Detailed information for compound 59873

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 447.483 | Formula: C25H25N3O5
  • H donors: 1 H acceptors: 4 LogP: 1.65 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1c3nc4ccc5c(c4c(c3Cn1c2=O)CC)N(C)CCO5
  • InChi: 1S/C25H25N3O5/c1-4-13-14-11-28-18(10-16-15(23(28)29)12-33-24(30)25(16,31)5-2)21(14)26-17-6-7-19-22(20(13)17)27(3)8-9-32-19/h6-7,10,31H,4-5,8-9,11-12H2,1-3H3/t25-/m0/s1
  • InChiKey: DEDSBNULGFPKPQ-VWLOTQADSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.0063
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0026 0.0056 0.0059
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0244 0.297
Loa Loa (eye worm) hypothetical protein 0.0087 0.055 0.0581
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0119 0.0805 1
Treponema pallidum uridine phosphorylase (udp) 0.0145 0.1008 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.017 0.1216 0.1216
Loa Loa (eye worm) hypothetical protein 0.0071 0.042 0.0443
Plasmodium falciparum purine nucleoside phosphorylase 0.0145 0.1008 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0066 0.007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0104 0.0685 0.0723
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.042 0.2695
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0244 0.0353
Leishmania major trypanothione reductase 0.004 0.0168 0.053
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0104 0.0685 0.0991
Brugia malayi glutathione reductase 0.004 0.0168 0.0178
Schistosoma mansoni hypothetical protein 0.0881 0.6909 0.6909
Brugia malayi nuclear hormone receptor 0.0104 0.0685 0.0723
Echinococcus granulosus cpg binding protein 0.0063 0.0352 0.0509
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0168 0.0482
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0049 0.0244 0.0353
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0007 0.001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0979 0.1418
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.1033 0.1495
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0104 0.0685 0.0723
Echinococcus granulosus microtubule associated protein 2 0.0786 0.6145 0.8894
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0007 0.0007
Plasmodium vivax polyprenol reductase, putative 0.0043 0.0193 0.0525
Echinococcus granulosus ecdysone induced protein 78C 0.0104 0.0685 0.0991
Plasmodium falciparum thioredoxin reductase 0.004 0.0168 0.0237
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0414 0.3167 1
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0168 0.0178
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0104 0.0685 0.0723
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.1033 0.1033
Echinococcus granulosus geminin 0.0881 0.6909 1
Entamoeba histolytica hypothetical protein 0.0189 0.1363 1
Mycobacterium ulcerans hydrolase/amidase 0.0629 0.4886 1
Brugia malayi Nuclear hormone receptor-like 1 0.0104 0.0685 0.0723
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0213 0.2111
Mycobacterium ulcerans aldehyde dehydrogenase 0.0135 0.0928 0.1899
Loa Loa (eye worm) ACC-1 protein 0.002 0.0007 0.0007
Echinococcus multilocularis ecdysone induced protein 78C 0.0104 0.0685 0.0991
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0043 0.0193 0.1912
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0007 0.001
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.042 0.1203
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0119 0.0805 0.0851
Schistosoma mansoni nAChR subunit 0.002 0.0007 0.0007
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0119 0.0805 0.555
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0043 0.0193 0.0609
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0043 0.0193 0.1049
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0396 0.3026 0.438
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.0318
Loa Loa (eye worm) ACC-1 protein 0.002 0.0007 0.0007
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0434 0.0459
Loa Loa (eye worm) hypothetical protein 0.0104 0.0685 0.0723
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0434 0.1371
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.042 0.042
Brugia malayi steroid hormone receptor 0.0104 0.0685 0.0723
Schistosoma mansoni tar DNA-binding protein 0.007 0.0413 0.0413
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.042 0.0443
Mycobacterium tuberculosis Hypothetical protein 0.0026 0.0056 0.0159
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0394 0.057
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0434 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0104 0.0685 0.0723
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0119 0.0805 0.555
Brugia malayi hypothetical protein 0.12 0.9464 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0434 0.1371
Brugia malayi Carboxylesterase family protein 0.0068 0.0394 0.0416
Echinococcus multilocularis purine nucleoside phosphorylase 0.0026 0.0056 0.008
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0049 0.0244 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0104 0.0685 0.0723
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.042 0.0859
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0414 0.3167 0.4584
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0188 0.0272
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0168 0.053
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.042 0.2695
Schistosoma mansoni hypothetical protein 0.0081 0.05 0.05
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0104 0.0685 0.0723
Echinococcus granulosus tumor protein p63 0.0385 0.2932 0.4244
Giardia lamblia Synaptic glycoprotein SC2 0.0043 0.0193 0.1016
Loa Loa (eye worm) hypothetical protein 0.0119 0.0805 0.0851
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0026 0.0056 0.0114
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0204
Trichomonas vaginalis cdc25b, putative 0.0119 0.0805 0.555
Schistosoma mansoni uridine phosphorylase 0.0026 0.0056 0.0056
Brugia malayi nuclear hormone receptor 0.0049 0.0244 0.0258
Loa Loa (eye worm) acetyltransferase 0.0148 0.1033 0.1091
Loa Loa (eye worm) nuclear receptor NHR-67 0.0049 0.0244 0.0258
Onchocerca volvulus Bile acid receptor homolog 0.0104 0.0685 0.849
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0414 0.3167 0.3347
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0007 0.0007
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0007 0.0007
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0194 0.1406 1
Trichomonas vaginalis cdc25b, putative 0.0119 0.0805 0.555
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.042 0.0607
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0043 0.0193 0.1016
Echinococcus granulosus jun protein 0.009 0.057 0.0825
Brugia malayi bZIP transcription factor family protein 0.009 0.057 0.0602
Echinococcus multilocularis purine nucleoside phosphorylase 0.0026 0.0056 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0104 0.0685 0.0723
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0056 0.0175
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0011 0.0011
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0145 0.1008 1
Brugia malayi CXXC zinc finger family protein 0.0057 0.0309 0.0326
Echinococcus multilocularis FTZ F1 alpha 0.0104 0.0685 0.0991
Trypanosoma brucei uridine phosphorylase 0.0026 0.0056 0.0175
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.1033 0.1091
Schistosoma mansoni intermediate filament proteins 0.0027 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Schistosoma mansoni purine nucleoside phosphorylase 0.0026 0.0056 0.0056
Brugia malayi Bromodomain containing protein 0.009 0.0568 0.06
Plasmodium falciparum polyprenol reductase, putative 0.0043 0.0193 0.0525
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0832 0.6518 0.9435
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.042 0.1203
Schistosoma mansoni nAChR subunit 0.002 0.0007 0.0007
Schistosoma mansoni nAChR subunit 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0104 0.0685 0.0723
Entamoeba histolytica hypothetical protein 0.0189 0.1363 1
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.042 0.1325
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0104 0.0685 0.0723
Loa Loa (eye worm) LGC-31 protein 0.002 0.0007 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.009 0.057 0.0825
Toxoplasma gondii aldehyde dehydrogenase 0.0135 0.0928 0.9204
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0043 0.0193 0.1016
Brugia malayi Serotonin receptor 0.0543 0.4202 0.444
Brugia malayi Steroid receptor seven-up type 2 0.0104 0.0685 0.0723
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) glutathione reductase 0.004 0.0168 0.0178
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Loa Loa (eye worm) hypothetical protein 0.0071 0.042 0.0443
Echinococcus multilocularis synaptic glycoprotein sc2 0.0043 0.0193 0.0279
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.0996 0.1053
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0244 0.0258
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.0575 0.8767
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0007 0.0007
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0026 0.0056 0.008
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0244 0.0244
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0145 0.1008 1
Echinococcus multilocularis sterol regulatory element binding protein 0.017 0.1216 0.176
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0394 0.057
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0148 0.0302
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.042 0.1203
Onchocerca volvulus 0.0071 0.0415 0.5116
Mycobacterium ulcerans aldehyde dehydrogenase 0.0135 0.0928 0.1899
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0163 0.0825
Brugia malayi ecdysone receptor 0.0049 0.0244 0.0258
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.05 0.0528
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0148 0.0704
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0007 0.001
Brugia malayi ecdysteroid receptor 0.0104 0.0685 0.0723
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0104 0.0685 0.0723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0996 0.0996
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.042 0.2695
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0135 0.0928 0.2661
Echinococcus granulosus sterol regulatory element binding protein 0.017 0.1216 0.176
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0194 0.1406 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0145 0.1008 0.7287
Mycobacterium ulcerans hypothetical protein 0.0071 0.042 0.0859
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0007 0.0007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.0575 0.1649
Schistosoma mansoni tar DNA-binding protein 0.007 0.0413 0.0413
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0996 0.1442
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0078 0.0476 0.0503
Loa Loa (eye worm) CYP4Cod1 0.0046 0.0221 0.0234
Onchocerca volvulus 0.0049 0.0244 0.297
Brugia malayi nuclear receptor NHR-88 0.0049 0.0244 0.0258
Loa Loa (eye worm) carboxylesterase 0.0068 0.0394 0.0416
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0049 0.0244 0.0258
Brugia malayi Carboxylesterase family protein 0.0068 0.0394 0.0416
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0119 0.0805 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0148 0.0156
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0026 0.0056 0.0059
Mycobacterium ulcerans beta-lactamase 0.0071 0.042 0.0859
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0193 0.0525
Loa Loa (eye worm) hypothetical protein 0.0055 0.0291 0.0308
Onchocerca volvulus 0.0043 0.0193 0.233
Schistosoma mansoni microtubule-associated protein tau 0.0786 0.6145 0.6145
Loa Loa (eye worm) hypothetical protein 0.0027 0.0066 0.007
Schistosoma mansoni thyroid hormone receptor 0.0501 0.3861 0.3861
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0101 0.0656 0.1881
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0193 0.0609
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0104 0.0685 0.0685
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0007 0.0007
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0104 0.0685 0.0723
Schistosoma mansoni thyroid hormone receptor 0.0501 0.3861 0.3861
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0244 0.297
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0056 0.008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0256 0.1904 0.2012
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0434 0.0434
Echinococcus granulosus nAChR subunit 0.002 0.0007 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0104 0.0685 0.0723
Echinococcus granulosus Protein patched homolog 1 0.017 0.1216 0.176
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0007 0.001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0148 0.0681
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0035 0.0037
Brugia malayi Cytochrome P450 family protein 0.0046 0.0221 0.0234
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0135 0.0928 0.293
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0394 0.057
Schistosoma mansoni bromodomain containing protein 0.0077 0.0465 0.0465
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0007 0.001
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0007 0.001
Echinococcus granulosus thyroid hormone receptor alpha 0.0049 0.0244 0.0353
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0007 0.001
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0434 0.0628
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0996 0.0996
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0291 0.0291
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0007 0.0007
Brugia malayi TAR-binding protein 0.007 0.0413 0.0437
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0026 0.0056 0.0175
Loa Loa (eye worm) hypothetical protein 0.0071 0.042 0.0443
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.042 0.0607
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0007 0.001
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0055 0.0291 0.0291
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0056 0.008
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0076
Schistosoma mansoni purine nucleoside phosphorylase 0.0026 0.0056 0.0056
Echinococcus granulosus GPCR family 2 0.0081 0.05 0.0724
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0104 0.0685 0.0991
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0256 0.1904 0.2012
Loa Loa (eye worm) hypothetical protein 0.0042 0.019 0.02
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0163 0.0798
Loa Loa (eye worm) hypothetical protein 0.0068 0.0394 0.0416
Brugia malayi Cytochrome P450 family protein 0.0059 0.0326 0.0344
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Echinococcus multilocularis purine nucleoside phosphorylase 0.0026 0.0056 0.008
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0119 0.0805 0.1166
Loa Loa (eye worm) hypothetical protein 0.0055 0.0291 0.0308
Brugia malayi hypothetical protein 0.0049 0.0244 0.0258
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0163 0.0184
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0266 0.1985 0.2097
Loa Loa (eye worm) RNA binding protein 0.007 0.0413 0.0437
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0148 0.0681
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0309 0.0326
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0996 0.1442
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0076 0.0076
Echinococcus multilocularis protein patched 0.017 0.1216 0.176
Onchocerca volvulus 0.0071 0.042 0.517
Schistosoma mansoni nAChR subunit 0.002 0.0007 0.0007
Brugia malayi hypothetical protein 0.0055 0.0291 0.0308
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0043 0.0193 0.0279
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0104 0.0685 0.0685
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.0685 0.0991
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0119 0.0805 0.555
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0148 0.0466
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0007 0.001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.0575 0.1649
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0026 0.0056 0.0159
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0026 0.0056 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.017 0.1216 0.8589
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0433 0.0627
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0193 0.1016
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0055 0.0291 0.0421
Echinococcus granulosus zinc finger protein 0.0028 0.0078 0.0113
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0056 0.0175
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0244 0.0353
Echinococcus granulosus uridine phosphorylase 1 0.0026 0.0056 0.008
Chlamydia trachomatis AMP nucleosidase 0.0026 0.0056 0.5
Loa Loa (eye worm) TAR-binding protein 0.007 0.0413 0.0437
Schistosoma mansoni hypothetical protein 0.0081 0.05 0.05
Onchocerca volvulus 0.0049 0.0244 0.297
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0244 0.0353
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0011 0.0016
Echinococcus multilocularis lamin dm0 0.0027 0.0066 0.0096
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0001 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0104 0.0685 0.0723
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0007 0.0007
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0119 0.0805 0.555
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0414 0.3167 0.4584
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0007 0.0007
Echinococcus multilocularis zinc finger protein 0.0028 0.0078 0.0113
Brugia malayi nuclear receptor NHR-67 0.0049 0.0244 0.0258
Mycobacterium leprae conserved hypothetical protein 0.0071 0.042 0.6395
Echinococcus multilocularis protein dispatched 1 0.017 0.1216 0.176
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0213 0.1164
Brugia malayi Cytochrome P450 family protein 0.0046 0.0221 0.0234
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0066 0.007
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0049 0.0244 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0193 0.1016
Echinococcus granulosus nuclear receptor nhr 48 0.0049 0.0244 0.0353
Mycobacterium leprae probable uridine phosphorylase 0.0026 0.0056 0.0847
Echinococcus granulosus lamin dm0 0.0027 0.0066 0.0096
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0168 0.0237
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0996 0.1442
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0101 0.0656 0.1881
Loa Loa (eye worm) hypothetical protein 0.12 0.9464 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Leishmania major nucleoside phosphorylase-like protein 0.0026 0.0056 0.0175
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Loa Loa (eye worm) hypothetical protein 0.017 0.1216 0.1285
Schistosoma mansoni hypothetical protein 0.0189 0.1363 0.1363
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0145 0.1008 0.7053
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0007 0.001
Brugia malayi hypothetical protein 0.0055 0.0291 0.0308
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0244 0.0258
Echinococcus multilocularis thyroid hormone receptor alpha 0.0501 0.3861 0.5588
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0056 0.0056
Echinococcus multilocularis jun protein 0.009 0.057 0.0825
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0007 0.0007
Brugia malayi Rhodanese-like domain containing protein 0.0119 0.0805 0.0851
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0135 0.0928 0.1343
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0056 0.0159
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.0575 0.1649
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0213 0.2111
Schistosoma mansoni nAChR subunit 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0071 0.042 0.0443
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0996 0.1442
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0119 0.0805 0.555
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0007 0.001
Brugia malayi PHD-finger family protein 0.0034 0.0125 0.0132
Trichomonas vaginalis cdc25c, putative 0.0119 0.0805 0.555
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0193 0.0609
Toxoplasma gondii Purine nucleoside phosphorylase 0.0145 0.1008 1
Trichomonas vaginalis esterase, putative 0.0071 0.042 0.2695
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0148 0.0466
Entamoeba histolytica hypothetical protein 0.0189 0.1363 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0007 0.001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0104 0.0685 0.0991
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0244 0.0244
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0026 0.0056 0.0175
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1216 0.176
Schistosoma mansoni hypothetical protein 0.0815 0.6379 0.6379
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0056 0.008
Echinococcus multilocularis nuclear receptor nhr 48 0.0049 0.0244 0.0353
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.0656 0.1881
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0193 0.0525
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.042 0.1203
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0104 0.0685 0.0723
Brugia malayi Synaptic glycoprotein SC2 0.0043 0.0193 0.0204
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0007 0.0007
Mycobacterium tuberculosis Conserved protein 0.0071 0.042 0.1203
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0145 0.1008 0.7287
Onchocerca volvulus 0.0057 0.0309 0.3781
Loa Loa (eye worm) hypothetical protein 0.0055 0.0291 0.0308
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.042 0.1203
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0396 0.3026 0.438
Brugia malayi Rhodanese-like domain containing protein 0.0119 0.0805 0.0851
Brugia malayi follicle stimulating hormone receptor 0.0266 0.1985 0.2097
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0434 0.1371
Onchocerca volvulus 0.0119 0.0805 1
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0414 0.3167 0.3167
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.042 0.042
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0055 0.0291 0.0308
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0007 0.0007
Echinococcus multilocularis purine nucleoside phosphorylase 0.0026 0.0056 0.008
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0119 0.0805 0.1166
Brugia malayi MH2 domain containing protein 0.0115 0.0774 0.0818
Toxoplasma gondii ABC1 family protein 0.0071 0.042 0.4161
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0104 0.0685 0.0723
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.0685 0.0991
Loa Loa (eye worm) hypothetical protein 0.0104 0.0685 0.0723
Schistosoma mansoni nuclear receptor nhr-48 0.0049 0.0244 0.0244
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1216 0.176
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0104 0.0685 0.0685
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0774 0.0818
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0007 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0193 0.1016
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0043 0.0193 0.1912
Loa Loa (eye worm) hypothetical protein 0.0104 0.0685 0.0723
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0007 0.001
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0026 0.0056 0.0114
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0414 0.3167 1
Brugia malayi Bromodomain containing protein 0.0046 0.0217 0.023
Schistosoma mansoni hypothetical protein 0.0081 0.05 0.05
Brugia malayi nuclear hormone receptor family member odr-7 0.0049 0.0244 0.0258
Schistosoma mansoni nuclear hormone receptor 0.0104 0.0685 0.0685
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.05 0.0528
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0104 0.0685 0.849
Echinococcus granulosus acetylcholinesterase 0.0068 0.0394 0.057
Toxoplasma gondii phosphorylase family protein 0.0026 0.0056 0.0551
Schistosoma mansoni tar DNA-binding protein 0.007 0.0413 0.0413
Brugia malayi conserved hypotetical protein 0.0049 0.0244 0.0258
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0204
Schistosoma mansoni nAChR subunit 0.002 0.0007 0.0007
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0213 0.0758
Onchocerca volvulus 0.0071 0.042 0.517
Entamoeba histolytica rodhanase-like domain containing protein 0.0119 0.0805 0.5734
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0996 0.0996
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0394 0.057
Brugia malayi hypothetical protein 0.0071 0.0415 0.0439
Loa Loa (eye worm) steroid hormone receptor 0.0104 0.0685 0.0723
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0193 0.1016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0244 0.0353
Schistosoma mansoni uridine phosphorylase 0.0026 0.0056 0.0056
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0043 0.0193 0.1912
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0104 0.0685 0.0723
Schistosoma mansoni memapsin-2 (A01 family) 0.0432 0.3308 0.3308
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0007 0.0007
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0007 0.001
Brugia malayi Thioredoxin reductase 0.004 0.0168 0.0178
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0001 0.0002
Echinococcus granulosus lamin 0.0027 0.0066 0.0096
Echinococcus multilocularis purine nucleoside phosphorylase 0.0026 0.0056 0.008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0768 0.7618
Onchocerca volvulus 0.0071 0.042 0.517
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.0575 0.1649
Plasmodium vivax glutathione reductase, putative 0.004 0.0168 0.0237
Loa Loa (eye worm) hypothetical protein 0.0043 0.0193 0.0204
Entamoeba histolytica rodhanase-like domain containing protein 0.0119 0.0805 0.5734
Entamoeba histolytica hypothetical protein 0.0043 0.0193 0.1049
Loa Loa (eye worm) hypothetical protein 0.011 0.0731 0.0772
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.3488 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.042 0.2695
Echinococcus multilocularis uridine phosphorylase 1 0.0026 0.0056 0.008
Brugia malayi nuclear receptor RXR 0.0049 0.0244 0.0258
Mycobacterium ulcerans hypothetical protein 0.0043 0.0193 0.0394
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0104 0.0685 0.0991
Schistosoma mansoni tar DNA-binding protein 0.007 0.0413 0.0413
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0148 0.0156
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0193 0.0609
Echinococcus granulosus tar DNA binding protein 0.007 0.0413 0.0598
Brugia malayi nuclear receptor NHR-88 0.0104 0.0685 0.0723
Toxoplasma gondii exonuclease III APE 0.0037 0.0148 0.1464
Loa Loa (eye worm) hypothetical protein 0.0071 0.042 0.0443
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0193 0.0609
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.017 0.1216 0.1285
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.042 0.0443
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0007 0.0007
Schistosoma mansoni lamin 0.0027 0.0066 0.0066
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0148 0.0214
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0291 0.0308
Loa Loa (eye worm) hypothetical protein 0.0071 0.042 0.0443
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0007 0.001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0104 0.0685 0.0685
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0076 0.011
Schistosoma mansoni zinc finger protein 0.0028 0.0078 0.0078
Toxoplasma gondii phosphorylase family protein 0.0026 0.0056 0.0551
Loa Loa (eye worm) hypothetical protein 0.0055 0.0291 0.0308
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0001 0.0001
Brugia malayi hypothetical protein 0.0189 0.1363 0.144
Schistosoma mansoni zinc finger protein 0.0049 0.0244 0.0244
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0026 0.0056 0.0114
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0244 0.0353
Plasmodium falciparum glutathione reductase 0.004 0.0168 0.0237
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0007 0.001
Schistosoma mansoni jun-related protein 0.0073 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0012
Echinococcus granulosus dnaJ subfamily B 0.0815 0.6379 0.9233
Brugia malayi CHE-14 protein 0.017 0.1216 0.1285
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0221 0.0234
Trypanosoma brucei trypanothione reductase 0.004 0.0168 0.053
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0414 0.3167 1
Brugia malayi intermediate filament protein 0.0027 0.0066 0.007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0239 0.0253
Echinococcus granulosus synaptic glycoprotein sc2 0.0043 0.0193 0.0279
Schistosoma mansoni ap endonuclease 0.0037 0.0148 0.0148
Entamoeba histolytica hypothetical protein 0.0189 0.1363 1
Brugia malayi uridine phosphorylase family protein 0.0026 0.0056 0.0059
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0168 0.0243
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0326 0.0344
Brugia malayi photoreceptor-specific nuclear receptor 0.0104 0.0685 0.0723
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0007 0.001
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0007 0.001
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0007 0.0007
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0007 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0104 0.0685 0.0685
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0049 0.0244 0.0244
Schistosoma mansoni hypothetical protein 0.0073 0.0435 0.0435
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0148 0.0966
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0066 0.007
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0056 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.0685 0.0991
Loa Loa (eye worm) nuclear hormone receptor 0.0049 0.0244 0.0258
Loa Loa (eye worm) hypothetical protein 0.0104 0.0685 0.0723
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0148 0.0214
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0007 0.001
Schistosoma mansoni coup transcription factor 0.0104 0.0685 0.0685
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0104 0.0685 0.0991
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0043 0.0193 0.0193
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0043 0.0193 0.0279
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0043 0.0193 0.1049
Brugia malayi Cation transporter family protein 0.002 0.0007 0.0007
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.0685 0.0991
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0049 0.0244 0.0244
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.042 0.1325
Echinococcus multilocularis tumor protein p63 0.0385 0.2932 0.4244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0104 0.0685 0.0723
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0256 0.1904 0.2012
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0434 0.0459
Brugia malayi nuclear hormone receptor family member nhr-6 0.0049 0.0244 0.0258
Brugia malayi beta-lactamase 0.0071 0.042 0.0443
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0213 0.0308
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0172 0.0249
Trypanosoma brucei cytochrome P450, putative 0.0046 0.0221 0.0699
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0148 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0007 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0135 0.0928 0.0928
Schistosoma mansoni cpg binding protein 0.0063 0.0352 0.0352
Schistosoma mansoni ap endonuclease 0.0037 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0066
Echinococcus multilocularis geminin 0.0881 0.6909 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Schistosoma mansoni lamin 0.0027 0.0066 0.0066
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0007 0.0007
Mycobacterium tuberculosis Conserved protein 0.0071 0.042 0.1203
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0189 0.1363 0.1973
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0043 0.0193 0.1049
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0007 0.001
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0414 0.3167 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0076 0.011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0007 0.0007
Schistosoma mansoni nAChR subunit 0.002 0.0007 0.0007
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0026 0.0056 0.0175
Echinococcus multilocularis tar DNA binding protein 0.007 0.0413 0.0598
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.009 0.057 0.0825
Brugia malayi hypothetical protein 0.0049 0.0244 0.0258
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0104 0.0685 0.0991
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0007 0.001
Onchocerca volvulus 0.0104 0.0685 0.849
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.023 0.1696 0.1696
Schistosoma mansoni hypothetical protein 0.0881 0.6909 0.6909
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0148 0.0681
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0056 0.0056
Toxoplasma gondii thioredoxin reductase 0.004 0.0168 0.1666
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0774 0.0818
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.042 0.1325
Schistosoma mansoni patched 1 0.017 0.1216 0.1216
Plasmodium vivax hypothetical protein, conserved 0.0071 0.042 0.316
Echinococcus multilocularis musashi 0.0027 0.0066 0.0096
Echinococcus granulosus methylthioadenosine phosphorylase 0.0026 0.0056 0.008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.042 0.1203
Echinococcus multilocularis nAChR subunit 0.002 0.0007 0.001
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0056 0.008
Leishmania major methylthioadenosine phosphorylase, putative 0.0026 0.0056 0.0175
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0011 0.0011
Brugia malayi beta-lactamase family protein 0.0071 0.042 0.0443
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0007 0.0007
Brugia malayi tailless protein 0.0049 0.0244 0.0258
Loa Loa (eye worm) hypothetical protein 0.0175 0.1254 0.1325
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0823 0.0823
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0056 0.008
Brugia malayi nuclear receptor RXR 0.0055 0.0291 0.0308
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0213 0.1164
Echinococcus granulosus FTZ F1 alpha 0.0104 0.0685 0.0991
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0414 0.3167 0.3347
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0291 0.0308
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0189 0.1363 0.1973
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0007 0.0007
Echinococcus multilocularis purine nucleoside phosphorylase 0.0026 0.0056 0.008
Onchocerca volvulus 0.0027 0.0066 0.0748
Mycobacterium tuberculosis Probable reductase 0.009 0.0575 0.1649
Loa Loa (eye worm) hypothetical protein 0.0104 0.0685 0.0723
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0007 0.0007
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0043 0.0193 0.0193
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0104 0.0685 0.0991
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.042 0.2695
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0055 0.0291 0.0421
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0396 0.3026 0.3026
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0104 0.0685 0.0723
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0104 0.0685 0.0723
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0056 0.0056
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0026 0.0056 0.0847
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0394 0.0416
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0001 0.0002
Schistosoma mansoni RAR-like nuclear receptor 0.0104 0.0685 0.0685
Schistosoma mansoni hypothetical protein 0.0023 0.0033 0.0033
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.042 0.0859
Echinococcus granulosus intermediate filament protein 0.0027 0.0066 0.0096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0244 0.0353
Entamoeba histolytica rodhanase-like domain containing protein 0.0119 0.0805 0.5734
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.05 0.0724
Schistosoma mansoni transcription factor LCR-F1 0.0189 0.1363 0.1363
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0033 0.0035
Schistosoma mansoni hypothetical protein 0.0081 0.05 0.05
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0119 0.0805 0.0805
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.05 0.0724
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0135 0.0928 0.1343
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0007 0.0007
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.042 0.1203
Brugia malayi RNA binding protein 0.007 0.0413 0.0437
Schistosoma mansoni cpg binding protein 0.0057 0.0309 0.0309
Brugia malayi Cation transporter family protein 0.002 0.0007 0.0007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0394 0.0394
Loa Loa (eye worm) uridine phosphorylase 0.0026 0.0056 0.0059
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.05 0.0724
Schistosoma mansoni nuclear receptor 0.0049 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0054 0.0282 0.0298
Loa Loa (eye worm) hypothetical protein 0.011 0.0731 0.0772
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0043 0.0193 0.0204
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0104 0.0685 0.0991
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0007 0.0007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.05 0.0724
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0148 0.0466
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0414 0.3167 0.6482
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Onchocerca volvulus 0.0056 0.0301 0.369
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.0575 0.1649
Schistosoma mansoni cpg binding protein 0.0063 0.0352 0.0352
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0104 0.0685 0.0991
Mycobacterium tuberculosis Conserved protein 0.0071 0.042 0.1203
Brugia malayi beta-lactamase family protein 0.0071 0.042 0.0443
Leishmania major cytochrome p450-like protein 0.0046 0.0221 0.0699
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0104 0.0685 0.0685
Echinococcus multilocularis microtubule associated protein 2 0.0786 0.6145 0.8894
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0056 0.0175
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0071 0.042 0.1325
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0043 0.0193 0.0609
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0172 0.0249
Onchocerca volvulus 0.0119 0.0805 1
Mycobacterium leprae Probable lipase LipE 0.0071 0.042 0.6395
Brugia malayi MTAP 0.0026 0.0056 0.0059
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0007 0.001
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0193 0.1016
Loa Loa (eye worm) hypothetical protein 0.0256 0.1904 0.2012
Loa Loa (eye worm) hypothetical protein 0.0068 0.0394 0.0416
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0007 0.0007
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0043 0.0193 0.1016
Loa Loa (eye worm) DR-78 0.0049 0.0244 0.0258
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0026 0.0056 0.0612
Echinococcus multilocularis GPCR, family 2 0.0081 0.05 0.0724
Schistosoma mansoni hypothetical protein 0.0175 0.1254 0.1254
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0049 0.0244 0.0353
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0101 0.0656 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0168 0.0243
Loa Loa (eye worm) hypothetical protein 0.0104 0.0685 0.0723
Brugia malayi Cation transporter family protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0104 0.0685 0.0723
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0056 0.008
Schistosoma mansoni tar DNA-binding protein 0.007 0.0413 0.0413
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0434 0.2895
Onchocerca volvulus Protein ultraspiracle homolog 0.0104 0.0685 0.849
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0007 0.0007
Schistosoma mansoni aldehyde dehydrogenase 0.0135 0.0928 0.0928
Echinococcus granulosus acetylcholinesterase 0.0068 0.0394 0.057
Schistosoma mansoni nuclear receptor 0.0049 0.0244 0.0244
Trypanosoma cruzi UDP-glucoronosyl and UDP-glucosyl transferase, putative 0.0026 0.006 0.0189
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0258
Echinococcus granulosus purine nucleoside phosphorylase 0.0026 0.0056 0.008
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.0221 0.0699
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0433 0.0627
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0007 0.0007
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.0221 0.0699
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0046 0.0221 0.0453
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.1254 0.1325
Onchocerca volvulus 0.0027 0.0066 0.0748
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0148 0.0423
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0188 0.0272
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0434 0.1371
Brugia malayi Latrophilin receptor protein 2 0.0081 0.05 0.0528
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0145 0.1008 0.7053
Mycobacterium ulcerans aldehyde dehydrogenase 0.0135 0.0928 0.1899
Brugia malayi orphan nuclear receptor NR2E1 0.0049 0.0244 0.0258
Loa Loa (eye worm) hypothetical protein 0.0081 0.05 0.0528
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0194 0.1406 1
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0194 0.1406 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Mycobacterium ulcerans lipase LipD 0.0071 0.042 0.0859
Loa Loa (eye worm) beta-lactamase 0.0071 0.042 0.0443
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0148 0.0466
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0043 0.0193 0.1016
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0413 0.0437
Echinococcus multilocularis dnaJ subfamily B 0.0815 0.6379 0.9233
Echinococcus multilocularis lamin 0.0027 0.0066 0.0096
Loa Loa (eye worm) hypothetical protein 0.0055 0.0291 0.0308
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.0996 0.1053
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0011 0.0016
Echinococcus multilocularis cpg binding protein 0.0063 0.0352 0.0509
Schistosoma mansoni steroid hormone receptor ad4bp 0.0104 0.0685 0.0685
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0104 0.0685 0.0723
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0104 0.0685 0.0723
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0221 0.0234
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0413 0.0437
Schistosoma mansoni retinoic acid receptor RXR 0.0104 0.0685 0.0685

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 76 nM In Vitro cytotoxicity against human lung cancer cell line (H128) ChEMBL. 11334569
IC50 (functional) = 76 nM In Vitro cytotoxicity against human lung cancer cell line (H128) ChEMBL. 11334569
IC50 (functional) = 85 nM In Vitro cytotoxicity against human lung cancer cell line (A549) ChEMBL. 11334569
IC50 (functional) = 85 nM In Vitro cytotoxicity against human lung cancer cell line (A549) ChEMBL. 11334569
IC50 (functional) = 107 nM In Vitro cytotoxicity against human breast cancer cell line (SK-BR-3) ChEMBL. 11334569
IC50 (functional) = 107 nM In Vitro cytotoxicity against human breast cancer cell line (SK-BR-3) ChEMBL. 11334569
IC50 (functional) = 135 nM In Vitro cytotoxicity against human colon cancer cell line (WiDr) ChEMBL. 11334569
IC50 (functional) = 135 nM In Vitro cytotoxicity against human colon cancer cell line (WiDr) ChEMBL. 11334569
IC50 (functional) = 142 nM In Vitro cytotoxicity against human ovarian cancer cell line (SK-OV-3) ChEMBL. 11334569
IC50 (functional) = 142 nM In Vitro cytotoxicity against human ovarian cancer cell line (SK-OV-3) ChEMBL. 11334569
IC50 (functional) = 152 nM In Vitro cytotoxicity against human stomach cancer cell line (MKN45) ChEMBL. 11334569
IC50 (functional) = 152 nM In Vitro cytotoxicity against human stomach cancer cell line (MKN45) ChEMBL. 11334569
IC50 (binding) = 1600 uM Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assay ChEMBL. 11334569
IC50 (binding) = 1600 uM Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assay ChEMBL. 11334569
Inhibition (binding) = 19 % Percent inhibition of acetylcholinesterase using ATCh1 as a substrate ChEMBL. 11334569
Inhibition (binding) = 19 % Percent inhibition of acetylcholinesterase using ATCh1 as a substrate ChEMBL. 11334569

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11334569

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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