TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 476.526 | Formula: C29H24N4O3
H donors: 3 H acceptors: 3 LogP: 5.56 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1ccc(cc1)NC(=O)Nc1cccc(c1)c1cccc(c1)c1nc2c([nH]1)cccc2
InChi: 1S/C29H24N4O3/c1-2-36-28(34)19-13-15-23(16-14-19)30-29(35)31-24-10-6-8-21(18-24)20-7-5-9-22(17-20)27-32-25-11-3-4-12-26(25)33-27/h3-18H,2H2,1H3,(H,32,33)(H2,30,31,35)
InChiKey: RRRYOPVRTCNUDR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0058	0.0562	0.0562
Schistosoma mansoni	nAChR subunit	0.0058	0.0562	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Echinococcus multilocularis	Smad4	0.0032	0.0166	0.0166
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0387	0.565	0.565
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0027	0.0079	0.0113
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0031	0.0148	0.0148
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0387	0.565	0.565
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Schistosoma mansoni	hypothetical protein	0.0204	0.2816	0.2816
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Brugia malayi	hypothetical protein	0.0027	0.0079	0.0113
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0121	0.1532	0.5
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0058	0.0562	0.0802
Schistosoma mansoni	lipoxygenase	0.0099	0.1196	0.1196
Echinococcus granulosus	histone lysine methyltransferase setb	0.0061	0.0606	0.0606
Onchocerca volvulus	Huntingtin homolog	0.0123	0.1571	0.2116
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0121	0.1532	0.1532
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0063	0.1035
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0027	0.0079	0.0113
Echinococcus multilocularis	smad	0.0032	0.0166	0.0166
Brugia malayi	Ets-domain containing protein	0.0071	0.0764	0.1091
Brugia malayi	Doublecortin family protein	0.0038	0.0256	0.0366
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0227	0.317	0.317
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0606	0.0866
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0058	0.0562	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0148	0.0212
Brugia malayi	hypothetical protein	0.0027	0.0079	0.0113
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0034	0.542
Onchocerca volvulus	Glucosylceramidase homolog	0.0166	0.2235	0.3058
Brugia malayi	Pre-SET motif family protein	0.0061	0.0606	0.0866
Schistosoma mansoni	hypothetical protein	0.032	0.4608	0.4608
Echinococcus granulosus	glycine receptor subunit beta	0.0058	0.0562	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Brugia malayi	hypothetical protein	0.0038	0.0256	0.0366
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0027	0.0079	0.0113
Echinococcus granulosus	polycomb protein SCMH1	0.0052	0.0469	0.0469
Brugia malayi	Cation transporter family protein	0.0058	0.0562	0.0802
Plasmodium vivax	SET domain protein, putative	0.0061	0.0606	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0032	0.0166	0.0166
Loa Loa (eye worm)	acetylcholine receptor protein	0.0027	0.0079	0.0113
Brugia malayi	Importin beta-1 subunit	0.0029	0.012	0.0171
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0058	0.0562	0.0562
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.2373	0.3329
Echinococcus granulosus	nAChR subunit	0.0058	0.0562	0.0562
Schistosoma mansoni	smad1 5 8 and	0.0032	0.0166	0.0166
Onchocerca volvulus		0.0031	0.0148	0.0098
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0058	0.0562	0.0562
Onchocerca volvulus		0.0031	0.0148	0.0098
Schistosoma mansoni	sex comb on midleg homolog	0.0052	0.0469	0.0469
Trichomonas vaginalis	glucosylceramidase, putative	0.0253	0.3582	0.5024
Loa Loa (eye worm)	transcription factor SMAD2	0.0475	0.7003	1
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0058	0.0562	0.0802
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0058	0.0562	0.0802
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0121	0.1532	0.1532
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0059	0.0581	0.0829
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0227	0.317	0.317
Brugia malayi	MH2 domain containing protein	0.0032	0.0166	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1571	0.2243
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0031	0.0148	0.0212
Schistosoma mansoni	lipoxygenase	0.0168	0.2259	0.2259
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0424	0.6223	0.8886
Onchocerca volvulus	Putative nachr subunit	0.0387	0.565	0.7902
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0063	0.009
Schistosoma mansoni	sex comb on midleg homolog	0.0052	0.0469	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0148	0.0212
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0094	0.1124	0.1124
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0227	0.317	0.317
Echinococcus granulosus	nAChR subunit	0.0031	0.0148	0.0148
Schistosoma mansoni	hypothetical protein	0.0094	0.1124	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0112	0.1391	0.1391
Onchocerca volvulus		0.0483	0.7129	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.2235	0.3135
Loa Loa (eye worm)	hypothetical protein	0.0154	0.2046	0.2922
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0059	0.0581	0.0581
Echinococcus granulosus	GPCR family 2	0.0094	0.1124	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0058	0.0562	0.0802
Brugia malayi	Melibiase family protein	0.0074	0.0816	0.1166
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0058	0.0562	0.0802
Onchocerca volvulus		0.0154	0.2046	0.279
Schistosoma mansoni	microtubule-associated protein tau	0.0669	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.2235	0.3135
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1571	0.2243
Echinococcus granulosus	importin subunit beta 1	0.0029	0.012	0.012
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0052	0.0469	0.0469
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0341	0.4937	0.4937
Loa Loa (eye worm)	MBCTL1	0.0059	0.0581	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0387	0.565	0.8068
Schistosoma mansoni	nAChR subunit	0.0027	0.0079	0.0079
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0058	0.0562	0.0802
Schistosoma mansoni	hypothetical protein	0.0338	0.4884	0.4884
Schistosoma mansoni	gabp alpha	0.0071	0.0764	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0058	0.0562	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Brugia malayi	Cation transporter family protein	0.0058	0.0562	0.0802
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0027	0.0079	0.0113
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0253	0.3582	0.5114
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0061	0.0606	0.3958
Brugia malayi	latrophilin 2 splice variant baaae	0.0204	0.2816	0.4021
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0298	0.4274	0.6103
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0387	0.565	0.8068
Echinococcus granulosus	GA binding protein alpha chain	0.0071	0.0764	0.0764
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0058	0.0562	0.0802
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0094	0.1124	0.1124
Loa Loa (eye worm)	MH2 domain-containing protein	0.0032	0.0166	0.0236
Loa Loa (eye worm)	fli-1 protein	0.0216	0.2999	0.4283
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.012	0.012
Entamoeba histolytica	hypothetical protein	0.0031	0.0148	1
Echinococcus multilocularis	GA binding protein alpha chain	0.0071	0.0764	0.0764
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0063	0.245
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Brugia malayi	Smad1	0.0032	0.0166	0.0236
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0298	0.4274	0.6103
Schistosoma mansoni	polycystin 1-related	0.0038	0.0256	0.0256
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0112	0.1391	0.1391
Echinococcus granulosus	tar DNA binding protein	0.019	0.2602	0.2602
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0061	0.0606	0.0606
Trichomonas vaginalis	set domain proteins, putative	0.0483	0.7129	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0058	0.0562	0.0562
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0606	0.0606
Onchocerca volvulus		0.0058	0.0562	0.0685
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0058	0.0562	0.0802
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0034	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0052	0.0469	0.0554
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0034	0.0048
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0058	0.0562	0.0562
Echinococcus granulosus	SAM and MBT domain containing protein	0.0052	0.0469	0.0469
Schistosoma mansoni	neurotransmitter gated ion channel	0.0031	0.0148	0.0148
Echinococcus granulosus	RUN	0.0038	0.0256	0.0256
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0027	0.0079	0.0079
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0027	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1124	0.1605
Leishmania major	hypothetical protein, conserved	0.0026	0.0063	0.041
Brugia malayi	hypothetical protein	0.0038	0.0256	0.0366
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0341	0.4937	0.4937
Trichomonas vaginalis	glucosylceramidase, putative	0.0253	0.3582	0.5024
Echinococcus granulosus	Smad4	0.0032	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0148	0.0212
Schistosoma mansoni	glutaminase	0.0265	0.3759	0.3759
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0253	0.3582	0.5114
Toxoplasma gondii	melibiase subfamily protein	0.0112	0.1391	0.9084
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.019	0.2602	0.3715
Loa Loa (eye worm)	hypothetical protein	0.0152	0.2019	0.2883
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0112	0.1391	0.1391
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0058	0.0562	0.0562
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0059	0.0581	0.0581
Brugia malayi	glutaminase DH11.1	0.0265	0.3759	0.5368
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0058	0.0562	0.0802
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.2235	0.3135
Schistosoma mansoni	aldehyde dehydrogenase	0.0121	0.1532	0.1532
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0031	0.0148	0.0212
Brugia malayi	hypothetical protein	0.0123	0.1571	0.2243
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0094	0.1124	0.1124
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0168	0.2259	0.2259
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0027	0.0079	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0148	0.0212
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0058	0.0562	0.0802
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0058	0.0562	0.0802
Echinococcus multilocularis	nAChR subunit	0.0058	0.0562	0.0562
Echinococcus multilocularis	glycine receptor subunit beta	0.0058	0.0562	0.0562
Schistosoma mansoni	hypothetical protein	0.0338	0.4884	0.4884
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0059	0.0581	0.0581
Schistosoma mansoni	tar DNA-binding protein	0.019	0.2602	0.2602
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0112	0.1391	0.1391
Echinococcus multilocularis	geminin	0.0338	0.4884	0.4884
Trichomonas vaginalis	glucosylceramidase, putative	0.0253	0.3582	0.5024
Schistosoma mansoni	hypothetical protein	0.0094	0.1124	0.1124
Loa Loa (eye worm)	glutaminase 2	0.0265	0.3759	0.5368
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0058	0.0562	0.0802
Brugia malayi	hypothetical protein	0.0026	0.0063	0.009
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0604	0.0863
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0027	0.0079	0.0079
Schistosoma mansoni	nAChR subunit	0.0058	0.0562	0.0562
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0074	0.0816	0.1145
Schistosoma mansoni	aldehyde dehydrogenase	0.0121	0.1532	0.1532
Echinococcus multilocularis	muscleblind protein 1	0.0152	0.2019	0.2019
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0387	0.565	0.565
Brugia malayi	RNA binding protein	0.019	0.2602	0.3715
Echinococcus multilocularis	GPCR, family 2	0.0094	0.1124	0.1124
Schistosoma mansoni	nAChR subunit	0.0058	0.0562	0.0562
Loa Loa (eye worm)	MH1 domain-containing protein	0.0032	0.0166	0.0236
Brugia malayi	mbt repeat family protein	0.0052	0.0469	0.067
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0038	0.0256	0.0256
Brugia malayi	hypothetical protein	0.0027	0.0079	0.0113
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.2235	0.3135
Loa Loa (eye worm)	hypothetical protein	0.0204	0.2816	0.4021
Echinococcus granulosus	snurportin 1	0.0314	0.4515	0.4515
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0027	0.0079	0.0079
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0209	0.2889	0.2889
Trichomonas vaginalis	glucosylceramidase, putative	0.0253	0.3582	0.5024
Loa Loa (eye worm)	hypothetical protein	0.0029	0.012	0.0171
Brugia malayi	mbt repeat family protein	0.0052	0.0469	0.067
Schistosoma mansoni	tar DNA-binding protein	0.019	0.2602	0.2602
Loa Loa (eye worm)	TAR-binding protein	0.019	0.2602	0.3715
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0	0.5
Brugia malayi	hypothetical protein	0.0027	0.0079	0.0113
Loa Loa (eye worm)	GABA receptor subunit	0.0031	0.0148	0.0212
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0094	0.1124	0.1605
Schistosoma mansoni	tar DNA-binding protein	0.019	0.2602	0.2602
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0387	0.565	0.565
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Schistosoma mansoni	nAChR subunit	0.0058	0.0562	0.0562
Schistosoma mansoni	rab6-interacting	0.0038	0.0256	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0063	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0038	0.0256	0.0256
Schistosoma mansoni	nAChR subunit	0.0027	0.0079	0.0079
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0027	0.0079	0.0113
Schistosoma mansoni	nAChR subunit	0.0058	0.0562	0.0562
Schistosoma mansoni	smad1 5 8 and	0.0032	0.0166	0.0166
Schistosoma mansoni	hypothetical protein	0.0038	0.0256	0.0256
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0094	0.1124	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0059	0.0572	0.0572
Brugia malayi	TAR-binding protein	0.019	0.2602	0.3715
Echinococcus multilocularis	snurportin 1	0.0314	0.4515	0.4515
Echinococcus granulosus	Polycystic kidney disease protein	0.0038	0.0256	0.0256
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0227	0.317	0.4527
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0387	0.565	0.565
Trichomonas vaginalis	glucosylceramidase, putative	0.0253	0.3582	0.5024
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0148	0.0212
Brugia malayi	hypothetical protein	0.0027	0.0079	0.0113
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0058	0.0562	0.0562
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0112	0.1391	0.1391
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0121	0.1532	1
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0027	0.0079	0.0113
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0038	0.0256	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0148	0.0212
Schistosoma mansoni	nAChR subunit	0.0058	0.0562	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Schistosoma mansoni	nAChR subunit	0.0058	0.0562	0.0562
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0058	0.0562	0.0802
Loa Loa (eye worm)	ACC-1 protein	0.0058	0.0562	0.0802
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0032	0.0166	0.0166
Brugia malayi	Latrophilin receptor protein 2	0.0094	0.1124	0.1605
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0058	0.0562	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0816	0.1166
Echinococcus granulosus	lipoxygenase domain containing protein	0.0038	0.0256	0.0256
Echinococcus granulosus	glycine receptor subunit beta	0.0058	0.0562	0.0562
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0031	0.0148	0.0212
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0341	0.4937	0.705
Plasmodium falciparum	importin beta, putative	0.0029	0.012	0.4681
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0298	0.4274	0.6103
Onchocerca volvulus		0.0038	0.0256	0.0251
Onchocerca volvulus		0.0038	0.0256	0.0251
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0027	0.0079	0.0079
Onchocerca volvulus		0.0058	0.0562	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0061	0.0606	0.0606
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0168	0.2259	0.2259
Onchocerca volvulus		0.0058	0.0562	0.0685
Schistosoma mansoni	hypothetical protein	0.0094	0.1124	0.1124
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0031	0.0148	0.0212
Echinococcus multilocularis	RUN	0.0038	0.0256	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0148	0.0212
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0227	0.317	0.317
Schistosoma mansoni	Smad4	0.0032	0.0166	0.0166
Brugia malayi	MH2 domain containing protein	0.0032	0.0166	0.0236
Echinococcus multilocularis	glycine receptor subunit beta	0.0058	0.0562	0.0562
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0112	0.1391	0.1391
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0058	0.0562	0.0562
Echinococcus multilocularis	polycomb protein SCMH1	0.0052	0.0469	0.0469
Echinococcus multilocularis	microtubule associated protein 2	0.0669	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0341	0.4937	0.4937
Brugia malayi	MH1 domain containing protein	0.0032	0.0166	0.0236
Echinococcus multilocularis	muscleblind protein	0.0152	0.2019	0.2019
Loa Loa (eye worm)	LGC-31 protein	0.0058	0.0562	0.0802
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0058	0.0562	0.0562
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0061	0.0606	0.0606
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0034	0.0222
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0227	0.317	0.317
Loa Loa (eye worm)	ACC-1 protein	0.0058	0.0562	0.0802
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0058	0.0562	0.0562
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.2373	0.3329
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0074	0.0816	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0406	0.058
Trichomonas vaginalis	glutaminase, putative	0.0265	0.3759	0.5273
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0071	0.0764	0.1091
Brugia malayi	excitatory GABA receptor EXP-1A	0.0058	0.0562	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0032	0.0166	0.0166
Onchocerca volvulus	Huntingtin homolog	0.0123	0.1571	0.2116
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0148	0.0212
Echinococcus multilocularis	tumor protein p63	0.0327	0.4726	0.4726
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Plasmodium vivax	multidomain scavenger receptor, putative	0.0038	0.0256	0.4226
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0058	0.0562	0.0802
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.012	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0227	0.317	0.4527
Echinococcus granulosus	histone acetyltransferase MYST2	0.0059	0.0581	0.0581
Loa Loa (eye worm)	Smad1	0.0032	0.0166	0.0236
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0063	0.245
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0256	0.0366
Loa Loa (eye worm)	glutaminase	0.0265	0.3759	0.5368
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0058	0.0562	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Echinococcus granulosus	smad	0.0032	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0256	0.0366
Echinococcus granulosus	muscleblind protein	0.0152	0.2019	0.2019
Onchocerca volvulus		0.0061	0.0606	0.0748
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0063	0.5234
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0034	0.0048
Brugia malayi	Cation transporter family protein	0.0058	0.0562	0.0802
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0227	0.317	0.317
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.012	1
Schistosoma mansoni	tar DNA-binding protein	0.019	0.2602	0.2602
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0058	0.0562	0.0802
Schistosoma mansoni	smad	0.0032	0.0166	0.0166
Plasmodium vivax	importin-beta 2, putative	0.0029	0.012	0.1978
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0341	0.4937	0.705
Echinococcus multilocularis	tar DNA binding protein	0.019	0.2602	0.2602
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0314	0.4515	0.6447
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0581	0.0829
Schistosoma mansoni	tar DNA-binding protein	0.019	0.2602	0.2602
Brugia malayi	Ets-domain containing protein	0.0071	0.0764	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0148	0.0212
Schistosoma mansoni	neurotransmitter gated ion channel	0.0027	0.0079	0.0079
Brugia malayi	Pre-SET motif family protein	0.0424	0.6223	0.8886
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0027	0.0079	0.0079
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0387	0.565	0.8068
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0074	0.0816	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Toxoplasma gondii	aldehyde dehydrogenase	0.0121	0.1532	1
Loa Loa (eye worm)	mbt repeat family protein	0.0052	0.0469	0.067
Trichomonas vaginalis	glucosylceramidase, putative	0.0253	0.3582	0.5024
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0052	0.0469	0.0469
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0058	0.0562	0.0562
Brugia malayi	MH1 domain containing protein	0.0032	0.0166	0.0236
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0058	0.0562	0.0802
Plasmodium falciparum	LCCL domain-containing protein	0.0038	0.0256	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.2019	0.2883
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0058	0.0562	0.0562
Entamoeba histolytica	hypothetical protein	0.0024	0.0034	0.2291
Brugia malayi	Fli-1 protein	0.0216	0.2999	0.4283
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0063	1
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0058	0.0562	0.0562
Brugia malayi	hypothetical protein	0.0154	0.2046	0.2922
Schistosoma mansoni	hypothetical protein	0.0094	0.1124	0.1124
Schistosoma mansoni	neurotransmitter gated ion channel	0.0027	0.0079	0.0079
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0058	0.0562	0.0802
Schistosoma mansoni	acetylcholine receptor-related	0.0027	0.0079	0.0079
Echinococcus granulosus	geminin	0.0338	0.4884	0.4884
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0606	0.0606
Onchocerca volvulus		0.0052	0.0469	0.0554
Brugia malayi	RNA recognition motif domain containing protein	0.019	0.2602	0.3715
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0209	0.2889	0.2889
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.2235	0.3135
Schistosoma mansoni	rab6-interacting	0.0038	0.0256	0.0256
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0112	0.1391	0.1391
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0298	0.4274	0.6103
Schistosoma mansoni	smad1 5 8 and	0.0032	0.0166	0.0166
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0058	0.0562	0.0562
Mycobacterium ulcerans	glutaminase	0.0265	0.3759	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0063	0.041
Loa Loa (eye worm)	doublecortin family protein	0.0038	0.0256	0.0366
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.2235	0.3135
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0094	0.1124	0.1605
Onchocerca volvulus		0.0058	0.0562	0.0685
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0058	0.0562	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0469	0.067
Echinococcus multilocularis	Polycystic kidney disease protein	0.0038	0.0256	0.0256
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0606	0.0606
Schistosoma mansoni	importin beta-1	0.0029	0.012	0.012
Loa Loa (eye worm)	MH2 domain-containing protein	0.0475	0.7003	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0031	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0562	0.0802
Brugia malayi	RNA, U transporter 1	0.0084	0.0957	0.1367
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0058	0.0562	0.0562
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0058	0.0562	0.0562
Schistosoma mansoni	ets-related	0.0216	0.2999	0.2999
Brugia malayi	Muscleblind-like protein	0.0152	0.2019	0.2883
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0058	0.0562	0.0802
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0027	0.0079	0.0113
Echinococcus granulosus	tumor protein p63	0.0327	0.4726	0.4726
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0032	0.0166	0.0166
Onchocerca volvulus		0.0058	0.0562	0.0685
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.2235	0.3135
Brugia malayi	MH2 domain containing protein	0.0475	0.7003	1
Schistosoma mansoni	hypothetical protein	0.0314	0.4515	0.4515
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0387	0.565	0.565
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0058	0.0562	0.0562
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.012	0.0783
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0227	0.317	0.317
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0058	0.0562	0.0802
Onchocerca volvulus		0.0048	0.0406	0.0464
Onchocerca volvulus		0.0058	0.0562	0.0685
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0032	0.0166	0.0166
Schistosoma mansoni	loxhd1	0.0038	0.0256	0.0256
Loa Loa (eye worm)	RNA binding protein	0.019	0.2602	0.3715
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0059	0.0581	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Echinococcus multilocularis	nAChR subunit	0.0031	0.0148	0.0148

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 0 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 7.84 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 8.27 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 10.43 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 76 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 99 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 100 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 9	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= -3 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 76 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 99 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 100 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 7.16	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.06866 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL545817
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 598385