Detailed information for compound 599123

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.515 | Formula: C22H33N3O4
  • H donors: 1 H acceptors: 3 LogP: 2.87 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1C(=O)N(C2(C1=O)CCN(CC2)Cc1ccc(cc1O)OC)CCC(C)C
  • InChi: 1S/C22H33N3O4/c1-5-24-20(27)22(25(21(24)28)11-8-16(2)3)9-12-23(13-10-22)15-17-6-7-18(29-4)14-19(17)26/h6-7,14,16,26H,5,8-13,15H2,1-4H3
  • InChiKey: WYWFEKNOCLSNES-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0254487 0.0190509 0.018853
Echinococcus granulosus g protein coupled receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00658465 0.00316469 0.00296362
Loa Loa (eye worm) hypothetical protein 0.0358909 0.0278447 0.0276486
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00426199 0.00120869 0.00100723
Schistosoma mansoni cercarial elastase (S01 family) 0.0123021 0.00797962 0.00777951
Schistosoma mansoni voltage-gated potassium channel 0.0201693 0.0146048 0.0144061
Brugia malayi tailless protein 0.0120045 0.00772901 0.0161313
Echinococcus granulosus hyperpolarization activated cyclic 0.00478903 0.00165254 0.00145116
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0123021 0.00797962 0.00777951
Brugia malayi neuropeptide F receptor 0.00426199 0.00120869 0.00215807
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00478903 0.00165254 0.00145116
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Brugia malayi Melatonin receptor type 1A 0.00426199 0.00120869 0.00215807
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus granulosus allatostatin A receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis somatostatin receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.00659124 0.00317025 0.00296918
Brugia malayi GnHR receptor homolog 0.00426199 0.00120869 0.00215807
Brugia malayi Dopamine receptor 0.00426199 0.00120869 0.00215807
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus slit 2 protein 0.00344673 0.000522123 0.000320516
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00478903 0.00165254 0.00145116
Brugia malayi steroid hormone receptor 0.0254487 0.0190509 0.0403943
Trypanosoma cruzi aminopeptidase, putative 0.0643836 0.0518396 1
Echinococcus multilocularis dro:myosuppressin receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0643836 0.0518396 0.0516483
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0120045 0.00772901 0.00752885
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.0134441 0.00894137 0.00874146
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.00467135 0.00155343 0.00135203
Brugia malayi Peptidase family M1 containing protein 0.0643836 0.0518396 0.110661
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Loa Loa (eye worm) neuropeptide F receptor 0.00426199 0.00120869 0.00100723
Brugia malayi nuclear hormone receptor family member odr-7 0.0120045 0.00772901 0.0161313
Brugia malayi hypothetical protein 0.00426199 0.00120869 0.00215807
Loa Loa (eye worm) hypothetical protein 0.0123021 0.00797962 0.00777951
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0134441 0.00894137 0.00874146
Loa Loa (eye worm) hypothetical protein 0.0123021 0.00797962 0.00777951
Brugia malayi nuclear receptor NHR-88 0.0120045 0.00772901 0.0161313
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Brugia malayi hypothetical protein 0.00426199 0.00120869 0.00215807
Echinococcus multilocularis FTZ F1 alpha 0.0254487 0.0190509 0.018853
Brugia malayi conserved hypotetical protein 0.0120045 0.00772901 0.0161313
Echinococcus granulosus neuropeptide Y receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Echinococcus granulosus neurogenic locus protein delta 0.00344673 0.000522123 0.000320516
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.00478903 0.00165254 0.00145116
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0120045 0.00772901 0.0161313
Loa Loa (eye worm) notch protein 0.00344673 0.000522123 0.000320516
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0254487 0.0190509 0.018853
Schistosoma mansoni growth hormone secretagogue receptor 0.00426199 0.00120869 0.00100723
Onchocerca volvulus 0.0643836 0.0518396 1
Loa Loa (eye worm) animal heme peroxidase 0.0106684 0.00660382 0.00640344
Brugia malayi putative neuropeptide receptor 0.00426199 0.00120869 0.00215807
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0254487 0.0190509 0.0403943
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0254487 0.0190509 0.0403943
Brugia malayi EGF-like domain containing protein 0.00344673 0.000522123 0.000686736
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0120045 0.00772901 0.00752885
Schistosoma mansoni nuclear hormone receptor 0.0120045 0.00772901 0.00752885
Loa Loa (eye worm) hypothetical protein 0.0254487 0.0190509 0.018853
Brugia malayi hypothetical protein 0.0123021 0.00797962 0.0166683
Schistosoma mansoni voltage-gated potassium channel 0.00410188 0.00107386 0.00087236
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00426199 0.00120869 0.00100723
Brugia malayi GCC2 and GCC3 family protein 0.00344673 0.000522123 0.000686736
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.00467135 0.00155343 0.00135203
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Schistosoma mansoni hypothetical protein 0.00344673 0.000522123 0.000320516
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0254487 0.0190509 0.018853
Brugia malayi ecdysteroid receptor 0.0254487 0.0190509 0.0403943
Echinococcus multilocularis neuropeptides capa receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Loa Loa (eye worm) hypothetical protein 0.0643836 0.0518396 0.0516483
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0120045 0.00772901 0.140437
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0120045 0.00772901 0.00752885
Echinococcus granulosus leukotriene A 4 hydrolase 1.19028 1 1
Onchocerca volvulus 0.0106684 0.00660382 0.118511
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0254487 0.0190509 0.018853
Brugia malayi hypothetical protein 0.0643836 0.0518396 0.110661
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00426199 0.00120869 0.00100723
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Loa Loa (eye worm) nuclear hormone receptor 0.0120045 0.00772901 0.00752885
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00478903 0.00165254 0.00145116
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0254487 0.0190509 0.018853
Echinococcus multilocularis g protein coupled receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0120045 0.00772901 0.00752885
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0254487 0.0190509 0.018853
Brugia malayi neuropeptide F receptor 0.00426199 0.00120869 0.00215807
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Schistosoma mansoni nuclear hormone receptor 0.0120045 0.00772901 0.00752885
Brugia malayi G-protein coupled receptor 0.00426199 0.00120869 0.00215807
Brugia malayi Muscle positioning protein 4 0.00344673 0.000522123 0.000686736
Trypanosoma cruzi aminopeptidase, putative 0.0643836 0.0518396 1
Brugia malayi Nuclear hormone receptor-like 1 0.0134441 0.00894137 0.0187294
Schistosoma mansoni neuropeptide receptor 0.100278 0.0820676 0.0818825
Leishmania major C-8 sterol isomerase-like protein 0.0358909 0.0278447 0.506982
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0643836 0.0518396 0.0516483
Schistosoma mansoni immunophilin 0.00635374 0.00297023 0.00276912
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00478903 0.00165254 0.00145116
Loa Loa (eye worm) hypothetical protein 0.0123021 0.00797962 0.00777951
Echinococcus multilocularis acetylcholinesterase 0.00321148 0.000324013 0.000122367
Brugia malayi Steroid receptor seven-up type 2 0.0254487 0.0190509 0.0403943
Echinococcus multilocularis fmrfamide receptor 0.00426199 0.00120869 0.00100723
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0643836 0.0518396 1
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Brugia malayi nuclear receptor RXR 0.0120045 0.00772901 0.0161313
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Trypanosoma brucei aminopeptidase, putative 0.0643836 0.0518396 1
Schistosoma mansoni biogenic amine receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis serotonin receptor 0.00426199 0.00120869 0.00100723
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00426199 0.00120869 0.00215807
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Brugia malayi hypothetical protein 0.00426199 0.00120869 0.00215807
Schistosoma mansoni nuclear receptor 0.0120045 0.00772901 0.00752885
Schistosoma mansoni cercarial elastase (S01 family) 0.0123021 0.00797962 0.00777951
Brugia malayi hypothetical protein 0.00426199 0.00120869 0.00215807
Echinococcus multilocularis rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Onchocerca volvulus Peroxidasin homolog 0.0106684 0.00660382 0.118511
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Loa Loa (eye worm) TYRA-2 protein 0.00426199 0.00120869 0.00100723
Schistosoma mansoni biogenic amine (5HT) receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00321148 0.000324013 0.000122367
Brugia malayi Cadherin domain containing protein 0.00344673 0.000522123 0.000686736
Echinococcus multilocularis carboxylesterase 5A 0.00321148 0.000324013 0.000122367
Schistosoma mansoni amine GPCR 0.00426199 0.00120869 0.00100723
Schistosoma mansoni cercarial elastase (S01 family) 0.0123021 0.00797962 0.00777951
Schistosoma mansoni immunophilin 0.00693521 0.00345992 0.0032589
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Echinococcus granulosus neuropeptide receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0254487 0.0190509 0.018853
Brugia malayi nuclear hormone receptor 0.0120045 0.00772901 0.0161313
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Loa Loa (eye worm) Notch2 0.00344673 0.000522123 0.000320516
Echinococcus granulosus tm gpcr rhodopsin 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis g-protein coupled receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Schistosoma mansoni neuropeptide F-like receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus somatostatin receptor 0.00426199 0.00120869 0.00100723
Brugia malayi EGF-like domain containing protein 0.00344673 0.000522123 0.000686736
Schistosoma mansoni zinc finger protein 0.0120045 0.00772901 0.00752885
Loa Loa (eye worm) hypothetical protein 0.0643836 0.0518396 0.0516483
Schistosoma mansoni cercarial elastase (S01 family) 0.0123021 0.00797962 0.00777951
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Schistosoma mansoni biogenic amine receptor 0.00426199 0.00120869 0.00100723
Brugia malayi Dopamine receptor protein 1 0.00426199 0.00120869 0.00215807
Echinococcus granulosus neural cadherin 0.00344673 0.000522123 0.000320516
Schistosoma mansoni hypothetical protein 0.00344673 0.000522123 0.000320516
Onchocerca volvulus Neuropeptide F receptor homolog 0.00426199 0.00120869 0.0133789
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00426199 0.00120869 0.00100723
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0254487 0.0190509 0.018853
Echinococcus granulosus thyroid hormone receptor alpha 0.0120045 0.00772901 0.00752885
Schistosoma mansoni biogenic amine (5HT) receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis neural cadherin 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Onchocerca volvulus Peroxidase homolog 0.0106684 0.00660382 0.118511
Echinococcus multilocularis g protein coupled receptor 0.00426199 0.00120869 0.00100723
Brugia malayi Calcium binding EGF domain containing protein 0.00344673 0.000522123 0.000686736
Schistosoma mansoni hypothetical protein 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis nuclear receptor nhr 48 0.0120045 0.00772901 0.00752885
Schistosoma mansoni cercarial elastase (S01 family) 0.0123021 0.00797962 0.00777951
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0123021 0.00797962 0.00777951
Brugia malayi putative neuropeptide receptor NPR1 0.00426199 0.00120869 0.00215807
Schistosoma mansoni steroid hormone receptor ad4bp 0.0254487 0.0190509 0.018853
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00426199 0.00120869 0.00100723
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0134441 0.00894137 0.00874146
Brugia malayi Trypsin family protein 0.0123021 0.00797962 0.0166683
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00658465 0.00316469 0.00296362
Brugia malayi Cadherin domain containing protein 0.00344673 0.000522123 0.000686736
Brugia malayi hypothetical protein 0.00426199 0.00120869 0.00215807
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00658465 0.00316469 0.00296362
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis voltage gated potassium channel 0.00658465 0.00316469 0.00296362
Brugia malayi hypothetical protein 0.0106684 0.00660382 0.01372
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis allatostatin A receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0358909 0.0278447 0.0592397
Schistosoma mansoni opsin-like receptor 0.00426199 0.00120869 0.00100723
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0643836 0.0518396 1
Echinococcus granulosus neurogenic locus notch protein 4 0.00344673 0.000522123 0.000320516
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0643836 0.0518396 1
Brugia malayi Nuclear hormone receptor-like 1 0.0254487 0.0190509 0.0403943
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.00659124 0.00317025 1
Schistosoma mansoni slit 0.00344673 0.000522123 0.000320516
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 1.19028 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.00426199 0.00120869 0.00100723
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.00478903 0.00165254 0.00145116
Trypanosoma cruzi Aminopeptidase M1, putative 0.0643836 0.0518396 1
Schistosoma mansoni laminin gamma-3 chain 0.00344673 0.000522123 0.000320516
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis neuropeptides capa receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni voltage-gated potassium channel 0.0239904 0.0178228 0.0176247
Schistosoma mansoni amine GPCR 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0254487 0.0190509 0.018853
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0120045 0.00772901 0.00752885
Loa Loa (eye worm) hypothetical protein 0.0158909 0.0110018 0.0108024
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Brugia malayi hypothetical protein 0.00426199 0.00120869 0.00215807
Schistosoma mansoni voltage-gated potassium channel 0.00658465 0.00316469 0.00296362
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0254487 0.0190509 0.018853
Schistosoma mansoni hypothetical protein 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) G-protein coupled receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus voltage gated potassium channel 0.00658465 0.00316469 0.00296362
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00478903 0.00165254 0.00145116
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0120045 0.00772901 0.00752885
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.00659124 0.00317025 0.0302412
Echinococcus granulosus G protein coupled receptor 139 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis G protein coupled receptor 139 0.100278 0.0820676 0.0818825
Echinococcus multilocularis g protein coupled receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Echinococcus granulosus alpha 1A adrenergic receptor 0.00426199 0.00120869 0.00100723
Brugia malayi nuclear hormone receptor 0.0254487 0.0190509 0.0403943
Loa Loa (eye worm) hypothetical protein 0.0643836 0.0518396 0.0516483
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0254487 0.0190509 0.0403943
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis neuropeptide FF receptor 2 0.00426199 0.00120869 0.00100723
Echinococcus granulosus nuclear receptor nhr 48 0.0120045 0.00772901 0.00752885
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0643836 0.0518396 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0643836 0.0518396 0.0516483
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0120045 0.00772901 0.00752885
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis transmembrane protease serine 3 0.0123021 0.00797962 0.00777951
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis potassium voltage gated channel protein 0.0239904 0.0178228 0.0176247
Brugia malayi hypothetical protein 0.0120045 0.00772901 0.0161313
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0254487 0.0190509 0.018853
Echinococcus granulosus rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Echinococcus granulosus g protein coupled receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.00635374 0.00297023 0.00276912
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.00659124 0.00317025 0.00296918
Echinococcus granulosus tachykinin peptides receptor 99D 0.00426199 0.00120869 0.00100723
Echinococcus granulosus rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Schistosoma mansoni voltage-gated potassium channel 0.0201693 0.0146048 0.0144061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00426199 0.00120869 0.00100723
Echinococcus granulosus acetylcholinesterase 0.00321148 0.000324013 0.000122367
Onchocerca volvulus 0.0643836 0.0518396 1
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0183736 0.0130927 0.0128936
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00426199 0.00120869 0.00215807
Echinococcus granulosus potassium voltage gated channel protein 0.0239904 0.0178228 0.0176247
Brugia malayi Animal haem peroxidase family protein 0.0106684 0.00660382 0.01372
Onchocerca volvulus Peroxidasin homolog 0.0106684 0.00660382 0.118511
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00426199 0.00120869 0.00100723
Schistosoma mansoni retinoic acid receptor RXR 0.0254487 0.0190509 0.018853
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Brugia malayi G protein-coupled receptor 0.00426199 0.00120869 0.00215807
Echinococcus multilocularis leukotriene A 4 hydrolase 1.19028 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0254487 0.0190509 0.018853
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Echinococcus multilocularis Mastin 0.0123021 0.00797962 0.00777951
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0160674 0.0111505 0.189251
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus aminopeptidase N 0.0643836 0.0518396 0.0516483
Brugia malayi Peptidase family M1 containing protein 0.0643836 0.0518396 0.110661
Toxoplasma gondii aminopeptidase N, putative 0.0643836 0.0518396 1
Echinococcus granulosus neuropeptide receptor 0.100278 0.0820676 0.0818825
Brugia malayi Carboxylesterase family protein 0.00321148 0.000324013 0.000262182
Onchocerca volvulus 0.0106684 0.00660382 0.118511
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0643836 0.0518396 1
Brugia malayi EGF-like domain containing protein 0.00344673 0.000522123 0.000686736
Echinococcus granulosus protein jagged 1 0.00344673 0.000522123 0.000320516
Echinococcus multilocularis notch 0.00344673 0.000522123 0.000320516
Mycobacterium ulcerans aminopeptidase N PepN 0.0643836 0.0518396 1
Schistosoma mansoni hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis fibropellin Ia 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.0254487 0.0190509 0.018853
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0254487 0.0190509 0.018853
Trichomonas vaginalis immunophilin, putative 0.00659124 0.00317025 0.0302412
Brugia malayi hypothetical protein 0.00426199 0.00120869 0.00215807
Schistosoma mansoni nuclear receptor 0.0120045 0.00772901 0.00752885
Brugia malayi Dopamine receptor protein 2 0.00426199 0.00120869 0.00215807
Loa Loa (eye worm) hypothetical protein 0.00321148 0.000324013 0.000122367
Loa Loa (eye worm) trypsin family protein 0.0123021 0.00797962 0.00777951
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0254487 0.0190509 0.018853
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0254487 0.0190509 0.018853
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Onchocerca volvulus Putative nachr subunit 0.00467135 0.00155343 0.0200965
Onchocerca volvulus 0.0254487 0.0190509 0.361062
Schistosoma mansoni thyroid hormone receptor 0.0254487 0.0190509 0.018853
Onchocerca volvulus Peroxidase homolog 0.0106684 0.00660382 0.118511
Schistosoma mansoni neuropeptide f receptor 76f 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00426199 0.00120869 0.00100723
Brugia malayi EGF-like domain containing protein 0.00344673 0.000522123 0.000686736
Brugia malayi ecdysone receptor 0.0120045 0.00772901 0.0161313
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0254487 0.0190509 0.0403943
Echinococcus multilocularis neuropeptide receptor A26 0.00426199 0.00120869 0.00100723
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0134441 0.00894137 0.00874146
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Schistosoma mansoni opsin-like receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus FTZ F1 alpha 0.0254487 0.0190509 0.018853
Echinococcus granulosus 7TM GPCR rhodopsin 0.00426199 0.00120869 0.00100723
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0643836 0.0518396 1
Echinococcus multilocularis neuropeptide receptor 0.100278 0.0820676 0.0818825
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Schistosoma mansoni voltage-gated potassium channel 0.0239904 0.0178228 0.0176247
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0766857 0.0621997 0.0620105
Brugia malayi Carboxylesterase family protein 0.00321148 0.000324013 0.000262182
Brugia malayi Trypsin family protein 0.0123021 0.00797962 0.0166683
Schistosoma mansoni cercarial elastase (S01 family) 0.0123021 0.00797962 0.00777951
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis neuropeptide receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus neuropeptide Y receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis fk506 binding protein 0.00659124 0.00317025 0.00296918
Echinococcus multilocularis rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00426199 0.00120869 0.00100723
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00426199 0.00120869 0.0133789
Schistosoma mansoni notch 0.00344673 0.000522123 0.000320516
Schistosoma mansoni notch 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0123021 0.00797962 0.00777951
Echinococcus granulosus acetylcholinesterase 0.00321148 0.000324013 0.000122367
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00426199 0.00120869 0.00100723
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0643836 0.0518396 1
Brugia malayi Nuclear hormone receptor E75 0.0120045 0.00772901 0.0161313
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0643836 0.0518396 0.0516483
Brugia malayi Delta serrate ligand family protein 0.00344673 0.000522123 0.000686736
Echinococcus granulosus Mastin 0.0123021 0.00797962 0.00777951
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0254487 0.0190509 0.018853
Echinococcus multilocularis hyperpolarization activated cyclic 0.00478903 0.00165254 0.00145116
Echinococcus granulosus rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Echinococcus multilocularis hyperpolarization activated cyclic 0.00478903 0.00165254 0.00145116
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00426199 0.00120869 0.00100723
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0123021 0.00797962 0.00777951
Echinococcus granulosus glycoprotein Antigen 5 0.0123021 0.00797962 0.00777951
Schistosoma mansoni biogenic amine receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus enteropeptidase 0.0123021 0.00797962 0.00777951
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis orexin receptor type 2 0.00426199 0.00120869 0.00100723
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0254487 0.0190509 0.361062
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.0134441 0.00894137 0.00874146
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0643836 0.0518396 1
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0123021 0.00797962 0.00777951
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0643836 0.0518396 0.0516483
Brugia malayi larval opioid receptor 0.00426199 0.00120869 0.00215807
Schistosoma mansoni hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus granulosus tm gpcr rhodopsin 0.00426199 0.00120869 0.00100723
Brugia malayi AKH receptor 0.00426199 0.00120869 0.00215807
Echinococcus granulosus g protein coupled receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) neuropeptide F receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Brugia malayi nuclear receptor RXR 0.0134441 0.00894137 0.0187294
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0183736 0.0130927 0.0128936
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Echinococcus granulosus rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Echinococcus granulosus neurogenic locus notch protein 0.00344673 0.000522123 0.000320516
Echinococcus multilocularis aminopeptidase N 0.0643836 0.0518396 0.0516483
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis acetylcholinesterase 0.00321148 0.000324013 0.000122367
Onchocerca volvulus Chorion peroxidase homolog 0.0106684 0.00660382 0.118511
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) peptidase family M1 containing protein 0.0643836 0.0518396 0.0516483
Brugia malayi nuclear hormone receptor family member nhr-6 0.0120045 0.00772901 0.0161313
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00426199 0.00120869 0.00100723
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.00659124 0.00317025 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0120045 0.00772901 0.00752885
Brugia malayi orphan nuclear receptor NR2E1 0.0120045 0.00772901 0.0161313
Brugia malayi Serotonin receptor 0.00426199 0.00120869 0.00215807
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0643836 0.0518396 0.0516483
Schistosoma mansoni immunophilin 0.00693521 0.00345992 0.0032589
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00426199 0.00120869 0.00100723
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0160674 0.0111505 0.189251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Echinococcus multilocularis rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0123021 0.00797962 0.0166683
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00426199 0.00120869 0.00100723
Brugia malayi Calcium binding EGF domain containing protein 0.00344673 0.000522123 0.000686736
Brugia malayi G-protein coupled receptor 0.00426199 0.00120869 0.00215807
Brugia malayi hypothetical protein 0.0134441 0.00894137 0.0187294
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Trypanosoma brucei Aminopeptidase M1, putative 0.0643836 0.0518396 1
Schistosoma mansoni amine GPCR 0.00426199 0.00120869 0.00100723
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0134441 0.00894137 0.00874146
Brugia malayi hypothetical protein 0.0120045 0.00772901 0.0161313
Echinococcus granulosus Nuclear hormone receptor HR96 0.0120045 0.00772901 0.00752885
Brugia malayi follicle stimulating hormone receptor 0.00426199 0.00120869 0.00215807
Echinococcus granulosus dro:myosuppressin receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni adenoreceptor 0.00426199 0.00120869 0.00100723
Brugia malayi Peroxidasin 0.0106684 0.00660382 0.01372
Brugia malayi Cyclic-nucleotide gated cation channel 0.00478903 0.00165254 0.00310924
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00426199 0.00120869 0.00215807
Onchocerca volvulus 0.0123021 0.00797962 0.145321
Loa Loa (eye worm) hypothetical protein 0.0239904 0.0178228 0.0176247
Schistosoma mansoni notch 0.00344673 0.000522123 0.000320516
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.00467135 0.00155343 0.00135203
Loa Loa (eye worm) hypothetical protein 0.0254487 0.0190509 0.018853
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0643836 0.0518396 0.0516483
Loa Loa (eye worm) hypothetical protein 0.0184296 0.0131398 0.0129407
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00478903 0.00165254 0.00145116
Schistosoma mansoni thyroid hormone receptor 0.0254487 0.0190509 0.018853
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.00659124 0.00317025 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0643836 0.0518396 0.0516483
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Brugia malayi Tachykinin-like peptides receptor 99D 0.00426199 0.00120869 0.00215807
Schistosoma mansoni peroxidasin 0.0106684 0.00660382 0.00640344
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00426199 0.00120869 0.00100723
Echinococcus granulosus carboxylesterase 5A 0.00321148 0.000324013 0.000122367
Echinococcus granulosus hyperpolarization activated cyclic 0.00478903 0.00165254 0.00145116
Schistosoma mansoni cercarial elastase (S01 family) 0.0123021 0.00797962 0.00777951
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0254487 0.0190509 0.0403943
Echinococcus multilocularis rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0643836 0.0518396 0.0516483
Schistosoma mansoni aminopeptidase A (M01 family) 0.0643836 0.0518396 0.0516483
Echinococcus granulosus protein jagged 2 0.00344673 0.000522123 0.000320516
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0123021 0.00797962 0.00777951
Mycobacterium ulcerans hypothetical protein 0.0123021 0.00797962 0.0988172
Echinococcus granulosus biogenic amine 5HT receptor 0.00426199 0.00120869 0.00100723
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0239904 0.0178228 0.0377626
Echinococcus multilocularis G-protein coupled receptor, putative 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0254487 0.0190509 0.018853
Brugia malayi Animal haem peroxidase family protein 0.0106684 0.00660382 0.01372
Onchocerca volvulus Bile acid receptor homolog 0.0254487 0.0190509 0.361062
Loa Loa (eye worm) hypothetical protein 0.00467135 0.00155343 0.00135203
Schistosoma mansoni cercarial elastase (S01 family) 0.0123021 0.00797962 0.00777951
Echinococcus granulosus fmrfamide receptor 0.00426199 0.00120869 0.00100723
Brugia malayi RE15519p 0.00426199 0.00120869 0.00215807
Loa Loa (eye worm) DR-78 0.0120045 0.00772901 0.00752885
Echinococcus granulosus notch 0.00344673 0.000522123 0.000320516
Echinococcus multilocularis neuropeptide Y receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni nuclear hormone receptor 0.0254487 0.0190509 0.018853
Schistosoma mansoni cercarial elastase (S01 family) 0.0123021 0.00797962 0.00777951
Brugia malayi photoreceptor-specific nuclear receptor 0.0254487 0.0190509 0.0403943
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0643836 0.0518396 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0254487 0.0190509 0.018853
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0643836 0.0518396 1
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0643836 0.0518396 1
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus granulosus sex peptide receptor 0.00426199 0.00120869 0.00100723
Onchocerca volvulus 0.0643836 0.0518396 1
Loa Loa (eye worm) hypothetical protein 0.0134441 0.00894137 0.00874146
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0643836 0.0518396 0.0516483
Schistosoma mansoni voltage-gated potassium channel 0.00478903 0.00165254 0.00145116
Echinococcus multilocularis protein jagged 2 0.00344673 0.000522123 0.000320516
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis neurogenic locus protein delta 0.00344673 0.000522123 0.000320516
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.00659124 0.00317025 0.00636174
Echinococcus granulosus neuropeptide FF receptor 2 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis ecdysone induced protein 78C 0.0254487 0.0190509 0.018853
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0254487 0.0190509 0.0403943
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Brugia malayi hypothetical protein 0.00426199 0.00120869 0.00215807
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0643836 0.0518396 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.00658465 0.00316469 0.00634983
Echinococcus multilocularis neurogenic locus notch protein 0.00344673 0.000522123 0.000320516
Brugia malayi hypothetical protein 0.00426199 0.00120869 0.00215807
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0254487 0.0190509 0.0403943
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus granulosus g-protein coupled receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni nuclear receptor nhr-48 0.0120045 0.00772901 0.00752885
Schistosoma mansoni septate junction protein 0.00344673 0.000522123 0.000320516
Brugia malayi nuclear receptor NHR-67 0.0120045 0.00772901 0.0161313
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0643836 0.0518396 0.0516483
Echinococcus multilocularis sex peptide receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00478903 0.00165254 0.00145116
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0123021 0.00797962 0.00777951
Brugia malayi EGF-like domain containing protein 0.00344673 0.000522123 0.000686736
Echinococcus granulosus delta-like protein 1 0.00344673 0.000522123 0.000320516
Echinococcus granulosus fibropellin Ia 0.00344673 0.000522123 0.000320516
Echinococcus granulosus transmembrane protease serine 3 0.0123021 0.00797962 0.00777951
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.00659124 0.00317025 0.0302412
Schistosoma mansoni 60S ribosomal protein L21 0.00410188 0.00107386 0.00087236
Schistosoma mansoni hypothetical protein 0.00344673 0.000522123 0.000320516
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0254487 0.0190509 0.0403943
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0123021 0.00797962 0.00777951
Loa Loa (eye worm) acetylcholinesterase 1 0.00321148 0.000324013 0.000122367
Onchocerca volvulus 0.0123021 0.00797962 0.145321
Loa Loa (eye worm) hypothetical protein 0.0123021 0.00797962 0.00777951
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0643836 0.0518396 0.0516483
Brugia malayi sulfakinin receptor protein 0.00426199 0.00120869 0.00215807
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni hypothetical protein 0.0123021 0.00797962 0.00777951
Loa Loa (eye worm) animal heme peroxidase 0.0106684 0.00660382 0.00640344
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0254487 0.0190509 0.018853
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0254487 0.0190509 0.0403943
Brugia malayi EGF-like domain containing protein 0.00344673 0.000522123 0.000686736
Brugia malayi notch-like transmembrane receptor 0.00344673 0.000522123 0.000686736
Loa Loa (eye worm) TATA binding protein associated factor 0.0643836 0.0518396 0.0516483
Schistosoma mansoni amine GPCR 0.00426199 0.00120869 0.00100723
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0123021 0.00797962 0.00777951
Brugia malayi EGF-like domain containing protein 0.00344673 0.000522123 0.000686736
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0120045 0.00772901 0.00752885
Echinococcus multilocularis enteropeptidase 0.0123021 0.00797962 0.00777951
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Schistosoma mansoni hypothetical protein 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0254487 0.0190509 0.018853
Echinococcus multilocularis thyroid hormone receptor alpha 0.0254487 0.0190509 0.018853
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus Nuclear hormone receptor HR96 0.0120045 0.00772901 0.00752885
Toxoplasma gondii aminopeptidase N protein 0.0643836 0.0518396 1
Brugia malayi Calcium binding EGF domain containing protein 0.00344673 0.000522123 0.000686736
Onchocerca volvulus 0.0120045 0.00772901 0.140437
Schistosoma mansoni voltage-gated potassium channel 0.00658465 0.00316469 0.00296362
Entamoeba histolytica aminopeptidase, putative 0.0643836 0.0518396 1
Loa Loa (eye worm) hypothetical protein 0.00601159 0.0026821 0.00248093
Schistosoma mansoni cell polarity protein 0.00344673 0.000522123 0.000320516
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0643836 0.0518396 1
Loa Loa (eye worm) FKBP5 protein 0.00659124 0.00317025 0.00296918
Schistosoma mansoni coup transcription factor 0.0254487 0.0190509 0.018853
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) steroid hormone receptor 0.0254487 0.0190509 0.018853
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0254487 0.0190509 0.0403943
Trichomonas vaginalis fk506-binding protein, putative 0.00659124 0.00317025 0.0302412
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.00467135 0.00155343 0.00135203
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.00467135 0.00155343 0.00289685
Echinococcus multilocularis glycoprotein Antigen 5 0.0123021 0.00797962 0.00777951
Echinococcus granulosus 7tm_1 domain containing protein 0.00426199 0.00120869 0.00100723
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0254487 0.0190509 0.018853
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Echinococcus granulosus neuropeptides capa receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) aminopeptidase N 0.0643836 0.0518396 0.0516483
Echinococcus granulosus peroxidasin 0.0106684 0.00660382 0.00640344
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni notch 0.00344673 0.000522123 0.000320516
Brugia malayi Trypsin-like protease protein 5 0.0123021 0.00797962 0.0166683
Loa Loa (eye worm) hypothetical protein 0.0123021 0.00797962 0.00777951
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0358909 0.0278447 0.506982
Echinococcus multilocularis neurogenic locus notch protein 4 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0183736 0.0130927 0.0128936
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0254487 0.0190509 0.0403943
Echinococcus granulosus protein jagged 2 0.00344673 0.000522123 0.000320516
Echinococcus multilocularis neuropeptide Y receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.00478903 0.00165254 0.00145116
Trypanosoma brucei C-8 sterol isomerase, putative 0.0358909 0.0278447 0.506982
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0254487 0.0190509 0.0403943
Loa Loa (eye worm) G-protein coupled receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.00693521 0.00345992 0.0032589
Brugia malayi Animal haem peroxidase family protein 0.0106684 0.00660382 0.01372
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Brugia malayi hypothetical protein 0.557166 0.466832 1
Echinococcus granulosus tm gpcr rhodopsin 0.00426199 0.00120869 0.00100723
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.00659124 0.00317025 0.00636174
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Echinococcus multilocularis protein jagged 1 0.00344673 0.000522123 0.000320516
Brugia malayi TATA binding protein associated factor 0.0643836 0.0518396 0.110661
Schistosoma mansoni cercarial elastase (S01 family) 0.0123021 0.00797962 0.00777951
Schistosoma mansoni cercarial elastase (S01 family) 0.0123021 0.00797962 0.00777951
Onchocerca volvulus 0.0123021 0.00797962 0.145321
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.00635374 0.00297023 0.00276912
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0254487 0.0190509 0.018853
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Loa Loa (eye worm) hypothetical protein 0.0134441 0.00894137 0.00874146
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00426199 0.00120869 0.00100723
Schistosoma mansoni hypothetical protein 0.00426199 0.00120869 0.00100723
Onchocerca volvulus 0.0120045 0.00772901 0.140437
Loa Loa (eye worm) hypothetical protein 0.00321148 0.000324013 0.000122367
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0254487 0.0190509 0.018853
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) animal heme peroxidase 0.0106684 0.00660382 0.00640344
Toxoplasma gondii aminopeptidase n, putative 0.0643836 0.0518396 1
Schistosoma mansoni peroxidasin 0.0106684 0.00660382 0.00640344
Schistosoma mansoni neuropeptide receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0254487 0.0190509 0.018853
Schistosoma mansoni amine GPCR 0.00426199 0.00120869 0.00100723
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0643836 0.0518396 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0643836 0.0518396 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00426199 0.00120869 0.00215807
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0254487 0.0190509 0.018853
Echinococcus granulosus rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0254487 0.0190509 0.018853
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0120045 0.00772901 0.00752885
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0232305 0.0171828 0.0169846
Loa Loa (eye worm) blistered cuticle protein 3 0.0106684 0.00660382 0.00640344
Onchocerca volvulus 0.0123021 0.00797962 0.145321
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00426199 0.00120869 0.00215807
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Brugia malayi hypothetical protein 0.0643836 0.0518396 0.110661
Schistosoma mansoni hypothetical protein 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Onchocerca volvulus 0.0123021 0.00797962 0.145321
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00426199 0.00120869 0.00100723
Schistosoma mansoni hypothetical protein 0.00344673 0.000522123 0.000320516
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0343763 0.0265692 0.0263728
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Echinococcus granulosus serotonin receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) animal heme peroxidase 0.0106684 0.00660382 0.00640344
Loa Loa (eye worm) hypothetical protein 0.0134441 0.00894137 0.00874146
Echinococcus multilocularis serotonin receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni notch 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00426199 0.00120869 0.00100723
Schistosoma mansoni notch 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) melatonin receptor type 1A 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Brugia malayi Animal haem peroxidase family protein 0.0106684 0.00660382 0.01372
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0183736 0.0130927 0.0276258
Schistosoma mansoni histamine h1 receptor 0.00426199 0.00120869 0.00100723
Brugia malayi Trypsin family protein 0.0123021 0.00797962 0.0166683
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.00467135 0.00155343 0.00135203
Echinococcus granulosus protein jagged 1 0.00344673 0.000522123 0.000320516
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00478903 0.00165254 0.00145116
Mycobacterium ulcerans aminopeptidase N PepN 0.0643836 0.0518396 1
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0239904 0.0178228 0.0176247
Schistosoma mansoni alpha-1 adrenergic receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis fmrfamide receptor 0.00426199 0.00120869 0.00100723
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0254487 0.0190509 0.018853
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Echinococcus granulosus rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Brugia malayi Serotonin receptor 0.00426199 0.00120869 0.00215807
Brugia malayi ORL1-like opioid receptor 0.00426199 0.00120869 0.00215807
Echinococcus multilocularis fat cadherin tumor suppressor 0.00344673 0.000522123 0.000320516
Brugia malayi Peptidase family M1 containing protein 0.0643836 0.0518396 0.110661
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0643836 0.0518396 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.00478903 0.00165254 0.00145116
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.00467135 0.00155343 0.00135203
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Echinococcus granulosus neuropeptide s receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.00344673 0.000522123 0.000320516
Echinococcus multilocularis protein jagged 1 0.00344673 0.000522123 0.000320516
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0123021 0.00797962 0.00777951
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Echinococcus multilocularis peroxidasin 0.0106684 0.00660382 0.00640344
Echinococcus granulosus hypothetical protein 0.00426199 0.00120869 0.00100723
Brugia malayi hypothetical protein 0.00426199 0.00120869 0.00215807
Loa Loa (eye worm) leukotriene A4 hydrolase 1.19028 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0120045 0.00772901 0.140437
Brugia malayi Animal haem peroxidase family protein 0.0106684 0.00660382 0.01372
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0254487 0.0190509 0.018853
Brugia malayi Nuclear hormone receptor E75 0.0120045 0.00772901 0.0161313
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.00478903 0.00165254 0.00145116
Onchocerca volvulus 0.0106684 0.00660382 0.118511
Brugia malayi hypothetical protein 0.0134441 0.00894137 0.0187294
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0123021 0.00797962 0.00777951
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Schistosoma mansoni opsin-like receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0134441 0.00894137 0.00874146
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0123021 0.00797962 0.00777951
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0643836 0.0518396 0.0516483
Schistosoma mansoni neuropeptide receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni RAR-like nuclear receptor 0.0254487 0.0190509 0.018853
Echinococcus granulosus biogenic amine 5HT receptor 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis slit 2 protein 0.00344673 0.000522123 0.000320516
Echinococcus granulosus rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Onchocerca volvulus Protein ultraspiracle homolog 0.0254487 0.0190509 0.361062
Onchocerca volvulus 0.0123021 0.00797962 0.145321
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00478903 0.00165254 0.00145116
Brugia malayi nuclear receptor NHR-88 0.0254487 0.0190509 0.0403943
Echinococcus multilocularis neuropeptide s receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus orexin receptor type 2 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Echinococcus granulosus neurogenic locus notch protein 0.00344673 0.000522123 0.000320516
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0254487 0.0190509 0.0403943
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0643836 0.0518396 0.0516483
Loa Loa (eye worm) hypothetical protein 0.0106684 0.00660382 0.00640344
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.00659124 0.00317025 0.00296918
Schistosoma mansoni hypothetical protein 0.0123021 0.00797962 0.00777951
Brugia malayi Trypsin family protein 0.0123021 0.00797962 0.0166683
Loa Loa (eye worm) hypothetical protein 0.0254487 0.0190509 0.018853
Onchocerca volvulus Dual oxidase homolog 0.0106684 0.00660382 0.118511
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Echinococcus multilocularis neurogenic locus notch protein 0.00344673 0.000522123 0.000320516
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0643836 0.0518396 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0643836 0.0518396 1
Echinococcus granulosus neuropeptides capa receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00478903 0.00165254 0.00145116
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus neuropeptide receptor A26 0.00426199 0.00120869 0.00100723
Schistosoma mansoni neuropeptide receptor 0.00426199 0.00120869 0.00100723
Schistosoma mansoni neuropeptide F-like receptor 0.00426199 0.00120869 0.00100723
Echinococcus granulosus ecdysone induced protein 78C 0.0254487 0.0190509 0.018853
Echinococcus multilocularis rhodopsin orphan GPCR 0.00426199 0.00120869 0.00100723
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0123021 0.00797962 0.00777951
Brugia malayi Nuclear hormone receptor-like 1 0.0134441 0.00894137 0.0187294
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.00467135 0.00155343 0.00135203
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) hypothetical protein 0.0254487 0.0190509 0.018853
Brugia malayi G protein-coupled receptor F59B2.13 0.00426199 0.00120869 0.00215807
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00426199 0.00120869 0.00100723
Brugia malayi Blistered cuticle protein 3 0.0106684 0.00660382 0.01372
Onchocerca volvulus 0.00426199 0.00120869 0.0133789
Loa Loa (eye worm) hypothetical protein 0.0120045 0.00772901 0.00752885
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00426199 0.00120869 0.00100723
Loa Loa (eye worm) carboxylesterase 0.00321148 0.000324013 0.000122367
Echinococcus multilocularis neurogenic locus protein delta 0.00344673 0.000522123 0.000320516
Schistosoma mansoni myosin xvIII 0.00426199 0.00120869 0.00100723
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00426199 0.00120869 0.00100723
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0254487 0.0190509 0.018853
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.00344673 0.000522123 0.000686736
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.00693521 0.00345992 0.0032589

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.94 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of parasite growth after 72 hrs by SYBR Green I method ChEMBL. 25797165
Inhibition (functional) = 3 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 3.01 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 5.4 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 13 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 77 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 89 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 0 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 4 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 13 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 77 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 89 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.06 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.86848 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum 25797165

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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