Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0075 | 0.0352 | 0.0634 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0075 | 0.0352 | 0.0634 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0075 | 0.0352 | 0.0634 |
Plasmodium vivax | hypothetical protein, conserved | 0.0195 | 0.1345 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0035 | 0.0028 | 0.0051 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0054 | 0.018 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0035 | 0.0028 | 0.0051 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0075 | 0.0352 | 0.0634 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0075 | 0.0352 | 0.1907 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0035 | 0.0028 | 0.0051 |
Brugia malayi | jmjC domain containing protein | 0.0038 | 0.0055 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0352 | 0.0634 |
Onchocerca volvulus | 0.0195 | 0.1345 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0195 | 0.1345 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0035 | 0.0028 | 0.0152 |
Schistosoma mansoni | jumonji domain containing protein | 0.0083 | 0.0418 | 0.0754 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0659 | 0.4339 |
Schistosoma mansoni | nuclear receptor | 0.0035 | 0.0028 | 0.0051 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0066 | 0.0283 | 0.1192 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0659 | 0.4339 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0035 | 0.0028 | 0.0051 |
Echinococcus granulosus | snurportin 1 | 0.0706 | 0.555 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 0.0194 | 0.0502 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0075 | 0.0352 | 0.1907 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.1345 | 0.2423 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0049 | 0.0139 | 0.0251 |
Plasmodium falciparum | importin beta, putative | 0.0066 | 0.0283 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0057 | 0.021 | 0.0378 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0075 | 0.0352 | 0.0634 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0163 | 0.1081 | 0.1948 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0112 | 0.0659 | 0.4311 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0035 | 0.0028 | 0.0051 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0035 | 0.0028 | 0.0051 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0075 | 0.0352 | 0.0634 |
Brugia malayi | jmjC domain containing protein | 0.0104 | 0.0594 | 0.3219 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0103 | 0.0589 | 0.1061 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0035 | 0.0028 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.052 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0075 | 0.0352 | 0.0634 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0075 | 0.0352 | 0.0634 |
Brugia malayi | conserved hypotetical protein | 0.0035 | 0.0028 | 0.0152 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0112 | 0.0659 | 0.4311 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0035 | 0.0028 | 0.0051 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0075 | 0.0352 | 0.0634 |
Toxoplasma gondii | ABC1 family protein | 0.0195 | 0.1345 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0063 | 0.0113 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0035 | 0.0028 | 0.0152 |
Trichomonas vaginalis | esterase, putative | 0.0195 | 0.1345 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0048 | 0.0134 | 0.0993 |
Brugia malayi | nuclear receptor NHR-88 | 0.0035 | 0.0028 | 0.0152 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0195 | 0.1345 | 0.2423 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0075 | 0.0352 | 0.0634 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0039 | 0.0063 | 0.0113 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0104 | 0.0594 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0063 | 0.034 |
Echinococcus granulosus | importin subunit beta 1 | 0.0066 | 0.0283 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0352 | 0.0634 |
Brugia malayi | nuclear hormone receptor | 0.0075 | 0.0352 | 0.1907 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0075 | 0.0352 | 0.1907 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0066 | 0.0283 | 0.2105 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0035 | 0.0028 | 0.0152 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0169 | 0.1133 | 0.2042 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.2762 | 0.4978 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0075 | 0.0352 | 0.0634 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0195 | 0.1345 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0075 | 0.0352 | 0.0634 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0172 | 0.0932 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0049 | 0.0139 | 0.4924 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Onchocerca volvulus | 0.0035 | 0.0028 | 0.0209 | |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0035 | 0.0028 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Schistosoma mansoni | ran | 0.0049 | 0.0139 | 0.0251 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0028 | 0.0152 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0153 | 0.0826 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0049 | 0.0139 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0063 | 0.0113 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0256 | 0.1846 | 0.3326 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0659 | 0.4339 |
Plasmodium vivax | importin-beta 2, putative | 0.0066 | 0.0283 | 0.2105 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.1345 | 0.2423 |
Schistosoma mansoni | nuclear hormone receptor | 0.0075 | 0.0352 | 0.0634 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0039 | 0.0063 | 0.0113 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0195 | 0.1345 | 0.5 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0035 | 0.0028 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0172 | 0.031 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0035 | 0.0028 | 0.0209 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0163 | 0.1081 | 0.1948 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Brugia malayi | nuclear receptor RXR | 0.0039 | 0.0063 | 0.034 |
Brugia malayi | beta-lactamase family protein | 0.0195 | 0.1345 | 0.7286 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0112 | 0.0659 | 0.1188 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0112 | 0.0659 | 0.4311 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0195 | 0.1345 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0075 | 0.0352 | 0.0634 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0039 | 0.0063 | 0.0113 |
Trypanosoma brucei | polo-like protein kinase | 0.0112 | 0.0659 | 0.4311 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.2762 | 0.4978 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0195 | 0.1345 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0659 | 0.4339 |
Schistosoma mansoni | hypothetical protein | 0.0706 | 0.555 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0256 | 0.1846 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0035 | 0.0028 | 0.0209 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0256 | 0.1846 | 0.3326 |
Schistosoma mansoni | coup transcription factor | 0.0075 | 0.0352 | 0.0634 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0158 | 0.1043 | 0.188 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0202 | 0.1403 | 0.2528 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0044 | 0.0101 | 0.3555 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0195 | 0.1345 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0075 | 0.0352 | 0.0634 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0195 | 0.1345 | 0.2423 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0669 | 0.5243 | 0.9448 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0038 | 0.0055 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0352 | 0.0634 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0075 | 0.0352 | 0.0634 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0.0153 | 0.1134 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0112 | 0.0659 | 0.4901 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0195 | 0.1345 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0075 | 0.0352 | 0.2618 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0195 | 0.1345 | 0.2423 |
Schistosoma mansoni | thyroid hormone receptor | 0.0075 | 0.0352 | 0.0634 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0048 | 0.0134 | 0.0241 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0112 | 0.0659 | 0.1188 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0195 | 0.1345 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0195 | 0.1345 | 0.7286 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0035 | 0.0028 | 0.0051 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0039 | 0.0063 | 0.034 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0072 | 0.013 |
Schistosoma mansoni | hypothetical protein | 0.031 | 0.2287 | 0.4122 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0075 | 0.0352 | 0.0634 |
Echinococcus multilocularis | peregrin | 0.0036 | 0.0033 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0057 | 0.021 | 0.0378 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0075 | 0.0352 | 0.0634 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0659 | 0.4339 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0038 | 0.0055 | 0.0099 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0112 | 0.0659 | 0.3571 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0035 | 0.0189 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.0589 | 0.1061 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0172 | 0.0932 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0153 | 0.0275 |
Echinococcus granulosus | geminin | 0.0367 | 0.2762 | 0.4978 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0038 | 0.0055 | 0.0099 |
Echinococcus multilocularis | geminin | 0.0367 | 0.2762 | 0.4978 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0195 | 0.1345 | 0.2423 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0057 | 0.021 | 0.0378 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0075 | 0.0352 | 0.1907 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0072 | 0.013 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0659 | 0.4339 |
Schistosoma mansoni | thyroid hormone receptor | 0.0075 | 0.0352 | 0.0634 |
Schistosoma mansoni | zinc finger protein | 0.0035 | 0.0028 | 0.0051 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0075 | 0.0352 | 0.1907 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0035 | 0.0028 | 0.0051 |
Onchocerca volvulus | 0.0195 | 0.1345 | 1 | |
Entamoeba histolytica | Ran family GTPase | 0.0049 | 0.0139 | 0.1148 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0048 | 0.0134 | 0.0993 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0072 | 0.013 |
Onchocerca volvulus | 0.0075 | 0.0352 | 0.2618 | |
Onchocerca volvulus | 0.0195 | 0.1345 | 1 | |
Echinococcus multilocularis | importin subunit beta 1 | 0.0066 | 0.0283 | 0.051 |
Brugia malayi | beta-lactamase | 0.0195 | 0.1345 | 0.7286 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0055 | 0.0099 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0104 | 0.0594 | 0.1071 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0075 | 0.0352 | 0.1907 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0172 | 0.031 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0075 | 0.0352 | 0.1907 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0075 | 0.0352 | 0.0634 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0169 | 0.1133 | 0.2042 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0202 | 0.1403 | 0.2528 |
Entamoeba histolytica | hypothetical protein | 0.0054 | 0.018 | 0.1842 |
Brugia malayi | nuclear receptor NHR-67 | 0.0035 | 0.0028 | 0.0152 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0039 | 0.0063 | 0.0113 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0153 | 0.0275 |
Brugia malayi | hypothetical protein | 0.004 | 0.0072 | 0.039 |
Loa Loa (eye worm) | mbt repeat family protein | 0.005 | 0.0153 | 0.0275 |
Mycobacterium leprae | Probable lipase LipE | 0.0195 | 0.1345 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0103 | 0.0589 | 0.1061 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0169 | 0.1133 | 0.6138 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.1345 | 0.2423 |
Schistosoma mansoni | nuclear receptor | 0.0035 | 0.0028 | 0.0051 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0195 | 0.1345 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0075 | 0.0352 | 0.0634 |
Brugia malayi | ecdysone receptor | 0.0035 | 0.0028 | 0.0152 |
Brugia malayi | Bromodomain containing protein | 0.0036 | 0.0033 | 0.0178 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0075 | 0.0352 | 0.1907 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0035 | 0.0028 | 0.0051 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0195 | 0.1345 | 1 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0049 | 0.0139 | 0.2115 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0103 | 0.0589 | 0.1061 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0352 | 0.0634 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0169 | 0.1133 | 0.2042 |
Echinococcus granulosus | jumonji domain containing protein | 0.0044 | 0.0102 | 0.0184 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0057 | 0.021 | 0.0378 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0028 | 0.0152 |
Onchocerca volvulus | 0.005 | 0.0153 | 0.1134 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 0.0194 | 0.0502 |
Schistosoma mansoni | nuclear hormone receptor | 0.0035 | 0.0028 | 0.0051 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0075 | 0.0352 | 0.0634 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0039 | 0.0063 | 0.0113 |
Trichomonas vaginalis | ran, putative | 0.0049 | 0.0139 | 0.0048 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.0589 | 0.1061 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0057 | 0.021 | 0.1137 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0075 | 0.0352 | 0.1907 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0049 | 0.0139 | 0.0251 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0075 | 0.0352 | 0.0634 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0063 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.1345 | 0.2423 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0075 | 0.0352 | 0.2618 |
Brugia malayi | steroid hormone receptor | 0.0075 | 0.0352 | 0.1907 |
Mycobacterium ulcerans | lipase LipD | 0.0195 | 0.1345 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.0112 | 0.0659 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0187 | 0.0336 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0075 | 0.0352 | 0.1907 |
Echinococcus multilocularis | snurportin 1 | 0.0706 | 0.555 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0112 | 0.0659 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.021 | 0.0378 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0163 | 0.1081 | 0.5857 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0035 | 0.0028 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.1345 | 0.2423 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.005 | 0.0153 | 0.0275 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0063 | 0.034 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0035 | 0.0028 | 0.0051 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0103 | 0.0589 | 0.1061 |
Schistosoma mansoni | nuclear hormone receptor | 0.0035 | 0.0028 | 0.0051 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0049 | 0.0139 | 0.0755 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0075 | 0.0352 | 0.0634 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0103 | 0.0589 | 0.1061 |
Loa Loa (eye worm) | DR-78 | 0.0035 | 0.0028 | 0.0051 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0195 | 0.1345 | 0.2423 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0352 | 0.0634 |
Schistosoma mansoni | importin beta-1 | 0.0066 | 0.0283 | 0.051 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0049 | 0.0139 | 0.0251 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0153 | 0.0826 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0054 | 0.018 | 0.0338 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0283 | 0.051 |
Brugia malayi | tailless protein | 0.0035 | 0.0028 | 0.0152 |
Leishmania major | importin beta-1 subunit, putative | 0.0054 | 0.018 | 0.0338 |
Brugia malayi | Importin beta-1 subunit | 0.0066 | 0.0283 | 0.1534 |
Trichomonas vaginalis | importin beta-1, putative | 0.0054 | 0.018 | 0.0385 |
Loa Loa (eye worm) | beta-lactamase | 0.0195 | 0.1345 | 0.2423 |
Echinococcus granulosus | peregrin | 0.0036 | 0.0033 | 0.0059 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0044 | 0.0101 | 0.1527 |
Brugia malayi | ecdysteroid receptor | 0.0075 | 0.0352 | 0.1907 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0044 | 0.0101 | 0.0488 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0075 | 0.0352 | 0.1907 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.0589 | 0.1061 |
Brugia malayi | nuclear receptor NHR-88 | 0.0075 | 0.0352 | 0.1907 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0195 | 0.1345 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0352 | 0.0634 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0072 | 0.013 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0066 | 0.0278 | 0.0501 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0112 | 0.0659 | 0.1188 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0057 | 0.021 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1133 | 0.2042 |
Mycobacterium leprae | conserved hypothetical protein | 0.0195 | 0.1345 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.0659 | 0.4339 |
Schistosoma mansoni | kinase | 0.0057 | 0.0207 | 0.0372 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0169 | 0.1133 | 0.6138 |
Mycobacterium ulcerans | beta-lactamase | 0.0195 | 0.1345 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0075 | 0.0352 | 0.2618 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0075 | 0.0352 | 0.0634 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0352 | 0.0634 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0048 | 0.0134 | 0.0993 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0063 | 0.0113 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0075 | 0.0352 | 0.1907 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0035 | 0.0028 | 0.0051 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0075 | 0.0352 | 0.1907 |
Mycobacterium ulcerans | hypothetical protein | 0.0195 | 0.1345 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.1345 | 0.2423 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Brugia malayi | RNA, U transporter 1 | 0.0188 | 0.1287 | 0.697 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0035 | 0.0063 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0035 | 0.0028 | 0.0152 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0153 | 0.0275 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0054 | 0.018 | 0.0385 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0035 | 0.0028 | 0.0051 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0049 | 0.0139 | 0.1036 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.005 | 0.0153 | 0.0275 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0066 | 0.0283 | 0.1192 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.005 | 0.0153 | 0.0275 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0075 | 0.0352 | 0.0634 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0075 | 0.0352 | 0.0634 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.005 | 0.0153 | 0.0275 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0055 | 0.0099 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0075 | 0.0352 | 0.0634 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0035 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0075 | 0.0352 | 0.1907 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0075 | 0.0352 | 0.0634 |
Loa Loa (eye worm) | acetyltransferase | 0.0163 | 0.1081 | 0.1948 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0035 | 0.0028 | 0.0152 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0195 | 0.1345 | 0.7286 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0039 | 0.0063 | 0.034 |
Schistosoma mansoni | ran | 0.0049 | 0.0139 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0028 | 0.0051 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0169 | 0.1133 | 0.2042 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0063 | 0.0113 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0112 | 0.0659 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0035 | 0.0028 | 0.0051 |
Onchocerca volvulus | 0.0035 | 0.0028 | 0.0209 | |
Loa Loa (eye worm) | MBCTL1 | 0.0057 | 0.021 | 0.0378 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0075 | 0.0352 | 0.0634 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0044 | 0.0102 | 0.0184 |
Echinococcus granulosus | FTZ F1 alpha | 0.0521 | 0.4029 | 0.726 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0706 | 0.555 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0075 | 0.0352 | 0.0634 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0075 | 0.0352 | 0.0634 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.005 | 0.0153 | 0.0275 |
Brugia malayi | nuclear receptor RXR | 0.0035 | 0.0028 | 0.0152 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0103 | 0.0589 | 0.3189 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0035 | 0.0028 | 0.0152 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -0.17 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.37 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.08 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 5 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 11 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 11 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 97 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 9.02 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 5 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 11 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 11 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 97 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.15 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.71534 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.