Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.1131 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.2508 | 0.2538 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.1131 | 0.1145 |
Echinococcus granulosus | muscleblind protein | 0.0151 | 0.9879 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0151 | 0.9879 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.1131 | 0.1145 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.1131 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0151 | 0.9879 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.9879 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.7353 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.7353 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.7353 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.6321 | 0.8342 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.6321 | 0.8342 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2508 | 0.2508 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.6321 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1351 | 0.1368 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.6321 | 0.8342 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.1131 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1351 | 0.1368 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.1131 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.7353 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.9879 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.2508 | 0.2538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2508 | 0.2508 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2508 | 0.2508 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.2508 | 0.2538 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.2508 | 0.2538 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.2508 | 0.1573 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2508 | 0.2508 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.1131 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.1131 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.2508 | 0.1573 |
Leishmania major | trypanothione reductase | 0.0048 | 0.1131 | 0.5 |
Brugia malayi | glutathione reductase | 0.0048 | 0.1131 | 0.1145 |
Brugia malayi | RNA binding protein | 0.0064 | 0.2508 | 0.2538 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.6321 | 0.8342 |
Echinococcus multilocularis | muscleblind protein | 0.0151 | 0.9879 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1351 | 0.1368 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1351 | 0.1368 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2508 | 0.2508 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.1131 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.6321 | 0.8342 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.1131 | 0.1145 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.2508 | 0.2538 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 130 % | Inotropic activity in cat papillary muscle at 10e-5 M expressed as percent of control | ChEMBL. | 3397997 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.