Detailed information for compound 599389

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.79 | Formula: C18H15ClN4O3
  • H donors: 4 H acceptors: 4 LogP: 2.49 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc(cc1)NC(=O)c1[nH]nc(c1)c1cc(Cl)ccc1O
  • InChi: 1S/C18H15ClN4O3/c1-10(24)20-12-3-5-13(6-4-12)21-18(26)16-9-15(22-23-16)14-8-11(19)2-7-17(14)25/h2-9,25H,1H3,(H,20,24)(H,21,26)(H,22,23)
  • InChiKey: KRQJJEHYENCIHG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0146 0.1362 0.7921
Entamoeba histolytica hypothetical protein 0.0039 0.0288 0.1532
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0431 0.0431
Schistosoma mansoni rab6-interacting 0.0021 0.0102 0.0102
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0054 0.0431 0.0431
Schistosoma mansoni lipoxygenase 0.0124 0.1138 0.1138
Brugia malayi intermediate filament protein 0.0029 0.019 0.0418
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0102
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0056 0.0456 0.0456
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0065 0.0481
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.000000000048208 0.00000000035397
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0046 0.0356 0.1934
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0288 0.0288
Entamoeba histolytica hypothetical protein 0.0039 0.0288 0.1532
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0146 0.1362 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.019 0.0418
Leishmania major lanosterol synthase, putative 0.0034 0.0236 0.1542
Schistosoma mansoni aminopeptidase A (M01 family) 0.0054 0.0431 0.0431
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0134 0.1236 0.1236
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0181 0.1711 1
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0181 0.1711 0.1711
Schistosoma mansoni microtubule-associated protein tau 0.0755 0.7457 0.7457
Onchocerca volvulus 0.0029 0.019 0.2663
Plasmodium vivax conserved Plasmodium protein, unknown function 0.009 0.08 0.5658
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0054 0.0431 0.3005
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0054 0.0431 0.3005
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0134 0.1236 0.1236
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0046 0.0356 0.2442
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0181 0.1711 0.1711
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.1138 0.1138
Loa Loa (eye worm) aminopeptidase N 0.0054 0.0431 0.0431
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0571 0.0571
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0102 0.0102
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0054 0.0431 0.3005
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0056 0.0456 0.3002
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0571 0.0571
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0102 0.0267
Loa Loa (eye worm) peptidase family M1 containing protein 0.0054 0.0431 0.0431
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0102 0.0102
Trypanosoma cruzi aminopeptidase, putative 0.0054 0.0431 0.3005
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0054 0.0431 0.0431
Entamoeba histolytica hypothetical protein 0.0039 0.0288 0.1532
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0102 0.075
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0054 0.0431 0.3005
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0054 0.0431 0.2808
Trypanosoma brucei lanosterol synthase 0.009 0.0798 0.5765
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.019 0.019
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0046 0.0356 0.2442
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0146 0.1362 0.7921
Onchocerca volvulus 0.0054 0.0431 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0151 0.0711
Loa Loa (eye worm) hypothetical protein 0.0054 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.0024 0.0132 0.0132
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0134 0.1236 0.7172
Mycobacterium ulcerans aminopeptidase N PepN 0.0054 0.0431 0.5
Loa Loa (eye worm) TATA binding protein associated factor 0.0054 0.0431 0.0431
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0146 0.1362 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0119 0.0877
Trypanosoma cruzi lanosterol synthase, putative 0.009 0.0798 0.5765
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0027 0.0169 0.0169
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1008 1 1
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0056 0.0456 0.3194
Loa Loa (eye worm) hypothetical protein 0.0029 0.019 0.019
Toxoplasma gondii aminopeptidase N, putative 0.0054 0.0431 0.3165
Echinococcus multilocularis musashi 0.0029 0.019 0.019
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0046 0.0356 0.2229
Echinococcus granulosus tar DNA binding protein 0.0068 0.0571 0.0571
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0134 0.1236 0.9027
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0181 0.1711 0.1711
Schistosoma mansoni rab6-interacting 0.0021 0.0102 0.0102
Plasmodium vivax geranylgeranyltransferase, putative 0.0056 0.0456 0.3002
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0146 0.1362 0.7921
Schistosoma mansoni loxhd1 0.0021 0.0102 0.0102
Echinococcus granulosus bloom syndrome protein 0.0026 0.0151 0.0151
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0052 0.0052
Trypanosoma cruzi aminopeptidase, putative 0.0054 0.0431 0.3005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0184 0.0184
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.0054 0.0431 0.0431
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0146 0.1362 0.7921
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0054 0.0431 0.3165
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0194 0.0194
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0181 0.1711 0.1711
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0571 0.0571
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0146 0.1362 0.1362
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0571 0.0571
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0134 0.1236 0.7172
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0151 0.0332
Brugia malayi RNA binding protein 0.0068 0.0571 0.1257
Loa Loa (eye worm) hypothetical protein 0.0054 0.0431 0.0431
Loa Loa (eye worm) RecQ helicase 0.0026 0.0151 0.0151
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0102 0.0102
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0134 0.1236 0.2722
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.2486 0.2486
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0054 0.0431 0.0431
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0054 0.0431 0.3005
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.2486 0.2486
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0456 0.3194
Schistosoma mansoni intermediate filament proteins 0.0029 0.019 0.019
Onchocerca volvulus 0.0046 0.0356 0.7722
Schistosoma mansoni hypothetical protein 0.0039 0.0288 0.0288
Toxoplasma gondii aminopeptidase N protein 0.0054 0.0431 0.3165
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0431 0.0431
Echinococcus granulosus intermediate filament protein 0.0029 0.019 0.019
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0054 0.0431 0.0431
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0027 0.0169 0.0371
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0431 0.0431
Trypanosoma brucei aminopeptidase, putative 0.0054 0.0431 0.3005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0102
Mycobacterium ulcerans aminopeptidase N PepN 0.0054 0.0431 0.5
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0056 0.0456 0.3194
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0456 0.3194
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0054 0.0431 0.3005
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0356 0.2442
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.009 0.0798 0.5
Loa Loa (eye worm) hypothetical protein 0.0129 0.1185 0.1185
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.015 0.071
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0146 0.1362 0.7921
Trypanosoma cruzi Aminopeptidase M1, putative 0.0054 0.0431 0.3005
Brugia malayi hypothetical protein 0.0259 0.2486 0.5475
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0146 0.1362 0.1362
Brugia malayi TAR-binding protein 0.0068 0.0571 0.1257
Brugia malayi hypothetical protein 0.0039 0.0288 0.0635
Onchocerca volvulus 0.0053 0.0423 0.9748
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0288 0.0288
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0181 0.1711 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.019 0.019
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0134 0.1236 0.1236
Trypanosoma brucei Aminopeptidase M1, putative 0.0054 0.0431 0.3005
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0288 0.0288
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0151 0.0711
Loa Loa (eye worm) RNA binding protein 0.0068 0.0571 0.0571
Echinococcus multilocularis microtubule associated protein 2 0.0755 0.7457 0.7457
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0056 0.0456 0.1005
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0431 0.0431
Leishmania major geranylgeranyltransferase, putative 0.0056 0.0456 0.3194
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0037 0.0037
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0054 0.0431 0.3165
Schistosoma mansoni survival motor neuron protein 0.0053 0.0423 0.0423
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0102 0.0102
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0027 0.0169 0.0169
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0054 0.0431 0.0431
Onchocerca volvulus 0.0054 0.0431 1
Leishmania major farnesyltransferase beta subunit 0.0146 0.1362 1
Giardia lamblia Prenyltransferase 0.0146 0.1362 1
Giardia lamblia Rab geranylgeranyltransferase 0.0056 0.0456 0.3349
Plasmodium falciparum geranylgeranyltransferase, putative 0.0056 0.0456 0.3349
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0056 0.0456 0.0456
Toxoplasma gondii hypothetical protein 0.0088 0.0774 0.5684
Brugia malayi hypothetical protein 0.0054 0.0431 0.0949
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0054 0.0431 0.238
Brugia malayi TATA binding protein associated factor 0.0054 0.0431 0.0949
Trypanosoma cruzi protein farnesyltransferase, putative 0.0146 0.1362 1
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0046 0.0356 0.1934
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0046 0.0356 0.0356
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0046 0.0356 0.0784
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0046 0.0356 0.0356
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0056 0.0456 0.3349
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0054 0.0431 0.3005
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1008 1 1
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0046 0.0356 0.2442
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0046 0.0356 0.2442
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0571 0.1257
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0046 0.0356 0.0356
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.015 0.071
Trypanosoma cruzi protein farnesyltransferase, putative 0.0146 0.1362 1
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0046 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0031
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0046 0.0356 0.2615
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0054 0.0431 0.238
Toxoplasma gondii hypothetical protein 0.0046 0.0356 0.2615
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0146 0.1362 0.1362
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0097 0.0097
Echinococcus granulosus aminopeptidase N 0.0054 0.0431 0.0431
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0046 0.0356 0.2442
Trypanosoma brucei Aminopeptidase M1, putative 0.0054 0.0431 0.3005
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0571 0.0571
Schistosoma mansoni lipoxygenase 0.0087 0.0764 0.0764
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0146 0.1362 0.7921
Brugia malayi Peptidase family M1 containing protein 0.0054 0.0431 0.0949
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0054 0.0431 0.0431
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0054 0.0431 0.238
Entamoeba histolytica hypothetical protein 0.0039 0.0288 0.1532
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0146 0.1362 1
Echinococcus multilocularis lamin dm0 0.0029 0.019 0.019
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0102 0.0102
Brugia malayi hypothetical protein 0.0054 0.0431 0.0949
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0046 0.0356 0.0356
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0054 0.0431 0.0431
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0102 0.0102
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0054 0.0431 0.2808
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1008 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0102 0.0102
Onchocerca volvulus 0.0029 0.019 0.2663
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0054 0.0431 0.0431
Echinococcus multilocularis RUN 0.0021 0.0102 0.0102
Brugia malayi hypothetical protein 0.0021 0.0102 0.0225
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0181 0.1711 0.3769
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.1138 0.1138
Brugia malayi hypothetical protein 0.0464 0.454 1
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0146 0.1362 0.1362
Echinococcus granulosus lamin 0.0029 0.019 0.019
Schistosoma mansoni hypothetical protein 0.0053 0.0423 0.0423
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0054 0.0431 0.0431
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0134 0.1236 0.7172
Schistosoma mansoni polycystin 1-related 0.0021 0.0102 0.0102
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0054 0.0431 0.3005
Brugia malayi Peptidase family M1 containing protein 0.0054 0.0431 0.0949
Giardia lamblia Rab geranylgeranyltransferase 0.0046 0.0356 0.2615
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0054 0.0431 0.0431
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0181 0.1711 0.1711
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0046 0.0356 0.2442
Schistosoma mansoni lamin 0.0029 0.019 0.019
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0056 0.0456 0.253
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0046 0.0356 0.2442
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0146 0.1362 0.3
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0134 0.1236 0.9075
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0027 0.0169 0.0169
Schistosoma mansoni lamin 0.0029 0.019 0.019
Giardia lamblia Rab geranylgeranyltransferase 0.0134 0.1236 0.9075
Echinococcus multilocularis aminopeptidase N 0.0054 0.0431 0.0431
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0037 0.0037
Brugia malayi Doublecortin family protein 0.0021 0.0102 0.0225
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0056 0.0456 0.253
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0054 0.0431 0.3005
Echinococcus granulosus lamin dm0 0.0029 0.019 0.019
Trypanosoma cruzi lanosterol synthase, putative 0.009 0.0798 0.5765
Loa Loa (eye worm) hypothetical protein 0.0259 0.2486 0.2486
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0571 0.0571
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0046 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0056 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0571 0.0571
Loa Loa (eye worm) hypothetical protein 0.0134 0.1236 0.1236
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0056 0.0456 0.3349
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0056 0.0456 0.253
Echinococcus granulosus RUN 0.0021 0.0102 0.0102
Echinococcus granulosus microtubule associated protein 2 0.0755 0.7457 0.7457
Echinococcus multilocularis lamin 0.0029 0.019 0.019
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0146 0.1362 1
Entamoeba histolytica aminopeptidase, putative 0.0054 0.0431 0.238
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0134 0.1236 0.1236
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0037
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0356 0.2442
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0571 0.0571
Brugia malayi Peptidase family M1 containing protein 0.0054 0.0431 0.0949
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0052 0.0116
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0423 0.0931
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0356 0.2442
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0088 0.0774 0.4422
Toxoplasma gondii aminopeptidase n, putative 0.0054 0.0431 0.3165
Brugia malayi hypothetical protein 0.0021 0.0102 0.0225
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0134 0.1236 0.7172
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0151 0.0151
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0146 0.1362 0.7921
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0056 0.0456 0.3349
Onchocerca volvulus 0.0054 0.0431 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0456 0.0456
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0054 0.0431 0.3005
Schistosoma mansoni hypothetical protein 0.0021 0.0102 0.0102
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0194 0.0194

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.35 uM Antimalarial activity: Asexual Blood Stage Plasmodium falciparum 3D7 IC50 (uM) ChEMBL. No reference
IC50 (functional) = 0.48 uM Antimalarial activity: Asexual Blood Stage Plasmodium falciparum Dd2 IC50 (uM) ChEMBL. No reference
IC50 (functional) = 0.51 uM Antimalarial activity: Asexual Blood Stage Plasmodium falciparum W2 IC50 (uM) ChEMBL. No reference
Inhibition (binding) Compound was evaluated for the inhibition of human FECH at 10uM MMV_PBOX. No reference
Inhibition (functional) = -0.51 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = -0.41 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 1 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 2.29 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 7 % HepG2 inhibition at 10 uM (%) Cytotoxicity ChEMBL. No reference
Inhibition (functional) = 100 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 100 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 0 uM Antimalarial activity: Liver Stage Plasmodium berghei sporozoite Luciferase assay: inhibition at 10 uM (%) ChEMBL. No reference
Inhibition (functional) = 6 uM Antimalarial activity: Gametocytes Plasmodium falciparum NF54 Gametocytes Stage V: inhibition at 10 uM (%) ChEMBL. No reference
Inhibition frequency index (IFI) (functional) = 1.94 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -2 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 1 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 100 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 100 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.75 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.17597 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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