Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ABC transporter, putative | 0.0013 | 0.0011 | 0.5 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0017 | 0.0178 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0013 | 0.0011 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.004 | 0.125 | 0.5 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0013 | 0.0011 | 0.0011 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0013 | 0.0011 | 0.0011 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0017 | 0.0178 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0013 | 0.0011 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0017 | 0.0178 | 0.5 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0013 | 0.0011 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0013 | 0.0011 | 0.5 |
Giardia lamblia | ABC transporter, putative | 0.0017 | 0.0178 | 1 |
Brugia malayi | multidrug resistance related protein 1 | 0.0017 | 0.0178 | 0.0284 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.004 | 0.125 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0017 | 0.0178 | 0.0178 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0013 | 0.0011 | 0.5 |
Plasmodium falciparum | multidrug resistance protein 1 | 0.0013 | 0.0011 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0226 | 1 | 1 |
Trichomonas vaginalis | abcb9, putative | 0.0013 | 0.0011 | 0.5 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0013 | 0.0011 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0017 | 0.0178 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0013 | 0.0011 | 0.0011 |
Trichomonas vaginalis | ABC transporter, putative | 0.0013 | 0.0011 | 0.5 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.0013 | 0.0011 | 0.0011 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0013 | 0.0011 | 0.5 |
Leishmania major | p-glycoprotein e | 0.0017 | 0.0178 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0017 | 0.0178 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0013 | 0.0011 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0017 | 0.0178 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0168 | 0.0168 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0179 | 0.7789 | 0.7789 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0093 | 0.3737 | 0.373 |
Trichomonas vaginalis | ABC transporter, putative | 0.0013 | 0.0011 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0033 | 0.0915 | 0.1531 |
Leishmania major | ABC-thiol transporter | 0.0017 | 0.0178 | 1 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0017 | 0.0178 | 0.5 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0013 | 0.0011 | 0.0011 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0013 | 0.0011 | 0.0011 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0013 | 0.0011 | 0.5 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.0013 | 0.0011 | 0.0011 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0017 | 0.0178 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0011 | 0.0011 |
Trichomonas vaginalis | abcb9, putative | 0.0013 | 0.0011 | 0.5 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0013 | 0.0011 | 0.0011 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0013 | 0.0011 | 0.0011 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0017 | 0.0178 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0017 | 0.0178 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0017 | 0.0178 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0013 | 0.0011 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0033 | 0.0915 | 0.1531 |
Onchocerca volvulus | Matrilysin homolog | 0.0133 | 0.5609 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.0013 | 0.0011 | 0.5 |
Trichomonas vaginalis | abcb9, putative | 0.0013 | 0.0011 | 0.5 |
Plasmodium vivax | multidrug resistance protein 1, putative | 0.0013 | 0.0011 | 0.5 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0013 | 0.0011 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0017 | 0.0178 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0033 | 0.0915 | 0.1531 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0013 | 0.0011 | 0.0011 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0013 | 0.0011 | 0.0011 |
Schistosoma mansoni | multidrug resistance protein | 0.0017 | 0.0178 | 0.0168 |
Schistosoma mansoni | multidrug resistance protein | 0.0017 | 0.0178 | 0.0168 |
Trypanosoma brucei | p-glycoprotein | 0.0017 | 0.0178 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0915 | 0.0915 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0013 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0915 | 0.0915 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0013 | 0.0011 | 0.5 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0017 | 0.0178 | 0.0284 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0017 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | matrixin family protein | 0.0073 | 0.2787 | 0.2787 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.125 | 0.125 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0179 | 0.7789 | 0.7789 |
Giardia lamblia | MRP-like ABC transporter | 0.0017 | 0.0178 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0226 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0104 | 0.4261 | 0.7198 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0011 | 0.0011 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0017 | 0.0178 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0017 | 0.0178 | 1 |
Trypanosoma brucei | multidrug resistance protein E | 0.0017 | 0.0178 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0017 | 0.0178 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0013 | 0.0011 | 0.5 |
Trichomonas vaginalis | taga, putative | 0.0013 | 0.0011 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.0017 | 0.0178 | 0.0168 |
Entamoeba histolytica | ABC transporter, putative | 0.0017 | 0.0178 | 1 |
Brugia malayi | Hemopexin family protein | 0.0046 | 0.1557 | 0.2619 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0073 | 0.2787 | 0.4959 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0013 | 0.0011 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0178 | 0.0178 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0013 | 0.0011 | 0.5 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0013 | 0.0011 | 0.0011 |
Onchocerca volvulus | Matrilysin homolog | 0.0033 | 0.0915 | 0.1615 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0017 | 0.0178 | 0.0178 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0017 | 0.0178 | 1 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0017 | 0.0178 | 0.0178 |
Brugia malayi | Matrixin family protein | 0.0139 | 0.5916 | 1 |
Chlamydia trachomatis | ABC transporter ATP binding protein/permease | 0.0013 | 0.0011 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0013 | 0.0011 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0013 | 0.0011 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0226 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.0017 | 0.0178 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.1557 | 0.1548 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.3737 | 0.3737 |
Brugia malayi | Matrixin family protein | 0.0033 | 0.0915 | 0.1531 |
Loa Loa (eye worm) | matrixin family protein | 0.0139 | 0.5916 | 0.5916 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0013 | 0.0011 | 0.5 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0013 | 0.0011 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.004 | 0.125 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0017 | 0.0178 | 1 |
Onchocerca volvulus | 0.0033 | 0.0915 | 0.1615 | |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0033 | 0.0915 | 0.0915 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0013 | 0.0011 | 0.0011 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0017 | 0.0178 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0013 | 0.0011 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.004 | 0.125 | 0.2098 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0013 | 0.0011 | 0.0011 |
Onchocerca volvulus | 0.0046 | 0.1557 | 0.2763 | |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0013 | 0.0011 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0017 | 0.0178 | 0.0178 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0013 | 0.0011 | 0.5 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0013 | 0.0011 | 0.0011 |
Leishmania major | pentamidine resistance protein 1 | 0.0017 | 0.0178 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0.65 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.36 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.1 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 6 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 12 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 81 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 95 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 3.47 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 6 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 12 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 81 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 95 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.15 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.71304 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.