Detailed information for compound 602581

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 335.396 | Formula: C21H21NO3
  • H donors: 1 H acceptors: 2 LogP: 4.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCOc1ccc(cc1)N=C1C=C(O)C(=O)c2c1cccc2
  • InChi: 1S/C21H21NO3/c1-2-3-6-13-25-16-11-9-15(10-12-16)22-19-14-20(23)21(24)18-8-5-4-7-17(18)19/h4-5,7-12,14,23H,2-3,6,13H2,1H3
  • InChiKey: HOIVKNBPVWBRNZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0052 0.0102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0014 0.0136
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0033 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0033 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0101 0.0198
Echinococcus granulosus GPCR family 2 0.0046 0.0052 0.0048
Loa Loa (eye worm) hypothetical protein 0.1785 0.5127 1
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0056 0.0051
Schistosoma mansoni hypothetical protein 0.029 0.0762 0.0758
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0129 0.0124
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0054 0.0165
Echinococcus granulosus tumor protein p63 0.0332 0.0887 0.0883
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.1785 0.5127 0.5125
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0033 0.0029
Mycobacterium ulcerans hypothetical protein 0.0047 0.0054 0.0165
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0054 0.0165
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0065
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0129 0.0124
Schistosoma mansoni hypothetical protein 0.0046 0.0052 0.0048
Onchocerca volvulus 0.0152 0.0359 0.0692
Brugia malayi mbt repeat family protein 0.0048 0.0056 0.0267
Onchocerca volvulus 0.0053 0.0072 0.0132
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0152 0.0359 0.1722
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0056 0.0109
Brugia malayi RNA binding protein 0.0063 0.0101 0.0486
Brugia malayi hypothetical protein 0.017 0.0412 0.1973
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.0346 0.1656
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0762 0.214 0.4169
Toxoplasma gondii ABC1 family protein 0.004 0.0033 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0054 0.0165
Echinococcus multilocularis Smad4 0.0033 0.0014 0.0009
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0019 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0019 0.5085
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0075 0.007
Loa Loa (eye worm) hypothetical protein 0.0052 0.0069 0.0135
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0054 0.0258
Loa Loa (eye worm) hypothetical protein 0.0049 0.0059 0.0115
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0038
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0019 0.0222
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0075 0.007
Loa Loa (eye worm) Smad1 0.0033 0.0014 0.0028
Mycobacterium tuberculosis Conserved protein 0.004 0.0033 0.0436
Echinococcus multilocularis geminin 0.0169 0.0411 0.0406
Onchocerca volvulus 0.004 0.0033 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0101 0.0097
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0105
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.1053 0.2992 1
Schistosoma mansoni lamin 0.0053 0.0072 0.0068
Schistosoma mansoni hypothetical protein 0.0046 0.0052 0.0048
Treponema pallidum phosphoglyceromutase 0.003 0.0005 0.5
Onchocerca volvulus 0.0047 0.0054 0.0096
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0056 0.0051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0033 0.0029
Schistosoma mansoni survival motor neuron protein 0.0152 0.0359 0.0355
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.0465 0.046
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0054 1
Entamoeba histolytica hypothetical protein 0.0073 0.0129 0.0416
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0056 0.0051
Mycobacterium ulcerans beta-lactamase 0.004 0.0033 0.0096
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0762 0.214 0.4169
Brugia malayi phosphoglycerate mutase family protein 0.003 0.0005 0.0022
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0762 0.214 0.4169
Brugia malayi UBASH3A protein homolog 0.003 0.0005 0.0022
Schistosoma mansoni Smad4 0.0033 0.0014 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0054 0.0165
Brugia malayi hypothetical protein 0.0125 0.0283 0.1355
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0052 0.0048
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0056 0.0051
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0072 0.0346
Brugia malayi mbt repeat family protein 0.0048 0.0056 0.0267
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0033 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0052 0.0048
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0059 0.0054
Mycobacterium ulcerans hypothetical protein 0.1053 0.2992 1
Entamoeba histolytica hypothetical protein 0.0073 0.0129 0.0416
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0033 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0033 0.016
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0019 0.0049
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0019 1
Schistosoma mansoni 6-phosphofructokinase 0.1785 0.5127 0.5125
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0065
Loa Loa (eye worm) hypothetical protein 0.0048 0.0056 0.0109
Leishmania major hypothetical protein, conserved 0.004 0.0033 0.0056
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1785 0.5127 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0033 0.0029
Schistosoma mansoni hypothetical protein 0.0169 0.0411 0.0406
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0101 0.0486
Schistosoma mansoni smad1 5 8 and 0.0033 0.0014 0.0009
Schistosoma mansoni smad1 5 8 and 0.0033 0.0014 0.0009
Echinococcus multilocularis smad 0.0033 0.0014 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0033 0.0056
Schistosoma mansoni hypothetical protein 0.0046 0.0052 0.0048
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0014 0.0009
Brugia malayi beta-lactamase 0.004 0.0033 0.016
Loa Loa (eye worm) hypothetical protein 0.0743 0.2087 0.407
Loa Loa (eye worm) hypothetical protein 0.0053 0.0072 0.0141
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0052 0.0251
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0033 0.0436
Echinococcus granulosus lamin 0.0053 0.0072 0.0068
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0056 0.0051
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1785 0.5127 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0065
Echinococcus granulosus intermediate filament protein 0.0053 0.0072 0.0068
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0054 0.0165
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0054 0.075
Schistosoma mansoni hypothetical protein 0.01 0.021 0.0205
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0075 0.007
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1785 0.5127 1
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.1755 0.5039 0.9828
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0072 0.0141
Onchocerca volvulus Huntingtin homolog 0.0125 0.0283 0.0543
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0033 0.0436
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0033 0.0056
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0054 0.0165
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0762 0.214 0.4169
Loa Loa (eye worm) hypothetical protein 0.1755 0.5039 0.9828
Brugia malayi beta-lactamase family protein 0.004 0.0033 0.016
Loa Loa (eye worm) hypothetical protein 0.1023 0.2904 0.5664
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0033 0.0436
Schistosoma mansoni microtubule-associated protein tau 0.3454 1 1
Schistosoma mansoni lamin 0.0053 0.0072 0.0068
Loa Loa (eye worm) hypothetical protein 0.0054 0.0075 0.0146
Brugia malayi intermediate filament protein 0.0053 0.0072 0.0346
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0105
Brugia malayi beta-lactamase family protein 0.004 0.0033 0.016
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0014 0.0136
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0054 0.075
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0052 0.0048
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0033 1
Onchocerca volvulus 0.1785 0.5127 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0101 0.0097
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.083 0.2339 0.2336
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0101 0.0198
Loa Loa (eye worm) MH2 domain-containing protein 0.049 0.1347 0.2627
Mycobacterium ulcerans hypothetical protein 0.004 0.0033 0.0096
Brugia malayi hypothetical protein 0.0073 0.0129 0.0618
Trichomonas vaginalis esterase, putative 0.004 0.0033 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0014 0.0009
Onchocerca volvulus Huntingtin homolog 0.0125 0.0283 0.0543
Echinococcus multilocularis lamin 0.0053 0.0072 0.0068
Schistosoma mansoni hypothetical protein 0.0046 0.0052 0.0048
Schistosoma mansoni hypothetical protein 0.0169 0.0411 0.0406
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0014 0.0009
Echinococcus granulosus survival motor neuron protein 1 0.0743 0.2087 0.2083
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0101 0.0097
Echinococcus multilocularis GPCR, family 2 0.0046 0.0052 0.0048
Entamoeba histolytica hypothetical protein 0.0073 0.0129 0.0416
Loa Loa (eye worm) MBCTL1 0.0054 0.0075 0.0146
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0054 0.0258
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0038
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.021 0.1006
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0033 0.0065
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0072 0.0141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0033 0.0029
Echinococcus multilocularis lamin dm0 0.0053 0.0072 0.0068
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0054 0.0165
Onchocerca volvulus 0.0049 0.0059 0.0106
Schistosoma mansoni hypothetical protein 0.0152 0.0359 0.0355
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1755 0.5039 0.9828
Brugia malayi phosphoglycerate mutase family protein 0.003 0.0005 0.0022
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0065
Loa Loa (eye worm) phosphoglycerate mutase 0.003 0.0005 0.0009
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.1785 0.5127 0.5125
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0052 0.0048
Schistosoma mansoni smad1 5 8 and 0.0033 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.017 0.0412 0.0803
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0075 0.007
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0054 0.0258
Mycobacterium leprae Probable lipase LipE 0.004 0.0033 0.5811
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.0465 0.046
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0056 0.0051
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0033 0.0436
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.0346 0.1656
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0014 0.0136
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0033 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0101 0.0097
Brugia malayi MH2 domain containing protein 0.0033 0.0014 0.0068
Brugia malayi MH2 domain containing protein 0.049 0.1347 0.6455
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1755 0.5039 0.9828
Echinococcus granulosus Smad4 0.0033 0.0014 0.0009
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1785 0.5127 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0075 0.0359
Mycobacterium leprae conserved hypothetical protein 0.004 0.0033 0.5811
Brugia malayi hypothetical protein 0.0743 0.2087 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0129 0.0124
Onchocerca volvulus 0.0053 0.0072 0.0132
Mycobacterium tuberculosis Conserved protein 0.004 0.0033 0.0436
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0054 0.0096
Brugia malayi TAR-binding protein 0.0063 0.0101 0.0486
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0033 0.0096
Giardia lamblia Hypothetical protein 0.1053 0.2992 0.5
Loa Loa (eye worm) RNA binding protein 0.0063 0.0101 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0101 0.0097
Entamoeba histolytica hypothetical protein 0.0073 0.0129 0.0416
Echinococcus granulosus geminin 0.0169 0.0411 0.0406
Echinococcus granulosus lamin dm0 0.0053 0.0072 0.0068
Schistosoma mansoni hypothetical protein 0.0073 0.0129 0.0124
Loa Loa (eye worm) transcription factor SMAD2 0.049 0.1347 0.2627
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0014 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0009
Brugia malayi MH2 domain containing protein 0.0033 0.0014 0.0068
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0014 0.0009
Onchocerca volvulus 0.0048 0.0056 0.01
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0038
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0056 0.0051
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.1755 0.5039 0.9828
Loa Loa (eye worm) hypothetical protein 0.0147 0.0346 0.0674
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0054 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0101 0.0097
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0033 0.0056
Echinococcus multilocularis tumor protein p63 0.0332 0.0887 0.0883
Loa Loa (eye worm) hypothetical protein 0.0125 0.0283 0.0551
Brugia malayi Smad1 0.0033 0.0014 0.0068
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0033 0.0436
Echinococcus multilocularis microtubule associated protein 2 0.3454 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0009
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0056 0.01
Brugia malayi MH1 domain containing protein 0.0033 0.0014 0.0068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.0346 0.0674
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0014 0.0136
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0105
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0014 0.0009
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0033 0.0436
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0052 0.0251
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0075 0.007
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.0662 1
Giardia lamblia Hypothetical protein 0.1053 0.2992 0.5
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0054 0.0165
Loa Loa (eye worm) beta-lactamase 0.004 0.0033 0.0065
Onchocerca volvulus 0.004 0.0033 0.0056
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0054 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0014 0.0028
Schistosoma mansoni smad 0.0033 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0125 0.0283 0.0551
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0038
Mycobacterium ulcerans lipase LipD 0.004 0.0033 0.0096
Echinococcus multilocularis survival motor neuron protein 1 0.0743 0.2087 0.2083
Onchocerca volvulus 0.017 0.0412 0.0795
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0054 0.0165
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0033 1
Onchocerca volvulus 0.004 0.0033 0.0056
Schistosoma mansoni intermediate filament proteins 0.0053 0.0072 0.0068
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0054 0.0165
Echinococcus granulosus tar DNA binding protein 0.0063 0.0101 0.0097
Loa Loa (eye worm) hypothetical protein 0.01 0.021 0.0409
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0033 0.0436
Echinococcus granulosus smad 0.0033 0.0014 0.0009
Mycobacterium tuberculosis Conserved protein 0.004 0.0033 0.0436
Loa Loa (eye worm) hypothetical protein 0.0046 0.0052 0.0102
Brugia malayi MH1 domain containing protein 0.0033 0.0014 0.0068
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.1053 0.2992 1
Echinococcus multilocularis musashi 0.0053 0.0072 0.0068

Activities

Activity type Activity value Assay description Source Reference
Inhibition frequency index (IFI) (functional) = 2.92 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -4 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 10 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 96 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 99 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.61 XC50 determination of P. falciparum 3D7 growth GSK. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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