Detailed information for compound 599144

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 476.415 | Formula: C21H22F6N4O2
  • H donors: 1 H acceptors: 2 LogP: 4.11 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCOc1ncc(cc1C(F)(F)F)NC(=O)N1CCc2c1cc(c(c2)C)C(F)(F)F)C
  • InChi: 1S/C21H22F6N4O2/c1-12-8-13-4-5-31(17(13)10-15(12)20(22,23)24)19(32)29-14-9-16(21(25,26)27)18(28-11-14)33-7-6-30(2)3/h8-11H,4-7H2,1-3H3,(H,29,32)
  • InChiKey: JQUVFRIGFRAJED-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0289 0.0519 1
Brugia malayi EGF-like domain containing protein 0.0034 0.005 0.0105
Brugia malayi jmjC domain containing protein 0.0011 0.0007 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0172 0.0172
Echinococcus granulosus cpg binding protein 0.0025 0.0033 0.0033
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0004 0.0004
Schistosoma mansoni protein phosphatase 2C 0.0011 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0009 0.0004 0.0004
Echinococcus multilocularis peroxidasin 0.0106 0.0182 0.0182
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0008 0.0008
Toxoplasma gondii EGF family domain-containing protein 0.0034 0.005 0.0928
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0004 0.0004
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0013 0.0013
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0013 0.0013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0038 0.0038
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0025 0.0025
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0026 0.0026
Echinococcus multilocularis slit 2 protein 0.0034 0.005 0.005
Brugia malayi Cadherin domain containing protein 0.0034 0.005 0.0105
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0289 0.0519 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0065 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0094 0.0094
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.019 0.0337 0.0334
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0013 0.0013
Trypanosoma brucei cAMP response protein 1, putative 0.0009 0.0004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Echinococcus multilocularis survival motor neuron protein 1 0.0164 0.0289 0.0289
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0009 0.0004 0.0038
Leishmania major hypothetical protein, unknown function 0.0009 0.0004 0.0038
Echinococcus granulosus peroxidasin 0.0106 0.0182 0.0182
Leishmania major hypothetical protein, conserved 0.0011 0.0007 0.0097
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0011 0.0007 0.0097
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0065 0.0062
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0009 0.0004 0.0004
Schistosoma mansoni phd/f-box containing protein 0.0011 0.0007 0.0007
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0013 0.0013
Onchocerca volvulus 0.0106 0.0182 0.3455
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0289 0.0519 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0016
Onchocerca volvulus 0.0028 0.0038 0.0659
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.0024
Schistosoma mansoni jumonji domain containing protein 0.0011 0.0007 0.0007
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0289 0.0519 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0013 0.0023
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.005
Trypanosoma cruzi cAMP response protein 1, putative 0.0009 0.0004 0.0038
Mycobacterium ulcerans aminopeptidase N PepN 0.0289 0.0519 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0294 0.0529 0.0529
Echinococcus granulosus tar DNA binding protein 0.0058 0.0094 0.0094
Loa Loa (eye worm) peptidase family M1 containing protein 0.0289 0.0519 0.0517
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0289 0.0519 0.0519
Echinococcus granulosus voltage gated potassium channel 0.002 0.0025 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0094 0.0094
Brugia malayi Blistered cuticle protein 3 0.0106 0.0182 0.0392
Echinococcus granulosus GPCR family 2 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0026 0.0455
Onchocerca volvulus Slit protein homolog 0.0034 0.005 0.0893
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0011 0.0007 0.0097
Echinococcus multilocularis protein jagged 1 0.0034 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0022
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0016
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0004 0.0004
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0289 0.0519 0.0519
Schistosoma mansoni peroxidasin 0.0106 0.0182 0.0182
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0289 0.0519 0.0517
Schistosoma mansoni hypothetical protein 0.0303 0.0546 0.0546
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0094 0.0094
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0013 0.0013
Loa Loa (eye worm) AGC/PKG protein kinase 0.0009 0.0004 0.0002
Schistosoma mansoni importin beta-1 0.0028 0.004 0.004
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0013 0.0013
Echinococcus multilocularis cpg binding protein 0.0025 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0182 0.0392
Brugia malayi notch-like transmembrane receptor 0.0034 0.005 0.0105
Leishmania major protein kinase A regulatory subunit, putative 0.0009 0.0004 0.0038
Onchocerca volvulus 0.0034 0.005 0.0893
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0494
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0005
Echinococcus multilocularis neurogenic locus protein delta 0.0034 0.005 0.005
Treponema pallidum catabolite gene activator 0.0009 0.0004 0.5
Echinococcus granulosus fibropellin Ia 0.0034 0.005 0.005
Treponema pallidum cyclic nucleotide binding protein 0.0009 0.0004 0.5
Brugia malayi RNA binding protein 0.0058 0.0094 0.0199
Echinococcus granulosus survival motor neuron protein 1 0.0164 0.0289 0.0289
Brugia malayi Importin beta-1 subunit 0.0028 0.004 0.0081
Entamoeba histolytica hypothetical protein 0.0023 0.003 0.0079
Trypanosoma cruzi cAMP binding protein, putative 0.0009 0.0004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0289 0.0519 0.0519
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0289 0.0519 0.0519
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0058 0.0094 0.0091
Loa Loa (eye worm) TAR-binding protein 0.0058 0.0094 0.0091
Brugia malayi Peptidase family M1 containing protein 0.0289 0.0519 0.1127
Loa Loa (eye worm) hypothetical protein 0.0289 0.0519 0.0517
Echinococcus granulosus protein jagged 2 0.0034 0.005 0.005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0078 0.0075
Schistosoma mansoni hypothetical protein 0.0034 0.0049 0.0049
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0289 0.0519 1
Onchocerca volvulus 0.0289 0.0519 1
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Brugia malayi jmjC domain containing protein 0.0011 0.0007 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0172 0.037
Brugia malayi Pre-SET motif family protein 0.019 0.0337 0.0729
Loa Loa (eye worm) hypothetical protein 0.0289 0.0519 0.0517
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0182 0.0392
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.0007 0.0007
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0009 0.0004 0.0038
Echinococcus multilocularis aminopeptidase N 0.0289 0.0519 0.0519
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0026 0.0455
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0128 0.0128
Echinococcus multilocularis isocitrate dehydrogenase 0.0008 0.0002 0.0002
Brugia malayi EGF-like domain containing protein 0.0034 0.005 0.0105
Trypanosoma cruzi cAMP response protein 1 0.0009 0.0004 0.0038
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0013 0.0013
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0289 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0075
Plasmodium falciparum cGMP-dependent protein kinase 0.0009 0.0004 0.0038
Brugia malayi Pre-SET motif family protein 0.0028 0.0038 0.0078
Treponema pallidum catabolite gene activator (Crp) 0.0009 0.0004 0.5
Trypanosoma brucei Aminopeptidase M1, putative 0.0289 0.0519 1
Leishmania major GTP-binding protein, putative 0.0021 0.0026 0.0455
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0005
Onchocerca volvulus Dual oxidase homolog 0.0106 0.0182 0.3455
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0289 0.0519 0.0519
Onchocerca volvulus 0.0289 0.0519 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0038 0.0695
Onchocerca volvulus 0.0034 0.005 0.0893
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0182 0.018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0172 0.0172
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0007 0.0005
Schistosoma mansoni cell polarity protein 0.0034 0.005 0.005
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.0455
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.0007 0.0007
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.0007 0.0007
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0002
Brugia malayi isocitrate dehydrogenase 0.0008 0.0002 0.0000080305
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.005
Leishmania major hypothetical protein, conserved 0.0009 0.0004 0.0038
Schistosoma mansoni notch 0.0034 0.005 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0007 0.0005
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0289 0.0519 1
Trypanosoma brucei protein kinase A regulatory subunit 0.0009 0.0004 0.0038
Echinococcus multilocularis geminin 0.0254 0.0456 0.0456
Echinococcus granulosus protein jagged 2 0.0034 0.005 0.005
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0009 0.0004 0.0002
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0289 0.0519 0.0519
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0004 0.0004
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.007 0.0116 0.0247
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0062 0.0062
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0013 0.0164
Echinococcus multilocularis leukotriene A 4 hydrolase 0.5431 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.007 0.0116 0.0114
Leishmania major protein kinase, putative 0.0009 0.0004 0.0038
Schistosoma mansoni notch 0.0034 0.005 0.005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0013 0.0164
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0016
Onchocerca volvulus 0.0106 0.0182 0.3455
Echinococcus granulosus neurogenic locus notch protein 0.0034 0.005 0.005
Brugia malayi EGF-like domain containing protein 0.0034 0.005 0.0105
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0009 0.0004 0.0004
Schistosoma mansoni aminopeptidase A (M01 family) 0.0289 0.0519 0.0519
Leishmania major hypothetical protein, conserved 0.0009 0.0004 0.0038
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0289 0.0519 1
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0009 0.0004 0.0004
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0038 0.0038
Echinococcus granulosus notch 0.0034 0.005 0.005
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0182 0.018
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) RNA binding protein 0.0058 0.0094 0.0091
Onchocerca volvulus Peroxidase homolog 0.0106 0.0182 0.3455
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0289 0.0519 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0065 0.0108 0.2002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0033 0.0049 0.0101
Echinococcus multilocularis tar DNA binding protein 0.0058 0.0094 0.0094
Plasmodium vivax importin-beta 2, putative 0.0028 0.004 0.0722
Echinococcus granulosus neurogenic locus protein delta 0.0034 0.005 0.005
Brugia malayi GCC2 and GCC3 family protein 0.0034 0.005 0.0105
Trypanosoma brucei Flagellar Member 6 0.0009 0.0004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Echinococcus granulosus cGMP dependent protein kinase 1 0.0009 0.0004 0.0004
Entamoeba histolytica aminopeptidase, putative 0.0289 0.0519 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.004 0.0722
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0016
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.0071 0.132
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0289 0.0519 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.5431 1 1
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0009 0.0004 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0038 0.0038
Plasmodium vivax SET domain protein, putative 0.0028 0.0038 0.0695
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0009 0.0004 0.0038
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0289 0.0519 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0025 0.0025
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0009 0.0004 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0013 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0078 0.0165
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0034 0.005 0.0893
Onchocerca volvulus Chorion peroxidase homolog 0.0106 0.0182 0.3455
Trypanosoma brucei Aminopeptidase M1, putative 0.0289 0.0519 1
Mycobacterium tuberculosis Conserved protein 0.0009 0.0004 1
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0009 0.0004 1
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0026 0.0455
Brugia malayi Muscle positioning protein 4 0.0034 0.005 0.0105
Leishmania major regulatory subunit of protein kinase a-like protein 0.0009 0.0004 0.0038
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0011 0.0007 0.0097
Echinococcus granulosus snurportin 1 0.0303 0.0546 0.0546
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Trypanosoma cruzi Flagellar Member 6 0.0009 0.0004 0.0038
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0009 0.0004 0.0004
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0009 0.0004 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0172 0.0172
Mycobacterium leprae Conserved hypothetical protein 0.0009 0.0004 0.5
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0009 0.0004 0.0004
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0034 0.005 0.0105
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0009 0.0004 0.0038
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0009 0.0004 0.0004
Onchocerca volvulus 0.0033 0.0049 0.0865
Onchocerca volvulus Peroxidasin homolog 0.0106 0.0182 0.3455
Schistosoma mansoni notch 0.0034 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.005 0.0105
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.005 0.0105
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0494
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.003 0.0028
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0016
Trichomonas vaginalis set domain proteins, putative 0.0216 0.0385 0.739
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0009 0.0004 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0172 0.0172
Brugia malayi jmjC domain containing protein 0.0041 0.0062 0.0131
Echinococcus granulosus phd:f box containing protein 0.0011 0.0007 0.0007
Brugia malayi RNA, U transporter 1 0.0081 0.0136 0.0292
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0013 0.0013
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0009 0.0004 0.0004
Schistosoma mansoni ran 0.0021 0.0026 0.0026
Brugia malayi CXXC zinc finger family protein 0.0023 0.003 0.0061
Onchocerca volvulus Peroxidase homolog 0.0106 0.0182 0.3455
Loa Loa (eye worm) hypothetical protein 0.0164 0.0289 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0038 0.0038
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0559 0.1019 0.1019
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0009 0.0004 0.0038
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0009 0.0004 0.0004
Echinococcus granulosus neurogenic locus notch protein 4 0.0034 0.005 0.005
Echinococcus multilocularis neurogenic locus notch protein 4 0.0034 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.0007 0.0007
Echinococcus multilocularis protein jagged 2 0.0034 0.005 0.005
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0009 0.0004 0.0038
Onchocerca volvulus 0.0216 0.0385 0.739
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.005
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0182 0.0392
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0016 0.003
Echinococcus multilocularis expressed conserved protein 0.0009 0.0004 0.0004
Echinococcus granulosus geminin 0.0254 0.0456 0.0456
Onchocerca volvulus 0.0106 0.0182 0.3455
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0172 0.0172
Echinococcus multilocularis notch 0.0034 0.005 0.005
Onchocerca volvulus Peroxidasin homolog 0.0106 0.0182 0.3455
Echinococcus granulosus protein jagged 1 0.0034 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0004 0.0038
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0009 0.0004 0.0004
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.0051
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0013 0.001
Brugia malayi RNA recognition motif domain containing protein 0.0058 0.0094 0.0199
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0026 0.0026
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0013 0.0013
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.0007 0.0007
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0013 0.0013
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0009 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0254 0.0456 0.0456
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0009 0.0004 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.0036 0.0036
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0003
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.005 0.0105
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0078 0.0165
Brugia malayi TAR-binding protein 0.0058 0.0094 0.0199
Echinococcus granulosus patatin phospholipase domain containing protein 0.0009 0.0004 0.0004
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0034 0.005 0.005
Echinococcus granulosus neural cadherin 0.0034 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Echinococcus granulosus protein jagged 1 0.0034 0.005 0.005
Schistosoma mansoni septate junction protein 0.0034 0.005 0.005
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0013 0.0013
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.4682
Brugia malayi jmjC domain containing protein 0.0042 0.0065 0.0136
Schistosoma mansoni notch 0.0034 0.005 0.005
Echinococcus granulosus aminopeptidase N 0.0289 0.0519 0.0519
Plasmodium falciparum importin beta, putative 0.0028 0.004 0.0722
Schistosoma mansoni notch 0.0034 0.005 0.005
Brugia malayi hypothetical protein 0.0106 0.0182 0.0392
Brugia malayi EGF-like domain containing protein 0.0034 0.005 0.0105
Trypanosoma cruzi aminopeptidase, putative 0.0289 0.0519 1
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0009 0.0004 0.0004
Schistosoma mansoni slit 0.0034 0.005 0.005
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0009 0.0004 0.0038
Mycobacterium tuberculosis Conserved hypothetical protein 0.0009 0.0004 1
Brugia malayi EGF-like domain containing protein 0.0034 0.005 0.0105
Schistosoma mansoni 60S ribosomal protein L21 0.0011 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0028 0.004 0.0037
Brugia malayi hypothetical protein 0.0164 0.0289 0.0624
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0289 0.0519 0.0519
Onchocerca volvulus 0.0289 0.0519 1
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Brugia malayi TATA binding protein associated factor 0.0289 0.0519 0.1127
Plasmodium vivax JmjC domain containing protein 0.0011 0.0007 0.0097
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0007 0.0005
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0013 0.0013
Echinococcus granulosus neurogenic locus notch protein 0.0034 0.005 0.005
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0289 0.0519 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0008 0.0002 0.0002
Echinococcus multilocularis neural cadherin 0.0034 0.005 0.005
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0182 0.0392
Onchocerca volvulus 0.0034 0.005 0.0893
Loa Loa (eye worm) Notch2 0.0034 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Toxoplasma gondii aminopeptidase N protein 0.0289 0.0519 1
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0009 0.0004 0.0038
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0009 0.0004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0002
Schistosoma mansoni laminin gamma-3 chain 0.0034 0.005 0.005
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0289 0.0519 1
Schistosoma mansoni cpg binding protein 0.0023 0.003 0.003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0041 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0009 0.0004 0.0004
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0011 0.0007 0.0097
Brugia malayi EGF-like domain containing protein 0.0034 0.005 0.0105
Trypanosoma cruzi Aminopeptidase M1, putative 0.0289 0.0519 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.004 0.0722
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0049 0.0102
Loa Loa (eye worm) TATA binding protein associated factor 0.0289 0.0519 0.0517
Onchocerca volvulus 0.0034 0.005 0.0893
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0065 0.0065
Brugia malayi Peptidase family M1 containing protein 0.0289 0.0519 0.1127
Echinococcus multilocularis fibropellin Ia 0.0034 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Onchocerca volvulus Putative cubilin 0.0034 0.005 0.0893
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0289 0.0519 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0038 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.008 0.008
Trypanosoma brucei aminopeptidase, putative 0.0289 0.0519 1
Echinococcus granulosus delta-like protein 1 0.0034 0.005 0.005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.003 0.0531
Echinococcus multilocularis neurogenic locus notch protein 0.0034 0.005 0.005
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0009 0.0004 0.0038
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0289 0.0519 1
Schistosoma mansoni hypothetical protein 0.0033 0.0049 0.0049
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0289 0.0519 0.0519
Echinococcus granulosus cGMP dependent protein kinase 1 0.0009 0.0004 0.0004
Echinococcus multilocularis GPCR, family 2 0.0016 0.0016 0.0016
Brugia malayi hypothetical protein 0.0289 0.0519 0.1127
Brugia malayi jmjC domain containing protein 0.0011 0.0007 0.0011
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0182 0.018
Onchocerca volvulus Neurogenic locus notch homolog 0.0034 0.005 0.0893
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0065 0.0065
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0026 0.0455
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0289 0.0519 1
Brugia malayi Egg laying defective protein 4 0.0009 0.0004 0.0004
Treponema pallidum cyclic nucleotide binding protein 0.0009 0.0004 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Echinococcus multilocularis neurogenic locus protein delta 0.0034 0.005 0.005
Brugia malayi Cadherin domain containing protein 0.0034 0.005 0.0105
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Echinococcus granulosus cGMP dependent protein kinase 0.0009 0.0004 0.0004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0016 0.0014
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0009 0.0004 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0008 0.0002 0.0002
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0009 0.0004 0.0038
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0009 0.0004 0.0004
Plasmodium falciparum JmjC domain-containing protein, putative 0.0011 0.0007 0.0097
Brugia malayi hypothetical protein 0.0289 0.0519 0.1127
Schistosoma mansoni ran 0.0021 0.0026 0.0026
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0008 0.0002 0.0002
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0009 0.0004 0.0004
Echinococcus multilocularis fat cadherin tumor suppressor 0.0034 0.005 0.005
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0182 0.018
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0009 0.0004 0.0038
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0008 0.0002 0.0002
Echinococcus multilocularis neurogenic locus notch protein 0.0034 0.005 0.005
Schistosoma mansoni notch 0.0034 0.005 0.005
Toxoplasma gondii aminopeptidase N, putative 0.0289 0.0519 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0008 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.005
Leishmania major cyclic nucleotide-binding protein-like protein 0.0009 0.0004 0.0038
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.007 0.0116 0.0116
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0172 0.017
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0016
Brugia malayi Peroxidasin 0.0106 0.0182 0.0392
Brugia malayi Isocitrate dehydrogenase 0.0008 0.0002 0.0000080305
Onchocerca volvulus 0.0034 0.005 0.0893
Loa Loa (eye worm) hypothetical protein 0.0061 0.0099 0.0097
Brugia malayi jmjC domain containing protein 0.0011 0.0007 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0038 0.0038
Trypanosoma brucei cAMP binding protein, putative 0.0009 0.0004 0.0038
Schistosoma mansoni survival motor neuron protein 0.0033 0.0049 0.0049
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0289 0.0519 0.0519
Trypanosoma cruzi aminopeptidase, putative 0.0289 0.0519 1
Brugia malayi EGF-like domain containing protein 0.0034 0.005 0.0105
Brugia malayi Delta serrate ligand family protein 0.0034 0.005 0.0105
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0289 0.0519 0.0519
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0182 0.0392
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.0546 0.0544
Schistosoma mansoni jumonji domain containing protein 0.0041 0.0062 0.0062
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.004 0.0722
Echinococcus multilocularis importin subunit beta 1 0.0028 0.004 0.004
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0025 0.0025
Echinococcus multilocularis voltage gated potassium channel 0.002 0.0025 0.0025
Brugia malayi hypothetical protein 0.2497 0.4591 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0013 0.0013
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.002 0.0025 0.0049
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0016
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0289 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Schistosoma mansoni cpg binding protein 0.0025 0.0033 0.0033
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0009 0.0004 0.0038
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0026 0.0455
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0041 0.0062 0.0062
Loa Loa (eye worm) aminopeptidase N 0.0289 0.0519 0.0517
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0009 0.0004 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0289 0.0519 0.0519
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0106 0.0182 0.018
Trypanosoma cruzi protein kinase A regulatory subunit 0.0009 0.0004 0.0038
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.005
Echinococcus granulosus importin subunit beta 1 0.0028 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Schistosoma mansoni hypothetical protein 0.0254 0.0456 0.0456
Onchocerca volvulus 0.0023 0.003 0.0505
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0004 0.0004
Loa Loa (eye worm) blistered cuticle protein 3 0.0106 0.0182 0.018
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0009 0.0004 0.0004
Leishmania major protein kinase, putative 0.0009 0.0004 0.0038
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0289 0.0519 0.0519
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.0007 0.0007
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0289 0.0519 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0065 0.0108 0.2002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.001
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0011 0.0007 0.0097
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.001 0.001
Loa Loa (eye worm) notch protein 0.0034 0.005 0.0048
Mycobacterium ulcerans aminopeptidase N PepN 0.0289 0.0519 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0003
Schistosoma mansoni peroxidasin 0.0106 0.0182 0.0182
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0016 0.003
Giardia lamblia High cysteine protein 0.0034 0.005 1
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0009 0.0004 0.0004
Echinococcus multilocularis snurportin 1 0.0303 0.0546 0.0546
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0009 0.0004 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0036
Echinococcus granulosus potassium voltage gated channel subfamily H 0.007 0.0116 0.0116
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0289 0.0519 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Echinococcus multilocularis protein jagged 1 0.0034 0.005 0.005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0094 0.0094
Brugia malayi N-terminal motif family protein 0.0009 0.0004 0.0004
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0009 0.0004 0.0038
Leishmania major importin beta-1 subunit, putative 0.0023 0.003 0.0531
Schistosoma mansoni cpg binding protein 0.0025 0.0033 0.0033
Brugia malayi Peptidase family M1 containing protein 0.0289 0.0519 0.1127
Mycobacterium tuberculosis Conserved hypothetical protein 0.0009 0.0004 1
Echinococcus granulosus slit 2 protein 0.0034 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0034 0.005 0.0048
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0008 0.0002 0.0002
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.001 0.001
Loa Loa (eye worm) leukotriene A4 hydrolase 0.5431 1 1
Trichomonas vaginalis ran, putative 0.0021 0.0026 0.0418
Toxoplasma gondii aminopeptidase n, putative 0.0289 0.0519 1
Echinococcus multilocularis phd:f box containing protein 0.0011 0.0007 0.0007
Trichomonas vaginalis importin beta-1, putative 0.0023 0.003 0.0494

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 6.3 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 6.97 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 7.92 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 25 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 28 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 88 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 6.04 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -2 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 25 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 28 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 88 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.01 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.96628 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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