Detailed information for compound 602740

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 522.894 | Formula: C26H30Cl3N3O2
  • H donors: 2 H acceptors: 2 LogP: 5.95 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(/C=C/c1ccc(cc1)Cl)NCCCCCN1CCCC(C1)C(=O)Nc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C26H30Cl3N3O2/c27-21-9-6-19(7-10-21)8-13-25(33)30-14-2-1-3-15-32-16-4-5-20(18-32)26(34)31-22-11-12-23(28)24(29)17-22/h6-13,17,20H,1-5,14-16,18H2,(H,30,33)(H,31,34)/b13-8+
  • InChiKey: SDXRGTOIFTWANP-MDWZMJQESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0373 0.0712
Brugia malayi beta-lactamase family protein 0.0039 0.0116 0.0222
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0699 0.1335
Schistosoma mansoni intermediate filament proteins 0.0169 0.0729 0.0729
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0699 0.0699
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0007 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Schistosoma mansoni ferritin light chain 0.0043 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0056
Echinococcus multilocularis zinc finger protein 0.0019 0.0021 0.0021
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0019 0.0019
Leishmania major cathepsin L-like protease 0.0064 0.0233 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0101 0.0912
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0019 0.0035
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1692 0.7921 0.7921
Schistosoma mansoni bromodomain containing protein 0.0061 0.0221 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.003 0.0056
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0161 0.0691 0.0691
Mycobacterium leprae Probable lipase LipE 0.0039 0.0116 0.1754
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.003 0.003
Echinococcus granulosus tar DNA binding protein 0.1124 0.5237 0.5237
Echinococcus granulosus lamin dm0 0.0169 0.0729 0.0729
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0164 0.1147
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1429 0.3075
Brugia malayi RNA recognition motif domain containing protein 0.1124 0.5237 1
Mycobacterium ulcerans hypothetical protein 0.0049 0.0164 0.2471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0233 1
Echinococcus granulosus lamin 0.0169 0.0729 0.0729
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.003 0.0056
Brugia malayi TAR-binding protein 0.1124 0.5237 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0233 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0035
Echinococcus granulosus survival motor neuron protein 1 0.0782 0.3626 0.3626
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.003 0.0056
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.003 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0233 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.003 0.003
Schistosoma mansoni survival motor neuron protein 0.016 0.0685 0.0685
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0102 0.4379
Brugia malayi MH1 domain containing protein 0.0041 0.0126 0.024
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0116 0.025
Onchocerca volvulus 0.0126 0.0526 0.1132
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0142 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0508 0.2331 0.4451
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.003 0.0064
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0029 0.0548
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0011 0.0011
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0201
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0102 0.022
Brugia malayi MH1 domain containing protein 0.0041 0.0126 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.0556 0.0556
Schistosoma mansoni microtubule-associated protein tau 0.2132 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0164 0.2471
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.003 0.003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0082 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0222
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0121 0.0261
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0105 0.2
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0164 0.2471
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0116 0.1048
Trichomonas vaginalis ran, putative 0.0021 0.0029 0.0062
Echinococcus multilocularis geminin 0.0347 0.157 0.157
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0207 0.8879
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0024
Schistosoma mansoni hypothetical protein 0.0132 0.0556 0.0556
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0164 0.7028
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.003 0.003
Schistosoma mansoni hypothetical protein 0.002 0.0026 0.0026
Loa Loa (eye worm) nuclear factor I 0.0023 0.0039 0.0075
Brugia malayi MH2 domain containing protein 0.0603 0.2778 0.5306
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0121 0.1826
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0126 0.024
Onchocerca volvulus 0.0039 0.0116 0.025
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0046 0.0046
Brugia malayi MH1 domain containing protein 0.0023 0.0039 0.0075
Schistosoma mansoni lamin 0.0169 0.0729 0.0729
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0373 0.0373
Brugia malayi nuclear receptor NHR-88 0.0021 0.003 0.0056
Echinococcus granulosus histone lysine methyltransferase setb 0.0142 0.0604 0.0604
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0121 0.5192
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.1429 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0126 0.0526 1
Echinococcus multilocularis expressed protein 0.0043 0.0133 0.0133
Leishmania major GTP-binding protein, putative 0.0021 0.0029 0.1236
Plasmodium vivax vivapain-2 0.0017 0.0011 0.0208
Schistosoma mansoni apoferritin-2 0.0043 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0782 0.3626 0.6924
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0101 0.1527
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0164 0.1147
Loa Loa (eye worm) hypothetical protein 0.0169 0.0729 0.1393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0075
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0007 0.0007
Schistosoma mansoni ferritin light chain 0.0043 0.0133 0.0133
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0011 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0233 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0161 0.0691 0.0691
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0102 0.022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1429 0.3075
Loa Loa (eye worm) hypothetical protein 0.0078 0.0302 0.0577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0233 1
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0116 0.1754
Schistosoma mansoni ferritin 0.0043 0.0133 0.0133
Schistosoma mansoni tar DNA-binding protein 0.1124 0.5237 0.5237
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0029 0.0055
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0161 0.0691 0.0691
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0029 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.003 0.0056
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0116 0.025
Schistosoma mansoni apoferritin-2 0.0043 0.0133 0.0133
Echinococcus multilocularis tar DNA binding protein 0.1124 0.5237 0.5237
Onchocerca volvulus 0.016 0.0685 0.1475
Entamoeba histolytica Ran family GTPase 0.0021 0.0029 0.0202
Loa Loa (eye worm) hypothetical protein 0.0082 0.0317 0.0605
Schistosoma mansoni zinc finger protein 0.0019 0.0021 0.0021
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0046 0.0872
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0102 0.0195
Brugia malayi Intermediate filament tail domain containing protein 0.0169 0.0729 0.1393
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0011 0.0024
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0116 0.1048
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0046 0.0872
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0166 0.0715 0.1365
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0164 0.2471
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0302 0.0302
Schistosoma mansoni hypothetical protein 0.0161 0.0691 0.0691
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0161 0.0691 0.0691
Mycobacterium tuberculosis Conserved protein 0.0039 0.0116 0.1048
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0019 0.0019
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0011 0.047
Schistosoma mansoni ran 0.0021 0.0029 0.0029
Schistosoma mansoni smad 0.0041 0.0126 0.0126
Echinococcus granulosus expressed protein 0.0043 0.0133 0.0133
Schistosoma mansoni smad1 5 8 and 0.0041 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0222
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0161 0.0691 0.0691
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.003 0.0056
Schistosoma mansoni nuclear hormone receptor 0.0021 0.003 0.003
Echinococcus granulosus GPCR family 2 0.0161 0.0691 0.0691
Toxoplasma gondii ABC1 family protein 0.0039 0.0116 0.221
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0046 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1429 0.3075
Echinococcus multilocularis musashi 0.0169 0.0729 0.0729
Schistosoma mansoni inositol monophosphatase 0.004 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0161 0.0691 0.0691
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.047
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0121 0.5192
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0029 0.1236
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0201
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0046 0.0088
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0102 0.022
Schistosoma mansoni hypothetical protein 0.0015 0.0002 0.0002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0121 0.0504 0.0504
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.003 0.003
Brugia malayi hypothetical protein 0.0078 0.0302 0.0577
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0096 0.0096
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0029 0.0548
Loa Loa (eye worm) TAR-binding protein 0.1124 0.5237 1
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0013 0.0024
Loa Loa (eye worm) RNA binding protein 0.1124 0.5237 1
Schistosoma mansoni ferritin 0.0043 0.0133 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0233 1
Brugia malayi MH2 domain containing protein 0.0041 0.0126 0.024
Brugia malayi intermediate filament protein 0.0169 0.0729 0.1393
Onchocerca volvulus 0.0017 0.0011 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0153 0.0653 0.0653
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.003 0.0056
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0007 0.0013
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.1124 0.5237 1
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0233 1
Loa Loa (eye worm) ctsf protein 0.0017 0.0011 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.003 0.0056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1429 0.3075
Loa Loa (eye worm) inositol-1 0.004 0.0121 0.0231
Echinococcus multilocularis GPCR, family 2 0.0161 0.0691 0.0691
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.003 0.003
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0096 0.0096
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0116 0.0222
Schistosoma mansoni smad1 5 8 and 0.0041 0.0126 0.0126
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0102 0.022
Echinococcus multilocularis cysteine protease 0.0017 0.0011 0.0011
Schistosoma mansoni importin beta-1 0.0028 0.0064 0.0064
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0011 0.0011
Mycobacterium ulcerans lipase LipD 0.0039 0.0116 0.1754
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0024
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0121 0.0261
Schistosoma mansoni Smad4 0.0018 0.0019 0.0019
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.003 0.003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0105 0.1587
Loa Loa (eye worm) hypothetical protein 0.0041 0.0127 0.0242
Brugia malayi isocitrate dehydrogenase 0.0016 0.0007 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0164 0.7028
Loa Loa (eye worm) hypothetical protein 0.0347 0.1572 0.3001
Plasmodium falciparum importin beta, putative 0.0028 0.0064 0.6042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0096 0.0863
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0019 0.0035
Echinococcus granulosus geminin 0.0347 0.157 0.157
Loa Loa (eye worm) hypothetical protein 0.0039 0.0118 0.0225
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0102 0.022
Leishmania major importin beta-1 subunit, putative 0.0023 0.0039 0.1659
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0011 0.0024
Brugia malayi Pre-SET motif family protein 0.0126 0.0526 0.1005
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0116 0.1048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.003 0.003
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0064 0.0064
Onchocerca volvulus 0.0017 0.0011 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0102 0.4379
Onchocerca volvulus 0.0169 0.0729 0.1569
Onchocerca volvulus 0.0017 0.0011 0.0024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0161 0.0691 0.1319
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0011 0.0077
Trichomonas vaginalis ferritin, putative 0.0043 0.0133 0.0287
Loa Loa (eye worm) cysteine protease 0.0017 0.0011 0.0021
Loa Loa (eye worm) intermediate filament protein 0.0169 0.0729 0.1393
Echinococcus multilocularis Smad4 0.0041 0.0126 0.0126
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0046 0.4359
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0056
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0164 0.2471
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0078 0.0302 0.0577
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.047
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0222
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0056
Echinococcus granulosus smad 0.0041 0.0126 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.003 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0096 0.0863
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0011 0.0011
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0035 0.0035
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.047
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0011 0.0024
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.003 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0116 0.4987
Echinococcus granulosus intermediate filament protein 0.0169 0.0729 0.0729
Onchocerca volvulus 0.0049 0.0164 0.0353
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0878 0.4076 0.7783
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0126 0.0526 0.0526
Onchocerca volvulus 0.0017 0.0011 0.0024
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0043 0.0133 0.1201
Brugia malayi Latrophilin receptor protein 2 0.0161 0.0691 0.1319
Echinococcus granulosus FTZ F1 alpha 0.0021 0.003 0.003
Echinococcus multilocularis microtubule associated protein 2 0.2132 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.003 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.003 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.003 0.0056
Trichomonas vaginalis chaperonin, putative 0.0024 0.0046 0.0099
Echinococcus multilocularis cysteine protease 0.0017 0.0011 0.0011
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.003 0.003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0007 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0096 0.0863
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0699 0.1335
Schistosoma mansoni tar DNA-binding protein 0.1124 0.5237 0.5237
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0046 0.1967
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0011 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1429 0.3075
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0046 0.1967
Echinococcus multilocularis lamin 0.0169 0.0729 0.0729
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.003 0.0056
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0116 0.025
Loa Loa (eye worm) hypothetical protein 0.0161 0.0691 0.1319
Schistosoma mansoni alpha-glucosidase 0.014 0.0592 0.0592
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0134
Schistosoma mansoni ferritin 0.0043 0.0133 0.0133
Plasmodium vivax SET domain protein, putative 0.0126 0.0526 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0043 0.0133 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.0663 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0021
Echinococcus multilocularis snurportin 1 0.0298 0.1338 0.1338
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0205 0.0205
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.047
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0373 0.0712
Mycobacterium tuberculosis Conserved protein 0.0039 0.0116 0.1048
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0699 0.0699
Leishmania major cathepsin L-like protease 0.0017 0.0011 0.047
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.003 0.0056
Schistosoma mansoni tar DNA-binding protein 0.1124 0.5237 0.5237
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0024
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0029 0.0029
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0039 0.0083
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.001 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0169 0.0729 0.1393
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0046 0.0046
Brugia malayi beta-lactamase family protein 0.0039 0.0116 0.0222
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0164 0.1476
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.003 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0116 0.025
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0043 0.0133 0.1201
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.003 0.0064
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0102 0.0195
Onchocerca volvulus 0.0039 0.0116 0.025
Loa Loa (eye worm) MH2 domain-containing protein 0.0603 0.2778 0.5306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0373 0.0373
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0126 0.0526 0.0526
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0011 0.0021
Mycobacterium ulcerans beta-lactamase 0.0039 0.0116 0.1754
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0699 0.0699
Trypanosoma brucei glucosidase, putative 0.0036 0.0102 0.4379
Mycobacterium ulcerans hypothetical protein 0.0039 0.0116 0.1754
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0102 0.0715
Schistosoma mansoni hypothetical protein 0.0347 0.157 0.157
Onchocerca volvulus 0.0094 0.0376 0.0808
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0508 0.2331 0.4451
Loa Loa (eye worm) hypothetical protein 0.0142 0.0604 0.1154
Schistosoma mansoni Smad4 0.0041 0.0126 0.0126
Echinococcus multilocularis lamin dm0 0.0169 0.0729 0.0729
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0169 0.7234
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0046 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0373 0.0373
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0029 0.1236
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.003 0.003
Leishmania major cathepsin L-like protease 0.0064 0.0233 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0164 0.7028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0164 0.1476
Echinococcus granulosus Smad4 0.0041 0.0126 0.0126
Brugia malayi RNA, U transporter 1 0.0079 0.0306 0.0585
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0164 0.2471
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0105 0.0948
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0007 0.0134
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0201
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0164 0.2471
Loa Loa (eye worm) transcription factor SMAD2 0.0603 0.2778 0.5306
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0126 0.024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.003 0.003
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0078 0.0302 0.0302
Onchocerca volvulus 0.0039 0.0116 0.025
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0056
Trypanosoma brucei ISWI complex protein 0.0015 0.0002 0.0075
Brugia malayi nuclear hormone receptor 0.0021 0.003 0.0056
Trichomonas vaginalis esterase, putative 0.0039 0.0116 0.025
Schistosoma mansoni hypothetical protein 0.0161 0.0691 0.0691
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0142 0.0604 0.0604
Brugia malayi Bromodomain containing protein 0.0037 0.0107 0.0204
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0116 0.1048
Echinococcus granulosus ferritin 0.0043 0.0133 0.0133
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0302
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.003 0.0056
Schistosoma mansoni coup transcription factor 0.0021 0.003 0.003
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0035 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0164 0.2471
Onchocerca volvulus 0.0999 0.4648 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0011 0.0021
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0019 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0373 0.0373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Trichomonas vaginalis set domain proteins, putative 0.0999 0.4648 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0024
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0121 0.0261
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0046 0.0099
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0018 0.0019 0.004
Onchocerca volvulus 0.0021 0.003 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0142 0.0604 0.0604
Brugia malayi steroid hormone receptor 0.0021 0.003 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0164 0.0313
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0011 0.1042
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0222
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0116 0.0116
Onchocerca volvulus 0.0169 0.0729 0.1569
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0011 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.003 0.003
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0011 0.047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0233 1
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0116 0.1048
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0056
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0121 0.2301
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0021
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0102 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1429 0.3075
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0007 0.0007
Plasmodium vivax importin-beta 2, putative 0.0028 0.0064 0.1209
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0116 0.1048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0096 0.0863
Onchocerca volvulus 0.0017 0.0011 0.0024
Onchocerca volvulus 0.0017 0.0011 0.0024
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0233 1
Schistosoma mansoni tar DNA-binding protein 0.1124 0.5237 0.5237
Schistosoma mansoni cellular tumor antigen P53 0.0247 0.1099 0.1099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.003 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.003 0.003
Schistosoma mansoni smad 0.0018 0.0019 0.0019
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0121 0.0847
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0102 0.0715
Brugia malayi Pre-SET motif family protein 0.0878 0.4076 0.7783
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0026 0.005
Entamoeba histolytica cysteine protease, putative 0.0017 0.0011 0.0077
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0039 0.1659
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0024
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.1338 0.2555
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0019 0.0019
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0011 0.1042
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.003 0.003
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0021
Loa Loa (eye worm) fibroinase 0.0017 0.0011 0.0021
Entamoeba histolytica hypothetical protein 0.0023 0.0039 0.0271
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0233 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0313
Trypanosoma cruzi ISWI complex protein 0.0015 0.0002 0.0075
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0302 0.0302
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0046 0.0088
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0126 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.003 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0056
Leishmania major cathepsin L-like protease 0.0064 0.0233 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0039 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0233 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.003 0.003
Schistosoma mansoni inositol monophosphatase 0.004 0.0121 0.0121
Entamoeba histolytica hypothetical protein 0.0078 0.0302 0.2114
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0011 0.0011
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0205 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.003 0.0056
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0121 0.0121
Echinococcus granulosus zinc finger protein 0.0019 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.003 0.0056
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0102 0.022
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0011 0.0024
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.0663 0.5974
Brugia malayi latrophilin 2 splice variant baaae 0.0347 0.1572 0.3001
Entamoeba histolytica hypothetical protein 0.0078 0.0302 0.2114
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0347 0.1572 0.1572
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0046 0.1967
Echinococcus multilocularis tumor protein p63 0.1689 0.7905 0.7905
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0046 0.0321
Onchocerca volvulus 0.0017 0.0011 0.0024
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0007 0.0013
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0021
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0116 0.1048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.003 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1429 0.3075
Brugia malayi MH1 domain containing protein 0.0023 0.0039 0.0075
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0508 0.2331 0.4451
Schistosoma mansoni Smad4 0.0018 0.0019 0.0019
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0373 0.0373
Onchocerca volvulus 0.0247 0.1099 0.2364
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0116 0.1754
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0116 0.025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0039 0.0083
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0043 0.0133 0.201
Echinococcus granulosus tumor protein p63 0.1689 0.7905 0.7905
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.1429 0.3075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0233 1
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0164 0.0313
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0011 0.1042
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0116 0.4987
Echinococcus granulosus snurportin 1 0.0298 0.1338 0.1338
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0064 0.2727
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0021
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0116 0.0222
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0116 0.0116
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0075
Toxoplasma gondii cathepsin CPL 0.0017 0.0011 0.0208
Echinococcus granulosus importin subunit beta 1 0.0028 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0024
Echinococcus granulosus cathepsin l1 0.0017 0.0011 0.0011
Schistosoma mansoni ferritin 0.0043 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0298 0.1338 0.1338
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0302 0.0302
Schistosoma mansoni thyroid hormone receptor 0.0153 0.0653 0.0653
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0064 0.2727
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0011 0.0024
Brugia malayi hypothetical protein 0.0782 0.3626 0.6924
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0164 0.2471
Brugia malayi ecdysteroid receptor 0.0021 0.003 0.0056
Trypanosoma cruzi ISWI complex protein 0.0015 0.0002 0.0075
Brugia malayi Calcitonin receptor-like protein seb-1 0.0508 0.2331 0.4451
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0164 0.0313
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0164 0.1147
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0029 0.1236
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0233 1
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0116 0.221
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0102 0.022
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0222
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.001 0.001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0007 0.0063
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0134
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0233 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0007
Brugia malayi MH2 domain containing protein 0.0041 0.0126 0.024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0526 0.0526
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.003 0.003
Schistosoma mansoni alpha-glucosidase 0.014 0.0592 0.0592
Giardia lamblia Fructose-bisphosphate aldolase 0.0317 0.1429 1
Loa Loa (eye worm) Smad1 0.0041 0.0126 0.024
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0302
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0102 0.1941
Schistosoma mansoni hypothetical protein 0.016 0.0685 0.0685
Echinococcus multilocularis smad 0.0041 0.0126 0.0126
Mycobacterium tuberculosis Conserved protein 0.0039 0.0116 0.1048
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0105 0.5
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.009 0.0359 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.003 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0201
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0011 0.0011
Brugia malayi Importin beta-1 subunit 0.0028 0.0064 0.0121
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0126 0.0126
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0046 0.0046
Echinococcus multilocularis ferritin 0.0043 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0068 0.0255 0.0487
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0121 0.5192
Brugia malayi beta-lactamase 0.0039 0.0116 0.0222
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0102 0.022
Schistosoma mansoni smad1 5 8 and 0.0041 0.0126 0.0126
Echinococcus multilocularis survival motor neuron protein 1 0.0782 0.3626 0.3626
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0019 0.0035
Schistosoma mansoni alpha glucosidase 0.0036 0.0102 0.0102
Brugia malayi PHD-finger family protein 0.0024 0.0046 0.0087
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0007 0.0669
Loa Loa (eye worm) hypothetical protein 0.0039 0.0116 0.0222
Schistosoma mansoni hypothetical protein 0.0347 0.157 0.157
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0056
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0102 0.0102
Schistosoma mansoni tar DNA-binding protein 0.1124 0.5237 0.5237
Brugia malayi cytoplasmic intermediate filament protein 0.009 0.0359 0.0686
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.003 0.0056
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.003 0.003
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0029 0.0029
Schistosoma mansoni zinc finger protein 0.0015 0.0002 0.0002
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.001 0.001
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0116 0.4987
Echinococcus multilocularis thyroid hormone receptor alpha 0.0153 0.0653 0.0653
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0021
Mycobacterium ulcerans bacterioferritin BfrB 0.0043 0.0133 0.201
Loa Loa (eye worm) hypothetical protein 0.0247 0.1099 0.2098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.003 0.0056
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0046 0.0088
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0116 0.0116
Brugia malayi Smad1 0.0041 0.0126 0.024
Schistosoma mansoni ran 0.0021 0.0029 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0164 0.2471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Mycobacterium ulcerans bacterioferritin BfrA 0.0043 0.0133 0.201
Brugia malayi MH2 domain containing protein 0.0018 0.0019 0.0035
Entamoeba histolytica hypothetical protein 0.0078 0.0302 0.2114
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0064 0.1209
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0007 0.0007
Brugia malayi Inositol-1 0.004 0.0121 0.0231
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.003 0.0056
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0082 0.0317 0.0317
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0105 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.0663 1
Plasmodium vivax vivapain-2 0.0017 0.0011 0.0208
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0046 0.0046
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.111 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0011 0.0024
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0029 0.2738
Brugia malayi Cathepsin L-like precursor 0.0017 0.0011 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.003 0.0056
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.1429 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0116 0.1754
Loa Loa (eye worm) beta-lactamase 0.0039 0.0116 0.0222
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0121 0.5192
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0126 0.0126
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.016 0.0685 0.1309
Schistosoma mansoni lamin 0.0169 0.0729 0.0729
Treponema pallidum fructose-bisphosphate aldolase 0.0317 0.1429 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0121
Entamoeba histolytica hypothetical protein 0.0078 0.0302 0.2114
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0313
Leishmania major hypothetical protein, conserved 0.0039 0.0116 0.4987
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.003 0.0056
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0107 0.0205
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.003 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0161 0.0691 0.1319
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0102 0.4379
Brugia malayi RNA binding protein 0.1124 0.5237 1
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0011 0.0077
Brugia malayi Bromodomain containing protein 0.0073 0.0275 0.0524
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0233 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0102 0.022

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 0.22 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 1.59 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 1.61 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 3 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 27 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 96 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 12.15 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -3 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 3 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 27 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 96 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.08 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.83295 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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