Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Acyl-CoA:cholesterol acyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma japonicum | ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus multilocularis | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma mansoni | sterol O-acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus granulosus | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | diacylglycerol O-acyltransferase 1 | Acyl-CoA:cholesterol acyltransferase | 305 aa | 278 aa | 21.9 % |
Neospora caninum | sterol O-acyltransferase, putative | Acyl-CoA:cholesterol acyltransferase | 305 aa | 258 aa | 20.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.0303 | 0.8764 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0 | 0.5 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0264 | 0.7204 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0083 | 0 | 0.5 |
Loa Loa (eye worm) | STAT protein | 0.0334 | 1 | 1 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0264 | 0.7204 | 1 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0264 | 0.7204 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0083 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0083 | 0 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0083 | 0 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0083 | 0 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0083 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.6179 | 0.2257 |
Brugia malayi | Telomerase reverse transcriptase | 0.022 | 0.547 | 0.0823 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.7204 | 0.4335 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0083 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.47 uM | Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit intestine microsomes. | ChEMBL. | 8496930 |
IC50 (binding) | = 0.47 uM | Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit intestine microsomes. | ChEMBL. | 8496930 |
IC50 (binding) | = 2.2 uM | Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit aorta homogenate. | ChEMBL. | 8496930 |
IC50 (binding) | = 2.2 uM | Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit aorta homogenate. | ChEMBL. | 8496930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.