.0137 0.0821 0.1373
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0545
Loa Loa (eye worm) hypothetical protein 0.0032 0.0069 0.0126
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0232 0.1507 0.551
Brugia malayi SPARC precursor 0.003 0.0054 0.009
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0094 0.0516 0.0516
Echinococcus multilocularis Polycystic kidney disease protein 0.0034 0.0079 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0257 0.1076
Trypanosoma cruzi polo-like protein kinase, putative 0.0075 0.0376 0.2022
Loa Loa (eye worm) hypothetical protein 0.0137 0.0821 0.1489
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0137 0.0821 0.0821
Trypanosoma cruzi proliferative cell nuclear antigen (PCNA), putative 0.0097 0.0535 0.2895
Mycobacterium leprae conserved hypothetical protein 0.0032 0.0068 0.0926
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0072 0.0072
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0034 0.008 0.008
Schistosoma mansoni zinc finger protein 0.0064 0.0301 0.0301
Onchocerca volvulus 0.0099 0.055 0.1992
Schistosoma mansoni hypothetical protein 0.0311 0.2081 0.2081
Loa Loa (eye worm) apoptosis regulator protein 0.0076 0.0383 0.0694
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0024 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0311 0.2081 0.2081
Echinococcus granulosus thyroid hormone receptor alpha 0.0064 0.0301 0.0301
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0072 0.0072
Brugia malayi nuclear hormone receptor family member nhr-6 0.0064 0.0301 0.0503
Onchocerca volvulus 0.0068 0.0325 0.1166
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0055 0.0236 0.135
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0137 0.0821 0.1489
Loa Loa (eye worm) hypothetical protein 0.003 0.0054 0.0097
Schistosoma mansoni nuclear receptor nhr-48 0.0064 0.0301 0.0301
Loa Loa (eye worm) histone methyltransferase 0.0032 0.007 0.0127
Toxoplasma gondii proliferating cell nuclear antigen PCNA2 0.0052 0.021 0.1361
Echinococcus granulosus muscleblind protein 0.0462 0.317 0.317
Brugia malayi hypothetical protein 0.0034 0.0079 0.0132
Loa Loa (eye worm) agrin synaptic family protein 0.003 0.0054 0.0097
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0034 0.008 0.008
Giardia lamblia Fructose-bisphosphate aldolase 0.0232 0.1507 1
Echinococcus granulosus ubiquitin specific protease 41 0.0034 0.008 0.008
Mycobacterium leprae Probable lipase LipE 0.0032 0.0068 0.0926
Loa Loa (eye worm) beta-lactamase 0.0032 0.0068 0.0122
Schistosoma mansoni hypothetical protein 0.0032 0.0069 0.0069
Plasmodium vivax SET domain protein, putative 0.0052 0.0214 0.3137
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0104 0.0584 0.4141
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.003 0.0054 0.009
Loa Loa (eye worm) CXXC zinc finger family protein 0.0099 0.055 0.0997
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0376 0.1354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0257 0.1076
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0137 0.0821 0.1373
Loa Loa (eye worm) nuclear hormone receptor 0.0064 0.0301 0.0545
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0027 0.0027
Echinococcus multilocularis aryl hydrocarbon receptor 0.0024 0.0008 0.0008
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.0301 0.0301
Brugia malayi glutaminase DH11.1 0.0244 0.1593 0.2664
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0072 0.0352 0.0639
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0064 0.0301 0.0503
Echinococcus granulosus beta LACTamase domain containing family member 0.0032 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0032 0.0069 0.0069
Schistosoma mansoni aldehyde dehydrogenase 0.0104 0.0584 0.0584
Brugia malayi Nuclear hormone receptor-like 1 0.0788 0.5514 0.9223
Onchocerca volvulus 0.0044 0.0154 0.0539
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0232 0.1507 0.551
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0052 0.0214 0.0388
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0075 0.0376 0.0376
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0067 0.0113
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0257 0.1369
Echinococcus multilocularis thyroid hormone receptor alpha 0.0833 0.5842 0.5842
Onchocerca volvulus 0.0032 0.0068 0.0219
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0032 0.0068 0.0113
Onchocerca volvulus 0.0034 0.0079 0.0261
Trichomonas vaginalis glutaminase, putative 0.0244 0.1593 0.5827
Onchocerca volvulus 0.0072 0.0352 0.1266
Plasmodium falciparum proliferating cell nuclear antigen 2 0.0052 0.021 0.2873
Trichomonas vaginalis set domain proteins, putative 0.0401 0.2728 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0034 0.008 0.008
Echinococcus granulosus lipoxygenase domain containing protein 0.0034 0.0079 0.0079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0104 0.0584 0.3385
Entamoeba histolytica hypothetical protein 0.0074 0.0368 0.2017
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0034 0.008 0.008
Schistosoma mansoni cpg binding protein 0.0105 0.059 0.059
Chlamydia trachomatis glutamine binding protein 0.0055 0.0236 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0076 0.0137
Loa Loa (eye worm) hypothetical protein 0.0137 0.0821 0.1489
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0573 0.0958
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.008 0.0266
Brugia malayi hypothetical protein 0.0044 0.0155 0.0259
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0545
Schistosoma mansoni glutamate receptor NMDA 0.0033 0.0072 0.0072
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0137 0.0821 0.0821
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0044 0.0155 0.0155
Brugia malayi hypothetical protein 0.0351 0.2368 0.396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0257 0.1076
Entamoeba histolytica serine/threonine protein kinase, putative 0.0075 0.0376 0.2074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0137 0.0821 0.1489
Echinococcus multilocularis geminin 0.0311 0.2081 0.2081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0515 0.0515
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0076 0.0383 0.0383
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0137 0.0821 0.1489
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0052 0.0214 0.1398
Loa Loa (eye worm) nuclear receptor NHR-67 0.0064 0.0301 0.0545
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0024 0.001 0.001
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0064 0.0301 0.0301
Echinococcus granulosus expressed protein 0.0438 0.2992 0.2992
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.001 0.0018
Trypanosoma cruzi proliferative cell nuclear antigen (PCNA), putative 0.0097 0.0535 0.2895
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0214 0.0214
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0076 0.0383 0.064
Onchocerca volvulus Putative organic anion transporter 0.0044 0.0155 0.054
Brugia malayi photoreceptor-specific nuclear receptor 0.0137 0.0821 0.1373
Echinococcus multilocularis lamin 0.0072 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0044 0.0155 0.0281
Schistosoma mansoni intermediate filament proteins 0.0072 0.0352 0.0352
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.008 0.0397
Brugia malayi ecdysone receptor 0.0064 0.0301 0.0503
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0137 0.0821 0.0821
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0137 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0137 0.0821 0.1489
Loa Loa (eye worm) steroid hormone receptor 0.0137 0.0821 0.1489
Echinococcus multilocularis follistatin 0.003 0.0054 0.0054
Schistosoma mansoni nuclear receptor 0.0064 0.0301 0.0301
Onchocerca volvulus 0.0401 0.2728 1
Schistosoma mansoni hypothetical protein 0.007 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0072 0.0356 0.0646
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0072 0.0356 0.0356
Schistosoma mansoni nuclear receptor 0.0064 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0545
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0143 0.087 0.5264
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0137 0.0821 0.0821
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0376 0.1354
Loa Loa (eye worm) hypothetical protein 0.0351 0.2368 0.4294
Loa Loa (eye worm) hypothetical protein 0.0351 0.2368 0.4294
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0137 0.0821 0.0821
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0137 0.0821 0.0821
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.1448 0.2627
Loa Loa (eye worm) hypothetical protein 0.0102 0.0573 0.1039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0257 0.1076
Schistosoma mansoni kinase 0.0038 0.0111 0.0111
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.008 0.0397
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0573 0.0958
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0104 0.0584 0.3163
Echinococcus granulosus proliferating cell nuclear antigen 0.0097 0.0535 0.0535
Giardia lamblia PcnA 0.0097 0.0535 0.3189
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.008 0.0397
Echinococcus granulosus glutamate receptor 2 0.0033 0.0072 0.0072
Brugia malayi Nuclear hormone receptor E75 0.0064 0.0301 0.0503
Loa Loa (eye worm) sodium-independent organic anion transporter 0.007 0.0339 0.0614
Treponema pallidum fructose-bisphosphate aldolase 0.0232 0.1507 1
Echinococcus granulosus GPCR family 2 0.0032 0.0069 0.0069
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0069 0.0126
Schistosoma mansoni hypothetical protein 0.0032 0.0069 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0104 0.0584 0.3385
Schistosoma mansoni organic anion transporter 0.007 0.0339 0.0339
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0035 0.0085 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0103 0.0351
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0368 0.0368
Echinococcus multilocularis lamin dm0 0.0072 0.0352 0.0352
Brugia malayi PAS domain containing protein 0.0092 0.0497 0.0831
Trypanosoma brucei proliferative cell nuclear antigen (PCNA), putative 0.0097 0.0535 0.2654
Echinococcus multilocularis muscleblind protein 0.0462 0.317 0.317
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0035 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0044 0.0155 0.0281
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0024 0.0008 0.0008
Onchocerca volvulus 0.0052 0.0214 0.0758
Echinococcus granulosus RUN 0.0034 0.0079 0.0079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0137 0.0821 0.0821
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.003 0.0054 0.0097
Loa Loa (eye worm) hypothetical protein 0.0032 0.0068 0.0122
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0033 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0462 0.317 0.5749
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0257 0.1076
Loa Loa (eye worm) hypothetical protein 0.003 0.0054 0.0097
Brugia malayi hypothetical protein 0.0074 0.0368 0.0615
Echinococcus multilocularis lipoxygenase domain containing protein 0.0034 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0034 0.0079 0.0143
Loa Loa (eye worm) hypothetical protein 0.0137 0.0821 0.1489
Echinococcus multilocularis lipoxygenase domain containing protein 0.0034 0.0079 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0137 0.0821 0.1373
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0076 0.0383 0.0694
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0232 0.1507 0.551
Leishmania major cathepsin L-like protease 0.0058 0.0257 0.1369
Plasmodium vivax multidomain scavenger receptor, putative 0.0034 0.0079 0.0244
Mycobacterium ulcerans putative regulatory protein 0.0068 0.0325 0.1689
Giardia lamblia Kinase, PLK 0.0075 0.0376 0.2074
Echinococcus multilocularis proliferating cell nuclear antigen 0.0097 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.003 0.0054 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.008 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0137 0.0821 0.1373
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0515 0.0933
Toxoplasma gondii hypothetical protein 0.0045 0.0158 0.0904
Schistosoma mansoni single-minded 0.0092 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0072 0.0356 0.0646
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0134 0.0801 0.1452
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0545
Echinococcus granulosus neuropeptide receptor A26 0.0441 0.3017 0.3017
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0072 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0545
Trypanosoma cruzi cruzipain precursor, putative 0.0058 0.0257 0.1369
Echinococcus granulosus aryl hydrocarbon receptor 0.0024 0.0008 0.0008
Onchocerca volvulus 0.007 0.0339 0.1216
Brugia malayi nuclear receptor NHR-67 0.0064 0.0301 0.0503
Schistosoma mansoni lipoxygenase 0.0034 0.0079 0.0079
Echinococcus granulosus geminin 0.0311 0.2081 0.2081
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0697 0.4857 0.4857
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0137 0.0821 0.1373
Onchocerca volvulus 0.0044 0.0155 0.054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0137 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0034 0.0079 0.0143
Onchocerca volvulus 0.0034 0.0079 0.0261
Echinococcus granulosus follistatin 0.003 0.0054 0.0054
Echinococcus multilocularis nuclear factor of activated T cells 5 0.007 0.0338 0.0338
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0276 0.1829 1
Schistosoma mansoni lamin 0.0072 0.0352 0.0352
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0072 0.0356 0.0356
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0076 0.0383 0.0383
Trypanosoma brucei polo-like protein kinase 0.0075 0.0376 0.1752
Loa Loa (eye worm) hypoxia-induced factor 1 0.0284 0.1881 0.3411
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0076 0.0383 0.0383
Brugia malayi nuclear hormone receptor 0.0064 0.0301 0.0503
Echinococcus granulosus ecdysone induced protein 78C 0.0137 0.0821 0.0821
Mycobacterium tuberculosis Conserved hypothetical protein 0.0146 0.0886 0.6563
Onchocerca volvulus Bile acid receptor homolog 0.0137 0.0821 0.2988
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0545
Trichomonas vaginalis proliferating cell nuclear antigen, putative 0.0097 0.0535 0.1938
Brugia malayi hypothetical protein 0.0044 0.0155 0.0259
Brugia malayi nuclear receptor NHR-88 0.0064 0.0301 0.0503
Loa Loa (eye worm) doublecortin family protein 0.0034 0.0079 0.0143
Echinococcus multilocularis GPCR, family 2 0.0032 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0137 0.0821 0.1373
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0131 0.0779 0.4236
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0545
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0137 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0545
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0788 0.5514 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0069 0.0116
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0064 0.0301 0.0301
Schistosoma mansoni hypothetical protein 0.0074 0.0368 0.0368
Onchocerca volvulus Putative organic anion transporter 0.0044 0.0155 0.054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.0301 0.0301
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0137 0.0821 0.0821
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0137 0.0821 0.1373
Echinococcus granulosus agrin 0.003 0.0054 0.0054
Leishmania major cathepsin L-like protease 0.0058 0.0257 0.1369
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0232 0.1507 1
Onchocerca volvulus 0.0044 0.0155 0.054
Leishmania major hypothetical protein, conserved 0.0032 0.0068 0.0328
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.008 0.0134
Loa Loa (eye worm) hypothetical protein 0.0032 0.0068 0.0122
Loa Loa (eye worm) hypothetical protein 0.0044 0.0155 0.0281
Schistosoma mansoni agrin 0.003 0.0054 0.0054
Echinococcus multilocularis nmda type glutamate receptor 0.0077 0.0392 0.0392
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0069 0.0069
Schistosoma mansoni glutaminase 0.0244 0.1593 0.1593
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.0301 0.0301
Brugia malayi nuclear hormone receptor 0.0137 0.0821 0.1373
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.0301 0.0301
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0068 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0137 0.0821 0.1373
Brugia malayi proliferating cell nuclear antigen (PCNA) 0.0097 0.0535 0.0895
Echinococcus multilocularis neuropeptide s receptor 0.0441 0.3017 0.3017
Trypanosoma cruzi MFS transporter, putative 0.0044 0.0155 0.0807
Brugia malayi Pre-SET motif family protein 0.0353 0.2379 0.3979
Plasmodium falciparum proliferating cell nuclear antigen 1 0.0097 0.0535 1
Leishmania major proliferative cell nuclear antigen (PCNA), putative 0.0097 0.0535 0.2895
Echinococcus granulosus intermediate filament protein 0.0072 0.0352 0.0352
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0104 0.0584 0.0584
Schistosoma mansoni rab6-interacting 0.0034 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0064 0.0301 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0137 0.0821 0.1373
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0024 0.0008 0.0014
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0072 0.0352 0.0639
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0232 0.1507 0.551
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0055 0.0236 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0077 0.0392 0.0392
Echinococcus multilocularis transfer RNA-Lys 0.0068 0.0325 0.0325
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.007 0.007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0068 0.0068
Schistosoma mansoni thyroid hormone receptor 0.0833 0.5842 0.5842
Schistosoma mansoni proliferating cell nuclear antigen 0.0097 0.0535 0.0535
Brugia malayi hypothetical protein 0.0307 0.2052 0.3433
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0113 0.0652 0.4689
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.007 0.0339 0.0339
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0232 0.1507 0.551
Brugia malayi orphan nuclear receptor NR2E1 0.0064 0.0301 0.0503
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0068 0.0328
Loa Loa (eye worm) intermediate filament protein 0.0072 0.0352 0.0639
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0027 0.0027
Brugia malayi beta-lactamase family protein 0.0032 0.0068 0.0113
Loa Loa (eye worm) hypothetical protein 0.0072 0.0356 0.0646
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.003 0.0054 0.009
Loa Loa (eye worm) DR-78 0.0064 0.0301 0.0545
Loa Loa (eye worm) hypothetical protein 0.007 0.0339 0.0614
Echinococcus granulosus FTZ F1 alpha 0.0137 0.0821 0.0821
Trypanosoma cruzi polo-like protein kinase, putative 0.0075 0.0376 0.2022
Brugia malayi nuclear receptor RXR 0.0064 0.0301 0.0503
Loa Loa (eye worm) hypothetical protein 0.0137 0.0821 0.1489
Echinococcus multilocularis FTZ F1 alpha 0.0137 0.0821 0.0821
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0039 0.0116 0.0596
Brugia malayi hypothetical protein 0.0064 0.0301 0.0503
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0075 0.0376 0.2022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0257 0.1076
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.001 0.001
Brugia malayi conserved hypotetical protein 0.0064 0.0301 0.0503
Brugia malayi intermediate filament protein 0.0072 0.0352 0.0589
Brugia malayi beta-lactamase 0.0032 0.0068 0.0113
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.001 0.001
Leishmania major protein kinase, putative 0.0024 0.001 0.001
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0113 0.0652 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.0301 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0376 0.1354
Brugia malayi ecdysteroid receptor 0.0137 0.0821 0.1373
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0137 0.0821 0.1373
Onchocerca volvulus 0.0044 0.0155 0.054
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0276 0.1829 1
Schistosoma mansoni hypothetical protein 0.0076 0.0383 0.0383

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 1.93 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 2 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 3.64 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 6.94 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 92 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 100 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 2.41 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -5 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 2 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 92 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 100 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.32 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.48031 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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