Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0054 | 0.0054 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0051 | 0.0051 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.6235 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.001 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3673 | 0.5882 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0.001 | 0.0018 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0992 | 0.1573 | 0.156 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0029 | 0.0029 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.001 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0029 | 0.0029 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0992 | 0.1573 | 0.1573 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0029 | 0.0029 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0016 | 0.0016 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0051 | 0.0051 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0174 | 0.0174 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0053 | 0.0064 | 0.0064 |
Echinococcus granulosus | thymidylate synthase | 0.0992 | 0.1573 | 0.1573 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0088 | 0.0088 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0007 | 0.0011 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0016 | 0.0016 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0016 | 0.0009 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.003 | 0.0027 | 0.0027 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0016 | 0.0016 |
Brugia malayi | thymidylate synthase | 0.0992 | 0.1573 | 0.1573 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3673 | 0.5882 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0472 | 0.0737 | 0.1254 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Loa Loa (eye worm) | thymidylate synthase | 0.0992 | 0.1573 | 0.1573 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.6235 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.001 | 0.0018 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.001 | 0.0004 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0054 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0088 | 0.0088 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0053 | 0.0064 | 0.0064 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0047 | 0.0054 | 0.0054 |
Brugia malayi | hypothetical protein | 0.003 | 0.0027 | 0.0027 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0007 | 0.0007 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0184 | 0.0274 | 0.0274 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0016 | 0.0009 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0005 | 0.0005 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3673 | 0.5882 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.001 | 0.001 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0001 | 0.0001 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.001 | 0.0018 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0053 | 0.0064 | 0.0064 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0007 | 0.0011 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0054 | 0.0054 |
Chlamydia trachomatis | dihydrofolate reductase | 0.6235 | 1 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0053 | 0.0064 | 0.0064 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.003 | 0.0027 | 0.0027 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0001 | 0.0001 |
Brugia malayi | Dihydrofolate reductase | 0.6235 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0016 | 0.3428 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Echinococcus multilocularis | thymidylate synthase | 0.0992 | 0.1573 | 0.1573 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Echinococcus multilocularis | geminin | 0.0174 | 0.0259 | 0.0259 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.001 | 0.0018 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0005 | 0.0005 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0472 | 0.0737 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0047 | 0.0054 | 0.0054 |
Echinococcus granulosus | dihydrofolate reductase | 0.6235 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.0259 | 0.0259 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0992 | 0.1573 | 0.1573 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0007 | 0.0007 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.003 | 0.0027 | 0.0027 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0001 | 0.0001 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0053 | 0.0064 | 0.0064 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0016 | 0.0027 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0029 | 0.0029 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.0138 | 0.0138 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.001 | 0.001 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.001 | 0.001 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.001 | 0.001 |
Echinococcus granulosus | zinc finger transcription factor gli2 | 0.0258 | 0.0393 | 0.0393 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0047 | 0.0054 | 0.0054 |
Schistosoma mansoni | dihydrofolate reductase | 0.6235 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Onchocerca volvulus | 0.0047 | 0.0054 | 0.0242 | |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0027 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0047 | 0.0054 | 0.0242 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0138 | 0.0138 |
Mycobacterium ulcerans | thymidylate synthase | 0.0992 | 0.1573 | 0.1568 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0001 | 0.0001 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0007 | 0.0007 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3673 | 0.5882 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.001 | 0.001 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0016 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0064 | 0.0064 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0016 | 0.0027 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0029 | 0.0029 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0005 | 0.0005 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0016 | 0.3428 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.001 | 0.001 |
Echinococcus multilocularis | zinc finger transcription factor gli2 | 0.0258 | 0.0393 | 0.0393 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0174 | 0.0174 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0054 | 0.0054 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0016 | 0.0016 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0007 | 0.0007 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0047 | 0.0054 | 0.0054 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.001 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | zinc finger protein | 0.0258 | 0.0393 | 0.0393 |
Onchocerca volvulus | 0.0992 | 0.1573 | 1 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0016 | 0.0016 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.6235 | 1 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.001 | 0.001 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.001 | 0.001 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0051 | 0.0051 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.0138 | 0.0138 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.001 | 0.001 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0016 | 0.0016 |
Echinococcus granulosus | geminin | 0.0174 | 0.0259 | 0.0259 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0007 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0283 | 0.0434 | 0.0434 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0174 | 0.0174 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0051 | 0.0051 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3673 | 0.5882 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0047 | 0.0054 | 0.0054 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0051 | 0.0051 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0053 | 0.0064 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0027 | 0.0027 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0016 | 0.0009 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0051 | 0.0051 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0016 | 0.0009 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0047 | 0.0054 | 0.0054 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.001 | 0.0018 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0051 | 0.0051 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | MBCTL1 | 0.0053 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0007 | 0.0007 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0016 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0016 | 0.0016 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.001 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0029 | 0.0029 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0184 | 0.0274 | 0.0274 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.001 | 0.001 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0016 | 0.0009 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0029 | 0.0029 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0016 | 0.0009 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.001 | 0.0018 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0016 | 0.0009 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0027 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.6235 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3673 | 0.5882 | 1 |
Brugia malayi | hypothetical protein | 0.0472 | 0.0737 | 0.0737 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0051 | 0.0051 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.0259 | 0.0259 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0051 | 0.0051 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.6235 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0472 | 0.0737 | 0.0737 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0029 | 0.0029 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.001 | 0.001 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0029 | 0.0029 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0016 | 0.3428 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.001 | 0.001 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0258 | 0.0393 | 0.0393 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0029 | 0.0029 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0001 | 0.0001 |
Trypanosoma brucei | unspecified product | 0.002 | 0.001 | 0.0018 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0005 | 0.0005 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1.71 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.99 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.18 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 37 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 3.03 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 0 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 37 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 100 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 101 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.08 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.82566 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.