TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 580.973 | Formula: C29H36Cl3N3O3
H donors: 1 H acceptors: 2 LogP: 6.77 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)N(C(=O)C(Oc1ccc(cc1)Cl)C)C
InChi: 1S/C29H36Cl3N3O3/c1-21(38-25-10-8-23(30)9-11-25)29(37)34(2)24-14-18-35(19-15-24)17-5-3-4-16-33-28(36)13-7-22-6-12-26(31)27(32)20-22/h6-13,20-21,24H,3-5,14-19H2,1-2H3,(H,33,36)/b13-7+
InChiKey: BLZPLDNMGSLTPO-NTUHNPAUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Smad4	0.0059	0.0188	0.0188
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0091	0.042	0.0421
Brugia malayi	beta-NAC-like protein	0.0036	0.0023	0.0039
Schistosoma mansoni	smad	0.0059	0.0188	0.0188
Schistosoma mansoni	tar DNA-binding protein	0.04	0.2637	0.2639
Loa Loa (eye worm)	beta-lactamase	0.0074	0.0296	0.0493
Loa Loa (eye worm)	jmjC domain-containing protein	0.0079	0.0334	0.0556
Schistosoma mansoni	zinc finger protein	0.0082	0.0353	0.0353
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0079	0.0334	0.0334
Toxoplasma gondii	PHD-finger domain-containing protein	0.0246	0.1533	1
Trypanosoma cruzi	ISWI complex protein	0.0082	0.0353	1
Echinococcus granulosus	microtubule associated protein 2	0.1422	0.999	0.999
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0038	0.0038
Schistosoma mansoni	jumonji domain containing protein	0.0079	0.0334	0.0334
Brugia malayi	AF-10 protein	0.008	0.0341	0.0568
Brugia malayi	PHD-finger family protein	0.0246	0.1533	0.2553
Brugia malayi	Doublecortin family protein	0.0062	0.0206	0.0343
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0023	0.0289
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.032	0.2066	0.2066
Brugia malayi	PAS domain containing protein	0.0051	0.0131	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0054	0.009
Echinococcus granulosus	peregrin	0.0259	0.1625	0.1625
Loa Loa (eye worm)	phosphatidylinositol 3	0.0047	0.0102	0.017
Schistosoma mansoni	lamin	0.0084	0.0366	0.0367
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0009	0.0029
Loa Loa (eye worm)	RNA binding protein	0.04	0.2637	0.439
Schistosoma mansoni	phosphatidylserine receptor	0.0079	0.0334	0.0334
Brugia malayi	MH2 domain containing protein	0.0868	0.6006	1
Loa Loa (eye worm)	intermediate filament protein	0.0084	0.0366	0.061
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0091	0.042	0.0421
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0308	0.198	0.1982
Onchocerca volvulus		0.005	0.0122	0.0418
Brugia malayi	Bromodomain containing protein	0.0402	0.2656	0.4422
Brugia malayi	F/Y-rich N-terminus family protein	0.0091	0.0415	0.0691
Echinococcus granulosus	GPCR family 2	0.0131	0.0705	0.0705
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0109	0.0109
Echinococcus multilocularis	survival motor neuron protein 1	0.0245	0.1527	0.1527
Schistosoma mansoni	hypothetical protein	0.0354	0.231	0.2312
Loa Loa (eye worm)	hypothetical protein	0.0329	0.2126	0.354
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0091	0.042	0.0421
Brugia malayi	hypothetical protein	0.0062	0.0206	0.0343
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0296	0.0297
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0102	0.3099
Trypanosoma cruzi	target of rapamycin kinase 3	0.0038	0.0033	0.094
Entamoeba histolytica	hypothetical protein	0.0072	0.0283	1
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0038	0.0038
Echinococcus granulosus	transcription factor btf3	0.0036	0.0023	0.0023
Brugia malayi	Intermediate filament tail domain containing protein	0.0084	0.0366	0.061
Brugia malayi	jmjC domain containing protein	0.0079	0.0334	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0206	0.0343
Schistosoma mansoni	smad1 5 8 and	0.0059	0.0188	0.0188
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0038	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1261	0.2099
Onchocerca volvulus		0.0074	0.0296	0.125
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0023	0.0289
Onchocerca volvulus		0.0074	0.0296	0.125
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0047	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0296	0.0493
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.0296	0.0493
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0193	0.1149	0.1149
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.008	0.0341	0.9677
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.0296	0.1933
Echinococcus granulosus	jumonji domain containing protein	0.0343	0.2227	0.2227
Echinococcus multilocularis	lysine specific demethylase 6a	0.0079	0.0334	0.0334
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0109	0.0109
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0131	0.0705	0.0705
Brugia malayi	bHLH-PAS transcription factor	0.0038	0.0035	0.0058
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0091	0.042	0.042
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0131	0.0705	0.0705
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.008	0.0341	0.9677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0033	0.0624
Echinococcus granulosus	lamin	0.0084	0.0366	0.0366
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.0283	0.0283
Loa Loa (eye worm)	PHD-finger family protein	0.0111	0.0558	0.093
Echinococcus granulosus	JmjC domain containing protein 4	0.0079	0.0334	0.0334
Trypanosoma brucei	transcription factor BTF3, putative	0.0036	0.0023	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0245	0.1527	0.2543
Onchocerca volvulus		0.0084	0.0366	0.1585
Loa Loa (eye worm)	hypothetical protein	0.0422	0.2798	0.4659
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0131	0.0705	0.0705
Brugia malayi	beta-lactamase	0.0074	0.0296	0.0493
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.0296	0.0493
Echinococcus multilocularis	tar DNA binding protein	0.04	0.2637	0.2637
Brugia malayi	jmjC domain containing protein	0.0308	0.198	0.3296
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0415	0.0691
Echinococcus multilocularis	geminin	0.0354	0.231	0.231
Loa Loa (eye worm)	bromodomain containing protein	0.0095	0.0444	0.0739
Toxoplasma gondii	PHD-finger domain-containing protein	0.008	0.0341	0.2226
Onchocerca volvulus	Alhambra homolog	0.0246	0.1533	0.7165
Brugia malayi	RNA recognition motif domain containing protein	0.04	0.2637	0.439
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0121	0.0632	0.0633
Echinococcus multilocularis	transfer RNA-Lys	0.0038	0.0035	0.0035
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0035	0.0015	0.01
Schistosoma mansoni	hypothetical protein	0.0131	0.0705	0.0706
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0074	0.0296	0.0934
Plasmodium vivax	basic transcription factor 3b, putative	0.0036	0.0023	0.0153
Loa Loa (eye worm)	ICD-1 protein	0.0036	0.0023	0.0039
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0109	0.0109
Schistosoma mansoni	transcription factor btf3	0.0036	0.0023	0.0023
Loa Loa (eye worm)	Smad1	0.0059	0.0188	0.0313
Echinococcus granulosus	lipoxygenase domain containing protein	0.0062	0.0206	0.0206
Echinococcus multilocularis	musashi	0.0084	0.0366	0.0366
Echinococcus multilocularis	lysine specific demethylase 5A	0.0298	0.1906	0.1906
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.008	0.0341	0.2226
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0047	0.0102	0.3038
Loa Loa (eye worm)	jmjC domain-containing protein	0.0508	0.3419	0.5692
Trypanosoma cruzi	PAB1-binding protein , putative	0.0077	0.0318	0.9023
Echinococcus granulosus	PHD finger protein rhinoceros	0.0246	0.1533	0.1533
Echinococcus multilocularis	phd:f box containing protein	0.0079	0.0334	0.0334
Trypanosoma cruzi	transcription factor btf3, putative	0.0036	0.0023	0.0664
Mycobacterium tuberculosis	Probable lipase LipD	0.0074	0.0296	0.0934
Brugia malayi	beta-lactamase family protein	0.0074	0.0296	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0296	0.0493
Loa Loa (eye worm)	MH2 domain-containing protein	0.0868	0.6006	1
Schistosoma mansoni	single-minded	0.0051	0.0131	0.0131
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0038	0.0812
Echinococcus multilocularis	jumonji domain containing 1A	0.0079	0.0334	0.0334
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0091	0.042	0.042
Schistosoma mansoni	hypothetical protein	0.0082	0.0353	0.0353
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0131	0.0705	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0206	0.0343
Onchocerca volvulus		0.0329	0.2126	1
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0059	0.0188	0.0188
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0245	0.1527	0.2542
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0296	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0109	0.0181
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0109	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0296	0.0493
Brugia malayi	hypothetical protein	0.0077	0.0318	0.053
Echinococcus granulosus	fetal alzheimer antigen falz	0.0121	0.0632	0.0632
Leishmania major	hypothetical protein, conserved	0.0079	0.0334	0.9473
Echinococcus granulosus	neuropeptide receptor A26	0.0968	0.6725	0.6725
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0334	0.0556
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.0296	0.0296
Toxoplasma gondii	LsmAD domain-containing protein	0.0077	0.0318	0.2075
Onchocerca volvulus		0.0062	0.0206	0.0818
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0038	0.0038	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.04	0.2637	0.439
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0998	0.1661
Trypanosoma cruzi	ISWI complex protein	0.0082	0.0353	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0041	0.0054	0.0054
Toxoplasma gondii	NAC domain-containing protein	0.0036	0.0023	0.0153
Toxoplasma gondii	ABC1 family protein	0.0074	0.0296	0.1933
Echinococcus granulosus	lysine specific demethylase 6a	0.0079	0.0334	0.0334
Entamoeba histolytica	hypothetical protein	0.0072	0.0283	1
Leishmania major	hypothetical protein, conserved	0.0082	0.0353	1
Schistosoma mansoni	smad1 5 8 and	0.0059	0.0188	0.0188
Echinococcus multilocularis	microtubule associated protein 2	0.1422	0.999	0.999
Echinococcus multilocularis	zinc finger protein	0.0105	0.0518	0.0518
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0193	0.1149	0.1149
Plasmodium falciparum	ataxin-2 like protein, putative	0.0077	0.0318	0.2075
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0091	0.042	0.042
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0023	0.0289
Brugia malayi	Inositol-1	0.0038	0.0038	0.0064
Plasmodium vivax	JmjC domain containing protein	0.0079	0.0334	0.2179
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0158	0.0902	0.1502
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0705	0.1174
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0047	0.0102	0.017
Brugia malayi	MH1 domain containing protein	0.0059	0.0188	0.0313
Schistosoma mansoni	lipoxygenase	0.0304	0.1947	0.1949
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0091	0.042	0.0421
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0047	0.0102	0.0102
Schistosoma mansoni	hypothetical protein	0.0283	0.1799	0.1801
Schistosoma mansoni	cellular tumor antigen P53	0.0208	0.1261	0.1262
Schistosoma mansoni	hypothetical protein	0.0035	0.0012	0.0012
Loa Loa (eye worm)	transcription factor SMAD2	0.0868	0.6006	1
Brugia malayi	jmjC domain containing protein	0.0806	0.5562	0.9261
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.0283	0.0283
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0047	0.0102	0.2904
Schistosoma mansoni	tar DNA-binding protein	0.04	0.2637	0.2639
Plasmodium falciparum	ataxin-2 like protein, putative	0.0077	0.0318	0.2075
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0841	0.5814	0.5814
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0038	0.0566
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0074	0.0296	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0077	0.0318	0.9023
Leishmania major	hypothetical protein, conserved	0.0077	0.0318	0.9023
Schistosoma mansoni	lamin	0.0084	0.0366	0.0367
Loa Loa (eye worm)	inositol-1	0.0038	0.0038	0.0064
Brugia malayi	hypoxia-induced factor 1	0.0158	0.0902	0.1502
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0296	1
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.009	0.0408	0.0408
Echinococcus granulosus	lamin dm0	0.0084	0.0366	0.0366
Mycobacterium ulcerans	lipase LipD	0.0074	0.0296	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0074	0.0296	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0062	0.0206	0.0206
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0414	0.2741	0.4564
Loa Loa (eye worm)	jmjC domain-containing protein	0.0079	0.0334	0.0556
Schistosoma mansoni	microtubule-associated protein tau	0.1422	0.999	1
Schistosoma mansoni	hypothetical protein	0.0131	0.0705	0.0706
Brugia malayi	Bromodomain containing protein	0.0205	0.124	0.2064
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0043	0.0071
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0414	0.2741	0.4564
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0047	0.0102	0.2904
Giardia lamblia	PHD finger protein 15	0.0246	0.1533	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0079	0.0334	0.0556
Brugia malayi	TAR-binding protein	0.04	0.2637	0.439
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0053	0.1331
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0246	0.1533	0.1535
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0079	0.0334	0.2179
Brugia malayi	hypothetical protein	0.005	0.0121	0.0202
Schistosoma mansoni	intermediate filament proteins	0.0084	0.0366	0.0367
Schistosoma mansoni	protein phosphatase 2C	0.0079	0.0334	0.0334
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0109	0.0109
Echinococcus granulosus	neuropeptide s receptor	0.0968	0.6725	0.6725
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0038	0.0812
Loa Loa (eye worm)	PHD-finger family protein	0.0246	0.1533	0.2553
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0035	0.0012	0.0012
Plasmodium vivax	multidomain scavenger receptor, putative	0.0062	0.0206	0.1344
Schistosoma mansoni	bromodomain containing protein	0.0339	0.2204	0.2206
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0296	0.0934
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0033	0.0624
Loa Loa (eye worm)	MH1 domain-containing protein	0.0059	0.0188	0.0313
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0296	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0304	0.1947	0.1947
Onchocerca volvulus		0.0062	0.0206	0.0818
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0131	0.0705	0.1174
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.008	0.0341	0.2226
Echinococcus multilocularis	peregrin	0.0259	0.1625	0.1625
Echinococcus granulosus	jumonji domain containing 1A	0.0079	0.0334	0.0334
Brugia malayi	PHD-finger family protein	0.0134	0.0723	0.1205
Brugia malayi	jmjC domain containing protein	0.0079	0.0334	0.0556
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0062	0.0206	0.0206
Schistosoma mansoni	hypothetical protein	0.0131	0.0705	0.0706
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.0283	0.0284
Brugia malayi	RNA binding protein	0.04	0.2637	0.439
Echinococcus granulosus	survival motor neuron protein 1	0.0245	0.1527	0.1527
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0355	0.0592
Toxoplasma gondii	PHD-finger domain-containing protein	0.0246	0.1533	1
Entamoeba histolytica	hypothetical protein	0.0072	0.0283	1
Loa Loa (eye worm)	hypothetical protein	0.0206	0.1243	0.2069
Echinococcus granulosus	lipoxygenase domain containing protein	0.0062	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0091	0.042	0.07
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0038	0.0033	0.094
Mycobacterium ulcerans	beta-lactamase	0.0074	0.0296	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0033	0.0624
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0033	0.0624
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0806	0.5562	0.5562
Schistosoma mansoni	rab6-interacting	0.0062	0.0206	0.0206
Onchocerca volvulus		0.0074	0.0296	0.125
Echinococcus multilocularis	Smad4	0.0059	0.0188	0.0188
Echinococcus multilocularis	lamin	0.0084	0.0366	0.0366
Schistosoma mansoni	hypothetical protein	0.0131	0.0705	0.0706
Schistosoma mansoni	hypothetical protein	0.0072	0.0283	0.0284
Plasmodium falciparum	basic transcription factor 3b, putative	0.0036	0.0023	0.0153
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.032	0.2066	0.2066
Trypanosoma brucei	ISWI complex protein	0.0082	0.0353	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0045	0.0086	0.0143
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0296	0.8403
Brugia malayi	beta-lactamase family protein	0.0074	0.0296	0.0493
Echinococcus multilocularis	RUN	0.0062	0.0206	0.0206
Brugia malayi	hypothetical protein	0.0072	0.0283	0.0472
Mycobacterium tuberculosis	Probable lipase LipE	0.0074	0.0296	0.0934
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0047	0.0102	0.0103
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0084	0.0366	0.061
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0296	1
Entamoeba histolytica	hypothetical protein	0.0072	0.0283	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0968	0.6725	0.6725
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0318	0.053
Echinococcus granulosus	smad	0.0059	0.0188	0.0188
Echinococcus granulosus	zinc finger protein	0.0105	0.0518	0.0518
Schistosoma mansoni	hypothetical protein	0.0354	0.231	0.2312
Schistosoma mansoni	hypothetical protein	0.0062	0.0206	0.0206
Echinococcus multilocularis	jumonji domain containing protein	0.0343	0.2227	0.2227
Schistosoma mansoni	lipoxygenase	0.0193	0.1149	0.115
Onchocerca volvulus		0.0084	0.0366	0.1585
Schistosoma mansoni	tar DNA-binding protein	0.04	0.2637	0.2639
Schistosoma mansoni	jumonji domain containing protein	0.0641	0.437	0.4375
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0038	0.1082
Echinococcus granulosus	lysine specific demethylase 5A	0.0308	0.198	0.198
Echinococcus multilocularis	JmjC domain containing protein 4	0.0079	0.0334	0.0334
Schistosoma mansoni	polycystin 1-related	0.0062	0.0206	0.0206
Brugia malayi	MH2 domain containing protein	0.0059	0.0188	0.0313
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0296	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0062	0.0206	0.0206
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0038	0.0119
Brugia malayi	jmjC domain containing protein	0.0079	0.0334	0.0556
Brugia malayi	hypothetical protein	0.0245	0.1527	0.2543
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0109	0.0109
Leishmania major	hypothetical protein, conserved	0.0074	0.0296	0.8403
Brugia malayi	Bromodomain containing protein	0.0259	0.1625	0.2705
Echinococcus multilocularis	GPCR, family 2	0.0131	0.0705	0.0705
Mycobacterium leprae	Probable lipase LipE	0.0074	0.0296	1
Onchocerca volvulus		0.0208	0.1261	0.5862
Echinococcus multilocularis	neuropeptide s receptor	0.0968	0.6725	0.6725
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0296	0.0493
Trypanosoma cruzi	transcription factor btf3, putative	0.0036	0.0023	0.0664
Loa Loa (eye worm)	TAR-binding protein	0.04	0.2637	0.439
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0109	0.0109
Brugia malayi	follicle stimulating hormone receptor	0.0245	0.1527	0.2542
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0043	0.0071
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0246	0.1533	0.1533
Schistosoma mansoni	rab6-interacting	0.0062	0.0206	0.0206
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0079	0.0334	0.2179
Echinococcus granulosus	Polycystic kidney disease protein	0.0062	0.0206	0.0206
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0047	0.0102	0.2904
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0038	0.1082
Echinococcus granulosus	histone lysine methyltransferase setb	0.0091	0.042	0.042
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1533	0.2553
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0474	0.3173	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0334	0.0556
Brugia malayi	Smad1	0.0059	0.0188	0.0313
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.0296	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0109	0.0109
Schistosoma mansoni	loxhd1	0.0062	0.0206	0.0206
Plasmodium falciparum	phd finger protein, putative	0.0246	0.1533	1
Brugia malayi	hypothetical protein	0.0329	0.2126	0.354
Brugia malayi	hypothetical protein	0.0172	0.0998	0.1661
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0033	0.0624
Plasmodium vivax	hypothetical protein, conserved	0.0246	0.1533	1
Echinococcus granulosus	tar DNA binding protein	0.04	0.2637	0.2637
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0038	0.0038
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0038	0.0249
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.0296	0.0296
Schistosoma mansoni	zinc finger protein	0.0105	0.0518	0.0518
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0121	0.0632	0.0632
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0038	0.1082
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0806	0.5562	0.5562
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0308	0.198	0.1982
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0047	0.0102	0.2904
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0038	0.0033	0.094
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0074	0.0296	0.0934
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0296	1
Echinococcus multilocularis	smad	0.0059	0.0188	0.0188
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0102	0.3099
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0296	0.8403
Echinococcus multilocularis	transcription factor btf3	0.0036	0.0023	0.0023
Mycobacterium tuberculosis	Probable esterase LipL	0.0074	0.0296	0.0934
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0122	0.0204
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0035	0.0012	0.0012
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0079	0.0334	0.2179
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0059	0.0188	0.0188
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0038	0.0812
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.009	0.0408	0.0408
Echinococcus granulosus	single minded 2	0.0038	0.0035	0.0035
Schistosoma mansoni	hypothetical protein	0.0246	0.1533	0.1535
Schistosoma mansoni	hypothetical protein	0.008	0.0341	0.0342
Echinococcus granulosus	mothers against decapentaplegic 5	0.0059	0.0188	0.0188
Schistosoma mansoni	tar DNA-binding protein	0.04	0.2637	0.2639
Brugia malayi	latrophilin 2 splice variant baaae	0.0283	0.1799	0.2995
Schistosoma mansoni	Smad4	0.0059	0.0188	0.0188
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0047	0.0102	0.2904
Loa Loa (eye worm)	jmjC domain-containing protein	0.0308	0.198	0.3296
Brugia malayi	MH1 domain containing protein	0.0059	0.0188	0.0313
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0296	0.0934
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0047	0.0102	0.2904
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0366	0.061
Schistosoma mansoni	smad1 5 8 and	0.0059	0.0188	0.0188
Loa Loa (eye worm)	doublecortin family protein	0.0062	0.0206	0.0343
Echinococcus multilocularis	tumor protein p63	0.1423	1	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0059	0.0188	0.0188
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0074	0.0296	0.0934
Schistosoma mansoni	hypothetical protein	0.0111	0.0558	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0296	0.0493
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0102	0.3099
Loa Loa (eye worm)	hypothetical protein	0.0414	0.2741	0.4564
Brugia malayi	cytoplasmic intermediate filament protein	0.0045	0.0086	0.0143
Brugia malayi	PHD-finger family protein	0.0091	0.0415	0.0691
Schistosoma mansoni	aryl hydrocarbon receptor	0.0051	0.0131	0.0131
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0079	0.0334	0.9473
Plasmodium vivax	ataxin-2 like protein, putative	0.0077	0.0318	0.2075
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.0296	0.8403
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0059	0.0188	0.0188
Echinococcus multilocularis	lamin dm0	0.0084	0.0366	0.0366
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0038	0.0038
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0079	0.0334	0.9473
Mycobacterium tuberculosis	Probable hydrolase	0.0074	0.0296	0.0934
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.008	0.0341	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0218	0.1334	0.2221
Loa Loa (eye worm)	hypothetical protein	0.0379	0.2491	0.4147
Echinococcus granulosus	RUN	0.0062	0.0206	0.0206
Plasmodium falciparum	LCCL domain-containing protein	0.0062	0.0206	0.1344
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0047	0.0102	0.3038
Schistosoma mansoni	tar DNA-binding protein	0.04	0.2637	0.2639
Leishmania major	basic transcription factor 3a, putative	0.0036	0.0023	0.0664
Brugia malayi	MH2 domain containing protein	0.0059	0.0188	0.0313
Echinococcus granulosus	geminin	0.0354	0.231	0.231
Brugia malayi	intermediate filament protein	0.0084	0.0366	0.061
Brugia malayi	jmjC domain containing protein	0.0079	0.0334	0.0556
Trypanosoma cruzi	PAB1-binding protein , putative	0.0077	0.0318	0.9023
Loa Loa (eye worm)	MH2 domain-containing protein	0.0059	0.0188	0.0313
Brugia malayi	Latrophilin receptor protein 2	0.0131	0.0705	0.1174
Schistosoma mansoni	survival motor neuron protein	0.005	0.0122	0.0123
Trichomonas vaginalis	esterase, putative	0.0074	0.0296	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0041	0.0054	0.0054
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0304	0.1947	0.1947
Echinococcus granulosus	phd:f box containing protein	0.0079	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0296	0.0493
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0079	0.0334	0.9473
Plasmodium vivax	hypothetical protein, conserved	0.008	0.0341	0.2226
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0296	0.0934
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0414	0.2741	0.4564
Schistosoma mansoni	hypothetical protein	0.005	0.0122	0.0123
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0131	0.0705	0.1174
Echinococcus granulosus	intermediate filament protein	0.0084	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0229	0.1408	0.2344
Brugia malayi	hypothetical protein	0.0062	0.0206	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0283	0.1799	0.2995
Schistosoma mansoni	phd/f-box containing protein	0.0079	0.0334	0.0334
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0296	0.0297

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 0 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 1.06 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 1.95 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 3.1 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 10 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 61 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 85 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 11.59	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= -2 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 10 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 61 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 85 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.02	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.95946 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL586909
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 602249