Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0025 | 0.0139 | 0.1014 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0559 | 0.0559 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0154 | 0.137 | 1 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.0048 | 0.0365 | 0.0365 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0012 | 0.0027 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.0884 | 0.0884 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0141 | 0.1244 | 0.1244 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0012 | 0.0012 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.0048 | 0.0365 | 0.0365 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.0056 | 0.044 | 0.044 |
Echinococcus granulosus | GPCR family 2 | 0.0069 | 0.0559 | 0.0559 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0056 | 0.044 | 0.044 |
Trypanosoma cruzi | geranylgeranyl transferase type II beta subunit, putative | 0.0059 | 0.0465 | 0.3393 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0103 | 0.0884 | 0.0884 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0012 | 0.0027 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0191 | 0.1719 | 0.1719 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0048 | 0.0365 | 0.2239 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0012 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0099 | 0.5 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0018 | 0.0075 | 0.0546 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0221 | 0.0487 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0029 | 0.0177 | 0.0177 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0056 | 0.044 | 0.044 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0025 | 0.0139 | 0.0941 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0154 | 0.137 | 1 |
Toxoplasma gondii | aminopeptidase N protein | 0.0056 | 0.044 | 0.3155 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0099 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0012 | 0.0027 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0141 | 0.1244 | 0.1244 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0012 | 0.0012 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0056 | 0.044 | 0.181 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0154 | 0.137 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.021 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0012 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0012 | 0.0012 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0018 | 0.0075 | 0.0075 |
Leishmania major | lanosterol synthase, putative | 0.0036 | 0.0245 | 0.1315 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0012 | 0.0012 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0365 | 0.2603 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0012 | 0.0012 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0012 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0559 | 0.0559 |
Toxoplasma gondii | Rab geranylgeranyl transferase type II beta subunit, putative | 0.0059 | 0.0465 | 0.3339 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0103 | 0.0884 | 0.1945 |
Echinococcus granulosus | serine protein kinase ATM | 0.0025 | 0.0139 | 0.0139 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0056 | 0.044 | 0.2681 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0018 | 0.0075 | 0.0469 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0018 | 0.0075 | 0.0075 |
Onchocerca volvulus | 0.0056 | 0.044 | 0.1769 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0012 | 0.0012 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.0154 | 0.137 | 0.137 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0031 | 0.0203 | 0.0203 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0012 | 0.0012 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0141 | 0.1244 | 0.5122 |
Schistosoma mansoni | geranylgeranyl transferase type II beta subunit | 0.0059 | 0.0465 | 0.0465 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0095 | 0.0807 | 0.5889 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0056 | 0.044 | 0.2681 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0103 | 0.0884 | 0.0884 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0141 | 0.1244 | 0.5122 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.044 | 0.044 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0056 | 0.044 | 0.181 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0154 | 0.137 | 0.137 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0056 | 0.044 | 1 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.0048 | 0.0365 | 0.2663 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.0586 | 0.129 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.1061 | 1 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0221 | 0.1548 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0056 | 0.044 | 0.044 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0059 | 0.0465 | 0.3339 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0099 | 0.0099 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0059 | 0.0465 | 0.3393 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0012 | 0.0012 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0031 | 0.0203 | 0.0203 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0069 | 0.0559 | 0.0559 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0056 | 0.044 | 0.321 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0048 | 0.0365 | 0.0802 |
Entamoeba histolytica | Rab geranylgeranyltransferase alpha subunit, putative | 0.0048 | 0.0365 | 0.2122 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0056 | 0.044 | 0.321 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0048 | 0.0365 | 0.2663 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0012 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0465 | 0.0465 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0056 | 0.044 | 0.2817 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0221 | 0.0221 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0012 | 0.0012 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0221 | 0.0221 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0069 | 0.0559 | 0.0559 |
Plasmodium falciparum | geranylgeranyltransferase, putative | 0.0059 | 0.0465 | 0.2878 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.0154 | 0.137 | 0.137 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0012 | 0.0027 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0141 | 0.1244 | 0.1244 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.0048 | 0.0365 | 0.0365 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0099 | 0.0722 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0069 | 0.0559 | 0.1231 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0092 | 0.0782 | 0.3222 |
Brugia malayi | hypothetical protein | 0.0056 | 0.044 | 0.0967 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.0586 | 0.0586 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.0884 | 0.0884 |
Brugia malayi | Peptidase family M1 containing protein | 0.0056 | 0.044 | 0.0967 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0191 | 0.1719 | 1 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0154 | 0.137 | 0.564 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0056 | 0.044 | 0.3155 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0025 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0012 | 0.0012 |
Brugia malayi | Peptidase family M1 containing protein | 0.0056 | 0.044 | 0.0967 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0056 | 0.044 | 0.3155 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0025 | 0.0139 | 0.0139 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0056 | 0.044 | 0.044 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0069 | 0.0559 | 0.0559 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0056 | 0.044 | 0.044 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0048 | 0.0365 | 0.2603 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0056 | 0.044 | 0.3155 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0012 | 0.0012 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0141 | 0.1244 | 0.1244 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0018 | 0.0075 | 0.0435 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0025 | 0.0139 | 0.0306 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0018 | 0.0075 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0011 | 0.0011 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0141 | 0.1244 | 0.7238 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0056 | 0.044 | 0.3155 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0018 | 0.0075 | 0.0075 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0018 | 0.0075 | 0.0469 |
Leishmania major | farnesyltransferase beta subunit | 0.0154 | 0.137 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0018 | 0.0075 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.1244 | 0.1244 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0012 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0059 | 0.0465 | 0.3393 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.044 | 0.044 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0029 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0106 | 0.0106 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0056 | 0.044 | 0.044 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0103 | 0.0884 | 0.0884 |
Trichomonas vaginalis | geranylgeranyl transferase type beta subunit, putative | 0.0154 | 0.137 | 0.564 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0056 | 0.044 | 0.321 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0056 | 0.044 | 0.044 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0056 | 0.044 | 0.044 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0018 | 0.0075 | 0.0165 |
Entamoeba histolytica | Rab geranylgeranyltransferase beta subunit, putative | 0.0059 | 0.0465 | 0.2704 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0103 | 0.0884 | 0.0884 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0012 | 0.0012 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Giardia lamblia | Prenyltransferase | 0.0154 | 0.137 | 1 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0018 | 0.0075 | 0.0469 |
Loa Loa (eye worm) | aminopeptidase N | 0.0056 | 0.044 | 0.044 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0056 | 0.044 | 0.044 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0012 | 0.0012 |
Plasmodium falciparum | geranylgeranyl transferase type-2 subunit alpha, putative | 0.0048 | 0.0365 | 0.2092 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0099 | 0.0099 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0221 | 0.0221 |
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.0048 | 0.0365 | 0.0365 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0056 | 0.044 | 0.2817 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0012 | 0.0027 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0012 | 0.0012 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0048 | 0.0365 | 0.2603 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0012 | 0.0027 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0221 | 0.0221 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0012 | 0.0012 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0048 | 0.0365 | 0.2663 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0011 | 0.0046 |
Trypanosoma brucei | geranylgeranyl transferase type II beta subunit, putative | 0.0059 | 0.0465 | 0.3339 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0056 | 0.044 | 0.044 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0365 | 0.2603 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0018 | 0.0075 | 0.0435 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0069 | 0.0559 | 0.1231 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0012 | 0.0027 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.0075 | 0.0075 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0027 | 0.0159 | 0.0656 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0012 | 0.0027 |
Trichomonas vaginalis | set domain proteins, putative | 0.0265 | 0.2428 | 1 |
Brugia malayi | hypothetical protein | 0.0488 | 0.4545 | 1 |
Brugia malayi | TATA binding protein associated factor | 0.0056 | 0.044 | 0.0967 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0056 | 0.044 | 0.321 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0012 | 0.0012 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0012 | 0.0012 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0099 | 0.0647 |
Onchocerca volvulus | 0.0033 | 0.0221 | 0.0866 | |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0012 | 0.0027 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.0884 | 0.0884 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.0139 | 0.0808 |
Toxoplasma gondii | hypothetical protein | 0.0092 | 0.0782 | 0.5677 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0012 | 0.0012 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0012 | 0.0027 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0056 | 0.044 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0012 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0012 | 0.0012 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0012 | 0.0012 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0154 | 0.137 | 0.3013 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0056 | 0.044 | 0.321 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0056 | 0.044 | 0.044 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0099 | 0.0099 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0012 | 0.0012 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0056 | 0.044 | 0.181 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0154 | 0.137 | 0.564 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0048 | 0.0365 | 0.0365 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0012 | 0.0012 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.044 | 0.044 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0056 | 0.044 | 0.2681 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0012 | 0.0027 |
Plasmodium vivax | geranylgeranyl transferase type2 beta subunit, putative | 0.0059 | 0.0465 | 0.2878 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0012 | 0.0012 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0095 | 0.0807 | 0.5889 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.0586 | 0.129 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.0018 | 0.0075 | 0.0003 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0012 | 0.0012 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.1061 | 1 | 1 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0365 | 0.2239 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0056 | 0.044 | 0.044 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0141 | 0.1244 | 0.9028 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0221 | 0.0221 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0012 | 0.0012 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0056 | 0.044 | 0.3155 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0365 | 0.2663 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.0586 | 0.0586 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0018 | 0.0075 | 0.0165 |
Brugia malayi | hypothetical protein | 0.0056 | 0.044 | 0.0967 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0012 | 0.0012 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1321 | 0.1321 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Plasmodium falciparum | geranylgeranyl transferase type2 beta subunit, putative | 0.0059 | 0.0465 | 0.2878 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0056 | 0.044 | 0.2681 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0191 | 0.1719 | 0.1719 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0099 | 0.0407 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0018 | 0.0075 | 0.0075 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0012 | 0.0027 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0191 | 0.1719 | 0.3781 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.0075 | 0.0075 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.0586 | 0.0586 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0056 | 0.044 | 0.2817 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0465 | 0.0465 |
Echinococcus multilocularis | GPCR, family 2 | 0.0069 | 0.0559 | 0.0559 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0559 | 0.0559 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0018 | 0.0075 | 0.0469 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0069 | 0.0559 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0012 |
Brugia malayi | Probable protein farnesyltransferase beta subunit, putative | 0.0059 | 0.0465 | 0.1022 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.0154 | 0.137 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0056 | 0.044 | 0.044 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Onchocerca volvulus | 0.0048 | 0.0365 | 0.1459 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0221 | 0.0221 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0018 | 0.0075 | 0.0469 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0056 | 0.044 | 0.321 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0141 | 0.1244 | 0.901 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0018 | 0.0075 | 0.0075 |
Brugia malayi | Pre-SET motif family protein | 0.0233 | 0.2122 | 0.4668 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.0056 | 0.044 | 0.044 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0021 | 0.0106 | 0.0773 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0012 | 0.0012 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0056 | 0.044 | 0.321 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0059 | 0.0465 | 0.3011 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0018 | 0.0075 | 0.0075 |
Entamoeba histolytica | aminopeptidase, putative | 0.0056 | 0.044 | 0.2558 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0056 | 0.044 | 0.044 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0012 | 0.0012 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0029 | 0.0177 | 0.0177 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0141 | 0.1244 | 0.901 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0018 | 0.0075 | 0.0469 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0056 | 0.044 | 0.044 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0099 | 0.0722 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0069 | 0.0559 | 0.0559 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0099 | 0.0407 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0141 | 0.1244 | 0.5122 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0095 | 0.0808 | 0.5581 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.0586 | 0.0586 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0154 | 0.137 | 0.564 |
Leishmania major | geranylgeranyltransferase, putative | 0.0059 | 0.0465 | 0.3011 |
Toxoplasma gondii | FATC domain-containing protein | 0.0025 | 0.0139 | 0.0941 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0012 | 0.0012 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.0154 | 0.137 | 0.137 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0048 | 0.0365 | 0.2603 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0103 | 0.0884 | 0.0884 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0221 | 0.0221 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0221 | 0.0964 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0099 | 0.0186 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0191 | 0.1719 | 0.1719 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.0586 | 0.0586 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0056 | 0.044 | 0.2817 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0149 | 0.1321 | 0.2906 |
Trypanosoma brucei | aminopeptidase, putative | 0.0056 | 0.044 | 0.3155 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0.0011 | 0.0046 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0221 | 0.0221 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0012 | 0.0027 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0012 | 0.0012 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0012 | 0.0012 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0141 | 0.1244 | 0.2737 |
Trichomonas vaginalis | protein farnesyltransferase beta subunit, putative | 0.0059 | 0.0465 | 0.1914 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.1321 | 0.1321 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0012 | 0.0027 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0012 | 0.0027 |
Onchocerca volvulus | 0.0265 | 0.2428 | 1 | |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0012 | 0.0012 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0027 | 0.0159 | 0.0656 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0218 | 0.1977 | 0.4349 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0018 | 0.0075 | 0.0546 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0191 | 0.1719 | 0.1719 |
Onchocerca volvulus | 0.0056 | 0.044 | 0.1769 | |
Trypanosoma brucei | lanosterol synthase | 0.0095 | 0.0807 | 0.5855 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0191 | 0.1719 | 0.1719 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.0586 | 0.0586 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0099 | 0.0099 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0218 | 0.1977 | 0.4349 |
Trichomonas vaginalis | type I geranylgeranyltransferase beta subunit, putative | 0.0154 | 0.137 | 0.564 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0559 | 0.0559 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.1061 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0012 | 0.0012 |
Entamoeba histolytica | protein farnesyltransferase beta subunit, putative | 0.0154 | 0.137 | 0.797 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.0154 | 0.137 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0018 | 0.0075 | 0.0546 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0012 | 0.0027 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0012 | 0.0027 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0012 | 0.0012 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0099 | 0.0647 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0154 | 0.137 | 0.564 |
Onchocerca volvulus | 0.0056 | 0.044 | 0.1769 | |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.0154 | 0.137 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0056 | 0.044 | 0.321 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0029 | 0.0177 | 0.039 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0095 | 0.0807 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0099 | 0.0218 |
Trichomonas vaginalis | protein farnesyltransferase beta subunit, putative | 0.0059 | 0.0465 | 0.1914 |
Echinococcus granulosus | aminopeptidase N | 0.0056 | 0.044 | 0.044 |
Plasmodium vivax | protein prenyltransferase alpha subunit, putative | 0.0048 | 0.0365 | 0.2092 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.0586 | 0.0586 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0191 | 0.1719 | 0.7077 |
Brugia malayi | Peptidase family M1 containing protein | 0.0056 | 0.044 | 0.0967 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0012 | 0.0012 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0056 | 0.044 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0139 | 0.0572 |
Brugia malayi | RNA binding protein | 0.0072 | 0.0586 | 0.129 |
Echinococcus multilocularis | Rab geranylgeranyltransferase, beta subunit | 0.0059 | 0.0465 | 0.0465 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0365 | 0.2663 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0048 | 0.0365 | 0.0365 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0012 | 0.0027 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0233 | 0.2122 | 0.2122 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0099 | 0.0186 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1977 | 0.1977 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0559 | 0.0559 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0018 | 0.0075 | 0.0546 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0218 | 0.1977 | 0.1977 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0075 | 0.0308 |
Echinococcus multilocularis | aminopeptidase N | 0.0056 | 0.044 | 0.044 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0048 | 0.0365 | 0.1502 |
Plasmodium vivax | geranylgeranyltransferase, putative | 0.0059 | 0.0465 | 0.2878 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0012 | 0.0027 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.0586 | 0.0586 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0099 | 0.0576 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0012 | 0.0012 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 13.36 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 16.17 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 16.77 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 43 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 58 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 86 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 11.61 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 43 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 58 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 86 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.96 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.09529 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.