TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 562.142 | Formula: C21H12I2N2O
H donors: 2 H acceptors: 2 LogP: 6.59 Rotable bonds: 1
Rule of 5 violations (Lipinski): 2
SMILES: Oc1ccc(cc1)c1nc2c([nH]1)c1cc(I)ccc1c1c2cc(I)cc1
InChi: 1S/C21H12I2N2O/c22-12-3-7-15-16-8-4-13(23)10-18(16)20-19(17(15)9-12)24-21(25-20)11-1-5-14(26)6-2-11/h1-10,26H,(H,24,25)
InChiKey: OKYGWRJVOOSZBR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0183	0.5256	0.5256
Onchocerca volvulus	Putative organic anion transporter	0.0019	0.0031	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Schistosoma mansoni	transcription factor LCR-F1	0.0025	0.0209	0.0333
Onchocerca volvulus		0.0019	0.0031	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0019	0.0031	0.0045
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0039	0.066	0.1058
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0039	0.066	0.066
Brugia malayi	hypothetical protein	0.0019	0.0031	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0039	0.066	0.066
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0073	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0011	0.0011
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0039	0.066	0.0657
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0042	0.0766	0.1537
Brugia malayi	hypothetical protein	0.0113	0.3012	0.301
Brugia malayi	nuclear receptor RXR	0.0021	0.0073	0.007
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0039	0.066	0.1058
Brugia malayi	Steroid receptor seven-up type 2	0.0039	0.066	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0039	0.066	0.066
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0039	0.066	0.066
Echinococcus multilocularis	transfer RNA-Lys	0.0025	0.021	0.0334
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0039	0.066	0.0657
Plasmodium falciparum	histone acetyltransferase GCN5	0.0027	0.0278	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0039	0.066	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0073
Onchocerca volvulus		0.0039	0.066	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0039	0.066	0.1323
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0039	0.066	0.0657
Loa Loa (eye worm)	steroid hormone receptor	0.0039	0.066	0.066
Echinococcus granulosus	survival motor neuron protein 1	0.0164	0.4627	0.932
Loa Loa (eye worm)	hypothetical protein	0.0039	0.066	0.066
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0039	0.066	0.0657
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0039	0.066	0.066
Onchocerca volvulus		0.0033	0.0479	0.7256
Brugia malayi	nuclear hormone receptor	0.0039	0.066	0.0657
Brugia malayi	nuclear receptor NHR-88	0.0039	0.066	0.0657
Brugia malayi	prostaglandin transporter	0.0019	0.0031	0.0028
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0097	0.252	0.5075
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0039	0.066	0.1323
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0021	0.0073	0.0142
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0019	0.0031	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0039	0.066	0.066
Schistosoma mansoni	hypothetical protein	0.0025	0.0209	0.0333
Echinococcus multilocularis	musashi	0.0019	0.0011	0.0013
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0042	0.0766	0.5
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0029	0.0356	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Schistosoma mansoni	thyroid hormone receptor	0.0213	0.6207	1
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0174	0.4964	0.7997
Loa Loa (eye worm)	acetyltransferase	0.01	0.261	0.261
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0039	0.066	0.1058
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0039	0.066	0.066
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0039	0.066	0.0657
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0042	0.0766	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0021	0.0073	0.0113
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0029	0.0356	0.5
Brugia malayi	steroid hormone receptor	0.0039	0.066	0.0657
Echinococcus multilocularis	lamin	0.0019	0.0011	0.0013
Schistosoma mansoni	hypothetical protein	0.0033	0.0479	0.0768
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0033	0.0479	0.0477
Schistosoma mansoni	RAR-like nuclear receptor	0.0039	0.066	0.1058
Echinococcus granulosus	single minded 2	0.0025	0.021	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0039	0.066	0.066
Onchocerca volvulus		0.0019	0.0031	0.0427
Schistosoma mansoni	intermediate filament proteins	0.0019	0.0011	0.0013
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0029	0.0356	0.0711
Schistosoma mansoni	aryl hydrocarbon receptor	0.0034	0.0489	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0031
Loa Loa (eye worm)	DR-78	0.0018	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0031
Onchocerca volvulus		0.0019	0.0011	0.012
Brugia malayi	hypothetical protein	0.0019	0.0031	0.0028
Brugia malayi	hypothetical protein	0.0021	0.0073	0.007
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0039	0.066	0.0657
Onchocerca volvulus		0.0025	0.021	0.3152
Onchocerca volvulus	Putative organic anion transporter	0.0019	0.0031	0.0427
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0042	0.0766	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0039	0.066	0.0657
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0018	0.0003	0.0003
Schistosoma mansoni	nuclear hormone receptor	0.0039	0.066	0.1058
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.01	0.261	0.4202
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0039	0.066	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0185	0.5327	0.5325
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0031
Giardia lamblia	Histone acetyltransferase GCN5	0.0027	0.0278	0.5
Schistosoma mansoni	hypothetical protein	0.0174	0.4964	0.7997
Schistosoma mansoni	hypothetical protein	0.0117	0.315	0.5073
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.01	0.261	0.4202
Echinococcus granulosus	lamin dm0	0.0019	0.0011	0.0016
Brugia malayi	hypoxia-induced factor 1	0.0104	0.2734	0.2732
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0213	0.6207	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0025	0.0209	0.0416
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0039	0.066	0.1058
Brugia malayi	hypothetical protein	0.0025	0.0209	0.0206
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0039	0.066	0.1323
Echinococcus granulosus	ecdysone induced protein 78C	0.0039	0.066	0.1323
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0039	0.066	0.0657
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0039	0.066	0.1323
Echinococcus multilocularis	survival motor neuron protein 1	0.0164	0.4627	0.7453
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0039	0.066	0.1323
Schistosoma mansoni	organic anion transporter	0.0019	0.0031	0.0045
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0029	0.0356	0.5
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0029	0.0356	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0039	0.066	0.0657
Onchocerca volvulus	Protein ultraspiracle homolog	0.0039	0.066	1
Echinococcus granulosus	geminin	0.0117	0.315	0.6344
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0073
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0039	0.066	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0073
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0104	0.2734	0.2734
Onchocerca volvulus	Bile acid receptor homolog	0.0039	0.066	1
Schistosoma mansoni	single-minded	0.0034	0.0489	0.0783
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0039	0.066	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Echinococcus multilocularis	ecdysone induced protein 78C	0.0039	0.066	0.1058
Echinococcus multilocularis	FTZ F1 alpha	0.0039	0.066	0.1058
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0185	0.5327	0.5327
Echinococcus multilocularis	lamin dm0	0.0019	0.0011	0.0013
Echinococcus granulosus	lamin	0.0019	0.0011	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0164	0.4627	0.4627
Trypanosoma cruzi	MFS transporter, putative	0.0019	0.0031	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0039	0.066	0.1058
Brugia malayi	Nuclear hormone receptor-like 1	0.0185	0.5327	0.5325
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0039	0.066	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0332	1	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0019	0.0011	0.0011
Entamoeba histolytica	acetyltransferase, GNAT family	0.0027	0.0278	1
Onchocerca volvulus		0.0019	0.0031	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0113	0.3012	0.3012
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0073
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0039	0.066	0.1323
Onchocerca volvulus		0.0019	0.0031	0.0427
Onchocerca volvulus		0.0019	0.0031	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0073	0.0073
Echinococcus granulosus	FTZ F1 alpha	0.0039	0.066	0.1323
Schistosoma mansoni	organic anion transporter	0.0019	0.0031	0.0045
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0039	0.066	0.0657
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0039	0.066	0.1058
Schistosoma mansoni	survival motor neuron protein	0.0033	0.0479	0.0768
Brugia malayi	sodium-independent organic anion transporter family protein	0.0019	0.0031	0.0028
Brugia malayi	hypothetical protein	0.0164	0.4627	0.4625
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0018	0.0003	0.0003
Schistosoma mansoni	retinoic acid receptor RXR	0.0039	0.066	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0039	0.066	0.066
Brugia malayi	ecdysteroid receptor	0.0039	0.066	0.0657
Brugia malayi	hypothetical protein	0.0021	0.0073	0.007
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0042	0.0766	1
Schistosoma mansoni	lamin	0.0019	0.0011	0.0013
Onchocerca volvulus		0.0019	0.0011	0.012
Onchocerca volvulus	Putative organic anion transporter	0.0019	0.0031	0.0427
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0042	0.0766	0.1229
Loa Loa (eye worm)	hypothetical protein	0.0039	0.066	0.066
Brugia malayi	Nuclear hormone receptor-like 1	0.0204	0.5913	0.5912
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0029	0.0356	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0039	0.066	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Brugia malayi	bHLH-PAS transcription factor	0.0025	0.021	0.0207
Schistosoma mansoni	coup transcription factor	0.0039	0.066	0.1058
Echinococcus granulosus	intermediate filament protein	0.0019	0.0011	0.0016
Schistosoma mansoni	hypothetical protein	0.0117	0.315	0.5073
Loa Loa (eye worm)	hypothetical protein	0.0039	0.066	0.066
Schistosoma mansoni	lamin	0.0019	0.0011	0.0013
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0019	0.0031	0.0031
Brugia malayi	photoreceptor-specific nuclear receptor	0.0039	0.066	0.0657
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0039	0.066	0.1323
Brugia malayi	sodium-independent organic anion transporter family protein	0.0019	0.0031	0.0028
Brugia malayi	acetyltransferase, GNAT family protein	0.01	0.261	0.2608
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0039	0.066	0.066
Schistosoma mansoni	thyroid hormone receptor	0.0213	0.6207	1
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0042	0.0766	0.0763
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0037	0.0596	0.0596
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0039	0.066	0.0657
Brugia malayi	sodium-independent organic anion transporter family protein	0.0019	0.0031	0.0028
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0025	0.0209	0.0333
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0019	0.0031	0.0045
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0042	0.0766	0.1229
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0031
Echinococcus multilocularis	geminin	0.0117	0.315	0.5073
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.0031
Brugia malayi	Intermediate filament tail domain containing protein	0.0019	0.0011	0.0008
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0019	0.0031	0.0056
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0174	0.4964	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0039	0.066	0.1058
Brugia malayi	PAS domain containing protein	0.0034	0.0489	0.0486
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0039	0.066	0.1058
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0039	0.066	0.1058
Brugia malayi	intermediate filament protein	0.0019	0.0011	0.0008
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0021	0.0073	0.0113
Loa Loa (eye worm)	intermediate filament protein	0.0019	0.0011	0.0011
Loa Loa (eye worm)	nuclear hormone receptor	0.0018	0.0003	0.0003
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0039	0.066	0.066
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0039	0.066	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0039	0.066	0.066

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= -2.11 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= -1.87 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 0 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 2 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 2.27 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 51 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 98 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 1.44	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= -3 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 2 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 51 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 98 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.01	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.97188 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL531721
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 602336