Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0201 | 0.1357 | 1 | |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.004 | 0.0076 | 0.0523 |
Mycobacterium leprae | Probable lipase LipE | 0.0201 | 0.1357 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0041 | 0.008 | 0.0163 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0061 | 0.0238 | 0.0489 |
Schistosoma mansoni | kinase | 0.0051 | 0.0163 | 0.0334 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0148 | 0.0824 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.005 | 0.0102 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0041 | 0.008 | 0.0163 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0149 | 0.0946 | 0.5252 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0558 | 0.3762 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.0076 | 0.04 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0053 | 0.0179 | 0.0368 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0044 | 0.0107 | 0.0628 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0115 | 0.0675 | 0.1385 |
Brugia malayi | jmjC domain containing protein | 0.0041 | 0.008 | 0.0442 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.0179 | 0.0368 |
Echinococcus multilocularis | importin subunit beta 1 | 0.006 | 0.0233 | 0.0479 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0558 | 0.3762 |
Onchocerca volvulus | 0.0201 | 0.1357 | 1 | |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0034 | 0.0023 | 0.0047 |
Brugia malayi | beta-lactamase family protein | 0.0201 | 0.1357 | 0.7536 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0201 | 0.1357 | 0.7536 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0201 | 0.1357 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.01 | 0.0551 | 0.3061 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.0551 | 0.1131 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.008 | 0.0163 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0115 | 0.0675 | 0.1385 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0128 | 0.0263 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0053 | 0.0179 | 0.0368 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0107 | 0.0608 | 0.4152 |
Brugia malayi | MH2 domain containing protein | 0.0257 | 0.1801 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.004 | 0.0076 | 0.0157 |
Onchocerca volvulus | 0.0053 | 0.0179 | 0.1322 | |
Mycobacterium tuberculosis | Probable hydrolase | 0.0201 | 0.1357 | 0.1291 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0044 | 0.0107 | 0.1432 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0558 | 0.3762 |
Brugia malayi | PHD-finger family protein | 0.0034 | 0.0023 | 0.0128 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0115 | 0.0675 | 0.3749 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0145 | 0.0913 | 0.1872 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0101 | 0.0558 | 0.3099 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0201 | 0.1357 | 0.2785 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0238 | 0.0489 |
Entamoeba histolytica | Ran family GTPase | 0.0044 | 0.0107 | 0.1122 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.0551 | 0.1131 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.0104 | 0.0219 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0107 | 0.0608 | 0.0536 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0023 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0739 | 0.1517 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0558 | 0.3762 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.0104 | 0.0219 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.005 | 0.0102 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0044 | 0.0107 | 0.1565 |
Schistosoma mansoni | hypothetical protein | 0.0534 | 0.4014 | 0.8235 |
Echinococcus multilocularis | geminin | 0.0534 | 0.4014 | 0.8235 |
Echinococcus multilocularis | snurportin 1 | 0.0642 | 0.4875 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0429 | 0.318 | 0.6524 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0075 | 0.0501 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0053 | 0.0179 | 0.1322 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.004 | 0.0076 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0257 | 0.1801 | 0.3695 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0023 | 0.0047 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0061 | 0.0238 | 0.0489 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.0739 | 0.1517 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0107 | 0.0608 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.0152 | 0.0591 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0215 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0179 | 0.0368 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0201 | 0.1357 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.004 | 0.0076 | 0.04 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0148 | 0.0824 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0044 | 0.0107 | 0.0238 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0201 | 0.1357 | 0.1291 |
Onchocerca volvulus | Alhambra homolog | 0.0034 | 0.0023 | 0.0169 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0034 | 0.0023 | 0.0047 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0201 | 0.1357 | 0.1291 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0149 | 0.0946 | 0.1941 |
Loa Loa (eye worm) | acetyltransferase | 0.0149 | 0.0946 | 0.1941 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.0104 | 0.061 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0111 | 0.0636 | 0.1304 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0201 | 0.1357 | 0.2785 |
Giardia lamblia | Kinase, PLK | 0.0101 | 0.0558 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0201 | 0.1357 | 0.1291 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.0104 | 0.061 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0115 | 0.0675 | 0.1385 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0201 | 0.1357 | 0.1291 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0023 | 0.0048 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0201 | 0.1357 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0201 | 0.1357 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0053 | 0.0179 | 0.0368 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0044 | 0.0107 | 0.0593 |
Brugia malayi | RNA, U transporter 1 | 0.0171 | 0.1118 | 0.6205 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0034 | 0.0023 | 0.0047 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0049 | 0.0143 | 0.0518 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0257 | 0.1801 | 0.3695 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0558 | 0.3762 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.0551 | 0.1131 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0218 | 0.1497 | 0.307 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0154 | 0.0986 | 0.2022 |
Echinococcus multilocularis | peregrin | 0.0037 | 0.0052 | 0.0107 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.0551 | 0.1131 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1357 | 0.2785 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0233 | 0.0479 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0111 | 0.0636 | 0.1304 |
Onchocerca volvulus | 0.0201 | 0.1357 | 1 | |
Loa Loa (eye worm) | beta-lactamase | 0.0201 | 0.1357 | 0.2785 |
Schistosoma mansoni | hypothetical protein | 0.0332 | 0.2407 | 0.4938 |
Mycobacterium ulcerans | hypothetical protein | 0.0201 | 0.1357 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0107 | 0.0608 | 0.4152 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.0179 | 0.0996 |
Schistosoma mansoni | hypothetical protein | 0.0642 | 0.4875 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0201 | 0.1357 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.0551 | 0.1131 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0201 | 0.1357 | 0.2785 |
Schistosoma mansoni | hypothetical protein | 0.0534 | 0.4014 | 0.8235 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0201 | 0.1357 | 0.1291 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.0179 | 0.0996 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0201 | 0.1357 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0201 | 0.1357 | 0.1291 |
Echinococcus granulosus | peregrin | 0.0037 | 0.0052 | 0.0107 |
Plasmodium vivax | importin-beta 2, putative | 0.006 | 0.0233 | 0.1577 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.004 | 0.0076 | 0.0996 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.0179 | 0.0368 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0101 | 0.0558 | 0.3762 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0101 | 0.0558 | 0.1145 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.005 | 0.0102 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0107 | 0.0608 | 0.4386 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0107 | 0.0608 | 0.4152 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0558 | 0.3762 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0107 | 0.0608 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0128 | 0.0263 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0101 | 0.0558 | 0.1145 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0101 | 0.0558 | 0.3762 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0149 | 0.0946 | 0.1941 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.0152 | 0.0591 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0044 | 0.0107 | 0.0219 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0201 | 0.1357 | 0.2785 |
Schistosoma mansoni | thyroid hormone receptor | 0.0154 | 0.0986 | 0.2022 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0201 | 0.1357 | 0.2785 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1357 | 0.2785 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0061 | 0.0238 | 0.0489 |
Schistosoma mansoni | importin beta-1 | 0.006 | 0.0233 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1357 | 0.2785 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.0739 | 0.1517 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.031 | 0.0635 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0044 | 0.0107 | 0.0238 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0115 | 0.0675 | 0.1385 |
Echinococcus granulosus | snurportin 1 | 0.0642 | 0.4875 | 1 |
Schistosoma mansoni | ap endonuclease | 0.004 | 0.0076 | 0.0157 |
Trichomonas vaginalis | importin beta-1, putative | 0.0049 | 0.0143 | 0.0518 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0101 | 0.0558 | 0.1145 |
Brugia malayi | Importin beta-1 subunit | 0.006 | 0.0233 | 0.1296 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.006 | 0.0233 | 0.1577 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0101 | 0.0558 | 0.1145 |
Echinococcus multilocularis | leucine aminopeptidase protein | 0.0107 | 0.0608 | 0.1248 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1357 | 0.2785 |
Brugia malayi | hypothetical protein | 0.0037 | 0.005 | 0.0276 |
Brugia malayi | beta-lactamase | 0.0201 | 0.1357 | 0.7536 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.006 | 0.0233 | 0.1226 |
Mycobacterium tuberculosis | Conserved protein | 0.0201 | 0.1357 | 0.1291 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0041 | 0.008 | 0.0163 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0107 | 0.0608 | 0.4152 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0107 | 0.0608 | 0.4386 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.004 | 0.0076 | 0.0157 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0201 | 0.1357 | 1 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0044 | 0.0107 | 0.0219 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0053 | 0.0179 | 0.0368 |
Leishmania major | GTP-binding protein, putative | 0.0044 | 0.0107 | 0.0238 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0049 | 0.0143 | 0.0518 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0075 | 0.0892 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.0104 | 0.0214 |
Entamoeba histolytica | hypothetical protein | 0.0049 | 0.0143 | 0.1828 |
Mycobacterium tuberculosis | Conserved protein | 0.0201 | 0.1357 | 0.1291 |
Echinococcus granulosus | geminin | 0.0534 | 0.4014 | 0.8235 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0049 | 0.0143 | 0.0518 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0101 | 0.0558 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.004 | 0.0076 | 0.0157 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.0429 | 0.088 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.006 | 0.0233 | 0.1226 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1357 | 0.2785 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.005 | 0.0102 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0023 | 0.013 |
Echinococcus granulosus | importin subunit beta 1 | 0.006 | 0.0233 | 0.0479 |
Trichomonas vaginalis | esterase, putative | 0.0201 | 0.1357 | 1 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0044 | 0.0107 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0148 | 0.0304 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0201 | 0.1357 | 1 |
Plasmodium falciparum | importin beta, putative | 0.006 | 0.0233 | 0.3595 |
Mycobacterium leprae | conserved hypothetical protein | 0.0201 | 0.1357 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.0551 | 0.1131 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0075 | 0.0975 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0053 | 0.0179 | 0.0368 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0023 | 0.0047 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.0551 | 0.1131 |
Toxoplasma gondii | ABC1 family protein | 0.0201 | 0.1357 | 1 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0107 | 0.0608 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.008 | 0.0163 |
Leishmania major | hypothetical protein, conserved | 0.0201 | 0.1357 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0201 | 0.1357 | 0.7536 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0201 | 0.1357 | 1 |
Echinococcus granulosus | leucine aminopeptidase protein | 0.0107 | 0.0608 | 0.1248 |
Trichomonas vaginalis | ran, putative | 0.0044 | 0.0107 | 0.0238 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0061 | 0.0238 | 0.0489 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0053 | 0.0179 | 0.0368 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.01 | 0.0551 | 0.1131 |
Loa Loa (eye worm) | MBCTL1 | 0.0061 | 0.0238 | 0.0489 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0201 | 0.1357 | 0.1291 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0061 | 0.0238 | 0.1323 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0218 | 0.1497 | 0.307 |
Schistosoma mansoni | ran | 0.0044 | 0.0107 | 0.0219 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.0076 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0675 | 0.1385 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0061 | 0.0238 | 0.0489 |
Plasmodium vivax | hypothetical protein, conserved | 0.0201 | 0.1357 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0148 | 0.0304 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.0052 | 0.029 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0115 | 0.0675 | 0.3749 |
Mycobacterium ulcerans | lipase LipD | 0.0201 | 0.1357 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1357 | 0.2785 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0101 | 0.0558 | 0.4113 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0101 | 0.0558 | 0.3762 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.0558 | 0.3762 |
Schistosoma mansoni | ap endonuclease | 0.004 | 0.0076 | 0.0157 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0044 | 0.0107 | 0.0628 |
Brugia malayi | jmjC domain containing protein | 0.0111 | 0.0636 | 0.3528 |
Schistosoma mansoni | thyroid hormone receptor | 0.0154 | 0.0986 | 0.2022 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.0104 | 0.061 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0642 | 0.4875 | 1 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0107 | 0.0608 | 0.4152 |
Schistosoma mansoni | jumonji domain containing protein | 0.0088 | 0.0454 | 0.0932 |
Trypanosoma brucei | polo-like protein kinase | 0.0101 | 0.0558 | 0.3762 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0201 | 0.1357 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0201 | 0.1357 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.004 | 0.0076 | 0.0424 |
Leishmania major | importin beta-1 subunit, putative | 0.0049 | 0.0143 | 0.0518 |
Schistosoma mansoni | ran | 0.0044 | 0.0107 | 0.0219 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0034 | 0.0023 | 0.0047 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0044 | 0.0107 | 0.0219 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 1.84 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.62 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 4.02 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 18 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 78 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 94 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 8.33 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 18 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 78 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 94 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.21 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.62198 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.