Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0155 | 0.44 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0023 | 0.0047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0047 | 0.0059 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3366 | 0.765 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0023 | 0.0047 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3366 | 0.765 |
Echinococcus multilocularis | 0.0023 | 0.0047 | 0.0108 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0124 | 0.3366 | 0.765 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0023 | 0.0047 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0023 | 0.0047 | 0.0108 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0124 | 0.3366 | 0.4039 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.7961 | 0.995 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0124 | 0.3366 | 0.4207 |
Onchocerca volvulus | 0.0023 | 0.0047 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.3694 | 0.8394 |
Brugia malayi | SWIRM domain containing protein | 0.0023 | 0.0047 | 0.0057 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0023 | 0.0047 | 0.0108 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0303 | 0.9246 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0023 | 0.0047 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3366 | 0.765 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0265 | 0.8001 | 0.96 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0023 | 0.0047 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0265 | 0.8001 | 0.96 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0155 | 0.44 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0023 | 0.0047 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0023 | 0.0047 | 0.0108 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0023 | 0.0047 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0047 | 0.0059 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0023 | 0.0047 | 0.5 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0047 | 0.0057 |
Brugia malayi | RNA binding protein | 0.0124 | 0.3366 | 0.4039 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0023 | 0.0047 | 0.0057 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0134 | 0.3694 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3366 | 0.765 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0047 | 0.0059 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0326 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0023 | 0.0047 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0023 | 0.0047 | 0.0108 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3366 | 0.765 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0023 | 0.0047 | 0.0108 |
Schistosoma mansoni | thyroid hormone receptor | 0.0155 | 0.44 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0275 | 0.8334 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0023 | 0.0047 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0023 | 0.0047 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0023 | 0.0047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0047 | 0.0059 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0134 | 0.3694 | 0.8394 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0047 | 0.0059 |
Loa Loa (eye worm) | TAR-binding protein | 0.0124 | 0.3366 | 0.4207 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0265 | 0.8001 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0023 | 0.0047 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0047 | 0.0059 |
Brugia malayi | TAR-binding protein | 0.0124 | 0.3366 | 0.4039 |
Echinococcus granulosus | tar DNA binding protein | 0.0124 | 0.3366 | 0.9113 |
Loa Loa (eye worm) | RNA binding protein | 0.0124 | 0.3366 | 0.4207 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0023 | 0.0047 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0023 | 0.0047 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0023 | 0.0047 | 0.0108 |
Leishmania major | UDP-galactopyranose mutase | 0.0023 | 0.0047 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -0.63 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1.72 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 5.22 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 22 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 50 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 5.84 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -1 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 22 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 50 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 101 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.15 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.70464 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.