Detailed information for compound 599394

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 311.421 | Formula: C19H25N3O
  • H donors: 3 H acceptors: 2 LogP: 3.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1CNC1CCCCC1)c1cnc(c(c1)C)N
  • InChi: 1S/C19H25N3O/c1-13-9-15(11-22-19(13)20)14-7-8-18(23)16(10-14)12-21-17-5-3-2-4-6-17/h7-11,17,21,23H,2-6,12H2,1H3,(H2,20,22)
  • InChiKey: JBGZVCNGAFNORC-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0372 0.065
Schistosoma mansoni hypothetical protein 0.0414 0.246 0.4321
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0247 0.6389
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0168 0.0387
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0372 0.0653
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0036 0.0729
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.005 0.0247 0.0247
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0634 0.38 0.6675
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0168 0.4105
Brugia malayi hypothetical protein 0.0435 0.2585 0.6801
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0168 0.0387
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0026 0.006
Toxoplasma gondii aminopeptidase N protein 0.005 0.0247 0.4957
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0026 0.006
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.0962 0.169
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0026 0.0062
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0008 0.0014
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0945 0.5692 0.5692
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0163 0.0287
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0006 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0026 0.006
Schistosoma mansoni eyes absent homolog 0.0087 0.0471 0.0827
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0168 0.0168
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0002 0.0004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0002 0.0002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0002 0.0004
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0945 0.5692 1
Schistosoma mansoni coup transcription factor 0.001 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0201
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0023 0.0084 0.0084
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0372 0.1264
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0515 0.0515
Schistosoma mansoni hypothetical protein 0.0511 0.3051 0.536
Toxoplasma gondii aminopeptidase n, putative 0.005 0.0247 0.4957
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.1696 1
Mycobacterium ulcerans lipase LipD 0.0071 0.0372 0.2266
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0016 0.0025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0163 0.0287
Loa Loa (eye worm) hypothetical protein 0.0071 0.0372 0.065
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0023 0.0084 0.0194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0219 0.0385
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0247 0.0247
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0071 0.0372 0.065
Entamoeba histolytica aminopeptidase, putative 0.005 0.0247 0.1456
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0168 0.0387
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1696 0.3915
Loa Loa (eye worm) T-complex protein 1 0.0023 0.0084 0.0144
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0036 0.0064
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0372 0.0858
Schistosoma mansoni cpg binding protein 0.0029 0.0118 0.0208
Brugia malayi hypothetical protein 0.0087 0.0471 0.1233
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0116 0.2338
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.005 0.0247 0.0434
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0036 0.0304
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0036 0.0304
Onchocerca volvulus 0.0722 0.4333 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0372 0.065
Echinococcus granulosus GPCR family 2 0.0032 0.0135 0.0237
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0219 0.0572
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1696 0.3915
Schistosoma mansoni thyroid hormone receptor 0.001 0.0002 0.0004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0163 0.0287
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0008 0.0008
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0688 0.1206
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0247 0.6389
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0168 0.0295
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0116 0.0201
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0004
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0372 0.1264
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0168 0.337
Plasmodium falciparum phd finger protein, putative 0.0029 0.0116 0.4717
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0962 0.0962
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0372 0.1264
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.036 0.0941
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0002 0.0004
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0247 0.0247
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0247 0.0434
Giardia lamblia TCP-1 chaperonin subunit beta 0.0023 0.0084 0.0495
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0036 0.0304
Mycobacterium tuberculosis Conserved protein 0.0071 0.0372 0.1264
Schistosoma mansoni aminopeptidase A (M01 family) 0.005 0.0247 0.0434
Schistosoma mansoni hypothetical protein 0.0032 0.0135 0.0237
Plasmodium vivax SET domain protein, putative 0.0092 0.0498 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0041
Trypanosoma brucei aminopeptidase, putative 0.005 0.0247 0.6389
Onchocerca volvulus 0.0097 0.0532 0.1223
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0168 0.099
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.0962 0.2527
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0185 0.0185
Brugia malayi Peptidase family M1 containing protein 0.005 0.0247 0.0644
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1696 0.3915
Echinococcus granulosus peregrin 0.0029 0.0116 0.0205
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0036 0.0036
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0023 0.0084 0.1683
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0168 0.099
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0026 0.0152
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.005 0.0247 0.4957
Schistosoma mansoni alpha-glucosidase 0.0144 0.082 0.144
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.0498 0.0498
Brugia malayi hypothetical protein 0.005 0.0247 0.0644
Loa Loa (eye worm) hypothetical protein 0.0049 0.0242 0.0421
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0168 0.0387
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0036 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1696 0.3915
Mycobacterium ulcerans hypothetical protein 0.0071 0.0372 0.2266
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0168 0.0387
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.005 0.0247 0.6389
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.2692 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1696 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0002 0.0002
Trichomonas vaginalis chaperonin, putative 0.0023 0.0084 0.0194
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0297 0.5957
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0023 0.0084 0.1683
Loa Loa (eye worm) hypothetical protein 0.0087 0.0471 0.0823
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0553 0.1451
Brugia malayi PHD-finger family protein 0.0029 0.0116 0.0301
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0036 0.147
Giardia lamblia PHD finger protein 15 0.0029 0.0116 0.0687
Brugia malayi Peptidase family M1 containing protein 0.005 0.0247 0.0644
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0118 0.0204
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0247 0.6389
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0553 0.1451
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.0498 0.0875
Echinococcus granulosus dnaJ subfamily B 0.0414 0.246 0.4321
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0372 0.0858
Schistosoma mansoni cpg binding protein 0.0031 0.0128 0.0225
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0036 0.0729
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0962 0.0962
Schistosoma mansoni cpg binding protein 0.0031 0.0128 0.0225
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0168 0.4105
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0303 0.0528
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0219 0.0385
Schistosoma mansoni hypothetical protein 0.0069 0.036 0.0632
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1696 0.3915
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.005 0.0247 0.4957
Onchocerca volvulus 0.0071 0.0372 0.0854
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0002 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0372 0.0858
Trypanosoma cruzi aminopeptidase, putative 0.005 0.0247 0.6389
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0002 0.0004
Leishmania major T-complex protein 1, beta subunit, putative 0.0023 0.0084 0.1683
Brugia malayi Peptidase family M1 containing protein 0.005 0.0247 0.0644
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0026 0.006
Trypanosoma cruzi aminopeptidase, putative 0.005 0.0247 0.6389
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0084 0.0148
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0006 0.001
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.005 0.0247 0.6389
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0116 0.2338
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0135 0.0135
Echinococcus multilocularis GPCR, family 2 0.0032 0.0135 0.0135
Trichomonas vaginalis set domain proteins, putative 0.0722 0.4333 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0016 0.0029
Brugia malayi beta-lactamase 0.0071 0.0372 0.0974
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0372 0.0653
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0247 0.0247
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0168 0.0387
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0372 0.0653
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0219 0.0219
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0135 0.035
Trypanosoma brucei glucosidase, putative 0.0037 0.0168 0.4105
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0247 0.0434
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0219 0.0382
Trichomonas vaginalis esterase, putative 0.0071 0.0372 0.0858
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0372 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0372 0.0974
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0002 0.0004
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0023 0.0084 0.0148
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0168 0.0387
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0153 0.0153
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0372 0.1264
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0023 0.0084 0.0495
Loa Loa (eye worm) TATA binding protein associated factor 0.005 0.0247 0.043
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0135 0.0135
Brugia malayi Pre-SET motif family protein 0.0634 0.38 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0168 0.0387
Loa Loa (eye worm) peptidase family M1 containing protein 0.005 0.0247 0.043
Echinococcus multilocularis peregrin 0.0029 0.0116 0.0116
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0023 0.0084 0.1687
Mycobacterium ulcerans beta-lactamase 0.0071 0.0372 0.2266
Echinococcus multilocularis cpg binding protein 0.0031 0.0128 0.0128
Echinococcus granulosus cpg binding protein 0.0031 0.0128 0.0225
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0026 0.006
Loa Loa (eye worm) hypothetical protein 0.0071 0.0372 0.065
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0372 0.1264
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.005 0.0247 0.057
Onchocerca volvulus 0.005 0.0247 0.0565
Trypanosoma brucei Aminopeptidase M1, putative 0.005 0.0247 0.6389
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0372 0.0858
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0016 0.0016
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0002 0.0004
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0036 0.0729
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0219 0.0385
Toxoplasma gondii t-complex protein beta subunit 0.0023 0.0084 0.1687
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0247 0.0434
Loa Loa (eye worm) hypothetical protein 0.0087 0.0471 0.0823
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.005 0.0247 0.057
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0945 0.5692 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0372 0.065
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0036 0.0304
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0101 0.0553 0.0969
Loa Loa (eye worm) hypothetical protein 0.0092 0.0498 0.0872
Trypanosoma cruzi Aminopeptidase M1, putative 0.005 0.0247 0.6389
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0084 0.0148
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0372 0.2266
Brugia malayi Pre-SET motif family protein 0.0092 0.0498 0.1306
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0063 0.0111
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0036 0.0036
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0002 0.0004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0002 0.0004
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0084 0.0148
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0002 0.0004
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.005 0.0247 0.6389
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0168 0.0291
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0337 0.0592
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.0498 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0002 0.0004
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0247 0.0247
Echinococcus granulosus leukotriene A 4 hydrolase 0.0945 0.5692 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0247 0.6389
Onchocerca volvulus 0.0092 0.0498 0.1145
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0247 0.0247
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0002 0.0004
Mycobacterium tuberculosis Conserved protein 0.0071 0.0372 0.1264
Onchocerca volvulus Alhambra homolog 0.0029 0.0116 0.0264
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0799 1
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0397 0.0697
Trypanosoma brucei Aminopeptidase M1, putative 0.005 0.0247 0.6389
Onchocerca volvulus 0.0029 0.0118 0.0268
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.005 0.0247 0.057
Mycobacterium tuberculosis Conserved protein 0.0071 0.0372 0.1264
Onchocerca volvulus 0.0071 0.0372 0.0854
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.005 0.0247 1
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0073 0.0186
Onchocerca volvulus 0.005 0.0247 0.0565
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0372 0.0372
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0219 0.0385
Brugia malayi Bromodomain containing protein 0.0029 0.0116 0.0301
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0036 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0498 0.0875
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0515 0.0904
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0163 0.0283
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0372 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0002 0.0002
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0084 0.0216
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0219 0.0385
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0032 0.0135 0.0237
Loa Loa (eye worm) hypothetical protein 0.0032 0.0135 0.0233
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.1696 0.5
Loa Loa (eye worm) beta-lactamase 0.0071 0.0372 0.065
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0116 0.0205
Loa Loa (eye worm) hypothetical protein 0.005 0.0247 0.043
Brugia malayi jmjC domain containing protein 0.0036 0.0163 0.0424
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.005 0.0247 0.6389
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0084 0.0216
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0498 0.0875
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0168 0.0387
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0799 0.2871
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0092 0.0498 0.0875
Echinococcus granulosus aminopeptidase N 0.005 0.0247 0.0434
Loa Loa (eye worm) hypothetical protein 0.005 0.0247 0.043
Brugia malayi MH2 domain containing protein 0.0123 0.0688 0.1806
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0474 0.0833
Onchocerca volvulus 0.005 0.0247 0.0565
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0372 0.0858
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0799 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0247 0.0434
Schistosoma mansoni hypothetical protein 0.0029 0.0116 0.0205
Echinococcus granulosus geminin 0.0511 0.3051 0.536
Plasmodium falciparum M1-family alanyl aminopeptidase 0.005 0.0247 1
Brugia malayi PHD-finger family protein 0.0011 0.0009 0.0017
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.005 0.0247 0.6389
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1696 1
Brugia malayi beta-lactamase family protein 0.0071 0.0372 0.0974
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0135 0.0237
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0036 0.0036
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.0498 0.0498
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0009 0.0382
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0002 0.0004
Schistosoma mansoni alpha-glucosidase 0.0144 0.082 0.144
Brugia malayi jmjC domain containing protein 0.0094 0.0515 0.135
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0372 0.1264
Echinococcus granulosus FTZ F1 alpha 0.001 0.0002 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0032 0.0135 0.0237
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0026 0.006
Onchocerca volvulus 0.0071 0.0372 0.0854
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0036 0.009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0002 0.0004
Loa Loa (eye worm) aminopeptidase N 0.005 0.0247 0.043
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.005 0.0247 0.0434
Echinococcus multilocularis geminin 0.0511 0.3051 0.3051
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0026 0.0054
Schistosoma mansoni alpha glucosidase 0.0037 0.0168 0.0295
Echinococcus granulosus jumonji domain containing protein 0.004 0.0185 0.0325
Brugia malayi CXXC zinc finger family protein 0.0029 0.0118 0.0306
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0168 0.4105
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0247 0.0434
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1696 0.3915
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0168 0.0436
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0026 0.006
Leishmania major hypothetical protein, conserved 0.0071 0.0372 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0036 0.006
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.005 0.0247 0.0434
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0135 0.035
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0372 0.2266
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0372 1
Schistosoma mansoni hypothetical protein 0.0032 0.0135 0.0237
Loa Loa (eye worm) hypothetical protein 0.0071 0.0372 0.065
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.005 0.0247 0.6389
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1696 0.3915
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0006 0.0006
Brugia malayi isocitrate dehydrogenase 0.0016 0.0036 0.009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1696 0.3915
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0116 0.0116
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0688 0.1206
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0002 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0009 0.0189
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0219 0.0219
Schistosoma mansoni thyroid hormone receptor 0.001 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0069 0.036 0.0628
Toxoplasma gondii aminopeptidase N, putative 0.005 0.0247 0.4957
Brugia malayi beta-lactamase family protein 0.0071 0.0372 0.0974
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.246 0.246
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.0962 0.1687
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0511 0.3051 0.536
Echinococcus multilocularis aminopeptidase N 0.005 0.0247 0.0247
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0026 0.006
Plasmodium falciparum T-complex protein 1 subunit beta 0.0023 0.0084 0.3403
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0247 0.0434
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0498 0.0875
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0135 0.0233
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0036 0.0304
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0372 0.1264
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0116 0.2338
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0116 0.0205
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0135 0.0237
Loa Loa (eye worm) hypothetical protein 0.005 0.0247 0.043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0553 0.0969
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0006 0.0006
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0002 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0372 0.7465
Brugia malayi TATA binding protein associated factor 0.005 0.0247 0.0644
Brugia malayi hypothetical protein 0.005 0.0247 0.0644
Toxoplasma gondii ABC1 family protein 0.0071 0.0372 0.7465

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 0.43 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0.95 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 10.33 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 27 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 100 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 100 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 3.33 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -4 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 27 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 100 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 102 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.69 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.20287 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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