Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0205 | 0.0481 | 0.0481 |
Echinococcus multilocularis | aminopeptidase N | 0.0205 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.3862 | 1 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0205 | 0.0481 | 0.5 |
Brugia malayi | hypothetical protein | 0.0205 | 0.0481 | 0.1052 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0205 | 0.0481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0481 | 0.0481 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0077 | 0.0148 | 0.0148 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0205 | 0.0481 | 0.0481 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0205 | 0.0481 | 0.0481 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0205 | 0.0481 | 0.0481 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0205 | 0.0481 | 0.0481 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0205 | 0.0481 | 0.5 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0205 | 0.0481 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.3862 | 1 | 1 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0205 | 0.0481 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0205 | 0.0481 | 0.5 |
Brugia malayi | hypothetical protein | 0.0205 | 0.0481 | 0.1052 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0205 | 0.0481 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0205 | 0.0481 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0205 | 0.0481 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0205 | 0.0481 | 0.5 |
Trypanosoma brucei | aminopeptidase, putative | 0.0205 | 0.0481 | 0.5 |
Onchocerca volvulus | 0.0205 | 0.0481 | 0.5 | |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0205 | 0.0481 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0205 | 0.0481 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0205 | 0.0481 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0205 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0481 | 0.0481 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0205 | 0.0481 | 0.0481 |
Brugia malayi | TATA binding protein associated factor | 0.0205 | 0.0481 | 0.1052 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0205 | 0.0481 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0205 | 0.0481 | 0.0481 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0205 | 0.0481 | 0.5 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0205 | 0.0481 | 0.0481 |
Brugia malayi | Peptidase family M1 containing protein | 0.0205 | 0.0481 | 0.1052 |
Toxoplasma gondii | aminopeptidase N protein | 0.0205 | 0.0481 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0205 | 0.0481 | 0.5 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.0205 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0481 | 0.0481 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0205 | 0.0481 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0071 | 0.0131 | 0.0287 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0205 | 0.0481 | 0.0481 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0071 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0071 | 0.0131 | 0.0131 |
Echinococcus granulosus | aminopeptidase N | 0.0205 | 0.0481 | 0.0481 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0205 | 0.0481 | 0.5 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0205 | 0.0481 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0205 | 0.0481 | 0.1052 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0205 | 0.0481 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0205 | 0.0481 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0205 | 0.0481 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0205 | 0.0481 | 1 |
Brugia malayi | hypothetical protein | 0.1776 | 0.4569 | 1 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0205 | 0.0481 | 0.0481 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.0205 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0205 | 0.0481 | 0.0481 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0205 | 0.0481 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0077 | 0.0148 | 0.0148 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0205 | 0.0481 | 0.0481 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0205 | 0.0481 | 0.0481 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.3862 | 1 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0205 | 0.0481 | 0.5 |
Onchocerca volvulus | 0.0205 | 0.0481 | 0.5 | |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0205 | 0.0481 | 0.5 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0205 | 0.0481 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0205 | 0.0481 | 0.1052 |
Onchocerca volvulus | 0.0205 | 0.0481 | 0.5 | |
Loa Loa (eye worm) | aminopeptidase N | 0.0205 | 0.0481 | 0.0481 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0071 | 0.0131 | 0.0131 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0205 | 0.0481 | 0.0481 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0205 | 0.0481 | 0.0481 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -1.8 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 4.88 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 5.82 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 13 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 25 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 85 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 2.61 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 0 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 13 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 25 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 85 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 7.19 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.06459 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.