Detailed information for compound 60187

Basic information

Technical information
  • TDR Targets ID: 60187
  • Name: 4-[(1S)-1-hydroxy-2,2-dimethylpropyl]benzoic acid
  • MW: 208.254 | Formula: C12H16O3
  • H donors: 2 H acceptors: 3 LogP: 2.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H](C(C)(C)C)c1ccc(cc1)C(=O)O
  • InChi: 1S/C12H16O3/c1-12(2,3)10(13)8-4-6-9(7-5-8)11(14)15/h4-7,10,13H,1-3H3,(H,14,15)/t10-/m1/s1
  • InChiKey: WVWUIXUDPBZIMS-SNVBAGLBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(1S)-1-hydroxy-2,2-dimethyl-propyl]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus microtubule associated protein 2 0.0726 0.6106 0.61
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0348 0.0334
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0331
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0015 0.0018 0.0004
Giardia lamblia Rrm3p helicase 0.1181 1 1
Brugia malayi hypothetical protein 0.0021 0.0067 0.0331
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0252 0.0252
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0015 0.0018 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Schistosoma mansoni hypothetical protein 0.1181 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0316 0.0316
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0316 0.2533
Schistosoma mansoni loxhd1 0.0021 0.0067 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0015 0.0072
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0055 0.0357 0.0342
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0335 0.0321
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0316 1
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0067 0.0052
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.0015 0.0117
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0055 0.0357 0.0342
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0015 0.0015
Leishmania major mitochondrial DNA polymerase beta 0.0301 0.2471 0.2471
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0024 0.0093 0.0079
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0059 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0191 0.1428
Brugia malayi hypothetical protein 0.0021 0.0067 0.0331
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0015 0.0018 0.0004
Echinococcus multilocularis RUN 0.0021 0.0067 0.0052
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0348 0.0334
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0059 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0015 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0072
Loa Loa (eye worm) hypothetical protein 0.0249 0.2019 1
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0316 0.2533
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0015 0.0018 0.0004
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0015 0.0018 0.0018
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0059 0.0469
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0059 0.5
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0015 0.0015
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0052 0.0335 0.1658
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.0015 0.0117
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0015 0.0072
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0208 0.1668
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0348 0.0348
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0015 0.0018 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0015 0.0072
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0387 0.0372
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0332 0.0332
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0093 0.0093
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.0015 0.0117
Echinococcus multilocularis tumor protein p63 0.0355 0.2933 0.2923
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0067 0.0052
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0059 0.0044
Brugia malayi hypothetical protein 0.0249 0.2019 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.0015 0.0117
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0348 0.0348
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0015 0.0022 0.0358
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0015 0.0018 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Schistosoma mansoni microtubule-associated protein tau 0.0726 0.6106 0.61
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0015 0.0018 0.0192
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0208 0.1032
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0316 0.2533
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0301 0.2471 0.2471
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0316 0.0316
Brugia malayi AMP-binding enzyme family protein 0.005 0.0316 0.1567
Schistosoma mansoni survival motor neuron protein 0.0051 0.0324 0.031
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0067 0.2694
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0244 0.1976 0.9783
Giardia lamblia DNA polymerase alpha subunit A 0.0046 0.0285 0.0267
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0316 0.0316
Brugia malayi Doublecortin family protein 0.0021 0.0067 0.0331
Echinococcus granulosus tumor protein p63 0.0355 0.2933 0.2923
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0348 0.0334
Schistosoma mansoni rab6-interacting 0.0021 0.0067 0.0052
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0348 0.0334
Schistosoma mansoni polycystin 1-related 0.0021 0.0067 0.0052
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0018 0.0018
Schistosoma mansoni lipoxygenase 0.0021 0.0067 0.0052
Brugia malayi DNA polymerase family B containing protein 0.0015 0.0018 0.0091
Echinococcus multilocularis microtubule associated protein 2 0.0726 0.6106 0.61
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1111 0.1111
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0072
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0015 0.0022 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0015 0.0072
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0055 0.0357 0.0342
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0316 0.2444
Loa Loa (eye worm) oxidoreductase 0.0015 0.0015 0.0072
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0037 0.0208 0.1032
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0015 0.0018 0.0146
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.0015 0.0117
Schistosoma mansoni rab6-interacting 0.0021 0.0067 0.0052
Plasmodium vivax DNA polymerase alpha, putative 0.0044 0.0268 1
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0348 0.0334
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0015 0.0018 0.0004
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0018 0.0018
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0348 0.0348
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0015 0.0018 0.0004
Mycobacterium ulcerans hypothetical protein 0.005 0.0316 0.2533
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.1111 0.1111
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0316 0.2444
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0059 0.0059
Onchocerca volvulus 0.0021 0.0067 0.101
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0015 0.0117
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0059 0.0044
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0067 0.0052
Brugia malayi DNA polymerase delta catalytic subunit 0.0015 0.0018 0.0091
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0015 0.0018 0.0004
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0018 0.0018
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0316 0.2533
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0208 0.7638
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.1181 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0316 0.2533
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0191 0.1428
Loa Loa (eye worm) hypothetical protein 0.0037 0.0208 0.1032
Echinococcus granulosus RUN 0.0021 0.0067 0.0052
Loa Loa (eye worm) hypothetical protein 0.0037 0.0208 0.1032
Entamoeba histolytica DNA repair and recombination protein, putative 0.1181 1 1
Schistosoma mansoni hypothetical protein 0.0021 0.0067 0.0052
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0059 0.004
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1111 0.1111
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0018 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0059 0.0044
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0015 0.0072
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0015 0.0018 0.0146
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.1181 1 1
Mycobacterium ulcerans hypothetical protein 0.0159 0.1249 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0348 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0316 0.1567
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0015 0.0015
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.2471 0.2471
Toxoplasma gondii exonuclease III APE 0.002 0.0059 0.1319
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.0015 0.0117
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.005 0.0316 0.1567
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0015 0.0015
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0059 0.2271
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0387 0.0372
Loa Loa (eye worm) hypothetical protein 0.0075 0.0532 0.2632
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0348 0.0348
Brugia malayi DNA polymerase alpha catalytic subunit 0.0044 0.0268 0.1328
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0252 0.0252
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.002 0.0064 0.005
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0015 0.0072
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0067 0.0052
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0324 0.1603
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0316 0.2533
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0208 1
Onchocerca volvulus 0.0021 0.0067 0.101
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0015 0.0018 0.0004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0853 0.7194 0.719
Trichomonas vaginalis conserved hypothetical protein 0.1181 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0059 0.1735
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0348 0.0334
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0331
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0208 0.5
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.1181 1 1
Onchocerca volvulus 0.0052 0.0335 0.6192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.1181 1 1
Brugia malayi AMP-binding enzyme family protein 0.005 0.0316 0.1567
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0067 0.0052
Onchocerca volvulus DNA polymerase homolog 0.0015 0.0018 0.0072
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0316 1
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0348 0.0334
Schistosoma mansoni lipoxygenase 0.0058 0.0387 0.0372
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.1181 1 1
Onchocerca volvulus 0.0051 0.0324 0.5979
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0015 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.005 0.0316 0.1567
Brugia malayi AMP-binding enzyme family protein 0.005 0.0316 0.1567
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Loa Loa (eye worm) hypothetical protein 0.0037 0.0208 0.1032
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0067 0.0052
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0252 0.0252
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0059 0.0059
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0059 0.029
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0059 0.0044
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0015 0.0018 0.0018
Onchocerca volvulus 0.005 0.0316 0.5837
Brugia malayi MAP kinase sur-1 0.0054 0.0348 0.1724
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1249 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0316 0.2533
Toxoplasma gondii DNA polymerase family B protein 0.0015 0.0018 0.0111
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0191 0.1428
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.2019 0.2008
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0075 0.0532 1
Trypanosoma brucei protein kinase, putative 0.0054 0.0348 0.0348
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0015 0.0018 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0015 0.0072
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0348 0.1724
Schistosoma mansoni ap endonuclease 0.002 0.0059 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0191 0.1428
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0348 0.0331
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0316 0.0302
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0015 0.0018 0.0146
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.1181 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0316 0.0302
Schistosoma mansoni hypothetical protein 0.0051 0.0324 0.031
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0015 0.0018 0.0018
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.0015 0.0117
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0015 0.0015
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0067 0.2058
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0044 0.0268 0.7603
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0059 0.0059
Toxoplasma gondii DNA polymerase 0.0015 0.0018 0.0111
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0348 0.0334
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.1181 1 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0015 0.0072
Schistosoma mansoni ap endonuclease 0.002 0.0059 0.0044
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0015 0.0018 0.0004
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0015 0.0018 0.0004
Entamoeba histolytica hypothetical protein, conserved 0.1181 1 1
Brugia malayi follicle stimulating hormone receptor 0.0244 0.1976 0.9783
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0015 0.0018 0.0004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0252 0.0252
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0015 0.0015
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.2471 0.2471
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0015 0.0015
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.1181 1 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0208 0.1569
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0348 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0348 0.0334
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.0015 0.0117
Toxoplasma gondii hypothetical protein 0.0049 0.0306 0.8723
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.2019 0.2008
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0067 0.0331
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0059 0.0059
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0024 0.0093 0.0093
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0059 0.0356
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0059 0.029
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0015 0.0018 0.0091
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0015 0.0018 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0316 0.0302
Trichomonas vaginalis DNA polymerase II, putative 0.0024 0.0093 0.0079

Activities

Activity type Activity value Assay description Source Reference
Control (functional) < 62 % Testes weight(treated)/body weight(treated)]/[testes weight(control)/body weight(control)] x 100 at a dose of 350 umol/kg/day ChEMBL. 9888840
Control (functional) < 80 % Ketone levels were determined in an acute in vivo study for inhibition of gluconeogenesis in normal male Sprague-Dawley rats ChEMBL. 9888840
Control (functional) = 94 % Glucose levels were determined in an acute in vivo study for inhibition of gluconeogenesis in normal male Sprague-Dawley rats ChEMBL. 9888840

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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