Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 1 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0094 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3302 | 0.3302 |
Giardia lamblia | Kinase, PLK | 0.0094 | 1 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 1 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0094 | 1 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0094 | 1 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0094 | 1 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0094 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0094 | 1 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3302 | 0.3302 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3302 | 0.3302 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3302 | 0.3302 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0094 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3302 | 0.3302 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 2.17 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.32 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.68 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 98 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 99 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 1.55 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 98 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 99 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.18 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.66369 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.