Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0641 | 0.4753 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.006 | 0.0229 | 0.0483 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.0097 | 0.0525 |
Loa Loa (eye worm) | acetyltransferase | 0.0146 | 0.09 | 0.1894 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0115 | 0.0653 | 0.1374 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0057 | 0.0204 | 0.0429 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0206 | 0.1364 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0206 | 0.1364 | 0.1293 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.006 | 0.0229 | 0.115 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0232 | 0.1569 | 0.33 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0206 | 0.1364 | 0.1293 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.1638 | 0.3446 |
Schistosoma mansoni | ran | 0.0044 | 0.0106 | 0.0223 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0153 | 0.0952 | 0.2002 |
Entamoeba histolytica | hypothetical protein | 0.0049 | 0.0141 | 0.1866 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0103 | 0.0562 | 0.1183 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0103 | 0.0562 | 0.412 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0044 | 0.0106 | 0.0188 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.0546 | 0.1148 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0044 | 0.0093 |
Brugia malayi | jmjC domain containing protein | 0.0111 | 0.0628 | 0.3546 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0562 | 0.3744 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0562 | 0.3744 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0101 | 0.0546 | 0.1148 |
Brugia malayi | mbt repeat family protein | 0.0057 | 0.0204 | 0.1152 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0054 | 0.0306 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0562 | 0.3744 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0158 | 0.0593 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0145 | 0.0816 |
Echinococcus multilocularis | geminin | 0.0354 | 0.2519 | 0.5299 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.0546 | 0.1148 |
Echinococcus multilocularis | peregrin | 0.0038 | 0.0054 | 0.0114 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0065 | 0.0265 | 0.0558 |
Onchocerca volvulus | 0.0206 | 0.1364 | 1 | |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0049 | 0.0141 | 0.0461 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.0097 | 0.0203 |
Schistosoma mansoni | ap endonuclease | 0.0041 | 0.0082 | 0.0172 |
Leishmania major | GTP-binding protein, putative | 0.0044 | 0.0106 | 0.0188 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0041 | 0.0082 | 0.0172 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.013 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0204 | 0.0429 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0206 | 0.1364 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0041 | 0.0082 | 0.0725 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0562 | 0.3744 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0111 | 0.0628 | 0.1321 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0041 | 0.0082 | 0.5 |
Onchocerca volvulus | 0.0057 | 0.0204 | 0.1495 | |
Leishmania major | hypothetical protein, conserved | 0.0206 | 0.1364 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0044 | 0.0093 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0206 | 0.1364 | 0.1293 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0215 | 0.0453 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0562 | 0.3744 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.0546 | 0.1148 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0206 | 0.1364 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0103 | 0.0562 | 0.1183 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.013 | 0.0273 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.006 | 0.0229 | 0.1518 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.0069 | 0.0791 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0041 | 0.0082 | 0.0172 |
Brugia malayi | hypothetical protein | 0.0241 | 0.1638 | 0.925 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.0097 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0229 | 0.0483 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0206 | 0.1364 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0111 | 0.0628 | 0.1321 |
Schistosoma mansoni | importin beta-1 | 0.006 | 0.0229 | 0.0483 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.0082 | 0.0172 |
Echinococcus granulosus | importin subunit beta 1 | 0.006 | 0.0229 | 0.0483 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0149 | 0.0839 |
Schistosoma mansoni | jumonji domain containing protein | 0.0088 | 0.045 | 0.0947 |
Plasmodium vivax | hypothetical protein, conserved | 0.0206 | 0.1364 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0206 | 0.1364 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0206 | 0.1364 | 0.2871 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0562 | 0.3744 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0206 | 0.1364 | 0.2871 |
Toxoplasma gondii | exonuclease III APE | 0.0041 | 0.0082 | 0.0416 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.0308 | 0.0648 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0026 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0265 | 0.0558 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0044 | 0.0093 |
Onchocerca volvulus | 0.0049 | 0.0145 | 0.1059 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0206 | 0.1364 | 0.7706 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0057 | 0.0204 | 0.0429 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0206 | 0.1364 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0049 | 0.0141 | 0.0461 |
Brugia malayi | mbt repeat family protein | 0.0057 | 0.0204 | 0.1152 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0034 | 0.0026 | 0.0055 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0206 | 0.1364 | 0.2871 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.0097 | 0.0525 |
Mycobacterium ulcerans | hypothetical protein | 0.0206 | 0.1364 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0057 | 0.0204 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0026 | 0.0055 |
Schistosoma mansoni | ran | 0.0044 | 0.0106 | 0.0223 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0044 | 0.0106 | 0.0596 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0026 | 0.0055 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0044 | 0.0106 | 0.0223 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0065 | 0.0265 | 0.0558 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0103 | 0.0562 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0206 | 0.1364 | 0.1293 |
Onchocerca volvulus | 0.0206 | 0.1364 | 1 | |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0041 | 0.0082 | 0.0172 |
Echinococcus granulosus | snurportin 1 | 0.0641 | 0.4753 | 1 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0044 | 0.0106 | 0.3924 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0103 | 0.0562 | 0.3744 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0044 | 0.0106 | 0.0188 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0206 | 0.1364 | 0.1293 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0115 | 0.0653 | 0.1374 |
Trypanosoma brucei | polo-like protein kinase | 0.0103 | 0.0562 | 0.3744 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0041 | 0.0082 | 0.0172 |
Giardia lamblia | Kinase, PLK | 0.0103 | 0.0562 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0206 | 0.1364 | 0.1293 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0562 | 0.3744 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1364 | 0.2871 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0044 | 0.0251 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0044 | 0.0106 | 0.1487 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.0714 | 0.1501 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0142 | 0.0868 | 0.1826 |
Brugia malayi | Importin beta-1 subunit | 0.006 | 0.0229 | 0.1296 |
Brugia malayi | beta-lactamase family protein | 0.0206 | 0.1364 | 0.7706 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0041 | 0.0082 | 0.0463 |
Mycobacterium ulcerans | lipase LipD | 0.0206 | 0.1364 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0206 | 0.1364 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0065 | 0.0265 | 0.0558 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0065 | 0.0265 | 0.0558 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0206 | 0.1364 | 1 |
Brugia malayi | PHD-finger family protein | 0.0034 | 0.0026 | 0.0149 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.0546 | 0.1148 |
Brugia malayi | beta-lactamase family protein | 0.0206 | 0.1364 | 0.7706 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0057 | 0.0204 | 0.0429 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0057 | 0.0204 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0653 | 0.1374 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0041 | 0.0082 | 0.0172 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0044 | 0.0106 | 0.0188 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0041 | 0.0082 | 0.0172 |
Schistosoma mansoni | kinase | 0.0052 | 0.0169 | 0.0355 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0103 | 0.0562 | 0.1183 |
Brugia malayi | jmjC domain containing protein | 0.0041 | 0.0082 | 0.0463 |
Brugia malayi | RNA, U transporter 1 | 0.0171 | 0.1091 | 0.6164 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0044 | 0.0093 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0145 | 0.0304 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0041 | 0.0082 | 0.5 |
Leishmania major | importin beta-1 subunit, putative | 0.0049 | 0.0141 | 0.0461 |
Mycobacterium leprae | Probable lipase LipE | 0.0206 | 0.1364 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.006 | 0.0229 | 0.115 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0206 | 0.1364 | 0.2871 |
Echinococcus granulosus | peregrin | 0.0038 | 0.0054 | 0.0114 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.2514 | 0.5289 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.2519 | 0.5299 |
Echinococcus granulosus | geminin | 0.0354 | 0.2519 | 0.5299 |
Schistosoma mansoni | hypothetical protein | 0.0641 | 0.4753 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0041 | 0.0082 | 0.274 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.0097 | 0.0525 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0034 | 0.0026 | 0.0055 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0146 | 0.09 | 0.1894 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0101 | 0.0546 | 0.3081 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0103 | 0.0562 | 0.3175 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0041 | 0.0082 | 0.0416 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0206 | 0.1364 | 0.2871 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.0546 | 0.1148 |
Plasmodium falciparum | importin beta, putative | 0.006 | 0.0229 | 1 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0044 | 0.0106 | 0.0223 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0065 | 0.0265 | 0.0558 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.0714 | 0.1501 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0146 | 0.09 | 0.5083 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0103 | 0.0562 | 0.3744 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0057 | 0.0204 | 0.0429 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0044 | 0.0106 | 0.0599 |
Onchocerca volvulus | 0.0206 | 0.1364 | 1 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0258 | 0.1771 | 0.3725 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.0069 | 0.0469 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0103 | 0.0562 | 0.3744 |
Entamoeba histolytica | Ran family GTPase | 0.0044 | 0.0106 | 0.119 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0115 | 0.0653 | 0.1374 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0149 | 0.0313 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0044 | 0.0106 | 0.0223 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.0158 | 0.0593 |
Schistosoma mansoni | ap endonuclease | 0.0041 | 0.0082 | 0.0172 |
Brugia malayi | beta-lactamase | 0.0206 | 0.1364 | 0.7706 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0026 | 0.0148 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0206 | 0.1364 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0206 | 0.1364 | 0.2871 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0206 | 0.1364 | 0.1293 |
Trichomonas vaginalis | ran, putative | 0.0044 | 0.0106 | 0.0188 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0232 | 0.1569 | 0.33 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.0546 | 0.1148 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.0714 | 0.1501 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0206 | 0.1364 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0153 | 0.0952 | 0.2002 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0115 | 0.0653 | 0.3689 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0044 | 0.0106 | 0.0596 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1364 | 0.2871 |
Schistosoma mansoni | thyroid hormone receptor | 0.0153 | 0.0952 | 0.2002 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0026 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1364 | 0.2871 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.0097 | 0.0114 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0049 | 0.0141 | 0.0461 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.0082 | 0.0172 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0103 | 0.0562 | 0.1183 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0145 | 0.0304 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0057 | 0.0204 | 0.1495 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0149 | 0.0313 |
Mycobacterium tuberculosis | Conserved protein | 0.0206 | 0.1364 | 0.1293 |
Plasmodium vivax | importin-beta 2, putative | 0.006 | 0.0229 | 0.1518 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0146 | 0.09 | 0.1894 |
Brugia malayi | MH2 domain containing protein | 0.0258 | 0.1771 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0034 | 0.0026 | 0.0055 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.0069 | 0.2088 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0149 | 0.0839 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0041 | 0.0082 | 0.1039 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0034 | 0.0026 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1364 | 0.2871 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1364 | 0.2871 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0206 | 0.1364 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0049 | 0.0141 | 0.0461 |
Echinococcus granulosus | FTZ F1 alpha | 0.0426 | 0.3076 | 0.6472 |
Trichomonas vaginalis | esterase, putative | 0.0206 | 0.1364 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0206 | 0.1364 | 0.1293 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.0415 | 0.0874 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0115 | 0.0653 | 0.1374 |
Mycobacterium leprae | conserved hypothetical protein | 0.0206 | 0.1364 | 0.5 |
Echinococcus multilocularis | snurportin 1 | 0.0641 | 0.4753 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0057 | 0.0204 | 0.0429 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.2519 | 0.5299 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1364 | 0.2871 |
Mycobacterium ulcerans | beta-lactamase | 0.0206 | 0.1364 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0115 | 0.0653 | 0.3689 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0057 | 0.0204 | 0.0429 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0241 | 0.1638 | 0.3446 |
Onchocerca volvulus | Alhambra homolog | 0.0034 | 0.0026 | 0.0193 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0065 | 0.0265 | 0.1498 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0206 | 0.1364 | 0.1293 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.0546 | 0.1148 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0065 | 0.0265 | 0.0558 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0241 | 0.1638 | 0.3446 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0258 | 0.1771 | 0.3725 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 10.06 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 17.86 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 29.87 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 42 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 66 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 93 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 11.03 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -6 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 42 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 66 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 93 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.03 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.92946 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.