Detailed information for compound 601929

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 440.577 | Formula: C29H32N2O2
  • H donors: 0 H acceptors: 1 LogP: 4.8 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)N1CCC(CC1)CN1CCOC(C1)(c1ccccc1)c1ccccc1
  • InChi: 1S/C29H32N2O2/c32-28(25-10-4-1-5-11-25)31-18-16-24(17-19-31)22-30-20-21-33-29(23-30,26-12-6-2-7-13-26)27-14-8-3-9-15-27/h1-15,24H,16-23H2
  • InChiKey: ODJKJMZENGPOBZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei polo-like protein kinase 0.0106 0.0733 0.5125
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0179
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0252 0.0462
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0189 0.143 0.143
Brugia malayi jmjC domain containing protein 0.0037 0.0154 0.0768
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0219 0.1529
Schistosoma mansoni hypothetical protein 0.0347 0.2763 0.5065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0118 0.0829 0.1519
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0252 0.0462
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0098 0.0486
Toxoplasma gondii ABC1 family protein 0.0189 0.143 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0098 0.0179
Loa Loa (eye worm) hypothetical protein 0.0189 0.143 0.2621
Loa Loa (eye worm) hypothetical protein 0.0189 0.143 0.2621
Schistosoma mansoni gabp alpha 0.0066 0.0396 0.0727
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0098 0.0179
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0154 0.0283
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0281 0.1969
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0098 0.0179
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0226 0.1583
Brugia malayi jmjC domain containing protein 0.0101 0.0692 0.3444
Brugia malayi Fli-1 protein 0.0201 0.1531 0.7616
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0309 0.0567
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0154 0.0283
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0226 0.0415
Schistosoma mansoni hypothetical protein 0.0031 0.01 0.0183
Giardia lamblia Kinase, PLK 0.0106 0.0733 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0098 0.0486
Mycobacterium tuberculosis Probable lipase LipE 0.0189 0.143 0.143
Echinococcus granulosus geminin 0.0347 0.2763 0.5065
Trichomonas vaginalis D-aminoacylase, putative 0.0189 0.143 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0154 0.0768
Entamoeba histolytica hypothetical protein 0.0051 0.0266 0.3627
Onchocerca volvulus 0.0189 0.143 1
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0098 0.0179
Loa Loa (eye worm) hypothetical protein 0.0049 0.0252 0.0462
Mycobacterium tuberculosis Probable esterase LipL 0.0189 0.143 0.143
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.03 0.0551
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.01 0.0183
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0733 0.5125
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0098 0.0179
Mycobacterium ulcerans beta-lactamase 0.0189 0.143 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0266 0.1859
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0654 0.1199
Entamoeba histolytica serine/threonine protein kinase, putative 0.0106 0.0733 1
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0098 0.0179
Entamoeba histolytica hypothetical protein 0.0038 0.0159 0.2176
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0226 0.0415
Loa Loa (eye worm) hypothetical protein 0.0053 0.0286 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0118 0.0829 0.4121
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0252 0.0462
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0098 0.0179
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0179
Brugia malayi beta-lactamase 0.0189 0.143 0.711
Leishmania major GTP-binding protein, putative 0.0046 0.0226 0.1583
Trichomonas vaginalis D-aminoacylase, putative 0.0189 0.143 1
Toxoplasma gondii HEAT repeat-containing protein 0.0062 0.0365 0.2554
Schistosoma mansoni coup transcription factor 0.0031 0.0098 0.0179
Loa Loa (eye worm) hypothetical protein 0.0189 0.143 0.2621
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0098 0.0179
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0733 0.5125
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0098 0.0179
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0179
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0733 0.1343
Brugia malayi beta-lactamase family protein 0.0189 0.143 0.711
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0189 0.143 0.2621
Echinococcus granulosus snurportin 1 0.0667 0.5455 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0098 0.0179
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0733 0.5125
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0098 0.0179
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0219 0.1529
Onchocerca volvulus 0.0049 0.0252 0.116
Schistosoma mansoni ran 0.0046 0.0226 0.0415
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0 0.5
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0226 0.3089
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0733 0.5125
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0226 0.1583
Schistosoma mansoni ran 0.0046 0.0226 0.0415
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 0.113 0.2071
Loa Loa (eye worm) hypothetical protein 0.0057 0.0316 0.0579
Echinococcus multilocularis snurportin 1 0.0667 0.5455 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0226 0.1583
Echinococcus granulosus importin subunit beta 1 0.0062 0.0365 0.0669
Mycobacterium ulcerans lipase LipD 0.0189 0.143 1
Mycobacterium ulcerans hypothetical protein 0.0189 0.143 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0098 0.0179
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0654 0.1199
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.01 0.0183
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0733 0.5125
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0179
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0098 0.0179
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0365 0.2554
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0106 0.0733 0.1343
Brugia malayi nuclear receptor NHR-88 0.0031 0.0098 0.0486
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0733 0.5125
Mycobacterium tuberculosis Conserved protein 0.0189 0.143 0.143
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0189 0.143 0.711
Schistosoma mansoni importin beta-1 0.0062 0.0365 0.0669
Loa Loa (eye worm) hypothetical protein 0.0062 0.0365 0.0669
Brugia malayi serine/threonine-protein kinase plk-2 0.0106 0.0733 0.3643
Schistosoma mansoni hypothetical protein 0.0087 0.057 0.1045
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0106 0.0733 0.1343
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0098 0.0179
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0098 0.0486
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0266 0.1859
Brugia malayi mbt repeat family protein 0.0049 0.0252 0.1254
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0189 0.143 0.2621
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0252 0.0462
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0098 0.0179
Entamoeba histolytica hypothetical protein 0.0038 0.0159 0.2176
Loa Loa (eye worm) hypothetical protein 0.0118 0.0829 0.1519
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0252 0.0462
Loa Loa (eye worm) transcription factor SMAD2 0.0258 0.2011 0.3686
Mycobacterium leprae conserved hypothetical protein 0.0189 0.143 0.5
Schistosoma mansoni ets-related 0.0201 0.1531 0.2807
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0202 0.037
Loa Loa (eye worm) hypothetical protein 0.0055 0.03 0.0551
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0187 0.2552
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0118 0.0829 0.4121
Echinococcus multilocularis geminin 0.0347 0.2763 0.5065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0098 0.0486
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0159 0.0292
Loa Loa (eye worm) hypothetical protein 0.0189 0.143 0.2621
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0219 0.1529
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0654 0.1199
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0309 0.0567
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.03 0.1494
Giardia lamblia PHD finger protein 15 0.0031 0.01 0.136
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0667 0.5455 1
Brugia malayi Ets-domain containing protein 0.0066 0.0396 0.1972
Brugia malayi ecdysteroid receptor 0.0031 0.0098 0.0486
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0159 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0098 0.0486
Echinococcus granulosus beta LACTamase domain containing family member 0.0189 0.143 0.2621
Onchocerca volvulus Alhambra homolog 0.0031 0.01 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0654 0.1199
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0377 0.0691
Trichomonas vaginalis penicillin-binding protein, putative 0.0189 0.143 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0309 0.0567
Entamoeba histolytica hypothetical protein 0.0038 0.0159 0.2176
Trichomonas vaginalis penicillin-binding protein, putative 0.0189 0.143 1
Echinococcus multilocularis peregrin 0.0035 0.0131 0.0241
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.01 0.0697
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0098 0.0179
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0654 0.1199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0098 0.0179
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0226 0.1125
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0309 0.1539
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0189 0.143 0.143
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.1093 0.2004
Loa Loa (eye worm) hypothetical protein 0.0031 0.01 0.0183
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0098 0.0179
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0226 0.1583
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0219 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0098 0.0486
Mycobacterium leprae Probable lipase LipE 0.0189 0.143 0.5
Echinococcus multilocularis GA binding protein alpha chain 0.0066 0.0396 0.0727
Trichomonas vaginalis ran, putative 0.0046 0.0226 0.1583
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0189 0.143 1
Brugia malayi Importin beta-1 subunit 0.0062 0.0365 0.1816
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0189 0.143 0.2621
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0654 0.1199
Loa Loa (eye worm) hypothetical protein 0.0056 0.0309 0.0567
Brugia malayi hypothetical protein 0.0038 0.0159 0.0793
Loa Loa (eye worm) MH2 domain-containing protein 0.0258 0.2011 0.3686
Mycobacterium tuberculosis Probable hydrolase 0.0189 0.143 0.143
Loa Loa (eye worm) acetyltransferase 0.0153 0.113 0.2071
Brugia malayi PHD-finger family protein 0.0031 0.01 0.0496
Echinococcus multilocularis beta LACTamase domain containing family member 0.0189 0.143 0.2621
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0098 0.0486
Brugia malayi mbt repeat family protein 0.0049 0.0252 0.1254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0098 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0098 0.0179
Brugia malayi Bromodomain containing protein 0.0035 0.0131 0.0653
Leishmania major hypothetical protein, conserved 0.0189 0.143 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.143 0.2621
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0154 0.0283
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.03 0.1494
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0219 0.1529
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0098 0.0179
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.1499 0.2749
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0118 0.0829 0.1519
Brugia malayi beta-lactamase family protein 0.0189 0.143 0.711
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0179
Schistosoma mansoni hypothetical protein 0.0667 0.5455 1
Schistosoma mansoni hypothetical protein 0.0037 0.0154 0.0283
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.0733 0.5125
Echinococcus multilocularis importin subunit beta 1 0.0062 0.0365 0.0669
Echinococcus multilocularis FTZ F1 alpha 0.0118 0.0829 0.1519
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0098 0.0179
Onchocerca volvulus 0.0189 0.143 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0226 0.6197
Trypanosoma cruzi hypothetical protein, conserved 0.0189 0.143 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0365 0.2554
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0654 0.1199
Echinococcus granulosus peregrin 0.0035 0.0131 0.0241
Loa Loa (eye worm) MBCTL1 0.0056 0.0309 0.0567
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0692 0.1269
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.01 0.0183
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0066 0.0396 0.0727
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0179
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0098 0.0179
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.0733 0.5125
Schistosoma mansoni hypothetical protein 0.0347 0.2763 0.5065
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0106 0.0733 0.1343
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0252 0.0462
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0266 0.1859
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0154 0.0283
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0219 0.1529
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0098 0.0179
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0202 0.037
Schistosoma mansoni kinase 0.0054 0.0293 0.0537
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0118 0.0829 0.1519
Onchocerca volvulus Serine\/threonine kinase homolog 0.0106 0.0733 0.4767
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0098 0.0179
Brugia malayi RNA, U transporter 1 0.0178 0.1335 0.664
Trichomonas vaginalis esterase, putative 0.0189 0.143 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0098 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0098 0.0486
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0098 0.0179
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0179
Loa Loa (eye worm) beta-lactamase 0.0189 0.143 0.2621
Schistosoma mansoni hypothetical protein 0.0302 0.2383 0.4368
Onchocerca volvulus 0.0189 0.143 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0098 0.0486
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0226 0.1583
Brugia malayi nuclear hormone receptor 0.0031 0.0098 0.0486
Loa Loa (eye worm) fli-1 protein 0.0201 0.1531 0.2807
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0189 0.143 0.143
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0654 0.3254
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0098 0.0486
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0252 0.116
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 0.113 0.2071
Brugia malayi MH2 domain containing protein 0.0258 0.2011 1
Schistosoma mansoni hypothetical protein 0.0038 0.0159 0.0292
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0252 0.0462
Mycobacterium ulcerans esterase/lipase LipP 0.0189 0.143 1
Echinococcus granulosus FTZ F1 alpha 0.044 0.3539 0.6488
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.1499 0.2749
Loa Loa (eye worm) hypothetical protein 0.0037 0.0154 0.0283
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0098 0.0179
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0098 0.0179
Mycobacterium tuberculosis Conserved protein 0.0189 0.143 0.143
Plasmodium falciparum importin beta, putative 0.0062 0.0365 1
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0281 0.1969
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0098 0.0179
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0226 0.0415
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0098 0.0179
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0098 0.0179
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0187 0.512
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0187 0.2552
Trichomonas vaginalis D-aminoacylase, putative 0.0189 0.143 1
Entamoeba histolytica hypothetical protein 0.0038 0.0159 0.2176
Plasmodium vivax hypothetical protein, conserved 0.0189 0.143 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0654 0.1199
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0098 0.0486
Leishmania major importin beta-1 subunit, putative 0.0051 0.0266 0.1859
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0106 0.0733 0.5125
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.01 0.0183
Trypanosoma brucei hypothetical protein, conserved 0.0189 0.143 1
Plasmodium vivax hypothetical protein, conserved 0.0031 0.01 0.0697
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0098 0.0486
Loa Loa (eye worm) hypothetical protein 0.0189 0.143 0.2621
Echinococcus granulosus GA binding protein alpha chain 0.0066 0.0396 0.0727
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0517 0.0948
Plasmodium vivax importin-beta 2, putative 0.0062 0.0365 0.2554
Plasmodium falciparum phd finger protein, putative 0.0031 0.01 0.2729
Mycobacterium tuberculosis Probable lipase LipD 0.0189 0.143 0.143
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0098 0.0486
Entamoeba histolytica Ran family GTPase 0.0046 0.0226 0.3089
Mycobacterium tuberculosis Conserved protein 0.0189 0.143 0.143
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0252 0.0462
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0098 0.0179
Brugia malayi steroid hormone receptor 0.0031 0.0098 0.0486
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0159 0.0292
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0266 0.1859
Brugia malayi Ets-domain containing protein 0.0066 0.0396 0.1972
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.01 0.0697
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0309 0.0567
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0309 0.0567
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0154 0.0283
Trypanosoma cruzi hypothetical protein, conserved 0.0189 0.143 1
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0733 0.5125
Brugia malayi acetyltransferase, GNAT family protein 0.0153 0.113 0.5618
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0098 0.0486
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0692 0.1269

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 1 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 2.8 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 3.71 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 3.92 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 14 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 94 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 95 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 2.33 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 1 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 14 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 94 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 95 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.3 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.49703 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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