TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 265.285 | Formula: C16H12FN3
H donors: 1 H acceptors: 1 LogP: 3.91 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc2c(c1)nccc2NN=Cc1ccccc1
InChi: 1S/C16H12FN3/c17-13-6-7-14-15(8-9-18-16(14)10-13)20-19-11-12-4-2-1-3-5-12/h1-11H,(H,18,20)
InChiKey: WTNKWDNZZSWXTP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	FTZ F1 alpha	0.0459	0.7114	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0059	0.0732	0.1411
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.027	0.0233
Brugia malayi	Pre-SET motif family protein	0.003	0.027	0.0772
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0302	0.4607	1
Schistosoma mansoni	thyroid hormone receptor	0.006	0.074	0.0705
Brugia malayi	Nuclear hormone receptor-like 1	0.006	0.074	0.2337
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.0095	0.0126
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0028	0.0236	0.0658
Loa Loa (eye worm)	DR-78	0.0028	0.0236	0.0311
Brugia malayi	hypothetical protein	0.0025	0.0177	0.0462
Brugia malayi	nuclear receptor RXR	0.0028	0.0236	0.0658
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0028	0.0236	0.028
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.006	0.074	0.2337
Loa Loa (eye worm)	steroid hormone receptor	0.006	0.074	0.1428
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.006	0.074	0.1428
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.006	0.074	0.2337
Brugia malayi	Pre-SET motif family protein	0.0204	0.3039	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0143	0.2071	0.2874
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0032	0.029	0.043
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0113	0.1596	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0028	0.0236	0.0658
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0152	0.0436
Loa Loa (eye worm)	hypothetical protein	0.006	0.074	0.1428
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0028	0.0236	0.0433
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0028	0.0236	0.0433
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.006	0.074	0.0705
Schistosoma mansoni	nuclear receptor	0.0028	0.0236	0.0199
Loa Loa (eye worm)	hypothetical protein	0.006	0.074	0.1428
Echinococcus multilocularis	cpg binding protein	0.0063	0.0786	0.1637
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.006	0.074	0.0992
Echinococcus multilocularis	nuclear receptor nhr 48	0.0028	0.0236	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0143	0.2071	0.6775
Loa Loa (eye worm)	hypothetical protein	0.0032	0.029	0.043
Brugia malayi	nuclear receptor NHR-88	0.0028	0.0236	0.0658
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.006	0.074	0.1428
Echinococcus granulosus	cpg binding protein	0.0063	0.0786	0.1057
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Loa Loa (eye worm)	hypothetical protein	0.006	0.074	0.1428
Schistosoma mansoni	hypothetical protein	0.0302	0.4607	0.4587
Brugia malayi	steroid hormone receptor	0.006	0.074	0.2337
Brugia malayi	hypothetical protein	0.0032	0.029	0.0837
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0152	0.0436
Schistosoma mansoni	cpg binding protein	0.0059	0.0732	0.0697
Brugia malayi	orphan nuclear receptor NR2E1	0.0028	0.0236	0.0658
Echinococcus granulosus	thyroid hormone receptor alpha	0.0028	0.0236	0.028
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0028	0.0236	0.0311
Brugia malayi	RNA, U transporter 1	0.008	0.107	0.3438
Brugia malayi	Nuclear hormone receptor E75	0.0028	0.0236	0.0658
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.029	0.0837
Entamoeba histolytica	hypothetical protein	0.0023	0.0152	0.5
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0028	0.0236	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Loa Loa (eye worm)	hypothetical protein	0.006	0.074	0.1428
Echinococcus multilocularis	thyroid hormone receptor alpha	0.006	0.074	0.1536
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0143	0.2071	0.445
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0237	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.027	0.0233
Loa Loa (eye worm)	hypothetical protein	0.006	0.074	0.1428
Brugia malayi	nuclear receptor RXR	0.0032	0.029	0.0837
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.006	0.074	0.2337
Leishmania major	hypothetical protein, conserved	0.0025	0.0177	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.027	0.0508
Schistosoma mansoni	nuclear receptor nhr-48	0.0028	0.0236	0.0199
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.006	0.074	0.1536
Schistosoma mansoni	thyroid hormone receptor	0.006	0.074	0.0705
Brugia malayi	photoreceptor-specific nuclear receptor	0.006	0.074	0.2337
Loa Loa (eye worm)	hypothetical protein	0.006	0.074	0.1428
Brugia malayi	hypothetical protein	0.0032	0.029	0.0837
Schistosoma mansoni	nuclear hormone receptor	0.006	0.074	0.0705
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.2071	0.2041
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0237	0.648
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.006	0.074	0.1536
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0143	0.2071	0.445
Loa Loa (eye worm)	hypothetical protein	0.0032	0.029	0.043
Schistosoma mansoni	nuclear hormone receptor	0.0028	0.0236	0.0199
Echinococcus multilocularis	snurportin 1	0.0302	0.4607	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.006	0.074	0.0705
Plasmodium vivax	SET domain protein, putative	0.003	0.027	1
Onchocerca volvulus		0.003	0.027	0.0106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.2071	0.2041
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.006	0.074	0.1428
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.006	0.074	0.1536
Brugia malayi	Nuclear hormone receptor E75	0.0028	0.0236	0.0658
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0028	0.0236	0.028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.006	0.074	0.1428
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.006	0.074	0.0705
Loa Loa (eye worm)	hypothetical protein	0.006	0.074	0.1428
Echinococcus granulosus	nuclear receptor nhr 48	0.0028	0.0236	0.028
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0028	0.0236	0.0199
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.0095	0.0082
Loa Loa (eye worm)	nuclear hormone receptor	0.0028	0.0236	0.0311
Onchocerca volvulus		0.0059	0.0732	0.1527
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.006	0.074	0.0992
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0232	0.0275
Brugia malayi	nuclear hormone receptor family member odr-7	0.0028	0.0236	0.0658
Onchocerca volvulus		0.0232	0.3485	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.006	0.074	0.2337
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0032	0.029	0.0253
Brugia malayi	nuclear hormone receptor	0.0028	0.0236	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0032	0.029	0.043
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.006	0.074	0.0992
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0028	0.0236	0.0433
Echinococcus multilocularis	FTZ F1 alpha	0.006	0.074	0.1536
Echinococcus multilocularis	ecdysone induced protein 78C	0.006	0.074	0.1536
Schistosoma mansoni	importin beta-1	0.0028	0.0237	0.02
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.006	0.074	0.0705
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.027	0.0508
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.006	0.074	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Onchocerca volvulus	Protein ultraspiracle homolog	0.006	0.074	0.1551
Brugia malayi	tailless protein	0.0028	0.0236	0.0658
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.006	0.074	0.2337
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.006	0.074	0.1428
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0237	1
Schistosoma mansoni	nuclear hormone receptor	0.0028	0.0236	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0032	0.029	0.043
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0127	0.181	0.1779
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0028	0.0236	0.028
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.006	0.074	0.2337
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0028	0.0236	0.0433
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0143	0.2071	0.2874
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.027	0.0233
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0177	1
Schistosoma mansoni	retinoic acid receptor RXR	0.006	0.074	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.006	0.074	0.0992
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.006	0.074	0.2337
Trichomonas vaginalis	set domain proteins, putative	0.0232	0.3485	1
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0237	0.0282
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.0387
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.006	0.074	0.2337
Brugia malayi	ecdysteroid receptor	0.006	0.074	0.2337
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.006	0.074	0.1428
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.006	0.074	0.1536
Loa Loa (eye worm)	hypothetical protein	0.0032	0.029	0.043
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.006	0.074	0.1536
Brugia malayi	conserved hypotetical protein	0.0028	0.0236	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0177	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0237	0.0424
Brugia malayi	hypothetical protein	0.0028	0.0236	0.0658
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.3039	0.6524
Brugia malayi	nuclear hormone receptor	0.006	0.074	0.2337
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.006	0.074	0.2337
Schistosoma mansoni	zinc finger protein	0.0028	0.0236	0.0199
Echinococcus granulosus	snurportin 1	0.0302	0.4607	0.6458
Schistosoma mansoni	cpg binding protein	0.0063	0.0786	0.0751
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.027	0.0233
Brugia malayi	nuclear receptor NHR-88	0.006	0.074	0.2337
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0028	0.0236	0.0311
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.006	0.074	0.0705
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.006	0.074	0.2337
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Onchocerca volvulus		0.006	0.074	0.1551
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.006	0.074	0.1551
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.006	0.074	0.2337
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0237	0.0437
Schistosoma mansoni	steroid hormone receptor ad4bp	0.006	0.074	0.0705
Brugia malayi	nuclear receptor NHR-67	0.0028	0.0236	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0177	0.0181
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0143	0.2071	0.4379
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0032	0.029	0.0253
Schistosoma mansoni	nuclear receptor	0.0028	0.0236	0.0199
Schistosoma mansoni	coup transcription factor	0.006	0.074	0.0705
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.0092	0.0178
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.006	0.074	0.2337
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0028	0.0236	0.028
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.006	0.074	0.0705
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.006	0.074	0.0992
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.029	0.0837
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.027	0.0328
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.006	0.074	0.2337
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.006	0.074	0.1428
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0237	0.0314
Loa Loa (eye worm)	hypothetical protein	0.006	0.074	0.1428
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0236	0.0311
Schistosoma mansoni	RAR-like nuclear receptor	0.006	0.074	0.0705
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.027	0.0654
Brugia malayi	Steroid receptor seven-up type 2	0.006	0.074	0.2337
Onchocerca volvulus	Bile acid receptor homolog	0.006	0.074	0.1551
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.006	0.074	0.1536
Echinococcus granulosus	ecdysone induced protein 78C	0.006	0.074	0.0992
Brugia malayi	hypothetical protein	0.0028	0.0236	0.0658
Brugia malayi	CXXC zinc finger family protein	0.0059	0.0732	0.2312
Plasmodium falciparum	importin beta, putative	0.0028	0.0237	1
Schistosoma mansoni	cpg binding protein	0.0063	0.0786	0.0751
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0032	0.029	0.0551
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0152	0.0436
Brugia malayi	Importin beta-1 subunit	0.0028	0.0237	0.0663
Brugia malayi	ecdysone receptor	0.0028	0.0236	0.0658
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0032	0.029	0.0356
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.006	0.074	0.0992
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.2071	0.2041

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= -1.55 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 1 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 1.07 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 2 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 2.29 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 99 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 100 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 2.88	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= 1 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 2 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 99 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 100 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.13	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.73943 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL548974
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 601746