Detailed information for compound 599643

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 393.399 | Formula: C21H22F3NO3
  • H donors: 1 H acceptors: 2 LogP: 4.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)O)CN1CCCC(C1)C(=O)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C21H22F3NO3/c1-28-18-9-6-15(19(26)11-18)12-25-10-2-3-16(13-25)20(27)14-4-7-17(8-5-14)21(22,23)24/h4-9,11,16,26H,2-3,10,12-13H2,1H3
  • InChiKey: FNGPGEHLNKUIHA-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania mexicana glucose transporter, lmgt2 Starlite/ChEMBL No references
Plasmodium falciparum hexose transporter Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 7 Starlite/ChEMBL No references
Plasmodium falciparum lysine--tRNA ligase Starlite/ChEMBL No references
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Starlite/ChEMBL No references
Plasmodium falciparum calcium-dependent protein kinase 1 Starlite/ChEMBL No references
Plasmodium falciparum mitogen-activated protein kinase 2 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Proline--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 6 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Leishmania braziliensis prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter 2A Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Giardia lamblia Lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Babesia bovis mitogen-activated protein kinase, putative Get druggable targets OG5_138034 All targets in OG5_138034
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Get druggable targets OG5_138034 All targets in OG5_138034
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania braziliensis lmgt2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma cruzi hexose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Neospora caninum Glucose transporter 1A, related Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Leishmania major lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii Ser/Thr protein kinase Get druggable targets OG5_145294 All targets in OG5_145294
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Giardia lamblia Prolyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania braziliensis glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 3, putative Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum IPR005828,General substrate transporter,domain-containing Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum ko:K01881 prolyl-tRNA synthetase [EC6.1.1.15], putative Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei gambiense glucose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis Kars protein Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium vivax lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium yoelii lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Theileria parva mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Cryptosporidium parvum proline-tRNA synthetase; class II aaRS (ybak RNA binding domain plus tRNA synthetase) Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium leprae Probable prolyl tRNA synthetase ProS Get druggable targets OG5_127154 All targets in OG5_127154
Babesia bovis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii cdk-related protein kinase 6-related Get druggable targets OG5_155179 All targets in OG5_155179
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi protein kinase 7, putative Get druggable targets OG5_145294 All targets in OG5_145294
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi hexose transporter, putative Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania donovani glucose transporter 3, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Babesia bovis lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum expressed protein Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trichomonas vaginalis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Brugia malayi lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum CMGC kinase, MAPK family, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium berghei proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei gambiense glucose transporter,glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 4, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii facilitative glucose transporter GT1 Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04567 lysyl-tRNA synthetase, class II, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania major glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii putative sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania mexicana glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Leishmania infantum glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Chlamydia trachomatis lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei glucose transporter 1E Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum IPR000924,Glutamyl-tRNA synthetase, class Ic;IPR001412,Aminoacyl-tRNA synthetase, class I,domain-containing Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum protein kinase, PfPK7 homolog, putative Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium knowlesi proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum lysyl-tRNA synthetase (NOB+tRNA synthetase) Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Cryptosporidium hominis aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Sugar transporter family protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium vivax proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii lysine-tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 1, putative Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium knowlesi mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2, facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania donovani glucose transporter 1 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium falciparum mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Loa Loa (eye worm) sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei glucose transporter, putative solute carrier family 2 (facilitated glucose transporter), member 1 492 aa 395 aa 23.5 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands Calcium-dependent protein kinase 4   528 aa 501 aa 28.9 %
Cryptosporidium hominis calmodulin-domain protein kinase 2 Calcium-dependent protein kinase 4   528 aa 468 aa 36.1 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 28.8 %
Entamoeba histolytica protein kinase, putative Calcium-dependent protein kinase 4   528 aa 429 aa 26.3 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 29.0 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Calcium-dependent protein kinase 4   528 aa 468 aa 35.9 %
Babesia bovis mitogen-activated protein kinase, putative Calcium-dependent protein kinase 4   528 aa 427 aa 23.4 %
Cryptosporidium parvum hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Theileria parva calmodulin-domain protein kinase, putative Calcium-dependent protein kinase 4   528 aa 454 aa 31.9 %
Leishmania braziliensis protein kinase, putative Calcium-dependent protein kinase 4   528 aa 490 aa 27.3 %
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Leishmania mexicana protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.2 %
Leishmania donovani protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Theileria parva protein kinase, putative Calcium-dependent protein kinase 4   528 aa 507 aa 27.4 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 527 aa 25.6 %
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase 7 343 aa 310 aa 25.2 %
Babesia bovis calcium-dependent protein kinase, putative Calcium-dependent protein kinase 4   528 aa 450 aa 30.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 517 aa 27.9 %
Toxoplasma gondii calcium-dependent protein kinase CDPK2 Calcium-dependent protein kinase 4   528 aa 480 aa 36.9 %
Neospora caninum CAM kinase, CDPK family, putative Calcium-dependent protein kinase 4   528 aa 463 aa 32.0 %
Toxoplasma gondii calcium-dependent protein kinase CDPK9 Calcium-dependent protein kinase 4   528 aa 500 aa 34.2 %
Giardia lamblia Kinase, NEK Calcium-dependent protein kinase 4   528 aa 509 aa 19.8 %
Neospora caninum Calcium-dependent protein kinase, related Calcium-dependent protein kinase 4   528 aa 516 aa 35.5 %
Trypanosoma brucei protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma brucei glucose transporter, putative hexose transporter 504 aa 426 aa 22.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 protein kinase 6 305 aa 338 aa 27.2 %
Cryptosporidium hominis hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Toxoplasma gondii calcium-dependent protein kinase CDPK6 Calcium-dependent protein kinase 4   528 aa 453 aa 34.0 %
Leishmania major protein kinase, putative Calcium-dependent protein kinase 4   528 aa 488 aa 27.5 %
Cryptosporidium hominis calcium-dependent protein kinase Calcium-dependent protein kinase 4   528 aa 502 aa 29.7 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 509 aa 25.5 %
Trypanosoma brucei gambiense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 522 aa 25.5 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 499 aa 29.3 %
Leishmania infantum protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Matrixin family protein 0.0042 0.012 0.0261
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0105 0.0105
Trypanosoma brucei glucose transporter, putative 0.0039 0.0109 0.1707
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Loa Loa (eye worm) hypothetical protein 0.0155 0.0507 0.0507
Trypanosoma brucei Aminopeptidase M1, putative 0.0155 0.0507 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0107 0.0507
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0107 0.0107
Toxoplasma gondii aminopeptidase N, putative 0.0155 0.0507 0.4141
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0155 0.0507 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.0409 0.0409
Brugia malayi nuclear hormone receptor family member nhr-6 0.0008 0.0003 0.0006
Brugia malayi Matrixin family protein 0.0017 0.0034 0.0075
Echinococcus granulosus histone deacetylase 8 0.0015 0.0027 0.0027
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0012 0.0016 0.0016
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0155 0.0507 1
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0034 0.0034
Loa Loa (eye worm) histone deacetylase 1 0.0054 0.0159 0.0159
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0394
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.0507 0.0507
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0012 0.0016 0.0016
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0034 0.0034
Onchocerca volvulus 0.0018 0.0035 0.0649
Brugia malayi Peptidase family M1 containing protein 0.0155 0.0507 0.1106
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0155 0.0507 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0034 0.0075
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.0409 0.0409
Loa Loa (eye worm) nuclear receptor NHR-67 0.0008 0.0003 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Schistosoma mansoni enhancer of zeste ezh 0.0061 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Brugia malayi major facilitator superfamily protein 0.0018 0.0035 0.0077
Trichomonas vaginalis histone deacetylase, putative 0.0054 0.0159 0.2921
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0109 0.1894
Brugia malayi Histone deacetylase family protein 0.0015 0.0027 0.0059
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0348 0.1172 0.1172
Onchocerca volvulus 0.0018 0.0035 0.0649
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0034 0.0075
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0071 0.416
Brugia malayi Eukaryotic aspartyl protease family protein 0.0012 0.0016 0.0035
Schistosoma mansoni nuclear receptor 0.0008 0.0003 0.0003
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.0003 0.0003
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0107 0.0507
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0034 0.0034
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0034 0.0075
Plasmodium vivax hexose transporter 0.0126 0.0409 0.2179
Brugia malayi hypothetical protein 0.0018 0.0035 0.0077
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.0507 0.0507
Echinococcus multilocularis solute carrier family 22 0.0018 0.0035 0.0035
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0035 0.0172
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0035 0.0077
Toxoplasma gondii aminopeptidase n, putative 0.0155 0.0507 0.4141
Brugia malayi Nuclear hormone receptor E75 0.0008 0.0003 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0109 0.1894
Loa Loa (eye worm) hypothetical protein 0.0054 0.0159 0.0159
Onchocerca volvulus 0.0018 0.0035 0.0649
Schistosoma mansoni memapsin-2 (A01 family) 0.0302 0.1013 0.1013
Loa Loa (eye worm) matrixin family protein 0.0042 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0006 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0034 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0047
Onchocerca volvulus 0.0018 0.0035 0.0649
Brugia malayi Sugar transporter family protein 0.0018 0.0035 0.0077
Echinococcus granulosus histone deacetylase 7 0.0015 0.0027 0.0027
Schistosoma mansoni sugar transporter 0.0018 0.0035 0.0035
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0006 0.0006
Schistosoma mansoni histone deacetylase 0.0054 0.0159 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0034 0.0075
Loa Loa (eye worm) hypothetical protein 0.0155 0.0507 0.0507
Echinococcus granulosus thyroid hormone receptor alpha 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Toxoplasma gondii sugar transporter ST3 0.0018 0.0035 0.0163
Schistosoma mansoni glucose transport protein 0.0126 0.0409 0.0409
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0006 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0107 0.186
Brugia malayi steroid hormone receptor 0.0017 0.0034 0.0075
Brugia malayi Matrixin family protein 0.0017 0.0034 0.0075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0034 0.0034
Brugia malayi ecdysteroid receptor 0.0017 0.0034 0.0075
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0071 0.0071
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0107 0.0234
Brugia malayi ecdysone receptor 0.0008 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.0409 0.0409
Brugia malayi Matrixin family protein 0.0017 0.0034 0.0075
Loa Loa (eye worm) histone deacetylase 11 0.0015 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0071 0.0071
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0071 0.092
Onchocerca volvulus 0.0018 0.0035 0.0649
Toxoplasma gondii histone deacetylase HDAC3 0.0054 0.0159 0.121
Echinococcus multilocularis histone deacetylase 1 0.0054 0.0159 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0034 0.0034
Onchocerca volvulus 0.0018 0.0035 0.0649
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0109 0.1707
Onchocerca volvulus 0.0018 0.0035 0.0649
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0107
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0126 0.093
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0012 0.0016 0.0016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0034 0.0034
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0155 0.0507 0.0507
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0155 0.0507 0.0507
Schistosoma mansoni protein kinase 0.0039 0.0107 0.0107
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0021 0.0047 0.0104
Brugia malayi nuclear receptor RXR 0.0009 0.0006 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0034 0.0075
Toxoplasma gondii histone deacetylase HDAC2 0.0054 0.0159 0.121
Schistosoma mansoni glucose transporter 0.0018 0.0035 0.0035
Trypanosoma cruzi Aminopeptidase M1, putative 0.0155 0.0507 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Onchocerca volvulus 0.0018 0.0035 0.0649
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0034 0.0629
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0034 0.0034
Trypanosoma cruzi aminopeptidase, putative 0.0155 0.0507 1
Toxoplasma gondii sugar transporter ST2 0.0018 0.0035 0.0163
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0034 0.0034
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0126 0.2065
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) TATA binding protein associated factor 0.0155 0.0507 0.0507
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0126 0.2065
Loa Loa (eye worm) nuclear hormone receptor 0.0008 0.0003 0.0003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0012 0.0016 0.0016
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0008 0.0003 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0034 0.0034
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0155 0.0507 1
Schistosoma mansoni nuclear receptor nhr-48 0.0008 0.0003 0.0003
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0063 0.0193 0.0193
Echinococcus granulosus General substrate transporter 0.0108 0.0348 0.0348
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0035 0.0107
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0006 0.0013
Leishmania major glucose transporter, lmgt3 0.0039 0.0109 0.1707
Leishmania major histone deacetylase, putative 0.0054 0.0159 0.2758
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.0409 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0034 0.0075
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0155 0.0507 1
Brugia malayi hypothetical protein 0.0155 0.0507 0.1106
Brugia malayi Nuclear hormone receptor E75 0.0008 0.0003 0.0006
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0105 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.0409 0.3312
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0021 0.0047 0.5696
Leishmania major glucose transporter, lmgt2 0.0039 0.0109 0.1707
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0034 0.0034
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0071 0.092
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0008 0.0003 0.0003
Trypanosoma cruzi aminopeptidase, putative 0.0155 0.0507 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0057 0.1602
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Plasmodium falciparum hexose transporter 0.0126 0.0409 0.2179
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.0507 0.0507
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0105
Echinococcus multilocularis aminopeptidase N 0.0155 0.0507 0.0507
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0109 0.1707
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0107 0.0107
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0026 0.0063 0.0063
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0155 0.0507 1
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0035 0.0394
Trypanosoma brucei glucose transporter, putative 0.0039 0.0109 0.1707
Mycobacterium ulcerans aminopeptidase N PepN 0.0155 0.0507 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0155 0.0507 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0107 0.0107
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0109 0.1707
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0034 0.0075
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0155 0.0507 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0035 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0034 0.0034
Echinococcus multilocularis histone deacetylase 3 0.0054 0.0159 0.0159
Mycobacterium ulcerans aminopeptidase N PepN 0.0155 0.0507 1
Onchocerca volvulus 0.0025 0.0059 0.1128
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Trypanosoma brucei glucose transporter, putative 0.0039 0.0109 0.1707
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0034 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0003 0.0003
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0035 0.0035
Echinococcus granulosus solute carrier family 22 0.0018 0.0035 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0126 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.0507 0.0507
Loa Loa (eye worm) histone deacetylase 7A 0.0015 0.0027 0.0027
Schistosoma mansoni histone deacetylase hda2 0.0015 0.0027 0.0027
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0071 0.0307
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0107 0.0107
Leishmania major glucose transporter, lmgt1 0.0039 0.0109 0.1707
Giardia lamblia Histone deacetylase 0.0054 0.0159 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.0507 0.0507
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0107 0.0507
Mycobacterium ulcerans sugar transporter 0.0018 0.0035 0.0309
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0003 0.0003
Entamoeba histolytica aminopeptidase, putative 0.0155 0.0507 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0107 0.0107
Brugia malayi major facilitator superfamily protein 0.0018 0.0035 0.0077
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0034 0.0034
Entamoeba histolytica protein kinase, putative 0.0039 0.0107 0.0828
Toxoplasma gondii histone deacetylase HDAC5 0.0015 0.0027 0.0094
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Brugia malayi Sugar transporter family protein 0.0018 0.0035 0.0077
Brugia malayi Hemopexin family protein 0.0025 0.0059 0.013
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0099 0.0099
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Trypanosoma brucei sugar transporter, putative 0.0018 0.0035 0.0172
Plasmodium falciparum histone deacetylase 1 0.0054 0.0159 0.0796
Loa Loa (eye worm) sugar transporter 0.0126 0.0409 0.0409
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0028 0.0028
Brugia malayi conserved hypotetical protein 0.0008 0.0003 0.0006
Brugia malayi orphan nuclear receptor NR2E1 0.0008 0.0003 0.0006
Brugia malayi aspartic protease BmAsp-1, identical 0.0012 0.0016 0.0035
Trichomonas vaginalis histone deacetylase, putative 0.0054 0.0159 0.2921
Loa Loa (eye worm) aspartyl protease 6 0.0012 0.0016 0.0016
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0061 0.0185 0.0185
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0155 0.0507 0.2724
Loa Loa (eye worm) histone deacetylase 3 0.0054 0.0159 0.0159
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0105 0.5582
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0155 0.0507 1
Echinococcus granulosus aminopeptidase N 0.0155 0.0507 0.0507
Toxoplasma gondii sugar transporter ST1 0.0018 0.0035 0.0163
Brugia malayi nuclear receptor NHR-88 0.0017 0.0034 0.0075
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0126 0.0612
Onchocerca volvulus 0.0017 0.0034 0.0629
Echinococcus multilocularis histone deacetylase 7 0.0015 0.0027 0.0027
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0035 0.0035
Leishmania major hypothetical protein, conserved 0.0018 0.0035 0.0172
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Loa Loa (eye worm) leukotriene A4 hydrolase 0.2913 1 1
Plasmodium vivax histone deacetylase, putative 0.0015 0.0027 0.0062
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Trypanosoma brucei Aminopeptidase M1, putative 0.0155 0.0507 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0008 0.0003 0.0006
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0035 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0394
Echinococcus multilocularis nuclear receptor nhr 48 0.0008 0.0003 0.0003
Brugia malayi hypothetical protein 0.0155 0.0507 0.1106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0034 0.0075
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0109 0.1707
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0034 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0034 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Schistosoma mansoni histone deacetylase 1 2 3 0.0015 0.0027 0.0027
Brugia malayi hypothetical protein 0.0009 0.0006 0.0013
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0105 0.0228
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0155 0.0507 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Plasmodium vivax sugar transporter, putative 0.0018 0.0035 0.0107
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0155 0.0507 0.2724
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0008 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0109 0.1894
Schistosoma mansoni histone deacetylase 4 5 0.0015 0.0027 0.0027
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0034 0.0034
Brugia malayi Peptidase family M1 containing protein 0.0155 0.0507 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Onchocerca volvulus 0.0012 0.0016 0.0265
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.0003 0.0003
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0026 0.0063 0.0063
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.0507 0.0507
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0071 0.0466
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Trichomonas vaginalis histone deacetylase, putative 0.0054 0.0159 0.2921
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0003 0.0003
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0105 0.0766
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0012 0.0016 0.0016
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0155 0.0507 0.2724
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0034 0.0034
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0012 0.0016 0.0016
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0034 0.0034
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0107 0.0771
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0071 0.0071
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0034 0.0034
Toxoplasma gondii histone deacetylase HDAC4 0.0015 0.0027 0.0094
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0063 0.0193 0.0193
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.0057 0.084
Brugia malayi Peptidase family M1 containing protein 0.0155 0.0507 0.1106
Trichomonas vaginalis histone deacetylase, putative 0.0054 0.0159 0.2921
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Brugia malayi hypothetical protein 0.0012 0.0016 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0109 0.1894
Trypanosoma brucei aminopeptidase, putative 0.0155 0.0507 1
Loa Loa (eye worm) DR-78 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Brugia malayi histone deacetylase 3 (HD3) 0.0054 0.0159 0.0348
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0035 0.0172
Toxoplasma gondii aminopeptidase N protein 0.0155 0.0507 0.4141
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0012 0.0016 0.0016
Trichomonas vaginalis histone deacetylase, putative 0.0054 0.0159 0.2921
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0026 0.0063 0.0138
Loa Loa (eye worm) matrixin family protein 0.0039 0.0108 0.0108
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.0676 0.5569
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0035 0.0077
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.002 0.5
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0126 0.0612
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Loa Loa (eye worm) matrix metalloproteinase 0.0017 0.0034 0.0034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Brugia malayi hypothetical protein 0.0018 0.0035 0.0077
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0105 0.1805
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0394
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0008 0.0003 0.0003
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0035 0.0163
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0035 0.0172
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0107 0.0107
Brugia malayi Cam kinase protein 1 0.0039 0.0107 0.0234
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0105 0.0228
Trypanosoma cruzi histone deacetylase 1, putative 0.0054 0.0159 0.2758
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0034 0.0629
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0155 0.0507 0.0507
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0107 0.0107
Onchocerca volvulus 0.0018 0.0035 0.0649
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0034 0.0034
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0071 0.2892
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0034 0.0034
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.0003 0.0003
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0071 0.1125
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0034 0.0629
Onchocerca volvulus 0.0018 0.0035 0.0649
Plasmodium vivax histone deacetylase 1, putative 0.0054 0.0159 0.0796
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.0003 0.0003
Echinococcus multilocularis histone deacetylase 6 0.0015 0.0027 0.0027
Schistosoma mansoni protein kinase 0.0039 0.0107 0.0107
Brugia malayi aspartic protease BmAsp-2, identical 0.0012 0.0016 0.0035
Onchocerca volvulus Histone deacetylase 10 homolog 0.0015 0.0027 0.0485
Brugia malayi TATA binding protein associated factor 0.0155 0.0507 0.1106
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0057 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Echinococcus multilocularis solute carrier family 22 0.0018 0.0035 0.0035
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0109 0.1707
Entamoeba histolytica histone deacetylase, putative 0.0054 0.0159 0.2024
Onchocerca volvulus 0.0018 0.0035 0.0649
Onchocerca volvulus 0.0155 0.0507 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Leishmania major histone deacetylase, putative 0.0054 0.0159 0.2758
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0071 0.092
Loa Loa (eye worm) aminopeptidase N 0.0155 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0034 0.0034
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.0057 0.084
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0026 0.0063 0.0063
Brugia malayi nuclear receptor RXR 0.0008 0.0003 0.0006
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Trypanosoma cruzi histone deacetylase 1, putative 0.0054 0.0159 0.2758
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0035 0.0035
Brugia malayi tailless protein 0.0008 0.0003 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0394
Brugia malayi nuclear hormone receptor family member odr-7 0.0008 0.0003 0.0006
Schistosoma mansoni protein kinase 0.0039 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Trypanosoma brucei histone deacetylase 1 0.0054 0.0159 0.2758
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0051
Schistosoma mansoni nuclear receptor 0.0008 0.0003 0.0003
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0054 0.0159 0.2921
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0034 0.0034
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0034 0.0034
Plasmodium falciparum protein kinase 7 0.0357 0.1202 0.6579
Echinococcus granulosus histone deacetylase 1 0.0054 0.0159 0.0159
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0071 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0008 0.0003 0.0003
Echinococcus multilocularis General substrate transporter 0.0108 0.0348 0.0348
Echinococcus granulosus histone deacetylase 3 0.0054 0.0159 0.0159
Trypanosoma brucei glucose transporter, putative 0.0039 0.0109 0.1707
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0034 0.0034
Schistosoma mansoni glucose transport protein 0.0126 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0035 0.0035
Onchocerca volvulus 0.0018 0.0035 0.0649
Brugia malayi Pepsin A precursor 0.0012 0.0016 0.0035
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0155 0.0507 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.2913 1 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0054 0.0159 0.2921
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Brugia malayi hypothetical protein 0.0012 0.0016 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) sugar transporter 0.0018 0.0035 0.0035
Echinococcus multilocularis histone deacetylase 6 0.0015 0.0027 0.0027
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0017 0.0034 0.0034
Echinococcus granulosus solute carrier family 22 0.0018 0.0035 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0034 0.0034
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0035 0.0394
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0107 0.0107
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0107 0.0771
Brugia malayi Histone deacetylase 1 0.0054 0.0159 0.0348
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Onchocerca volvulus 0.0018 0.0035 0.0649
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0034 0.0034
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.2913 1 1
Trypanosoma brucei glucose transporter 1E 0.0039 0.0109 0.1707
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0034 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0035 0.0035
Brugia malayi SET domain containing protein 0.0061 0.0185 0.0404
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0057 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0034 0.0034
Loa Loa (eye worm) peptidase family M1 containing protein 0.0155 0.0507 0.0507
Onchocerca volvulus 0.0017 0.0034 0.063
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0034 0.0075
Trypanosoma brucei glucose transporter, putative 0.0039 0.0109 0.1707
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0059 0.0882
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0107 0.0507
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0034 0.0034
Trypanosoma brucei glucose transporter, putative 0.0039 0.0109 0.1707
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0025 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0012 0.0016 0.0016
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0035 0.0394
Schistosoma mansoni sugar transporter 0.0018 0.0035 0.0035
Echinococcus granulosus histone deacetylase 6 0.0015 0.0027 0.0027
Plasmodium vivax histone deacetylase, putative 0.0015 0.0027 0.0062
Loa Loa (eye worm) histone deacetylase 0.0015 0.0027 0.0027
Echinococcus granulosus solute carrier family 22 0.0018 0.0035 0.0035
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0035 0.0172
Echinococcus multilocularis histone deacetylase 6 0.0015 0.0027 0.0027
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0012 0.0016 0.0016
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0071 0.0307
Brugia malayi hypothetical protein 0.0009 0.0006 0.0013
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0034 0.0034
Onchocerca volvulus 0.0155 0.0507 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0034 0.0075
Trypanosoma brucei glucose transporter 2A 0.0039 0.0109 0.1707
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0071 0.0071
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Trypanosoma brucei glucose transporter, putative 0.0039 0.0109 0.1707
Echinococcus granulosus nuclear receptor nhr 48 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0105 0.0105
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0035 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0034 0.0075
Onchocerca volvulus Putative transporter 0.0018 0.0035 0.0649
Schistosoma mansoni cathepsin D (A01 family) 0.0012 0.0016 0.0016
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0034 0.0034
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0107 0.0107
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0109 0.1707
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0155 0.0507 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0409 0.7998
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.0676 0.3664
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0034 0.0034
Echinococcus granulosus solute carrier family 22 0.0018 0.0035 0.0035
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0155 0.0507 1
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0048 0.0434
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0071 0.0071
Brugia malayi nuclear hormone receptor 0.0017 0.0034 0.0075
Loa Loa (eye worm) hypothetical protein 0.0028 0.0071 0.0071
Brugia malayi hypothetical protein 0.0008 0.0003 0.0006
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0107 0.0507
Loa Loa (eye worm) hypothetical protein 0.0155 0.0507 0.0507
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0155 0.0507 0.2724
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.0507 0.0507
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0012 0.0016 0.0016
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0071 0.0155
Echinococcus multilocularis histone deacetylase 8 0.0015 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Trichomonas vaginalis histone deacetylase, putative 0.0054 0.0159 0.2921
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0012 0.0016 0.0016
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.0409 0.0409
Brugia malayi histone deacetylase 11 0.0015 0.0027 0.0059
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0012 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0035 0.5
Brugia malayi hypothetical protein 0.0018 0.0035 0.0077
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0109 0.1894
Brugia malayi nuclear receptor NHR-88 0.0008 0.0003 0.0006
Mycobacterium ulcerans hydrolase 0.0021 0.0047 0.0558
Brugia malayi nuclear receptor NHR-67 0.0008 0.0003 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0109 0.1894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0071 0.1047
Plasmodium falciparum protein kinase 6 0.0536 0.1818 1
Toxoplasma gondii histone deacetylase HDAC1 0.0015 0.0027 0.0094
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0035 0.0077
Schistosoma mansoni histone deacetylase 0.0054 0.0159 0.0159
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0107 0.0507
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0034 0.0034
Brugia malayi Sugar transporter family protein 0.0126 0.0409 0.0892
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.008
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0109 0.1707
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0035 0.0394
Plasmodium falciparum histone deacetylase, putative 0.0015 0.0027 0.0062
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0107 0.0507
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0034 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Onchocerca volvulus 0.0018 0.0035 0.0649
Brugia malayi Histone deacetylase family protein 0.0015 0.0027 0.0059
Brugia malayi nuclear hormone receptor 0.0008 0.0003 0.0006
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0107 0.0507
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0054 0.0159 0.2921
Trypanosoma cruzi hexose transporter 0.0039 0.0109 0.1707
Trypanosoma brucei glucose transporter, putative 0.0039 0.0109 0.1707
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Toxoplasma gondii protein kinase, putative 0.0357 0.1202 1
Schistosoma mansoni zinc finger protein 0.0008 0.0003 0.0003
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0107 0.1671
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0155 0.0507 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0034 0.0075
Onchocerca volvulus Matrilysin homolog 0.0039 0.0108 0.2081
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0109 0.1894
Schistosoma mansoni histone deacetylase hda2 0.0015 0.0027 0.0027
Schistosoma mansoni aminopeptidase A (M01 family) 0.0155 0.0507 0.0507
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0105
Echinococcus multilocularis solute carrier family 22 0.0018 0.0035 0.0035
Brugia malayi Matrixin family protein 0.0017 0.0034 0.0075
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0107 0.0771
Onchocerca volvulus 0.0018 0.0035 0.0649
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Brugia malayi hypothetical protein 0.1339 0.4584 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Plasmodium falciparum histone deacetylase 2 0.0015 0.0027 0.0062
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0071 0.1047
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0035 0.0309
Loa Loa (eye worm) SET domain-containing protein 0.0061 0.0185 0.0185
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.0676 0.3664
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0006 0.0013
Onchocerca volvulus 0.0155 0.0507 1
Echinococcus granulosus histone deacetylase 0.0015 0.0027 0.0027
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0061 0.0185 0.0185
Onchocerca volvulus 0.0012 0.0016 0.0265
Schistosoma mansoni cathepsin D (A01 family) 0.0012 0.0016 0.0016
Leishmania major protein kinase, putative 0.0039 0.0107 0.1671
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0126 0.2065
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0012 0.0016 0.0016
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0126 0.2065
Onchocerca volvulus Matrilysin homolog 0.0017 0.0034 0.063
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0155 0.0507 1
Onchocerca volvulus 0.0018 0.0035 0.0649
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0107 0.0107
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 0.1818 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0071 0.0071
Onchocerca volvulus Matrix metalloproteinase homolog 0.0039 0.0108 0.2081
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0155 0.0507 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0034 0.0034
Echinococcus multilocularis histone deacetylase 0.0015 0.0027 0.0027
Brugia malayi hypothetical protein 0.0008 0.0003 0.0006
Plasmodium vivax histone deacetylase 2, putative 0.0015 0.0027 0.0062
Echinococcus multilocularis solute carrier family 22 0.0018 0.0035 0.0035
Entamoeba histolytica protein kinase, putative 0.0039 0.0107 0.0828
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0034 0.0075
Echinococcus granulosus histone deacetylase 6 0.0015 0.0027 0.0027
Echinococcus granulosus histone deacetylase 6 0.0015 0.0027 0.0027
Schistosoma mansoni sugar transporter 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0107 0.0507
Schistosoma mansoni histone deacetylase 4 5 0.0015 0.0027 0.0027
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0006 0.0006
Schistosoma mansoni sugar transporter 0.0018 0.0035 0.0035
Schistosoma mansoni glucose transport protein 0.0126 0.0409 0.0409
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0034 0.0075
Brugia malayi histone deacetylase 1 (HD1) 0.0054 0.0159 0.0348
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0035 0.0035
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0126 0.2065
Schistosoma mansoni coup transcription factor 0.0017 0.0034 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0035 0.0394

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 728 nM MMV: Inhibition of Plasmodium falciparum K1 (EC50). ChEMBL. No reference
Growth Inhibition (functional) = 43.708 % MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. ChEMBL. No reference
IC50 (functional) = 635.4 nM MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 > 32 uM MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). ChEMBL. No reference
Inhibition (functional) = -17.4548388332222 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -17.454838833222187 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -4.73229006096484 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = -4.7322900609648375 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = 0 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 1.85 % MMV: Screen against Mtb, single point, non replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 3.56 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4.48 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4.79 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 6.88878867660097 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 35.3 % MMV: Screen against Mtb, single point, replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 36.0864211725026 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 58 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 88 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 97 % MMV: Inhibition of Plasmodium falciparum 3D7 at 5uM compound concentration. ChEMBL. No reference
Inhibition (functional) = 98 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 100 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition frequency index (IFI) (functional) = 4.65 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -3 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = -2 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 88 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 98 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
Ratio (functional) = 0.885245901639344 MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. ChEMBL. No reference
Relative Growth (functional) = -0.9168 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = -0.4404 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = -0.2476 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
XC50 (functional) = 6.07 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.84864 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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