Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0096 | 0.0266 | 0.5255 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0042 | 0.0078 | 0.0078 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0058 | 0.0169 |
Schistosoma mansoni | ferritin light chain | 0.0043 | 0.008 | 0.008 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.0441 | 0.0441 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0181 | 0.0496 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0093 | 0.0257 | 0.0257 |
Schistosoma mansoni | apoferritin-2 | 0.0043 | 0.008 | 0.008 |
Schistosoma mansoni | alpha-glucosidase | 0.0142 | 0.0427 | 0.0427 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0025 | 0.0015 | 0.0041 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.1059 | 0.415 |
Echinococcus granulosus | Smad4 | 0.0042 | 0.0078 | 0.0078 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0096 | 0.0266 | 0.2404 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0093 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.1548 | 0.4244 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.051 | 0.1398 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0156 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0096 | 0.0266 | 0.0729 |
Schistosoma mansoni | microtubule-associated protein tau | 0.2868 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0169 | 0.0521 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0181 | 0.0496 |
Onchocerca volvulus | 0.0169 | 0.0521 | 0.2059 | |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0025 | 0.0015 | 0.0015 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0068 | 0.2198 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0028 | 0.0028 | 0.0514 |
Onchocerca volvulus | 0.0253 | 0.0818 | 0.3232 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0156 | 1 |
Brugia malayi | Inositol-1 | 0.0041 | 0.0072 | 0.0197 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0146 | 0.0441 | 0.121 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0068 | 0.0068 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0058 | 0.0407 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0068 | 0.0211 |
Echinococcus granulosus | expressed protein | 0.0043 | 0.008 | 0.008 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0146 | 0.0441 | 0.0441 |
Mycobacterium ulcerans | hypothetical protein | 0.0096 | 0.0266 | 0.5255 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0068 | 0.0672 |
Echinococcus granulosus | geminin | 0.0505 | 0.1704 | 0.1704 |
Onchocerca volvulus | 0.0028 | 0.0028 | 0.0111 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.0197 | 0.0197 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0096 | 0.0266 | 0.5255 |
Schistosoma mansoni | apoferritin-2 | 0.0043 | 0.008 | 0.008 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0051 | 0.0108 | 0.6557 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0156 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0197 | 0.0197 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0068 | 0.0888 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0156 | 1 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0028 | 0.0028 | 0.0913 |
Brugia malayi | beta-lactamase | 0.004 | 0.0068 | 0.0187 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0093 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0068 | 0.0187 |
Trichomonas vaginalis | set domain proteins, putative | 0.0741 | 0.2531 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0043 | 0.008 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0028 | 0.0077 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0028 | 0.0171 |
Schistosoma mansoni | ferritin | 0.0043 | 0.008 | 0.008 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0093 | 0.0257 | 0.0257 |
Brugia malayi | MH2 domain containing protein | 0.0042 | 0.0078 | 0.0213 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0461 | 0.1548 | 0.4244 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0197 | 0.1746 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0028 | 0.0028 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.1036 | 0.2839 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.0072 | 0.0968 |
Brugia malayi | AMP-binding enzyme family protein | 0.0096 | 0.0266 | 0.0729 |
Echinococcus granulosus | GPCR family 2 | 0.0146 | 0.0441 | 0.0441 |
Leishmania major | cathepsin L-like protease | 0.0065 | 0.0156 | 0.5632 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0096 | 0.0266 | 0.5255 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0262 | 0.0262 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0025 | 0.0015 | 0.0015 |
Brugia malayi | intermediate filament protein | 0.0169 | 0.0521 | 0.1428 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0025 | 0.0015 | 0.0041 |
Brugia malayi | RNA binding protein | 0.1059 | 0.3648 | 1 |
Leishmania major | cathepsin L-like protease | 0.0065 | 0.0156 | 0.5632 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0028 | 0.0028 | 0.0077 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0043 | 0.008 | 0.0819 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0068 | 0.2198 |
Echinococcus granulosus | smad | 0.0042 | 0.0078 | 0.0078 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0042 | 0.0078 | 0.0078 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0146 | 0.0441 | 0.0441 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0651 | 0.2215 | 0.6072 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0065 | 0.0156 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0028 | 0.0028 | 0.0913 |
Echinococcus granulosus | intermediate filament protein | 0.0169 | 0.0521 | 0.0521 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0028 | 0.0028 | 0.0171 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0315 | 0.1036 | 0.2839 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0068 | 0.0187 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.1059 | 0.415 |
Schistosoma mansoni | thyroid hormone receptor | 0.0145 | 0.0436 | 0.0436 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0068 | 0.0211 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0072 | 0.4015 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0262 | 0.0262 |
Trypanosoma brucei | glucosidase, putative | 0.0037 | 0.0058 | 0.3004 |
Brugia malayi | Pre-SET motif family protein | 0.0651 | 0.2215 | 0.6072 |
Echinococcus granulosus | ferritin | 0.0043 | 0.008 | 0.008 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0028 | 0.0028 | 0.0779 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0146 | 0.0441 | 0.121 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0025 | 0.0015 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0365 | 0.0365 |
Echinococcus granulosus | lamin | 0.0169 | 0.0521 | 0.0521 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0072 | 0.0181 | 0.3374 |
Brugia malayi | MH1 domain containing protein | 0.0042 | 0.0078 | 0.0213 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0068 | 0.0672 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0043 | 0.008 | 0.1151 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0068 | 0.0167 | 0.1901 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0028 | 0.0028 | 0.0028 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0037 | 0.0058 | 0.1692 |
Schistosoma mansoni | alpha glucosidase | 0.0037 | 0.0058 | 0.0058 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0028 | 0.0077 |
Echinococcus multilocularis | expressed protein | 0.0043 | 0.008 | 0.008 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0028 | 0.0028 | 0.0124 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0156 | 1 |
Onchocerca volvulus | 0.004 | 0.0068 | 0.027 | |
Schistosoma mansoni | ferritin | 0.0043 | 0.008 | 0.008 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0059 | 0.0137 | 0.8604 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0058 | 0.3004 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0058 | 0.0169 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0197 | 0.1746 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0156 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0068 | 0.0888 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0096 | 0.0266 | 0.5255 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0096 | 0.0266 | 0.5255 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0028 | 0.0028 | 0.0051 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.0156 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.0072 | 0.0544 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0093 | 0.0257 | 0.0257 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.0262 | 0.0262 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0072 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0266 | 0.0729 |
Onchocerca volvulus | 0.0169 | 0.0521 | 0.2059 | |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0028 | 0.0028 | 0.0171 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0068 | 0.0187 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0754 | 0.2578 | 0.2578 |
Schistosoma mansoni | ferritin | 0.0043 | 0.008 | 0.008 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0072 | 0.0226 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0058 | 0.0169 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0521 | 0.1428 |
Onchocerca volvulus | 0.004 | 0.0068 | 0.027 | |
Echinococcus multilocularis | Smad4 | 0.0042 | 0.0078 | 0.0078 |
Echinococcus multilocularis | musashi | 0.0169 | 0.0521 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0068 | 0.0187 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0028 | 0.0028 | 0.0534 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0181 | 0.0496 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0215 | 0.0589 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0028 | 0.0171 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0028 | 0.0028 | 0.0171 |
Brugia malayi | MH1 domain containing protein | 0.0042 | 0.0078 | 0.0213 |
Toxoplasma gondii | propionate-CoA ligase | 0.0028 | 0.0028 | 0.0534 |
Schistosoma mansoni | tar DNA-binding protein | 0.1059 | 0.3648 | 0.3648 |
Echinococcus multilocularis | tumor protein p63 | 0.1729 | 0.6001 | 0.6001 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0266 | 0.0729 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0028 | 0.0077 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0096 | 0.0266 | 0.5255 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0156 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0068 | 0.3761 |
Echinococcus multilocularis | GPCR, family 2 | 0.0146 | 0.0441 | 0.0441 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0028 | 0.0028 | 0.0171 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0068 | 0.2118 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0156 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.0197 | 0.0197 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.1059 | 0.415 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0028 | 0.0028 | 0.0913 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0072 | 0.4015 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0042 | 0.0078 | 0.0213 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.009 | 0.0246 | 0.0675 |
Brugia malayi | MH2 domain containing protein | 0.0042 | 0.0078 | 0.0213 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0096 | 0.0266 | 0.2404 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.0441 | 0.121 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0093 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0621 | 0.2109 | 0.5783 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.009 | 0.0246 | 0.0675 |
Loa Loa (eye worm) | Smad1 | 0.0042 | 0.0078 | 0.0213 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0028 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0181 | 0.0496 |
Echinococcus multilocularis | lamin dm0 | 0.0169 | 0.0521 | 0.0521 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0072 | 0.0181 | 0.2072 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0072 | 0.0181 | 0.5 |
Echinococcus multilocularis | lamin | 0.0169 | 0.0521 | 0.0521 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0754 | 0.2578 | 0.2578 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0165 | 0.0508 | 0.0508 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0169 | 0.0521 | 0.1428 |
Schistosoma mansoni | hypothetical protein | 0.0505 | 0.1704 | 0.1704 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0257 | 0.0704 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0025 | 0.0015 | 0.0015 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0096 | 0.0266 | 0.5255 |
Onchocerca volvulus | 0.0096 | 0.0266 | 0.1051 | |
Brugia malayi | Smad1 | 0.0042 | 0.0078 | 0.0213 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0042 | 0.0078 | 0.0078 |
Onchocerca volvulus | 0.0093 | 0.0257 | 0.1015 | |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0058 | 0.0407 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0253 | 0.0818 | 0.0818 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0081 | 0.0215 | 0.0215 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0068 | 0.0672 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0068 | 0.3761 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0322 | 0.1059 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0253 | 0.0818 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.0072 | 0.2347 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0028 | 0.0028 | 0.0514 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0068 | 0.0888 |
Loa Loa (eye worm) | nuclear factor I | 0.0023 | 0.0011 | 0.0031 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0068 | 0.0187 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0096 | 0.0266 | 0.2404 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.0441 | 0.0441 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.0441 | 0.0441 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0068 | 0.0672 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0146 | 0.0441 | 0.0441 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0068 | 0.0211 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0028 | 0.0077 |
Schistosoma mansoni | alpha-glucosidase | 0.0142 | 0.0427 | 0.0427 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0093 | 0.0257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0068 | 0.0187 |
Loa Loa (eye worm) | oxidoreductase | 0.0028 | 0.0028 | 0.0077 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0154 | 0.0469 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0068 | 0.0187 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0197 | 0.1746 |
Brugia malayi | RNA recognition motif domain containing protein | 0.1059 | 0.3648 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.0072 | 0.0072 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0068 | 0.0888 |
Loa Loa (eye worm) | RNA binding protein | 0.1059 | 0.3648 | 1 |
Onchocerca volvulus | 0.0028 | 0.0028 | 0.0111 | |
Schistosoma mansoni | ferritin | 0.0043 | 0.008 | 0.008 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0068 | 0.0888 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.1059 | 0.415 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.0262 | 0.0718 |
Echinococcus multilocularis | smad | 0.0042 | 0.0078 | 0.0078 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.0441 | 0.0441 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0042 | 0.0078 | 0.0078 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0037 | 0.0058 | 0.0058 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0197 | 0.1746 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.0365 | 0.0365 |
Onchocerca volvulus | 0.0095 | 0.0264 | 0.1043 | |
Brugia malayi | MH1 domain containing protein | 0.0023 | 0.0011 | 0.0031 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0068 | 0.0068 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.0262 | 0.0262 |
Onchocerca volvulus | 0.0028 | 0.0028 | 0.0111 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.0818 | 0.2242 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0068 | 0.0672 |
Brugia malayi | TAR-binding protein | 0.1059 | 0.3648 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0096 | 0.0266 | 0.5255 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0461 | 0.1548 | 0.4244 |
Brugia malayi | Pre-SET motif family protein | 0.0093 | 0.0257 | 0.0704 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0156 | 1 |
Onchocerca volvulus | 0.004 | 0.0068 | 0.027 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0068 | 0.0211 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0043 | 0.008 | 0.1151 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0068 | 0.0672 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0037 | 0.0058 | 0.0158 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0096 | 0.0266 | 0.3132 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0204 | 0.0559 |
Echinococcus multilocularis | geminin | 0.0505 | 0.1704 | 0.1704 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0058 | 0.0169 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.0262 | 0.0262 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0068 | 0.0888 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.0156 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0068 | 0.0211 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0037 | 0.0058 | 0.0058 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.009 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.0262 | 0.0718 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0068 | 0.0187 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0072 | 0.4015 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0028 | 0.0028 | 0.0077 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0096 | 0.0266 | 0.5255 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0028 | 0.0077 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.0057 | 0.0638 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0037 | 0.0058 | 0.0169 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0461 | 0.1548 | 0.4244 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.1059 | 0.415 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0068 | 0.3761 |
Schistosoma mansoni | thyroid hormone receptor | 0.0145 | 0.0436 | 0.0436 |
Brugia malayi | MH1 domain containing protein | 0.0023 | 0.0011 | 0.0031 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0165 | 0.0508 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0068 | 0.0187 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0072 | 0.0181 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0058 | 0.0169 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0157 | 0.0481 | 1 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0028 | 0.0028 | 0.0028 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.2868 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0068 | 0.0167 | 0.1901 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0096 | 0.0266 | 0.3132 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0043 | 0.008 | 0.1151 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.1059 | 0.415 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0058 | 0.1756 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0181 | 0.0496 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0068 | 0.0167 | 0.1901 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0028 | 0.0028 | 0.0028 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.0365 | 0.0365 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0028 | 0.0028 | 0.0514 |
Schistosoma mansoni | survival motor neuron protein | 0.0154 | 0.0469 | 0.0469 |
Echinococcus granulosus | lamin dm0 | 0.0169 | 0.0521 | 0.0521 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0068 | 0.0672 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0028 | 0.0028 | 0.0051 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.0072 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0266 | 0.0729 |
Plasmodium vivax | SET domain protein, putative | 0.0093 | 0.0257 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0157 | 0.0481 | 0.5805 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0156 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0505 | 0.1704 | 0.1704 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0025 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0204 | 0.0559 |
Onchocerca volvulus | 0.0741 | 0.2531 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.0262 | 0.0262 |
Trichomonas vaginalis | ferritin, putative | 0.0043 | 0.008 | 0.0259 |
Loa Loa (eye worm) | intermediate filament protein | 0.0169 | 0.0521 | 0.1428 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0322 | 0.1059 | 1 |
Brugia malayi | hypothetical protein | 0.0754 | 0.2578 | 0.7067 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0028 | 0.0028 | 0.0913 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0068 | 0.0672 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0058 | 0.0169 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0028 | 0.0028 | 0.0171 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0072 | 0.0072 |
Schistosoma mansoni | Smad4 | 0.0042 | 0.0078 | 0.0078 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0028 | 0.0028 | 0.0534 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0028 | 0.0028 | 0.0913 |
Loa Loa (eye worm) | TAR-binding protein | 0.1059 | 0.3648 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0093 | 0.0257 | 0.0257 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0072 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0068 | 0.0187 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0068 | 0.0167 | 0.1901 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0145 | 0.0436 | 0.0436 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0011 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0028 | 0.0077 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0072 | 0.2261 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0165 | 0.0508 | 0.1393 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0028 | 0.0028 | 0.0077 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0157 | 0.0481 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.0072 | 0.0197 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0146 | 0.0441 | 0.121 |
Leishmania major | cathepsin L-like protease | 0.0065 | 0.0156 | 0.5632 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.0156 | 1 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0028 | 0.0028 | 0.0171 |
Schistosoma mansoni | tar DNA-binding protein | 0.1059 | 0.3648 | 0.3648 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0.0072 | 0.0226 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.0057 | 0.053 |
Echinococcus granulosus | tar DNA binding protein | 0.1059 | 0.3648 | 0.3648 |
Loa Loa (eye worm) | hypothetical protein | 0.0754 | 0.2578 | 0.7067 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0072 | 0.0181 | 0.6855 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0262 | 0.0262 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0037 | 0.0058 | 0.0169 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0165 | 0.0508 | 0.1393 |
Schistosoma mansoni | smad1 5 8 and | 0.0042 | 0.0078 | 0.0078 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0096 | 0.0266 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0058 | 0.0169 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0068 | 0.0888 |
Echinococcus multilocularis | ferritin | 0.0043 | 0.008 | 0.008 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0028 | 0.0028 | 0.0534 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0068 | 0.0068 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0028 | 0.0028 | 0.0171 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0043 | 0.008 | 0.0819 |
Schistosoma mansoni | ferritin light chain | 0.0043 | 0.008 | 0.008 |
Schistosoma mansoni | smad | 0.0042 | 0.0078 | 0.0078 |
Echinococcus multilocularis | tar DNA binding protein | 0.1059 | 0.3648 | 0.3648 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0165 | 0.0508 | 0.0508 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0197 | 0.0541 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.1059 | 0.415 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0081 | 0.0215 | 0.0215 |
Schistosoma mansoni | smad1 5 8 and | 0.0042 | 0.0078 | 0.0078 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0058 | 0.3004 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0322 | 0.1059 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0068 | 0.0672 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0068 | 0.0068 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.0156 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0169 | 0.0521 | 0.1428 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0068 | 0.0211 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0042 | 0.0078 | 0.0078 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.1059 | 0.415 |
Schistosoma mansoni | lamin | 0.0169 | 0.0521 | 0.0521 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.0469 | 0.0469 |
Brugia malayi | MH2 domain containing protein | 0.0621 | 0.2109 | 0.5783 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0096 | 0.0266 | 1 |
Onchocerca volvulus | 0.0154 | 0.0469 | 0.1854 | |
Schistosoma mansoni | smad1 5 8 and | 0.0042 | 0.0078 | 0.0078 |
Schistosoma mansoni | tar DNA-binding protein | 0.1059 | 0.3648 | 0.3648 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0621 | 0.2109 | 0.5783 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0146 | 0.0441 | 0.0441 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.2439 | 0.8492 | 0.8492 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0068 | 0.0187 |
Schistosoma mansoni | tar DNA-binding protein | 0.1059 | 0.3648 | 0.3648 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0025 | 0.0015 | 0.0041 |
Schistosoma mansoni | tar DNA-binding protein | 0.1059 | 0.3648 | 0.3648 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0068 | 0.0672 |
Schistosoma mansoni | lamin | 0.0169 | 0.0521 | 0.0521 |
Brugia malayi | AMP-binding enzyme family protein | 0.0096 | 0.0266 | 0.0729 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.1059 | 0.3648 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0037 | 0.0058 | 0.0158 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0042 | 0.0078 | 0.0213 |
Schistosoma mansoni | hypothetical protein | 0.0315 | 0.1036 | 0.1036 |
Onchocerca volvulus | 0.0028 | 0.0028 | 0.0111 | |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0096 | 0.0266 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0322 | 0.1059 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0028 | 0.0028 | 0.0913 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0028 | 0.0171 |
Echinococcus granulosus | tumor protein p63 | 0.1729 | 0.6001 | 0.6001 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 3.16 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.86 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 5.28 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 15 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 99 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 2.1 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 0 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 4 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 15 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 99 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.82 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.50962 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.