Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0038 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0038 | 0.0059 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0038 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.2461 | 0.378 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.2461 | 0.378 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0038 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0066 | 0.2461 | 0.2432 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0038 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.2461 | 0.378 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0056 | 0.0017 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0038 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0156 | 0.024 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.2461 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0066 | 0.2461 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0038 | 0.0059 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0038 | 0.0156 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0038 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.2297 | 0.3528 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0208 | 1 | 1 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.028 | 0.0243 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0142 | 0.651 | 0.6497 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.651 | 0.6497 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0066 | 0.2461 | 0.2432 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2688 | 0.266 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.2461 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1212 | 0.1179 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.2461 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.086 | 0.3493 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1112 | 0.1078 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0038 | 0.0156 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.086 | 0.3493 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0038 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.2913 | 0.2885 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0038 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0156 | 0.0634 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.2461 | 0.2432 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0038 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.2109 | 0.8569 |
Echinococcus multilocularis | GPCR, family 2 | 0.0066 | 0.2461 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0038 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.2461 | 0.378 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0988 | 0.0953 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.2109 | 0.8569 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0156 | 0.0634 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0038 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0066 | 0.2461 | 0.2432 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0038 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.651 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.2461 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0056 | 0.0085 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0038 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0038 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0038 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0984 | 0.0949 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 1.17 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.21 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.34 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 17 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 78 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 90 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 0 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 3 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 17 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 78 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 90 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.92 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.21205 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.