Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.428 | 0.6877 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0431 | 0.0693 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0063 | 0.5738 | 0.5 |
Onchocerca volvulus | 0.0019 | 0.0431 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5738 | 0.5738 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0022 | 0.0709 | 0.1235 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0019 | 0.0431 | 0.0752 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.7079 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0019 | 0.0431 | 0.0752 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.428 | 0.6877 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0063 | 0.5738 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0051 | 0.428 | 0.428 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.003 | 0.1689 | 0.9965 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.6224 | 1 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.003 | 0.1694 | 0.1694 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.7079 | 1 |
Onchocerca volvulus | 0.0019 | 0.0431 | 1 | |
Schistosoma mansoni | lipoxygenase | 0.0044 | 0.3482 | 0.5594 |
Onchocerca volvulus | 0.0019 | 0.0431 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1842 | 0.2959 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.003 | 0.1694 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.0431 | 0.0752 |
Onchocerca volvulus | Cathepsin L homolog | 0.0019 | 0.0431 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.1842 | 0.321 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.1842 | 0.1842 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.0431 | 0.0752 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.6224 | 0.6224 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.003 | 0.1689 | 0.1892 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0063 | 0.5738 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.003 | 0.1694 | 0.2952 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0063 | 0.5738 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.1842 | 0.321 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.3149 | 0.5059 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.003 | 0.1689 | 0.2944 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.003 | 0.1694 | 0.1899 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.0431 | 0.0752 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0058 | 0.515 | 0.7098 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0044 | 0.3482 | 0.6068 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.003 | 0.1689 | 0.1892 |
Onchocerca volvulus | 0.0019 | 0.0431 | 1 | |
Loa Loa (eye worm) | fibroinase | 0.0019 | 0.0431 | 0.0431 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.003 | 0.1694 | 0.2952 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.003 | 0.1694 | 0.2952 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.003 | 0.1694 | 0.1899 |
Brugia malayi | Inositol-1 | 0.003 | 0.1689 | 0.1689 |
Schistosoma mansoni | inositol monophosphatase | 0.003 | 0.1689 | 0.2714 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1842 | 0.2959 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.003 | 0.1694 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.003 | 0.1694 | 0.2721 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.7079 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3149 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.7079 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3149 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0041 | 0.3095 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0431 | 0.0693 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1842 | 0.1842 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0431 | 0.0431 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0063 | 0.5738 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.428 | 0.6877 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.0431 | 0.0752 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0019 | 0.0431 | 0.0752 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.003 | 0.1694 | 0.2952 |
Loa Loa (eye worm) | inositol-1 | 0.003 | 0.1689 | 0.1689 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0063 | 0.5738 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.003 | 0.1694 | 0.1899 |
Onchocerca volvulus | 0.0019 | 0.0431 | 1 | |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.003 | 0.1694 | 0.0008 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.1842 | 0.1842 |
Onchocerca volvulus | 0.0019 | 0.0431 | 1 | |
Brugia malayi | RNA binding protein | 0.0051 | 0.428 | 0.428 |
Echinococcus multilocularis | tar DNA binding protein | 0.0051 | 0.428 | 0.746 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0431 | 0.0431 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0063 | 0.5738 | 0.9219 |
Leishmania major | cathepsin L-like protease | 0.0074 | 0.7079 | 1 |
Plasmodium vivax | vivapain-2 | 0.0019 | 0.0431 | 0.0752 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.003 | 0.1694 | 0.4645 |
Onchocerca volvulus | Cathepsin L homolog | 0.0019 | 0.0431 | 1 |
Brugia malayi | TAR-binding protein | 0.0051 | 0.428 | 0.428 |
Loa Loa (eye worm) | ctsf protein | 0.0019 | 0.0431 | 0.0431 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.003 | 0.1694 | 0.2952 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0431 | 0.0431 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.0431 | 0.0752 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0063 | 0.5738 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.0431 | 0.0752 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0041 | 0.3095 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.7079 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.0431 | 0.0752 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.428 | 0.6877 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.003 | 0.1694 | 0.2721 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.1842 | 0.321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.7079 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0051 | 0.428 | 0.746 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0063 | 0.5738 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3149 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1842 | 0.2959 |
Loa Loa (eye worm) | TAR-binding protein | 0.0051 | 0.428 | 0.428 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0041 | 0.3095 | 0.4744 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0431 | 0.0431 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3149 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0063 | 0.5738 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.6224 | 0.6224 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.7079 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0019 | 0.0431 | 0.0431 |
Toxoplasma gondii | hypothetical protein | 0.0022 | 0.0709 | 0.0523 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.3149 | 0.5059 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.003 | 0.1689 | 0.4629 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0027 | 0.131 | 0.1194 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0074 | 0.7079 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0074 | 0.7079 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0067 | 0.6297 | 0.8824 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.1842 | 0.1842 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0019 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0074 | 0.7079 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0044 | 0.3482 | 0.6068 |
Brugia malayi | Probable ClpP-like protease | 0.0063 | 0.5738 | 0.5738 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1842 | 0.2959 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0096 | 0.9778 | 0.9778 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0063 | 0.5738 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.428 | 0.6877 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.003 | 0.1694 | 0.2952 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0051 | 0.428 | 0.428 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0063 | 0.5738 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0051 | 0.428 | 0.428 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0019 | 0.0431 | 0.0431 |
Brugia malayi | hypothetical protein | 0.0042 | 0.3149 | 0.3149 |
Onchocerca volvulus | 0.0019 | 0.0431 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0431 | 0.0431 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.7079 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0063 | 0.5738 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.1842 | 0.321 |
Plasmodium vivax | vivapain-2 | 0.0019 | 0.0431 | 0.0752 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.1694 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.7079 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.003 | 0.1689 | 0.2944 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.3149 | 0.5488 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0431 | 0.0431 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0019 | 0.0431 | 0.0752 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.003 | 0.1694 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0063 | 0.5738 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.7079 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.003 | 0.1689 | 0.9965 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1694 | 0.1694 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.1842 | 0.321 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0019 | 0.0431 | 0.0752 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.1842 | 0.321 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0041 | 0.3095 | 0.5393 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.003 | 0.1689 | 0.1892 |
Loa Loa (eye worm) | cysteine protease | 0.0019 | 0.0431 | 0.0431 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.3149 | 0.5488 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0074 | 0.7079 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0041 | 0.3095 | 0.5393 |
Schistosoma mansoni | inositol monophosphatase | 0.003 | 0.1689 | 0.2714 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.003 | 0.1689 | 0.237 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.003 | 0.1689 | 0.9965 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.7079 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0019 | 0.0431 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0022 | 0.0709 | 0.1235 |
Leishmania major | cathepsin L-like protease | 0.0074 | 0.7079 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0096 | 0.9778 | 0.9778 |
Leishmania major | cathepsin L-like protease | 0.0074 | 0.7079 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0096 | 0.9778 | 0.9778 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 2.19 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.24 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 5.47 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 56 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 99 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 14.04 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 56 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 99 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 101 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.46 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.34588 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.