Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0007 | 0.0005 | 0.003 |
Brugia malayi | RNA binding protein | 0.0064 | 0.2974 | 0.6063 |
Trypanosoma cruzi | Inositol phosphosphingolipids phospholipase C | 0.0008 | 0.0065 | 0.036 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0159 |
Leishmania major | RNA-editing complex protein MP100, putative | 0.0008 | 0.0065 | 0.036 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0074 | 0.3506 | 0.3503 |
Trypanosoma cruzi | Endonuclease/Exonuclease/phosphatase family, putative | 0.0008 | 0.0065 | 0.036 |
Echinococcus multilocularis | deoxyribonuclease 1 2 | 0.0008 | 0.0065 | 0.006 |
Leishmania major | hypothetical protein, conserved | 0.0008 | 0.0065 | 0.036 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.1319 | 0.1314 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0039 | 0.1664 | 0.166 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0025 | 0.0957 | 0.0953 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0033 | 0.0028 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0132 | 0.6499 | 0.6497 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0008 | 0.0065 | 0.039 |
Trypanosoma cruzi | mitochondrial protein 99, putative | 0.0008 | 0.0065 | 0.036 |
Trypanosoma brucei | DNA-(apurinic or apyrimidinic site) lyase, putative | 0.0008 | 0.0065 | 0.036 |
Echinococcus multilocularis | neutral sphingomyelinase | 0.0008 | 0.0065 | 0.006 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0033 | 0.0028 |
Schistosoma mansoni | synaptojanin | 0.0008 | 0.0065 | 0.006 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0052 | 0.2342 | 0.2338 |
Trypanosoma brucei | Endonuclease/Exonuclease/phosphatase family, putative | 0.0008 | 0.0065 | 0.036 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.3751 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.3751 | 0.5 |
Leishmania major | T-complex protein 1, beta subunit, putative | 0.0025 | 0.0957 | 0.5741 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0039 | 0.1664 | 0.166 |
Echinococcus granulosus | synaptojanin 1 | 0.0008 | 0.0065 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4902 | 0.4899 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.2974 | 0.6063 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0079 | 0.3751 | 0.3748 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0039 | 0.1664 | 1 |
Brugia malayi | CCR4 | 0.0008 | 0.0065 | 0.0122 |
Toxoplasma gondii | exonuclease III APE | 0.0039 | 0.1664 | 0.4428 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0039 | 0.1664 | 0.166 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3161 | 0.3158 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0199 | 1 | 1 |
Trypanosoma cruzi | RNA-editing complex protein MP100, putative | 0.0008 | 0.0065 | 0.036 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0079 | 0.3751 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.1664 | 0.166 |
Echinococcus granulosus | geminin | 0.0175 | 0.874 | 0.8739 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.3751 | 0.3748 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2974 | 0.2971 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0039 | 0.1664 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0132 | 0.6499 | 0.6497 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0065 | 0.006 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0025 | 0.0957 | 0.5754 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0052 | 0.2342 | 1 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0122 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0132 | 0.6499 | 0.6497 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0025 | 0.0957 | 0.1945 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0025 | 0.0957 | 0.0953 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0132 | 0.6499 | 0.6497 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2974 | 0.2971 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0033 | 0.0028 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0079 | 0.3751 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.2974 | 0.2971 |
Trypanosoma brucei | RNA editing exonuclease 2 | 0.0008 | 0.0065 | 0.036 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0193 | 0.9655 | 0.9655 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0074 | 0.3506 | 0.3503 |
Trichomonas vaginalis | chaperonin, putative | 0.0025 | 0.0957 | 0.5754 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.2974 | 0.2971 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0122 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0039 | 0.1664 | 1 |
Echinococcus granulosus | neutral sphingomyelinase | 0.0008 | 0.0065 | 0.006 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0008 | 0.0065 | 0.006 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0008 | 0.0065 | 0.036 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.1159 | 0.1155 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0052 | 0.2342 | 1 |
Echinococcus granulosus | traf and tnf receptor associated protein | 0.0008 | 0.0065 | 0.006 |
Leishmania major | endonuclease/exonuclease protein-like protein | 0.0008 | 0.0065 | 0.036 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0122 |
Loa Loa (eye worm) | CCR4-NOT transcription complex subunit 6 family protein | 0.0008 | 0.0065 | 0.006 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0084 | 0.4033 | 1 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0008 | 0.0065 | 0.039 |
Onchocerca volvulus | 0.0008 | 0.0065 | 0.0517 | |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0008 | 0.0065 | 0.039 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.3751 | 1 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0159 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0025 | 0.0957 | 0.0953 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0079 | 0.3751 | 1 |
Trypanosoma cruzi | T-complex protein 1, beta subunit, putative | 0.0025 | 0.0957 | 0.5741 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.4902 | 1 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0084 | 0.4033 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.25 | 0.6661 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0027 | 0.107 | 0.2726 |
Trypanosoma cruzi | Endonuclease/Exonuclease/phosphatase family, putative | 0.0008 | 0.0065 | 0.036 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0008 | 0.0065 | 0.006 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.1664 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.1664 | 0.4337 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1319 | 0.1314 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.284 | 0.2836 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0122 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0008 | 0.0065 | 0.006 |
Trypanosoma cruzi | inositol 5-phosphatase 1, putative | 0.0008 | 0.0065 | 0.036 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0132 | 0.6499 | 0.6497 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1319 | 0.1314 |
Trypanosoma brucei | Inositol phosphosphingolipids phospholipase C | 0.0008 | 0.0065 | 0.036 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0039 | 0.1664 | 0.3387 |
Echinococcus multilocularis | CCR4 NOT transcription complex subunit 6 | 0.0008 | 0.0065 | 0.006 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.874 | 0.8739 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0199 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0175 | 0.874 | 0.8739 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0193 | 0.9655 | 0.9655 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0159 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0033 | 0.0028 |
Schistosoma mansoni | carbon catabolite repressor protein | 0.0008 | 0.0065 | 0.006 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0027 | 0.107 | 0.2726 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.1664 | 0.166 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1319 | 0.1314 |
Schistosoma mansoni | ocrl type II inositol 5-phosphatase | 0.0008 | 0.0065 | 0.006 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0124 | 0.0119 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0159 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0025 | 0.0957 | 0.2249 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.4902 | 0.4899 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.1159 | 0.2357 |
Onchocerca volvulus | 0.0008 | 0.0065 | 0.0517 | |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0025 | 0.0957 | 0.2421 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.4033 | 0.403 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0008 | 0.0065 | 0.036 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.2974 | 0.2971 |
Leishmania major | hypothetical protein, conserved | 0.0008 | 0.0065 | 0.036 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0065 | 0.006 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0079 | 0.3751 | 0.3748 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0008 | 0.0065 | 0.006 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0008 | 0.0065 | 0.039 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0008 | 0.0065 | 0.036 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.3751 | 1 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0008 | 0.0065 | 0.039 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0159 |
Schistosoma mansoni | transient receptor potential channel | 0.0132 | 0.6499 | 0.6497 |
Leishmania major | inositol phosphosphingolipid phospholipase C-Like | 0.0008 | 0.0065 | 0.036 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2974 | 0.2971 |
Trypanosoma brucei | inositol/phosphatidylinositol phosphatase, putative | 0.0008 | 0.0065 | 0.036 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0025 | 0.0957 | 0.0953 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0124 | 0.0119 |
Schistosoma mansoni | synaptojanin | 0.0008 | 0.0065 | 0.006 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0025 | 0.0957 | 0.2421 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1319 | 0.1314 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.2974 | 0.2971 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0079 | 0.3751 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2974 | 0.2971 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0159 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.3751 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.1319 | 0.1314 |
Trypanosoma brucei | T-complex protein 1, beta subunit, putative | 0.0025 | 0.0957 | 0.5741 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0007 | 0.0005 | 0.003 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.1319 | 0.2683 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.1245 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.3506 | 0.3503 |
Brugia malayi | Transient-receptor-potential like protein | 0.0074 | 0.3506 | 0.7149 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0039 | 0.1664 | 0.4337 |
Echinococcus multilocularis | inositol polyphosphate 5 phosphatase OCRL 1 | 0.0008 | 0.0065 | 0.006 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0122 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.3751 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.1664 | 0.4337 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0124 | 0.0119 |
Schistosoma mansoni | nocturnin | 0.0008 | 0.0065 | 0.006 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0033 | 0.0028 |
Schistosoma mansoni | neutral sphingomyelinase | 0.0008 | 0.0065 | 0.006 |
Leishmania major | hypothetical protein, conserved | 0.0008 | 0.0065 | 0.036 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.2974 | 0.2971 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.3243 | 0.6613 |
Trypanosoma cruzi | Endonuclease/Exonuclease/phosphatase family, putative | 0.0008 | 0.0065 | 0.036 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0025 | 0.0957 | 0.5582 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.1245 | 0.124 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1319 | 0.1314 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0122 |
Schistosoma mansoni | transient receptor potential channel | 0.0199 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0052 | 0.2342 | 0.4744 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0039 | 0.1664 | 0.4029 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0122 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0008 | 0.0065 | 0.039 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1159 | 0.1155 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.1245 | 0.124 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.1319 | 0.2683 |
Onchocerca volvulus | Putative neutral sphingomyelinase | 0.0008 | 0.0065 | 0.0517 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1319 | 0.1314 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0008 | 0.0065 | 0.039 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1319 | 0.1314 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1319 | 0.1314 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0027 | 0.107 | 0.2726 |
Toxoplasma gondii | t-complex protein beta subunit | 0.0025 | 0.0957 | 0.2542 |
Trypanosoma brucei | Endonuclease/Exonuclease/phosphatase family, putative | 0.0008 | 0.0065 | 0.036 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.1245 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0065 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0065 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.1664 | 1 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0025 | 0.0957 | 0.0953 |
Echinococcus granulosus | inositol polyphosphate 5 phosphatase OCRL 1 | 0.0008 | 0.0065 | 0.006 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0039 | 0.1664 | 0.7022 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.3751 | 1 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0008 | 0.0065 | 0.006 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0118 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3243 | 0.324 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.4902 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0052 | 0.2342 | 0.2338 |
Trypanosoma cruzi | endonuclease/exonuclease/phosphatase, putative | 0.0008 | 0.0065 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.6155 | 0.6153 |
Trypanosoma brucei | Endonuclease/Exonuclease/phosphatase family, putative | 0.0008 | 0.0065 | 0.036 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.1664 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.1664 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1319 | 0.1314 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0159 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.2974 | 0.6063 |
Trypanosoma cruzi | Endonuclease/Exonuclease/phosphatase family, putative | 0.0008 | 0.0065 | 0.036 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.3243 | 0.324 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0008 | 0.0065 | 0.039 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0079 | 0.3751 | 0.3748 |
Toxoplasma gondii | hypothetical protein | 0.0027 | 0.107 | 0.2842 |
Trypanosoma cruzi | Endonuclease/Exonuclease/phosphatase family, putative | 0.0008 | 0.0065 | 0.036 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.1319 | 0.1314 |
Leishmania major | inositol/phosphatidylinositol phosphatase, putative | 0.0008 | 0.0065 | 0.036 |
Onchocerca volvulus | 0.0029 | 0.1159 | 1 | |
Trypanosoma cruzi | mitochondrial protein 99, putative | 0.0008 | 0.0065 | 0.036 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0008 | 0.0065 | 0.006 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0025 | 0.0957 | 0.0953 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0008 | 0.0065 | 0.0122 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.874 | 0.8739 |
Leishmania major | pantothenate kinase subunit, putative | 0.0008 | 0.0065 | 0.036 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0025 | 0.0957 | 0.1945 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2974 | 0.2971 |
Echinococcus multilocularis | synaptojanin 1 | 0.0008 | 0.0065 | 0.006 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0008 | 0.0065 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0065 | 0.006 |
Echinococcus multilocularis | traf and tnf receptor associated protein | 0.0008 | 0.0065 | 0.006 |
Trypanosoma brucei | inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative | 0.0008 | 0.0065 | 0.036 |
Schistosoma mansoni | cript-related | 0.0008 | 0.0065 | 0.006 |
Echinococcus granulosus | CCR4 NOT transcription complex subunit 6 | 0.0008 | 0.0065 | 0.006 |
Brugia malayi | Probable ClpP-like protease | 0.0079 | 0.3751 | 0.765 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0008 | 0.0065 | 0.039 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 7.46 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 8.91 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 13.77 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 22 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 27 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 92 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 3.85 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 22 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 27 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 92 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.95 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.11201 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.