Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.004 | 0.0151 | 0.0373 | |
Brugia malayi | hypothetical protein | 0.0065 | 0.0403 | 0.0766 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0065 | 0.0403 | 0.0403 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0145 | 0.0145 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0087 | 0.0621 | 0.0912 |
Onchocerca volvulus | Alhambra homolog | 0.0145 | 0.1204 | 0.4279 |
Brugia malayi | PHD-finger family protein | 0.0126 | 0.1022 | 0.2112 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0151 | 0.0233 |
Schistosoma mansoni | lamin | 0.003 | 0.005 | 0.0074 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.0156 | 0.0156 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0259 | 0.0381 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0145 | 0.1485 |
Brugia malayi | jmjC domain containing protein | 0.0473 | 0.4514 | 0.9704 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0047 | 0.0219 | 0.0379 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2337 | 0.3436 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0403 | 0.0777 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0259 | 0.0381 |
Plasmodium falciparum | conserved Plasmodium membrane protein, unknown function | 0.0047 | 0.0225 | 0.1139 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0701 | 0.6801 | 0.6801 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1568 | 0.3308 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.005 | 0.0074 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0047 | 0.0225 | 0.0331 |
Brugia malayi | Doublecortin family protein | 0.0065 | 0.0403 | 0.0766 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.3361 | 0.7201 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0487 | 0.465 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0303 | 0.2798 | 0.2798 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0047 | 0.0219 | 0.0219 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0175 | 0.151 | 0.151 |
Echinococcus granulosus | RUN | 0.0065 | 0.0403 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1187 | 0.248 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.005 | 0.005 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0415 | 0.061 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0055 | 0.0308 | 0.4824 |
Echinococcus multilocularis | neuropeptide s receptor | 0.1019 | 1 | 1 |
Brugia malayi | beta-NAC-like protein | 0.0038 | 0.0134 | 0.0182 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.0308 | 0.4824 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0091 | 0.0087 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0185 | 0.1608 | 0.2364 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.0308 | 0.1884 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0259 | 0.0259 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0054 | 0.0292 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.005 | 0.0012 |
Brugia malayi | bHLH-PAS transcription factor | 0.004 | 0.0151 | 0.0219 |
Brugia malayi | PHD-finger family protein | 0.0057 | 0.0323 | 0.0593 |
Brugia malayi | PAS domain containing protein | 0.0054 | 0.0292 | 0.0525 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0145 | 0.1204 | 0.2518 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0201 | 0.1774 | 0.1774 |
Plasmodium vivax | hypothetical protein, conserved | 0.0145 | 0.1204 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0151 | 0.0219 |
Echinococcus multilocularis | GPCR, family 2 | 0.0066 | 0.0415 | 0.0415 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0151 | 0.1193 |
Trypanosoma brucei | ISWI complex protein | 0.0078 | 0.0531 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0415 | 0.061 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0303 | 0.2798 | 0.2798 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0156 | 0.0166 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.0113 | 0.0062 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0046 | 0.0209 | 0.0232 |
Loa Loa (eye worm) | bromodomain containing protein | 0.009 | 0.0652 | 0.1318 |
Schistosoma mansoni | jumonji domain containing protein | 0.0047 | 0.0219 | 0.0322 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.0415 | 0.0415 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0298 | 0.2753 | 0.5882 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.2348 | 0.5002 |
Brugia malayi | hypothetical protein | 0.0036 | 0.011 | 0.013 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0156 | 0.1303 |
Schistosoma mansoni | transcription factor btf3 | 0.0038 | 0.0134 | 0.0197 |
Echinococcus granulosus | peregrin | 0.0157 | 0.1325 | 0.1325 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0066 | 0.0415 | 0.0415 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0182 | 0.1585 | 0.1585 |
Brugia malayi | Smad1 | 0.0033 | 0.0084 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.1709 | 0.3614 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0033 | 0.0084 | 0.0085 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0151 | 0.016 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0151 | 1 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0087 | 0.0621 | 0.0621 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.0156 | 0.2889 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0308 | 0.4824 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0087 | 0.0621 | 0.0621 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0308 | 0.0559 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0258 | 0.2348 | 0.2348 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0151 | 0.0233 |
Schistosoma mansoni | protein phosphatase 2C | 0.0047 | 0.0219 | 0.0322 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0151 | 0.0231 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.0156 | 0.0241 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.032 | 0.2966 | 0.2966 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0259 | 0.0259 |
Brugia malayi | MH2 domain containing protein | 0.0033 | 0.0084 | 0.0073 |
Schistosoma mansoni | single-minded | 0.0054 | 0.0292 | 0.0429 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0033 | 0.0084 | 0.0085 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.005 | 0.005 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.1019 | 1 | 1 |
Echinococcus multilocularis | phd:f box containing protein | 0.0047 | 0.0219 | 0.0219 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0087 | 0.0621 | 0.0912 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0151 | 0.0233 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0046 | 0.0209 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0038 | 0.0134 | 0.0801 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0046 | 0.0209 | 0.0209 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0145 | 0.0213 |
Schistosoma mansoni | hypothetical protein | 0.0373 | 0.3499 | 0.5146 |
Brugia malayi | Inositol-1 | 0.004 | 0.0156 | 0.0229 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0066 | 0.0415 | 0.0793 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0259 | 0.0259 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0151 | 0.0466 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0099 | 0.0751 | 0.1104 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0046 | 0.0209 | 0.2539 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0151 | 0.1193 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0065 | 0.0403 | 0.0403 |
Brugia malayi | jmjC domain containing protein | 0.0047 | 0.0219 | 0.0368 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0046 | 0.0209 | 0.0345 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0036 | 0.0115 | 0.0371 |
Brugia malayi | beta-lactamase | 0.004 | 0.0151 | 0.0219 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0415 | 0.061 |
Brugia malayi | hypothetical protein | 0.0298 | 0.2747 | 0.5864 |
Echinococcus granulosus | zinc finger protein | 0.0099 | 0.0749 | 0.0749 |
Trypanosoma cruzi | ISWI complex protein | 0.0078 | 0.0531 | 1 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0047 | 0.0225 | 0.2915 |
Schistosoma mansoni | hypothetical protein | 0.0373 | 0.3499 | 0.5146 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0156 | 0.0229 |
Echinococcus granulosus | lamin | 0.003 | 0.005 | 0.005 |
Schistosoma mansoni | phd/f-box containing protein | 0.0047 | 0.0219 | 0.0322 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0056 | 0.0317 | 0.0317 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.0058 | 0.0045 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0151 | 0.1193 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0145 | 0.1204 | 0.1204 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0033 | 0.0084 | 0.0084 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0046 | 0.0209 | 0.0232 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0065 | 0.0403 | 0.2745 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0033 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0066 | 0.0415 | 0.0804 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0473 | 0.4514 | 0.4514 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0114 | 0.0901 | 0.0901 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.028 | 0.0499 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0047 | 0.0219 | 0.0219 |
Echinococcus granulosus | transcription factor btf3 | 0.0038 | 0.0134 | 0.0134 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0151 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0323 | 0.0604 |
Onchocerca volvulus | 0.0065 | 0.0403 | 0.1307 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2337 | 0.3436 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.1927 | 0.4088 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0151 | 0.0219 |
Echinococcus multilocularis | Smad4 | 0.0033 | 0.0084 | 0.0084 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0701 | 0.6801 | 1 |
Echinococcus multilocularis | geminin | 0.0373 | 0.3499 | 0.3499 |
Leishmania major | hypothetical protein, conserved | 0.0047 | 0.0219 | 0.2778 |
Brugia malayi | MH1 domain containing protein | 0.0033 | 0.0084 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.183 | 0.3877 |
Echinococcus multilocularis | tumor protein p63 | 0.0679 | 0.6587 | 0.6587 |
Brugia malayi | hypothetical protein | 0.0181 | 0.1568 | 0.33 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.028 | 0.0411 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0046 | 0.0209 | 0.2539 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0134 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1204 | 0.2518 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0065 | 0.0403 | 0.0403 |
Echinococcus multilocularis | lamin | 0.003 | 0.005 | 0.005 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0035 | 0.0099 | 0.0073 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0047 | 0.0219 | 0.2778 |
Loa Loa (eye worm) | TAR-binding protein | 0.0257 | 0.2337 | 0.4978 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0047 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0621 | 0.125 |
Echinococcus multilocularis | tar DNA binding protein | 0.0257 | 0.2337 | 0.2337 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0036 | 0.0115 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0151 | 0.0231 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0056 | 0.0317 | 0.0317 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0115 | 0.0116 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0035 | 0.0099 | 0.0146 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.0156 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.032 | 0.2966 | 0.2966 |
Onchocerca volvulus | 0.004 | 0.0151 | 0.0373 | |
Onchocerca volvulus | 0.0298 | 0.2747 | 1 | |
Brugia malayi | MH2 domain containing protein | 0.0033 | 0.0084 | 0.0073 |
Schistosoma mansoni | zinc finger protein | 0.0078 | 0.0531 | 0.0781 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0091 | 0.0087 |
Echinococcus multilocularis | transcription factor btf3 | 0.0038 | 0.0134 | 0.0134 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2337 | 0.3436 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0145 | 0.0206 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.005 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0151 | 0.0231 |
Schistosoma mansoni | smad1 5 8 and | 0.0033 | 0.0084 | 0.0123 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0151 | 0.0151 |
Giardia lamblia | PHD finger protein 15 | 0.0145 | 0.1204 | 1 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0046 | 0.0209 | 0.2539 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0885 | 0.866 | 0.866 |
Brugia malayi | jmjC domain containing protein | 0.0047 | 0.0219 | 0.0368 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.1204 | 0.1771 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.0156 | 0.0578 |
Brugia malayi | Bromodomain containing protein | 0.0194 | 0.1705 | 0.3599 |
Echinococcus granulosus | Smad4 | 0.0033 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | RNA binding protein | 0.0257 | 0.2337 | 0.4978 |
Onchocerca volvulus | 0.004 | 0.0151 | 0.0373 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0143 | 0.1187 | 0.2471 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0145 | 0.1204 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.0803 | 0.1181 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0134 | 0.0139 |
Schistosoma mansoni | rab6-interacting | 0.0065 | 0.0403 | 0.0592 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0151 | 0.0233 |
Echinococcus granulosus | phd:f box containing protein | 0.0047 | 0.0219 | 0.0219 |
Schistosoma mansoni | Smad4 | 0.0033 | 0.0084 | 0.0123 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0403 | 0.0592 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0046 | 0.0209 | 0.2539 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0257 | 0.2337 | 0.4978 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0047 | 0.0219 | 0.0322 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0258 | 0.2348 | 0.2348 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.1187 | 0.1745 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0156 | 0.0166 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0151 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0057 | 0.0323 | 0.0593 |
Echinococcus multilocularis | transfer RNA-Lys | 0.004 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | Smad1 | 0.0033 | 0.0084 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0308 | 0.0571 |
Echinococcus granulosus | jumonji domain containing protein | 0.0201 | 0.1774 | 0.1774 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0145 | 0.0145 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.0308 | 0.1884 |
Brugia malayi | hypoxia-induced factor 1 | 0.0167 | 0.1427 | 0.2994 |
Echinococcus granulosus | smad | 0.0033 | 0.0084 | 0.0084 |
Schistosoma mansoni | rab6-interacting | 0.0065 | 0.0403 | 0.0592 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.0259 | 0.0466 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0259 | 0.0381 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0035 | 0.0099 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2747 | 0.5869 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0151 | 0.0231 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0036 | 0.0115 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0151 | 0.0231 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0151 | 0.0233 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0055 | 0.0308 | 0.1943 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.0156 | 0.0166 |
Brugia malayi | hypothetical protein | 0.0065 | 0.0403 | 0.0766 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0115 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.2244 | 0.4775 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0047 | 0.0225 | 0.2915 |
Schistosoma mansoni | lamin | 0.003 | 0.005 | 0.0074 |
Brugia malayi | Isocitrate dehydrogenase | 0.0035 | 0.0099 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0151 | 0.0231 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0145 | 0.1204 | 0.1771 |
Schistosoma mansoni | lipoxygenase | 0.032 | 0.2966 | 0.4361 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0219 | 0.0379 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0035 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | ICD-1 protein | 0.0038 | 0.0134 | 0.0194 |
Schistosoma mansoni | zinc finger protein | 0.0099 | 0.0749 | 0.1102 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0046 | 0.0209 | 0.2539 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.1852 | 0.3924 |
Echinococcus multilocularis | zinc finger protein | 0.0099 | 0.0749 | 0.0749 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0185 | 0.1608 | 0.1608 |
Echinococcus granulosus | single minded 2 | 0.004 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0046 | 0.0209 | 0.0357 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0065 | 0.0403 | 0.2745 |
Brugia malayi | TAR-binding protein | 0.0257 | 0.2337 | 0.4972 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.005 | 0.0012 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0055 | 0.0308 | 0.1884 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0156 | 0.1303 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0473 | 0.4514 | 0.4514 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0156 | 0.1303 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0151 | 0.0535 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0209 | 0.1852 | 0.3917 |
Onchocerca volvulus | 0.0065 | 0.0403 | 0.1307 | |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0415 | 0.061 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0047 | 0.0219 | 0.0379 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0047 | 0.0219 | 0.0219 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0065 | 0.0403 | 0.0403 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0487 | 0.465 | 1 |
Brugia malayi | RNA binding protein | 0.0257 | 0.2337 | 0.4972 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0829 | 0.8095 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0376 | 0.3535 | 0.5197 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0047 | 0.0219 | 0.2778 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0033 | 0.0084 | 0.0084 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0115 | 0.0116 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0151 | 0.016 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0046 | 0.0209 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0033 | 0.0084 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0415 | 0.0804 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0066 | 0.0415 | 0.0793 |
Schistosoma mansoni | lipoxygenase | 0.0203 | 0.1791 | 0.2633 |
Brugia malayi | jmjC domain containing protein | 0.0047 | 0.0219 | 0.0368 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0033 | 0.0084 | 0.0123 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0046 | 0.0209 | 0.0307 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0099 | 0.0099 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0145 | 0.1485 |
Schistosoma mansoni | polycystin 1-related | 0.0065 | 0.0403 | 0.0592 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0087 | 0.0621 | 0.0621 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0047 | 0.0219 | 0.0219 |
Brugia malayi | isocitrate dehydrogenase | 0.0035 | 0.0099 | 0.0107 |
Leishmania major | basic transcription factor 3a, putative | 0.0038 | 0.0134 | 0.0801 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0151 | 0.016 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0145 | 0.1204 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0151 | 0.0231 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0182 | 0.1585 | 0.1585 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0038 | 0.0134 | 0.0313 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0151 | 0.0151 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0046 | 0.0209 | 0.0209 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0114 | 0.0901 | 0.0901 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0151 | 0.0222 |
Leishmania major | hypothetical protein, conserved | 0.0078 | 0.0531 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0258 | 0.2347 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0035 | 0.0099 | 0.0099 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0115 | 0.0116 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0047 | 0.0219 | 0.0322 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0087 | 0.0621 | 0.0912 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0047 | 0.0225 | 0.1203 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2337 | 0.3436 |
Echinococcus multilocularis | smad | 0.0033 | 0.0084 | 0.0084 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0087 | 0.0621 | 0.0621 |
Toxoplasma gondii | NAC domain-containing protein | 0.0038 | 0.0134 | 0.0383 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0145 | 0.1485 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0151 | 0.0233 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.028 | 0.0411 |
Brugia malayi | hypothetical protein | 0.0258 | 0.2348 | 0.4996 |
Loa Loa (eye worm) | doublecortin family protein | 0.0065 | 0.0403 | 0.0777 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0145 | 0.1485 |
Plasmodium vivax | hypothetical protein, conserved | 0.0047 | 0.0225 | 0.1139 |
Brugia malayi | Bromodomain containing protein | 0.0381 | 0.3579 | 0.7673 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0091 | 0.0087 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0046 | 0.0209 | 0.0232 |
Echinococcus multilocularis | peregrin | 0.0157 | 0.1325 | 0.1325 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0099 | 0.0099 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0151 | 0.016 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0047 | 0.0219 | 0.0379 |
Echinococcus multilocularis | RUN | 0.0065 | 0.0403 | 0.0403 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0259 | 0.0259 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0185 | 0.1608 | 0.3395 |
Schistosoma mansoni | smad1 5 8 and | 0.0033 | 0.0084 | 0.0123 |
Echinococcus granulosus | tar DNA binding protein | 0.0257 | 0.2337 | 0.2337 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0024 | 0.0003 |
Toxoplasma gondii | WD domain, G-beta repeat-containing protein | 0.0047 | 0.0225 | 0.1203 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.1019 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0209 | 0.1852 | 0.3924 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0047 | 0.0219 | 0.0219 |
Brugia malayi | PHD-finger family protein | 0.0145 | 0.1204 | 0.2509 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0091 | 0.0087 |
Echinococcus multilocularis | musashi | 0.003 | 0.005 | 0.005 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0091 | 0.0087 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0038 | 0.0134 | 0.0801 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0185 | 0.1608 | 0.2364 |
Brugia malayi | follicle stimulating hormone receptor | 0.0258 | 0.2347 | 0.4994 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0151 | 0.016 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0151 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0751 | 0.1533 |
Trypanosoma cruzi | ISWI complex protein | 0.0078 | 0.0531 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.0156 | 1 |
Echinococcus granulosus | geminin | 0.0373 | 0.3499 | 0.3499 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.0415 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0219 | 0.0379 |
Brugia malayi | MH2 domain containing protein | 0.0487 | 0.465 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0048 | 0.0033 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0047 | 0.0219 | 0.115 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0134 | 0.0139 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0151 | 0.0233 |
Schistosoma mansoni | loxhd1 | 0.0065 | 0.0403 | 0.0592 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.0156 | 0.0156 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0024 | 0.0003 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0151 | 0.016 |
Brugia malayi | jmjC domain containing protein | 0.0047 | 0.0219 | 0.0368 |
Schistosoma mansoni | smad | 0.0033 | 0.0084 | 0.0123 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0038 | 0.0134 | 0.0313 |
Schistosoma mansoni | bromodomain containing protein | 0.0321 | 0.2981 | 0.4383 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.005 | 0.0012 |
Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.0047 | 0.0219 | 0.115 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0035 | 0.0099 | 0.0119 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0151 | 0.0231 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0156 | 0.0229 |
Onchocerca volvulus | 0.0053 | 0.028 | 0.0851 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.0259 | 0.0455 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0151 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0403 | 0.0777 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0038 | 0.0134 | 0.0801 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0065 | 0.0403 | 0.0403 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0065 | 0.0403 | 0.0403 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0701 | 0.6801 | 0.6801 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0115 | 0.0116 |
Plasmodium falciparum | phd finger protein, putative | 0.0145 | 0.1204 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0142 | 0.0149 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0047 | 0.0219 | 0.1085 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0151 | 0.1193 |
Onchocerca volvulus | 0.004 | 0.0151 | 0.0373 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0024 | 0.0003 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2337 | 0.3436 |
Echinococcus granulosus | tumor protein p63 | 0.0679 | 0.6587 | 0.6587 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0091 | 0.0087 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0091 | 0.0087 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0257 | 0.2337 | 0.4972 |
Brugia malayi | jmjC domain containing protein | 0.0185 | 0.1608 | 0.3387 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0225 | 0.0331 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0167 | 0.1427 | 0.3002 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0114 | 0.0901 | 0.1325 |
Brugia malayi | MH1 domain containing protein | 0.0033 | 0.0084 | 0.0073 |
Plasmodium vivax | JmjC domain containing protein | 0.0047 | 0.0219 | 0.1085 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0046 | 0.0209 | 0.2539 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.0308 | 0.4824 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0209 | 0.1852 | 0.3917 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0255 | 0.2312 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0151 | 0.0233 |
Brugia malayi | Bromodomain containing protein | 0.0157 | 0.1325 | 0.2772 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0066 | 0.0415 | 0.0415 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0151 | 0.0219 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0087 | 0.0621 | 0.0912 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0099 | 0.0099 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0145 | 0.1204 | 0.1204 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0156 | 0.1303 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0033 | 0.0084 | 0.0084 |
Onchocerca volvulus | 0.0099 | 0.0751 | 0.2597 | |
Brugia malayi | AF-10 protein | 0.0047 | 0.0225 | 0.038 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0531 | 0.0781 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0105 | 0.0803 | 0.1647 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0047 | 0.0219 | 0.2778 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0145 | 0.0213 |
Echinococcus granulosus | GPCR family 2 | 0.0066 | 0.0415 | 0.0415 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -1.69 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0.91 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.21 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 8 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 37 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 85 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 6.86 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 8 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 37 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 85 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.85 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.41549 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.