Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | polo-like protein kinase | 0.0106 | 0.0733 | 0.5125 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0098 | 0.0179 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0049 | 0.0252 | 0.0462 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0189 | 0.143 | 0.143 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0154 | 0.0768 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.0219 | 0.1529 |
Schistosoma mansoni | hypothetical protein | 0.0347 | 0.2763 | 0.5065 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0118 | 0.0829 | 0.1519 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.0252 | 0.0462 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0031 | 0.0098 | 0.0486 |
Toxoplasma gondii | ABC1 family protein | 0.0189 | 0.143 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0031 | 0.0098 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.143 | 0.2621 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.143 | 0.2621 |
Schistosoma mansoni | gabp alpha | 0.0066 | 0.0396 | 0.0727 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.0098 | 0.0179 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0154 | 0.0283 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0281 | 0.1969 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.0098 | 0.0179 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0046 | 0.0226 | 0.1583 |
Brugia malayi | jmjC domain containing protein | 0.0101 | 0.0692 | 0.3444 |
Brugia malayi | Fli-1 protein | 0.0201 | 0.1531 | 0.7616 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0056 | 0.0309 | 0.0567 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0154 | 0.0283 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0046 | 0.0226 | 0.0415 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.01 | 0.0183 |
Giardia lamblia | Kinase, PLK | 0.0106 | 0.0733 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0031 | 0.0098 | 0.0486 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0189 | 0.143 | 0.143 |
Echinococcus granulosus | geminin | 0.0347 | 0.2763 | 0.5065 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0189 | 0.143 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0154 | 0.0768 |
Entamoeba histolytica | hypothetical protein | 0.0051 | 0.0266 | 0.3627 |
Onchocerca volvulus | 0.0189 | 0.143 | 1 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.0098 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0252 | 0.0462 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0189 | 0.143 | 0.143 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.03 | 0.0551 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0031 | 0.01 | 0.0183 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.0733 | 0.5125 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0031 | 0.0098 | 0.0179 |
Mycobacterium ulcerans | beta-lactamase | 0.0189 | 0.143 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0051 | 0.0266 | 0.1859 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.0654 | 0.1199 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0106 | 0.0733 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0031 | 0.0098 | 0.0179 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0159 | 0.2176 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0046 | 0.0226 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0286 | 0.0524 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0118 | 0.0829 | 0.4121 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.0252 | 0.0462 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.0098 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0098 | 0.0179 |
Brugia malayi | beta-lactamase | 0.0189 | 0.143 | 0.711 |
Leishmania major | GTP-binding protein, putative | 0.0046 | 0.0226 | 0.1583 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0189 | 0.143 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0062 | 0.0365 | 0.2554 |
Schistosoma mansoni | coup transcription factor | 0.0031 | 0.0098 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.143 | 0.2621 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.0098 | 0.0179 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.0733 | 0.5125 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0031 | 0.0098 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0098 | 0.0179 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0106 | 0.0733 | 0.1343 |
Brugia malayi | beta-lactamase family protein | 0.0189 | 0.143 | 0.711 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0189 | 0.143 | 0.2621 |
Echinococcus granulosus | snurportin 1 | 0.0667 | 0.5455 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.0098 | 0.0179 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.0733 | 0.5125 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.0098 | 0.0179 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.0219 | 0.1529 |
Onchocerca volvulus | 0.0049 | 0.0252 | 0.116 | |
Schistosoma mansoni | ran | 0.0046 | 0.0226 | 0.0415 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0046 | 0.0226 | 0.3089 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.0733 | 0.5125 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0046 | 0.0226 | 0.1583 |
Schistosoma mansoni | ran | 0.0046 | 0.0226 | 0.0415 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0153 | 0.113 | 0.2071 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0316 | 0.0579 |
Echinococcus multilocularis | snurportin 1 | 0.0667 | 0.5455 | 1 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0046 | 0.0226 | 0.1583 |
Echinococcus granulosus | importin subunit beta 1 | 0.0062 | 0.0365 | 0.0669 |
Mycobacterium ulcerans | lipase LipD | 0.0189 | 0.143 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0189 | 0.143 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.0098 | 0.0179 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.0654 | 0.1199 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0031 | 0.01 | 0.0183 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.0733 | 0.5125 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0098 | 0.0179 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0031 | 0.0098 | 0.0179 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0062 | 0.0365 | 0.2554 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0106 | 0.0733 | 0.1343 |
Brugia malayi | nuclear receptor NHR-88 | 0.0031 | 0.0098 | 0.0486 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.0733 | 0.5125 |
Mycobacterium tuberculosis | Conserved protein | 0.0189 | 0.143 | 0.143 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0189 | 0.143 | 0.711 |
Schistosoma mansoni | importin beta-1 | 0.0062 | 0.0365 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0365 | 0.0669 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0106 | 0.0733 | 0.3643 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.057 | 0.1045 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0106 | 0.0733 | 0.1343 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0031 | 0.0098 | 0.0179 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.0098 | 0.0486 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0051 | 0.0266 | 0.1859 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.0252 | 0.1254 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0189 | 0.143 | 0.2621 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0049 | 0.0252 | 0.0462 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.0098 | 0.0179 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0159 | 0.2176 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0829 | 0.1519 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0049 | 0.0252 | 0.0462 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0258 | 0.2011 | 0.3686 |
Mycobacterium leprae | conserved hypothetical protein | 0.0189 | 0.143 | 0.5 |
Schistosoma mansoni | ets-related | 0.0201 | 0.1531 | 0.2807 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.0202 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.03 | 0.0551 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.0187 | 0.2552 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0118 | 0.0829 | 0.4121 |
Echinococcus multilocularis | geminin | 0.0347 | 0.2763 | 0.5065 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.0098 | 0.0486 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0159 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.143 | 0.2621 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.0219 | 0.1529 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.0654 | 0.1199 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0056 | 0.0309 | 0.0567 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.03 | 0.1494 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0.01 | 0.136 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0667 | 0.5455 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0066 | 0.0396 | 0.1972 |
Brugia malayi | ecdysteroid receptor | 0.0031 | 0.0098 | 0.0486 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0159 | 0.0292 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0031 | 0.0098 | 0.0486 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0189 | 0.143 | 0.2621 |
Onchocerca volvulus | Alhambra homolog | 0.0031 | 0.01 | 0.0014 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.0654 | 0.1199 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.0377 | 0.0691 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0189 | 0.143 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0056 | 0.0309 | 0.0567 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0159 | 0.2176 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0189 | 0.143 | 1 |
Echinococcus multilocularis | peregrin | 0.0035 | 0.0131 | 0.0241 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.01 | 0.0697 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.0098 | 0.0179 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0097 | 0.0654 | 0.1199 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0031 | 0.0098 | 0.0179 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0046 | 0.0226 | 0.1125 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0056 | 0.0309 | 0.1539 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0189 | 0.143 | 0.143 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0149 | 0.1093 | 0.2004 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.01 | 0.0183 |
Schistosoma mansoni | nuclear hormone receptor | 0.0031 | 0.0098 | 0.0179 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0046 | 0.0226 | 0.1583 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.0219 | 0.0401 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0031 | 0.0098 | 0.0486 |
Mycobacterium leprae | Probable lipase LipE | 0.0189 | 0.143 | 0.5 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0066 | 0.0396 | 0.0727 |
Trichomonas vaginalis | ran, putative | 0.0046 | 0.0226 | 0.1583 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0189 | 0.143 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0062 | 0.0365 | 0.1816 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0189 | 0.143 | 0.2621 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.0654 | 0.1199 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0309 | 0.0567 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0159 | 0.0793 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0258 | 0.2011 | 0.3686 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0189 | 0.143 | 0.143 |
Loa Loa (eye worm) | acetyltransferase | 0.0153 | 0.113 | 0.2071 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.01 | 0.0496 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0189 | 0.143 | 0.2621 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.0098 | 0.0486 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.0252 | 0.1254 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0031 | 0.0098 | 0.0179 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0031 | 0.0098 | 0.0179 |
Brugia malayi | Bromodomain containing protein | 0.0035 | 0.0131 | 0.0653 |
Leishmania major | hypothetical protein, conserved | 0.0189 | 0.143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.143 | 0.2621 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.0154 | 0.0283 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.03 | 0.1494 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.0219 | 0.1529 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0031 | 0.0098 | 0.0179 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0197 | 0.1499 | 0.2749 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0118 | 0.0829 | 0.1519 |
Brugia malayi | beta-lactamase family protein | 0.0189 | 0.143 | 0.711 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0098 | 0.0179 |
Schistosoma mansoni | hypothetical protein | 0.0667 | 0.5455 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0154 | 0.0283 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0106 | 0.0733 | 0.5125 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0062 | 0.0365 | 0.0669 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0118 | 0.0829 | 0.1519 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.0098 | 0.0179 |
Onchocerca volvulus | 0.0189 | 0.143 | 1 | |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0046 | 0.0226 | 0.6197 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0189 | 0.143 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0062 | 0.0365 | 0.2554 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.0654 | 0.1199 |
Echinococcus granulosus | peregrin | 0.0035 | 0.0131 | 0.0241 |
Loa Loa (eye worm) | MBCTL1 | 0.0056 | 0.0309 | 0.0567 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0101 | 0.0692 | 0.1269 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0031 | 0.01 | 0.0183 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0066 | 0.0396 | 0.0727 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0098 | 0.0179 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0031 | 0.0098 | 0.0179 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0106 | 0.0733 | 0.5125 |
Schistosoma mansoni | hypothetical protein | 0.0347 | 0.2763 | 0.5065 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0106 | 0.0733 | 0.1343 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0049 | 0.0252 | 0.0462 |
Trichomonas vaginalis | importin beta-1, putative | 0.0051 | 0.0266 | 0.1859 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.0154 | 0.0283 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0045 | 0.0219 | 0.1529 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.0098 | 0.0179 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.0202 | 0.037 |
Schistosoma mansoni | kinase | 0.0054 | 0.0293 | 0.0537 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0118 | 0.0829 | 0.1519 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0106 | 0.0733 | 0.4767 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 0.0098 | 0.0179 |
Brugia malayi | RNA, U transporter 1 | 0.0178 | 0.1335 | 0.664 |
Trichomonas vaginalis | esterase, putative | 0.0189 | 0.143 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0031 | 0.0098 | 0.0179 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0031 | 0.0098 | 0.0486 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0031 | 0.0098 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0098 | 0.0179 |
Loa Loa (eye worm) | beta-lactamase | 0.0189 | 0.143 | 0.2621 |
Schistosoma mansoni | hypothetical protein | 0.0302 | 0.2383 | 0.4368 |
Onchocerca volvulus | 0.0189 | 0.143 | 1 | |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0031 | 0.0098 | 0.0486 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0046 | 0.0226 | 0.1583 |
Brugia malayi | nuclear hormone receptor | 0.0031 | 0.0098 | 0.0486 |
Loa Loa (eye worm) | fli-1 protein | 0.0201 | 0.1531 | 0.2807 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0189 | 0.143 | 0.143 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0097 | 0.0654 | 0.3254 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0031 | 0.0098 | 0.0486 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0049 | 0.0252 | 0.116 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0153 | 0.113 | 0.2071 |
Brugia malayi | MH2 domain containing protein | 0.0258 | 0.2011 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0159 | 0.0292 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0049 | 0.0252 | 0.0462 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0189 | 0.143 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.044 | 0.3539 | 0.6488 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0197 | 0.1499 | 0.2749 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0154 | 0.0283 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0031 | 0.0098 | 0.0179 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0031 | 0.0098 | 0.0179 |
Mycobacterium tuberculosis | Conserved protein | 0.0189 | 0.143 | 0.143 |
Plasmodium falciparum | importin beta, putative | 0.0062 | 0.0365 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0281 | 0.1969 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0031 | 0.0098 | 0.0179 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0046 | 0.0226 | 0.0415 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0031 | 0.0098 | 0.0179 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0031 | 0.0098 | 0.0179 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.0187 | 0.512 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.0187 | 0.2552 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0189 | 0.143 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0159 | 0.2176 |
Plasmodium vivax | hypothetical protein, conserved | 0.0189 | 0.143 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.0654 | 0.1199 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.0098 | 0.0486 |
Leishmania major | importin beta-1 subunit, putative | 0.0051 | 0.0266 | 0.1859 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0106 | 0.0733 | 0.5125 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0031 | 0.01 | 0.0183 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0189 | 0.143 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.01 | 0.0697 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0031 | 0.0098 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.143 | 0.2621 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0066 | 0.0396 | 0.0727 |
Schistosoma mansoni | jumonji domain containing protein | 0.0081 | 0.0517 | 0.0948 |
Plasmodium vivax | importin-beta 2, putative | 0.0062 | 0.0365 | 0.2554 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0.01 | 0.2729 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0189 | 0.143 | 0.143 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.0098 | 0.0486 |
Entamoeba histolytica | Ran family GTPase | 0.0046 | 0.0226 | 0.3089 |
Mycobacterium tuberculosis | Conserved protein | 0.0189 | 0.143 | 0.143 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0049 | 0.0252 | 0.0462 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0031 | 0.0098 | 0.0179 |
Brugia malayi | steroid hormone receptor | 0.0031 | 0.0098 | 0.0486 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0159 | 0.0292 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0051 | 0.0266 | 0.1859 |
Brugia malayi | Ets-domain containing protein | 0.0066 | 0.0396 | 0.1972 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.01 | 0.0697 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0056 | 0.0309 | 0.0567 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0056 | 0.0309 | 0.0567 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0154 | 0.0283 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0189 | 0.143 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.0733 | 0.5125 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0153 | 0.113 | 0.5618 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0031 | 0.0098 | 0.0486 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0101 | 0.0692 | 0.1269 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 1 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 2.8 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.71 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.92 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 14 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 94 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 95 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 2.33 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 1 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 14 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 94 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 95 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.3 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.49703 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.