Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | importin beta-1 | 0.006 | 0.0373 | 0.0682 |
Plasmodium vivax | hypothetical protein, conserved | 0.0182 | 0.1435 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0045 | 0.0237 | 0.1606 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0049 | 0.0278 | 0.1893 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0023 | 0.0042 |
Leishmania major | importin beta-1 subunit, putative | 0.0049 | 0.0274 | 0.1864 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0182 | 0.1435 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0176 | 0.2369 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0054 | 0.0318 | 0.058 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.0237 | 0.0432 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0653 | 0.1193 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0152 | 0.1175 | 0.2145 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.01 | 0.0718 | 0.1312 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0007 | 0.0014 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0176 | 0.0321 |
Echinococcus multilocularis | snurportin 1 | 0.0643 | 0.5476 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0054 | 0.0318 | 0.1527 |
Plasmodium vivax | hypothetical protein, conserved | 0.003 | 0.0107 | 0.0697 |
Mycobacterium tuberculosis | Conserved protein | 0.0182 | 0.1435 | 0.1429 |
Entamoeba histolytica | Ran family GTPase | 0.0044 | 0.0234 | 0.319 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0209 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0738 | 0.1349 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0044 | 0.0234 | 0.1126 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.01 | 0.0718 | 0.1312 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0182 | 0.1435 | 0.1429 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0023 | 0.0111 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0653 | 0.1193 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0023 | 0.0042 |
Trichomonas vaginalis | ran, putative | 0.0044 | 0.0234 | 0.1588 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0182 | 0.1435 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0023 | 0.0042 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0023 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1435 | 0.2621 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0023 | 0.0042 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.01 | 0.0718 | 0.1312 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.026 | 0.1252 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.0718 | 0.4978 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.006 | 0.0373 | 0.2563 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0718 | 0.4978 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0007 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.0653 | 0.1193 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.0653 | 0.1193 |
Trichomonas vaginalis | esterase, putative | 0.0182 | 0.1435 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.026 | 0.0475 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0162 | 0.0296 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0107 | 0.0697 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0007 | 0.0014 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0044 | 0.0234 | 0.0428 |
Mycobacterium ulcerans | hypothetical protein | 0.0182 | 0.1435 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0007 | 0.0014 |
Schistosoma mansoni | hypothetical protein | 0.0348 | 0.2895 | 0.5288 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0054 | 0.0318 | 0.058 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0023 | 0.0042 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.0653 | 0.3141 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0044 | 0.0234 | 0.1588 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0007 | 0.0036 |
Entamoeba histolytica | hypothetical protein | 0.0049 | 0.0274 | 0.3746 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0049 | 0.0274 | 0.1864 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0023 | 0.0042 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0182 | 0.1435 | 0.1429 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0007 | 0.5 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0049 | 0.0274 | 0.1864 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0023 | 0.0111 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0718 | 0.4978 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0182 | 0.1435 | 0.1429 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0023 | 0.0042 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0102 | 0.0738 | 0.1349 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.01 | 0.0718 | 0.3454 |
Toxoplasma gondii | ABC1 family protein | 0.0182 | 0.1435 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.006 | 0.0373 | 0.1796 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0023 | 0.0111 |
Brugia malayi | beta-lactamase family protein | 0.0182 | 0.1435 | 0.6903 |
Brugia malayi | RNA, U transporter 1 | 0.0171 | 0.1346 | 0.6472 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0162 | 0.0296 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.003 | 0.0107 | 0.0195 |
Giardia lamblia | PHD finger protein 15 | 0.003 | 0.0107 | 0.14 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0023 | 0.0042 |
Brugia malayi | MH2 domain containing protein | 0.0255 | 0.2079 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0102 | 0.0738 | 0.3551 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0044 | 0.0234 | 0.1588 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0182 | 0.1435 | 0.1429 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.0237 | 0.1606 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.003 | 0.0107 | 0.0195 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0182 | 0.1435 | 0.2621 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.006 | 0.0373 | 0.2563 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0182 | 0.1435 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0405 | 0.3392 | 0.6194 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0023 | 0.0042 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0255 | 0.2079 | 0.3797 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.019 | 0.1511 | 0.2759 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0007 | 0.0014 |
Loa Loa (eye worm) | acetyltransferase | 0.0152 | 0.1175 | 0.2145 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0333 | 0.1599 |
Onchocerca volvulus | 0.0182 | 0.1435 | 1 | |
Trypanosoma brucei | polo-like protein kinase | 0.01 | 0.0718 | 0.4978 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0023 | 0.0042 |
Schistosoma mansoni | hypothetical protein | 0.0291 | 0.2396 | 0.4377 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.0718 | 0.4978 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1435 | 0.2621 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0643 | 0.5476 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0023 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1435 | 0.2621 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1435 | 0.2621 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0023 | 0.0111 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0023 | 0.0042 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0182 | 0.1435 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0049 | 0.0274 | 0.1864 |
Leishmania major | GTP-binding protein, putative | 0.0044 | 0.0234 | 0.1588 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0182 | 0.1435 | 0.2621 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0023 | 0.0111 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0152 | 0.1175 | 0.2145 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0023 | 0.0111 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0561 | 0.1025 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0047 | 0.026 | 0.0475 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.01 | 0.0718 | 1 |
Echinococcus granulosus | peregrin | 0.0034 | 0.014 | 0.0255 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0182 | 0.1435 | 0.2621 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.0204 | 0.2768 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0293 | 0.0536 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0102 | 0.0738 | 0.1349 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0023 | 0.0042 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.0385 | 0.0703 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0176 | 0.2369 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0162 | 0.0779 |
Echinococcus multilocularis | geminin | 0.0348 | 0.2895 | 0.5288 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0023 | 0.0042 |
Schistosoma mansoni | hypothetical protein | 0.0348 | 0.2895 | 0.5288 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0718 | 0.4978 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0023 | 0.0042 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0718 | 0.4978 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0255 | 0.2079 | 0.3797 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0023 | 0.0111 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0047 | 0.026 | 0.0475 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0176 | 0.0321 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.0653 | 0.1193 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.01 | 0.0718 | 0.4922 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0023 | 0.0042 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0023 | 0.0042 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0098 | 0.0701 | 0.128 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0182 | 0.1435 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0162 | 0.0296 |
Mycobacterium tuberculosis | Conserved protein | 0.0182 | 0.1435 | 0.1429 |
Mycobacterium tuberculosis | Conserved protein | 0.0182 | 0.1435 | 0.1429 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0179 | 0.0326 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0718 | 0.4978 |
Loa Loa (eye worm) | MBCTL1 | 0.0054 | 0.0318 | 0.058 |
Plasmodium vivax | importin-beta 2, putative | 0.006 | 0.0373 | 0.2563 |
Trichomonas vaginalis | importin beta-1, putative | 0.0049 | 0.0274 | 0.1864 |
Leishmania major | hypothetical protein, conserved | 0.0182 | 0.1435 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.019 | 0.1511 | 0.2759 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0176 | 0.2369 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0023 | 0.0042 |
Plasmodium falciparum | phd finger protein, putative | 0.003 | 0.0107 | 0.272 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0023 | 0.0042 |
Onchocerca volvulus | 0.0047 | 0.026 | 0.1679 | |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0023 | 0.0042 |
Mycobacterium leprae | conserved hypothetical protein | 0.0182 | 0.1435 | 0.5 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0044 | 0.0234 | 0.6196 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0023 | 0.0042 |
Mycobacterium leprae | Probable lipase LipE | 0.0182 | 0.1435 | 0.5 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.026 | 0.0475 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0182 | 0.1435 | 0.2621 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0023 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0107 | 0.0195 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0023 | 0.0042 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0176 | 0.0321 |
Brugia malayi | jmjC domain containing protein | 0.0098 | 0.0701 | 0.3369 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0653 | 0.1193 |
Onchocerca volvulus | 0.0182 | 0.1435 | 1 | |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.0204 | 0.2768 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0023 | 0.0042 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0023 | 0.0042 |
Schistosoma mansoni | kinase | 0.0051 | 0.0289 | 0.0528 |
Mycobacterium ulcerans | lipase LipD | 0.0182 | 0.1435 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0023 | 0.0042 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0182 | 0.1435 | 0.1429 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.0653 | 0.1193 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0148 | 0.1137 | 0.2077 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0044 | 0.0234 | 0.319 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0152 | 0.1175 | 0.5648 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0023 | 0.0042 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0182 | 0.1435 | 1 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0054 | 0.0318 | 0.058 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0047 | 0.026 | 0.0475 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0182 | 0.1435 | 0.6903 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0102 | 0.0738 | 0.3551 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0176 | 0.2369 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0318 | 0.058 |
Echinococcus granulosus | snurportin 1 | 0.0643 | 0.5476 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0047 | 0.026 | 0.1679 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0023 | 0.0111 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.0653 | 0.1193 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0023 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0373 | 0.0682 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0023 | 0.0111 |
Giardia lamblia | Kinase, PLK | 0.01 | 0.0718 | 1 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0044 | 0.0234 | 0.1588 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0107 | 0.0195 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0179 | 0.0859 |
Schistosoma mansoni | ran | 0.0044 | 0.0234 | 0.0428 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0176 | 0.0846 |
Echinococcus multilocularis | importin subunit beta 1 | 0.006 | 0.0373 | 0.0682 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0044 | 0.0234 | 0.1588 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0023 | 0.0111 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0107 | 0.0515 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0718 | 0.4978 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.006 | 0.0373 | 0.2563 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0182 | 0.1435 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0182 | 0.1435 | 0.1429 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0162 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0023 | 0.0042 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0098 | 0.0701 | 0.128 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0102 | 0.0738 | 0.1349 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.0204 | 0.5376 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.0718 | 0.1312 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0209 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1435 | 0.2621 |
Onchocerca volvulus | 0.0182 | 0.1435 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1435 | 0.2621 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.026 | 0.0475 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0023 | 0.0042 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0044 | 0.0234 | 0.0428 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.0237 | 0.1606 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.002 | 0.0023 | 0.0042 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0054 | 0.0318 | 0.058 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.0718 | 0.4978 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0047 | 0.026 | 0.0475 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0044 | 0.0234 | 0.1588 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0176 | 0.0321 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0182 | 0.1435 | 1 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0023 | 0.0111 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0023 | 0.0042 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0023 | 0.0042 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0182 | 0.1435 | 0.1429 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.0237 | 0.1606 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0007 | 0.0014 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0023 | 0.0042 |
Loa Loa (eye worm) | beta-lactamase | 0.0182 | 0.1435 | 0.2621 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0023 | 0.0042 |
Mycobacterium ulcerans | beta-lactamase | 0.0182 | 0.1435 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0333 | 0.0607 |
Plasmodium falciparum | importin beta, putative | 0.006 | 0.0373 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0023 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0023 | 0.0042 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0047 | 0.026 | 0.0475 |
Brugia malayi | beta-lactamase family protein | 0.0182 | 0.1435 | 0.6903 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0182 | 0.1435 | 1 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.026 | 0.1252 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0047 | 0.026 | 0.0475 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0023 | 0.0111 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0049 | 0.0278 | 0.1893 |
Echinococcus granulosus | importin subunit beta 1 | 0.006 | 0.0373 | 0.0682 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0182 | 0.1435 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0023 | 0.0111 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0182 | 0.1435 | 0.2621 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0333 | 0.1599 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0023 | 0.0042 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0333 | 0.0607 |
Echinococcus multilocularis | peregrin | 0.0034 | 0.014 | 0.0255 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0023 | 0.0111 |
Loa Loa (eye worm) | PHD-finger family protein | 0.003 | 0.0107 | 0.0195 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.003 | 0.0107 | 0.0195 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0044 | 0.0234 | 0.0428 |
Brugia malayi | Bromodomain containing protein | 0.0034 | 0.014 | 0.0671 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0107 | 0.0697 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0179 | 0.0326 |
Schistosoma mansoni | jumonji domain containing protein | 0.0078 | 0.0525 | 0.0959 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0054 | 0.0318 | 0.058 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0162 | 0.0296 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0023 | 0.0111 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.01 | 0.0718 | 0.4978 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0023 | 0.0042 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0023 | 0.0111 |
Echinococcus granulosus | geminin | 0.0348 | 0.2895 | 0.5288 |
Schistosoma mansoni | hypothetical protein | 0.0643 | 0.5476 | 1 |
Schistosoma mansoni | ran | 0.0044 | 0.0234 | 0.0428 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.0237 | 0.1606 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0023 | 0.0042 |
Onchocerca volvulus | Alhambra homolog | 0.003 | 0.0107 | 0.0594 |
Brugia malayi | beta-lactamase | 0.0182 | 0.1435 | 0.6903 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0102 | 0.0738 | 0.1349 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0023 | 0.0042 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0023 | 0.0042 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1.99 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.08 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.1 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 77 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 1.32 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -7 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 77 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 101 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.67 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.21382 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.