Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein kinase c epsilon type | 0.0026 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | serotonin transporter b | 0.0165 | 0.5801 | 0.5784 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0105 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3308 | 0.3282 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0028 | 0.0142 | 0.0142 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0028 | 0.0129 | 0.0129 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0267 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3308 | 0.3282 |
Loa Loa (eye worm) | trypsin family protein | 0.0105 | 0.3308 | 0.3282 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.3308 | 0.3308 |
Echinococcus granulosus | protein kinase C gamma type | 0.0046 | 0.085 | 0.085 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0113 | 0.3631 | 0.3606 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.003 | 0.0207 | 0.0207 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0165 | 0.5801 | 0.5784 |
Onchocerca volvulus | 0.0105 | 0.3308 | 0.5606 | |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0028 | 0.0129 | 0.0129 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0165 | 0.5801 | 0.5801 |
Echinococcus multilocularis | acetylcholinesterase | 0.0113 | 0.3631 | 0.3631 |
Echinococcus multilocularis | serotonin receptor | 0.0267 | 1 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0043 | 0.0753 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0113 | 0.3631 | 0.3631 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0028 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0634 | 0.0597 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0129 | 0.0116 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0028 | 0.0129 | 0.0129 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0105 | 0.3308 | 0.3308 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0028 | 0.0129 | 0.0129 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3308 | 0.3282 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Brugia malayi | Trypsin family protein | 0.0105 | 0.3308 | 0.4236 |
Plasmodium falciparum | plasmepsin I | 0.0043 | 0.0753 | 1 |
Brugia malayi | hypothetical protein | 0.0105 | 0.3308 | 0.4236 |
Echinococcus granulosus | acetylcholinesterase | 0.0113 | 0.3631 | 0.3631 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0129 | 0.009 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0129 | 0.009 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0028 | 0.0129 | 0.0129 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0046 | 0.085 | 0.085 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.5801 | 0.5784 |
Echinococcus granulosus | acetylcholinesterase | 0.0113 | 0.3631 | 0.3631 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0028 | 0.0129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.5801 | 0.5784 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0127 | 0.4229 | 0.4229 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0028 | 0.0129 | 0.0129 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.7757 | 0.7748 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0105 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0129 | 0.009 |
Echinococcus multilocularis | serotonin transporter | 0.0165 | 0.5801 | 0.5801 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0028 | 0.0129 | 0.0129 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0043 | 0.0753 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0043 | 0.0753 | 1 |
Onchocerca volvulus | 0.0105 | 0.3308 | 0.5606 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0129 | 0.0116 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0043 | 0.0753 | 0.0717 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0165 | 0.5801 | 0.7465 |
Echinococcus multilocularis | acetylcholinesterase | 0.0113 | 0.3631 | 0.3631 |
Plasmodium falciparum | plasmepsin IV | 0.0043 | 0.0753 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 1 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.003 | 0.0207 | 0.0207 |
Echinococcus granulosus | serotonin transporter | 0.0165 | 0.5801 | 0.5801 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0753 | 0.0717 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0043 | 0.0753 | 0.0753 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.3631 | 0.3606 |
Loa Loa (eye worm) | carboxylesterase | 0.0113 | 0.3631 | 0.3606 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0129 | 0.009 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0028 | 0.0129 | 0.0129 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0028 | 0.0129 | 0.0129 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0043 | 0.0753 | 0.0753 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0043 | 0.0753 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3302 | 0.3275 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3302 | 0.3275 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0028 | 0.0129 | 0.0129 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0028 | 0.0129 | 0.0129 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0028 | 0.0129 | 0.0129 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.1277 | 0.1277 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3729 | 0.3704 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0105 | 0.3308 | 0.4236 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0105 | 0.3308 | 0.3308 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0113 | 0.3631 | 0.3631 |
Plasmodium vivax | plasmepsin IV, putative | 0.0043 | 0.0753 | 1 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0028 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.5801 | 0.5784 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0129 | 0.009 |
Brugia malayi | Protein kinase c protein 2 | 0.0042 | 0.0686 | 0.0838 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Onchocerca volvulus | 0.0165 | 0.5801 | 1 | |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0043 | 0.0753 | 0.0753 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0213 | 0.7757 | 0.7757 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3302 | 0.3275 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.3631 | 0.3606 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0105 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.3906 | 0.3882 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0127 | 0.4229 | 0.4229 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0026 | 0.0039 | 0.0039 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0043 | 0.0753 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3308 | 0.3282 |
Onchocerca volvulus | 0.0105 | 0.3308 | 0.5606 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0129 | 0.009 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0165 | 0.5801 | 0.5801 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0105 | 0.3308 | 0.4236 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0028 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3308 | 0.3282 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0028 | 0.0129 | 0.0129 |
Echinococcus granulosus | enteropeptidase | 0.0105 | 0.3308 | 0.3308 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0028 | 0.0129 | 0.0116 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0165 | 0.5801 | 0.5784 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0026 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.7757 | 0.7748 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0165 | 0.5801 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3308 | 0.3282 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0028 | 0.0129 | 0.0129 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0105 | 0.3308 | 0.3308 |
Brugia malayi | Trypsin family protein | 0.0105 | 0.3308 | 0.4236 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0028 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3308 | 0.3282 |
Echinococcus multilocularis | serotonin receptor | 0.0267 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0105 | 0.3308 | 0.4236 |
Brugia malayi | Carboxylesterase family protein | 0.0113 | 0.3631 | 0.4654 |
Brugia malayi | Carboxylesterase family protein | 0.0113 | 0.3631 | 0.4654 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0207 | 0.0168 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0028 | 0.0129 | 0.0129 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.3308 | 0.3308 |
Echinococcus granulosus | Mastin | 0.0105 | 0.3308 | 0.3308 |
Mycobacterium ulcerans | hypothetical protein | 0.0105 | 0.3308 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0129 | 0.009 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0056 | 0.1277 | 0.1277 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0129 | 0.0116 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0129 | 0.0116 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0056 | 0.1277 | 0.1277 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0031 | 0.026 | 0.0221 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.1277 | 0.1277 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0105 | 0.3308 | 0.3308 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0129 | 0.009 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0043 | 0.0753 | 1 |
Onchocerca volvulus | 0.0105 | 0.3308 | 0.5606 | |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0213 | 0.7757 | 1 |
Brugia malayi | Trypsin family protein | 0.0105 | 0.3308 | 0.4236 |
Echinococcus granulosus | carboxylesterase 5A | 0.0113 | 0.3631 | 0.3631 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.003 | 0.0207 | 0.0207 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0028 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0129 | 0.009 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0028 | 0.0129 | 0.0129 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0105 | 0.3308 | 0.3308 |
Echinococcus multilocularis | Mastin | 0.0105 | 0.3308 | 0.3308 |
Onchocerca volvulus | 0.0105 | 0.3302 | 0.5594 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Echinococcus multilocularis | enteropeptidase | 0.0105 | 0.3308 | 0.3308 |
Onchocerca volvulus | 0.0105 | 0.3308 | 0.5606 | |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 1 | 1 |
Onchocerca volvulus | 0.0105 | 0.3308 | 0.5606 | |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.6772 | 0.6759 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0105 | 0.3308 | 0.3308 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1.68 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.69 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.49 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 14 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 11.76 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 14 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 100 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 101 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.87 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.13509 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.